CN106539972A - It is a kind of to treat medicine of nasopharyngeal carcinoma and preparation method thereof - Google Patents

It is a kind of to treat medicine of nasopharyngeal carcinoma and preparation method thereof Download PDF

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CN106539972A
CN106539972A CN201611136291.2A CN201611136291A CN106539972A CN 106539972 A CN106539972 A CN 106539972A CN 201611136291 A CN201611136291 A CN 201611136291A CN 106539972 A CN106539972 A CN 106539972A
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董凤岩
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Abstract

The invention discloses a kind of treat medicine of nasopharyngeal carcinoma and preparation method thereof, which is to be prepared from by Radix Rehmanniae, Cortex Moutan, Marchantia polymorpha L., Radix Sophorae Tonkinensiss, Ramulus Uncariae Cum Uncis, Scorpio, Spica Prunellae, Retinervus Luffae Fructuss, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus according to a certain weight ratio, medicine of the present invention has clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, dredge the meridian passage, removing heat-phlegm, draw out pus by applying a plaster to the affected part, the function of liver heat removing eliminating stagnation, for treating nasopharyngeal carcinoma instant effect, good effect, does not recur.

Description

It is a kind of to treat medicine of nasopharyngeal carcinoma and preparation method thereof
Technical field
The present invention relates to a kind of treat medicine of nasopharyngeal carcinoma and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Nasopharyngeal carcinoma refers to the malignant tumor betided at the top of cavum nasopharyngeum with side wall.The traditional Chinese medical science then thinks that nasopharyngeal carcinoma is invaded with pyretic toxicity Attack, qi depression to blood stasis, the turbid interior life of expectorant is relevant.Due to western medicine large side effects, therefore Chinese medicine of the people to effectively treatment nasopharyngeal carcinoma There is great demand in medicine, up to now, it has not been found that with regard to the relevant report of the present invention.
The content of the invention
The present inventor have found effectively treatment nasopharynx finally according to the research and the checking repeatedly of clinical trial of theory of Chinese medical science The medicine of cancer, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment nasopharyngeal carcinoma.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention be select Radix Rehmanniae, Cortex Moutan, Marchantia polymorpha L., Radix Sophorae Tonkinensiss, Ramulus Uncariae Cum Uncis, Scorpio, Spica Prunellae, Retinervus Luffae Fructuss, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Caulis Spatholobi, Fructus Xanthii medicine are combined preparation, cause each efficacy of drugs to produce association these drug regimens Same-action such that it is able to effectively treatment nasopharyngeal carcinoma.Wherein it is because that its nature and flavor is sweet from Radix Rehmanniae, trembles with fear, GUIXIN, liver and kidney channel has Clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid control pyreticosis polydipsia, and yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, Heat Diabetes are spitted blood, and epistaxis sends out speckle Dermexanthesis.It is because that its nature and flavor is worked hard from Cortex Moutan, cool, enter the heart, liver and kidney channel have heat clearing away, removing heat from blood, and blood, the function of repercussive, The pathogenic heat attacking blood system in febrile diseases is controlled, speckle ， Jing Epilepsy is sent out, is told, is defeated in battle, has blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer flutter damage.It is because from Marchantia polymorpha L. Its nature and flavor is cool, and taste is scorching, has granulation promoting, draws out pus by applying a plaster to the affected part, the function of heat clearing away.It is because that its nature and flavor is bitter from Radix Sophorae Tonkinensiss, trembles with fear, enter the heart, lung, large intestine Three Jing, relieve inflammation or internal heat, and retropharyngeal abscess is controlled in removing toxic substances, detumescence, the function of pain relieving, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, under