CN105412705A

CN105412705A - Medicine for treating acute nasosinusitis and preparation method thereof

Info

Publication number: CN105412705A
Application number: CN201510986706.4A
Authority: CN
Inventors: 卢文华
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-26
Filing date: 2015-12-26
Publication date: 2016-03-23

Abstract

The invention discloses a medicine for treating acute nasosinusitis and a preparation method thereof. The medicine is mainly prepared from cocklebur fruit, pinellia ternate, flos chrysanthemi indici, violet magnolia, fructus viticis, centipeda minima, agastache rugosus, rhizoma drynariae, semen coicis, kudzuvine roots, radix rubiae, cordate houttuynia, rhizoma paridis, rhizoma anemarrhenae, codonopsis pilosula, cortex lycii radicis, cortex albiziae, radix angelicae, fructus forsythiae, radix scrophulariae, platycodon grandiflorum, peach kernels, cimicifugae foetidae and radix isatidis according to a certain weight ratio. The medicine has the functions of dispelling wind and opening the orifices, dispelling wind and clearing heat, strengthening the spleen and supplementing the lung, clearing heat and promoting diuresis and treating heat disease strong heat persistence and is capable of rapidly achieving the effects, good in treating effect and not prone to relapse when the medicine is used for treating the acute nasosinusitis.