Dysentery, haemorrhoids, heat are swollen, tinea alba, scabies, Serpentiss, worm, lyssodexis.It is because that its nature and flavor is bitter from Ramulus Uncariae Cum Uncis, cool, enter liver, heart channel have clear Hot suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. control little Jing Epilepsy Chi Zong, and adult's slight Hypertension is dizzy, dizzy, married woman's eclampsia.From Scorpio It is because that its nature and flavor is salty pungent, puts down, it is poisonous, there is a wind-dispelling, relieving convulsion, dredging collateral, the function of removing toxic substances control convulsion with spasms ， epilepsy, apoplexy, and half Body is unsuccessful, and Kou Yan wo are oblique, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitiss, rubella sore swells.Which is because from Spica Prunellae Nature and flavor toil, trembles with fear, and enter liver, gallbladder meridian have liver heat removing, and the function of eliminating stagnation controls scrofula, goiter, acute mastitis, breast carcinoma, mesh pearl nyctalgia, photophobia stream Tear, the vertigo, facial hemiparalysiss, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.From Fructus Luffae Network is because that its nature and flavor is sweet, puts down, has dredge the meridian passage, and the function of removing heat-phlegm controls pain in chest and hypochondrium, stomachache, lumbago, painful and swollen testis, Lung-heat productive cough, women's amenorrhea, galactostasiss, carbuncle, anal fistula.It is because that its nature and flavor is bitter from Rhizoma Polygoni Cuspidati, puts down have wind-dispelling, dampness removing breaks The stasis of blood, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasises ， mass in the abdomen product Poly-, anal fistula hematochezia, injury from falling down are scalded, malignant boil tinea.It is because that its nature and flavor is pungent, salty from Bombyx Batryticatus, puts down, Return liver, lung meridian.Dispel Wind spasmolytic, dissipating phlegm and resolving masses.For apoplexy facial hemiparalysiss, twitch, head are grant, sore throat, scrofula tuberculosis, rubella erysipelas.From chicken Caulis seu Radix Schisandrae Henryi is because its nature and flavor bitter sweet, temperature, and enter the heart, two Jing of spleen have the function of promoting blood circulation, relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, the moon Jing is uncomfortable.It is because that its nature and flavor is sweet from Fructus Xanthii, temperature is poisonous, enters lung, Liver Channel, has scattered wind, pain relieving, damp eliminating, the work(of parasite killing Can, control headche due to wind-cold, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four foot spasm and pain, mange, prurituss.
Specific embodiment
The drug dose of instant component be also inventor through groping in a large number to summarize what is drawn, the consumption of each component is following heavy All there is in the range of amount preferable curative effect：
10-20 gram of Radix Rehmanniae, 5-15 gram of Cortex Moutan, 25-35 gram of Marchantia polymorpha L., 5-15 gram of Radix Sophorae Tonkinensiss, 10-20 gram of Ramulus Uncariae Cum Uncis, Scorpio 4- 8 grams, 10-20 gram of Spica Prunellae, 5-15 gram of Retinervus Luffae Fructuss, 25-35 gram of Rhizoma Polygoni Cuspidati, 5-15 gram of Bombyx Batryticatus, 25-35 gram of Caulis Spatholobi, Fructus Xanthii 5- 15 grams.
Preferably：
15 grams of Radix Rehmanniae, 10 grams of Cortex Moutan, 30 grams of Marchantia polymorpha L., 10 grams of Radix Sophorae Tonkinensiss, l5 gram of Ramulus Uncariae Cum Uncis, 6 grams of Scorpio, l5 gram of Spica Prunellae, 10 grams of Retinervus Luffae Fructuss, 30 grams of Rhizoma Polygoni Cuspidati, 10 grams of Bombyx Batryticatus, 30 grams of Caulis Spatholobi, 10 grams of Fructus Xanthii.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Radix Rehmanniae：Crude drug is taken, impurity is removed, is cleaned, is slightly moistened, cut sheet, be dried, weed out chip；
2nd, Cortex Moutan：Impurity is picked, core is removed, is cleaned, is run through, cut into slices, dry；
3rd, Marchantia polymorpha L.：Net impurity is picked, is dried；
4th, Radix Sophorae Tonkinensiss：Net impurity is picked, thickness stepping is soaked in water, pulls out, cut into slices after running through, dry；
5th, Ramulus Uncariae Cum Uncis：Old stalk, impurity are picked, is cleaned, is dried；
6th, Scorpio：Clear water floats the matter that desalts, and dries, or low baking temperature roasting is used；
7th, Spica Prunellae：Crude drug is taken, except discarding stalk, blade and impurity, grey bits is weeded out；
8th, Retinervus Luffae Fructuss：Clean and dry, cutting；
9th, Rhizoma Polygoni Cuspidati：Adopt after, smooth file is dried；
10th, Bombyx Batryticatus：Crude drug is taken, residual silk, impurity is removed；
11st, Caulis Spatholobi：Run through with water, cut into slices, or cut into slices after steaming is soft while hot, dried；
12nd, Fructus Xanthii：Most impurity is picked, deburring weeds out grey bits, and micro- stir-fry to yellow, taking-up are cooled.
2nd, prepare
1st, by the Radix Rehmanniae of the weight, Cortex Moutan, Marchantia polymorpha L., Radix Sophorae Tonkinensiss, Ramulus Uncariae Cum Uncis, Scorpio, Spica Prunellae, Retinervus Luffae Fructuss, Rhizoma Polygoni Cuspidati, deadlock Silkworm, Caulis Spatholobi, Fructus Xanthii are put in decocting container, are added water for the first time 6 times and are measured, and after soaking 100 minutes, are fried by intense fire to boil and are risen, then With being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, first time decoction liquor is poured in container；
2nd, the medicinal residues of filtration are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.
There is clearing away heat and cooling blood with Radix Rehmanniae in prescription, the function of YIN nourishing and the production of body fluid promoting is monarch drug；Retinervus Luffae Fructuss dredge the meridian passage, heat clearing away Expectorant；Marchantia polymorpha L. has granulation promoting, draws out pus by applying a plaster to the affected part, the function of heat clearing away, and the two is ministerial drug, and three taste medicines play clearing away heat and cooling blood jointly, and YIN nourishing and the production of body fluid promoting is led to Channels and activating collaterals, removing heat-phlegm are drawn out pus by applying a plaster to the affected part, the effect of granulation promoting, and treatment nasopharyngeal carcinoma effect is comprehensive, and with clearing away heat and cooling blood, dredge the meridian passage, heat clearing away Resolving sputum, draw out pus by applying a plaster to the affected part based on can effect a permanent cure, Spica Prunellae has liver heat removing eliminating stagnation function for adjuvant drug, and Rhizoma Polygoni Cuspidati has wind-dispelling, dampness removing, removing blood stasis with potent drugs, the work(for stimulating the menstrual flow Can be to make medicine, remaining all medicines are to take stopgap measures.
Medicine of the present invention has clearing away heat and cooling blood, and YIN nourishing and the production of body fluid promoting, dredge the meridian passage, removing heat-phlegm are drawn out pus by applying a plaster to the affected part, the work(of liver heat removing eliminating stagnation Can, for treating nasopharyngeal carcinoma, short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight are divided to two groups, 15 per group, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept nasopharyngeal carcinoma out-patient totally 27 for medical treatment.
2nd, diagnostic criteria
Classical symptom be tears blood, auditory dysesthesia, nasal obstruction, headache, visual disorder, severe patient is with cranial nerve lesions, organ failure Deng.
3rd, Therapeutic Method
From above-mentioned medicament, take to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 15 days a course for the treatment of, continuously Take 3 courses for the treatment of.
4th, efficacy assessment standard
It is effective：Nasopharynx cancerous symptom disappears, and body constitution recovers normal；
Take a turn for the better：Patient's tears blood, auditory dysesthesia, nasal obstruction, headache, the phenomenon of visual disorder mitigate, and nasopharynx cancerous symptom is clearly better, body Matter is progressively recovered；
It is invalid：Improvement standard person is not reached.
5th, therapeutic outcome（See the table below）
In above-mentioned treatment, with Drug therapy Nasopharyngeal Carcinoma Patients of the present invention 27, as a result effective 22, obvious effective rate is 81.49%, Take a turn for the better 3, improvement rate is 11.11%, and invalid 2, total effective rate is 92.6%.

Claims (3)

1. a kind of medicine for treating nasopharyngeal carcinoma, it is characterised in that：It is made up of the crude drug in following weight range：
10-20 gram of Radix Rehmanniae, 5-15 gram of Cortex Moutan, 25-35 gram of Marchantia polymorpha L., 5-15 gram of Radix Sophorae Tonkinensiss, 10-20 gram of Ramulus Uncariae Cum Uncis, Scorpio 4- 8 grams, 10-20 gram of Spica Prunellae, 5-15 gram of Retinervus Luffae Fructuss, 25-35 gram of Rhizoma Polygoni Cuspidati, 5-15 gram of Bombyx Batryticatus, 25-35 gram of Caulis Spatholobi, Fructus Xanthii 5- 15 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is：
15 grams of Radix Rehmanniae, 10 grams of Cortex Moutan, 30 grams of Marchantia polymorpha L., 10 grams of Radix Sophorae Tonkinensiss, l5 gram of Ramulus Uncariae Cum Uncis, 6 grams of Scorpio, l5 gram of Spica Prunellae, 10 grams of Retinervus Luffae Fructuss, 30 grams of Rhizoma Polygoni Cuspidati, 10 grams of Bombyx Batryticatus, 30 grams of Caulis Spatholobi, 10 grams of Fructus Xanthii.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Radix Rehmanniae：Crude drug is taken, impurity is removed, is cleaned, is slightly moistened, cut sheet, be dried, weed out chip；
（2）Cortex Moutan：Impurity is picked, core is removed, is cleaned, is run through, cut into slices, dry；
（3）Marchantia polymorpha L.：Net impurity is picked, is dried；
（4）Radix Sophorae Tonkinensiss：Net impurity is picked, thickness stepping is soaked in water, pulls out, cut into slices after running through, dry；
（5）Ramulus Uncariae Cum Uncis：Old stalk, impurity are picked, is cleaned, is dried；
（6）Scorpio：Clear water floats the matter that desalts, and dries, or low baking temperature roasting is used；
（7）Spica Prunellae：Crude drug is taken, except discarding stalk, blade and impurity, grey bits is weeded out；
（8）Retinervus Luffae Fructuss：Clean and dry, cutting；
（9）Rhizoma Polygoni Cuspidati：Adopt after, smooth file is dried；
（10）Bombyx Batryticatus：Crude drug is taken, residual silk, impurity is removed；
（11）Caulis Spatholobi：Run through with water, cut into slices, or cut into slices after steaming is soft while hot, dried；
（12）Fructus Xanthii：Most impurity is picked, deburring weeds out grey bits, and micro- stir-fry to yellow, taking-up are cooled；
（Two）Prepare
（1）By the Radix Rehmanniae of the weight, Cortex Moutan, Marchantia polymorpha L., Radix Sophorae Tonkinensiss, Ramulus Uncariae Cum Uncis, Scorpio, Spica Prunellae, Retinervus Luffae Fructuss, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Caulis Spatholobi, Fructus Xanthii are put in decocting container, are added water 6 times and are measured, and after immersion 100 minutes, are fried by intense fire to boil and are risen, then with text Fire is decocted 20 minutes, filters to obtain first time decoction liquor, first time decoction liquor is poured in container；
（2）The medicinal residues of filtration are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.
CN201611136291.2A 2016-12-12 2016-12-12 It is a kind of to treat medicine of nasopharyngeal carcinoma and preparation method thereof Withdrawn CN106539972A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679898A (en) * 2005-01-13 2005-10-12 刘桂香 Chinese medicine composition for treating hepatitis and cancers
CN104324280A (en) * 2014-11-24 2015-02-04 万海涛 Traditional Chinese medicine composition for treating nasopharynx cancer and preparation method of traditional Chinese medicine composition
CN104740061A (en) * 2015-03-09 2015-07-01 陆莎 Traditional Chinese medicine composition for treating nasopharyngeal carcinoma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1679898A (en) * 2005-01-13 2005-10-12 刘桂香 Chinese medicine composition for treating hepatitis and cancers
CN104324280A (en) * 2014-11-24 2015-02-04 万海涛 Traditional Chinese medicine composition for treating nasopharynx cancer and preparation method of traditional Chinese medicine composition
CN104740061A (en) * 2015-03-09 2015-07-01 陆莎 Traditional Chinese medicine composition for treating nasopharyngeal carcinoma

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Application publication date: 20170329