Description

A kind of medicine for the treatment of acute sinusitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of acute sinusitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Acute sinusitis is that one or more nasal sinuses is inflamed and is called acute sinusitis, the nasal sinuses involved comprises: maxillary sinus, sieve hole, sinus frontalis and sphenoid sinus, this is a kind of disease that sickness rate is higher in crowd, affect patients ' life quality, acute sinusitis is many to be caused by upper respiratory tract infection, and antibacterial and viral infection can be simultaneously concurrent.The traditional Chinese medical science then thinks acute sinusitis and wind and heat in the lung meridian, and damp-heat in the spleen and stomach, liver and gall intenseness of heat is relevant.Because western medicine side effect is large, therefore there is great demand to the Chinese medicine of effectively treating acute sinusitis in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment acute sinusitis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment acute sinusitis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Fructus Xanthii, the Rhizoma Pinelliae, Flos Chrysanthemi Indici, Flos Magnoliae, Fructus Viticis, Herba Centipedae, Herba Pogostemonis, Rhizoma Drynariae, Semen Coicis, Radix Puerariae, Radix Rubiae, Herba Houttuyniae, Rhizoma Paridis, the Rhizoma Anemarrhenae, Radix Codonopsis, Cortex Lycii, Cortex Albiziae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scrophulariae, Radix Platycodonis, Semen Persicae, Rhizoma Cimicifugae, Radix Isatidis, Folium Isatidis, Radix Saposhnikoviae, Gypsum Fibrosum, Rhizoma Atractylodis, Radix Trichosanthis, Flos Lonicerae, Cortex Mori medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat acute sinusitis.Wherein, Fructus Xanthii is selected to be that temperature, poisonous, enter lung, Liver Channel, have loose wind, pain relieving, damp eliminating, the function of parasite killing, controls headche due to wind-cold, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four foot spasm and pain, mange, pruritus because its nature and flavor are sweet.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Flos Chrysanthemi Indici is selected to be that cool, enter lung, Liver Channel, have wind and heat dispersing, the function of subduing swelling and detoxicating, controls anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters because its nature and flavor toil.Flos Magnoliae is selected to be that temperature, enter lung, stomach warp, dispel the wind, sensible function, controls headache, nasal sinusitis, has a stuffy nose obstructed, toothache because its nature and flavor are pungent.Select Fructus Viticis to be because its nature and flavor toil, cool, enter liver, stomach, urinary bladder channel, have dispelling wind and heat pathogens, the function of the clear sharp head, controls anemopyretic cold, just, migraine, and toothache, pain in order eyeball.Select Herba Centipedae to be that temperature, enters meridian of Hand-TAI YIN edema caused by disorder of QI, dispel the wind, cold expelling because its nature and flavor are pungent, victory is wet, removing nebula, the function of stuffy nose relieving plug, cure cold, asthma of cold-type, sore throat, pertussis, eruptive disease is suffered from abdominal pain, amebic dysentery, malaria, infantile malnutrition with diarrhea, nasal sinusitis, polyp, corneal nebula is puckery itches, ecthyma, scabies, traumatic injury.Herba Pogostemonis is selected to be that tepor, enters lung, spleen, stomach warp, have fast gas because its nature and flavor are pungent, and in, ward off dirty, the function of damp eliminating, cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.Rhizoma Drynariae is selected to be that temperature, enters liver, kidney channel, have the kidney invigorating, invigorate blood circulation, the function of hemostasis, control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus because its nature and flavor are bitter.Semen Coicis is selected to be that cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea because its property slightly sweet flavor.Select Radix Puerariae to be that flat, enter spleen, stomach warp, have yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is only drunk, cure the wound cold, cure the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery because its nature and flavor are sweet pungent, skin eruption is not saturating, hypertension, and angina pectoris is deaf.Radix Rubiae is selected to be because its nature and flavor are bitter, cold, there is cooling blood for hemostasis, the function that blood stasis dispelling stimulates the menstrual flow, control haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.Herba Houttuyniae is selected to be that cold, enter meridian of Hand-TAI YIN, have heat-clearing and toxic substances removing, the function of inducing diuresis to remove edema, controls pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies because its nature and flavor are pungent.Select Rhizoma Paridis to be because its nature and flavor are bitter, be slightly cold, slightly poisonous, return Liver Channel, have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the function of cool liver arresting convulsion, controls furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutter the pain of injury, convulsion with spasms.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Optionally Cortex Lycii is because its nature and flavor are sweet, cold, and enter lung, liver, kidney channel, have heat clearing away, the function of removing heat from blood, control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Cortex Albiziae is selected to be because its nature and flavor are sweet, flat, enter the heart, Liver Channel, have resolving depression, and blood, mind calming, the function of subduing inflammation, controls irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Radix Scrophulariae to be because its nature and flavor hardship is salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select Radix Isatidis to be because its nature and flavor are bitter, cold, enter liver, stomach blood system, have heat clearing away, removing toxic substances, the function of removing heat from blood, controls influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, and pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash.Folium Isatidis is selected to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, have heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Gypsum Fibrosum is selected to be because its property acrid-sweet flavor, cold, enter lung, stomach warp, raw with there being expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst, controls calentura high fever and does not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forges deposited promoting tissue regeneration and ulcer healing, external treatment ulcer sores, bursts and does not regain, the burning hot wound of soup.Rhizoma Atractylodis are selected to be that temperature, enters spleen, stomach warp, have spleen invigorating, dampness, resolving depression, ward off dirty function because its nature and flavor are worked hard, control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Radix Trichosanthis is selected to be that cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula because its nature and flavor sweetness and bitterness acid.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Cortex Mori to be that cold, enter lung, spleen channel, have eliminating pathogen from the lung for relieving asthma, the function of line water detumescence, controls dyspnea and cough due to lung-heat because its nature and flavor are sweet, spit blood, edema, beriberi, dysuria.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Fructus Xanthii 10-20 gram, Rhizoma Pinelliae 5-15 gram, Flos Chrysanthemi Indici 10-20 gram, Flos Magnoliae 10-20 gram, Fructus Viticis 5-15 gram, Herba Centipedae 10-20 gram, Herba Pogostemonis 10-20 gram, Rhizoma Drynariae 5-15 gram, Semen Coicis 10-15 gram, Radix Puerariae 7-12 gram, Radix Rubiae 5-15 gram, Herba Houttuyniae 10-20 gram, Rhizoma Paridis 5-15 gram, Rhizoma Anemarrhenae 10-15 gram, Radix Codonopsis 10-20 gram, Cortex Lycii 5-15 gram, Cortex Albiziae 5-15 gram, Radix Angelicae Dahuricae 5-15 gram, Fructus Forsythiae 5-15 gram, Radix Scrophulariae 10-20 gram, Radix Platycodonis 15-20 gram, Semen Persicae 5-15 gram, Rhizoma Cimicifugae 7-12 gram, Radix Isatidis 5-15 gram, Folium Isatidis 10-20 gram, Radix Saposhnikoviae 10-20 gram, Gypsum Fibrosum 5-15 gram, Rhizoma Atractylodis 7-12 gram, Radix Trichosanthis 15-20 gram, Flos Lonicerae 5-15 gram, Cortex Mori 10-20.

Be preferably:

Fructus Xanthii 15 grams, the Rhizoma Pinelliae 10 grams, Flos Chrysanthemi Indici 15 grams, Flos Magnoliae 15 grams, Fructus Viticis 10 grams, Herba Centipedae 15 grams, Herba Pogostemonis 15 grams, Rhizoma Drynariae 10 grams, Semen Coicis 12 grams, Radix Puerariae 9 grams, 10 grams, Radix Rubiae, Herba Houttuyniae 15 grams, Rhizoma Paridis 10 grams, the Rhizoma Anemarrhenae 12 grams, Radix Codonopsis 15 grams, Cortex Lycii 10 grams, Cortex Albiziae 10 grams, the Radix Angelicae Dahuricae 10 grams, Fructus Forsythiae 10 grams, Radix Scrophulariae 15 grams, Radix Platycodonis 18 grams, 10 grams, Semen Persicae, Rhizoma Cimicifugae 9 grams, Radix Isatidis 10 grams, Folium Isatidis 15 grams, Radix Saposhnikoviae 15 grams, 10 grams, Gypsum Fibrosum, Rhizoma Atractylodis 9 grams, Radix Trichosanthis 18 grams, Flos Lonicerae 10 grams, Cortex Mori 15 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

2, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

3, Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;

4, Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces;

5, Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;

6, Herba Centipedae: pick clean impurity, cutting, dry;

7, Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;

8, Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;

9, Semen Coicis: get crude drug, removing residual cot, impurity;

10, Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;

11, Radix Rubiae: removing impurity, cleans, runs through, cut sheet or section, and dry, sieve removes chip;

12, Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;

13, Rhizoma Paridis: removing fibrous root, cleaning, drying;

14, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

15, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

16, Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;

17, Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into equal greatly rectangular after moistening, then stripping and slicing or shredding, dry;

18, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

19, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

20, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

21, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

22, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

23, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

24, Radix Isatidis: pick clean impurity, cleans, runs through, and section, dries;

25, Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;

26, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

27, Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

28, Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

29, Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

30, Flos Lonicerae: sieve removes silt, picks clean impurity;

31, Cortex Mori: brush away ash bits, clean, run through rear shredding, dry.

Two, prepare

1, by the Fructus Xanthii cooked, the Rhizoma Pinelliae, Flos Chrysanthemi Indici, Flos Magnoliae, Fructus Viticis, Herba Centipedae, Herba Pogostemonis, Rhizoma Drynariae, Semen Coicis, Radix Puerariae, Radix Rubiae, Herba Houttuyniae, Rhizoma Paridis, the Rhizoma Anemarrhenae, Radix Codonopsis, Cortex Lycii, Cortex Albiziae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scrophulariae, Radix Platycodonis, Semen Persicae, Rhizoma Cimicifugae, Radix Isatidis, Folium Isatidis, Radix Saposhnikoviae, Gypsum Fibrosum, Rhizoma Atractylodis, Radix Trichosanthis, Flos Lonicerae, Cortex Mori puts into decocting container, add water 8 times amount for the first time, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,

2, the medicinal residues of filtration are added 6 times amount, intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

3, by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.

In prescription, Flos Magnoliae dispels the wind, sensible, controls headache, nasal sinusitis, and obstructed function of having a stuffy nose is monarch drug; The Radix Angelicae Dahuricae dispels the wind, dampness; Fructus Viticis has dispelling wind and heat pathogens, and the clear sharp head, controls the function of anemopyretic cold, the two is ministerial drug, and three taste medicines jointly play and dispel the wind, sensible, dampness, dispelling wind and heat pathogens, the clear sharp head, control headache, nasal sinusitis, obstructed effect of having a stuffy nose, treatment acute sinusitis effect is comprehensive, and with expelling pathogenic wind and restoring the functions of orifices in face, dispelling wind and heat pathogens, dampness is that master can be effected a permanent cure, and Gypsum Fibrosum has expelling pathogenic factors from muscles for clearing heat, and relieving restlessness is quenched the thirst, control calentura high fever not move back, lung-heat dyspnea with rapid respiration, the function of hyperactivity of toxic heat is adjuvant drug, and Semen Coicis has spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, for making medicine, is take stopgap measures with all medicines of remainder.

Medicine of the present invention has expelling pathogenic wind and restoring the functions of orifices in face, wind-dispelling heat-dissipating, strengthening the spleen and tonifying the lung, clearing away heat-damp and promoting diuresis, controls the function that calentura high fever does not move back, is used for the treatment of acute sinusitis, short treating period, instant effect, non-relapse after healing.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Taking medicinal liquid super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept acute sinusitis out-patient totally 31 examples for medical treatment.

2, diagnostic criteria

Classical symptom is nasal obstruction, pus tears, local pain and headache, and olfactory sensation declines, fear of cold heating, the whole body discomfort, lassitude, loss of appetite etc.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 7 days, is a course for the treatment of, takes 2 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: acute sinusitis symptom disappears, body constitution recovers normal, recovery from illness;

Take a turn for the better: patient has a stuffy nose, heating, lassitude, nasal cavity rhinorrhea, olfactory sensation decline phenomenon alleviates, and acute sinusitis symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy acute sinusitis patient 31 example of the present invention, effective 27 examples of result, obvious effective rate is 87.10%, and take a turn for the better 3 examples, and improvement rate is 9.67%, and invalid 1 example, total effective rate is 96.77%.

Claims

1. treat a medicine for acute sinusitis, it is characterized in that: it is made up of the crude drug in following weight range:

2. medicine according to claim 1, wherein the consumption of each crude drug is:

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

(2) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

(3) Flos Chrysanthemi Indici: remove impurity, removing undesirable root, cleans cutting, dries;

(4) Flos Magnoliae: pick clean branch stalk impurity, smash use to pieces;

(5) Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;

(6) Herba Centipedae: pick clean impurity, cutting, dry;

(7) Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;

(8) Rhizoma Drynariae: remove sediment contamination, cleans, slightly soaks, run through, and section, dries;

(9) Semen Coicis: get crude drug, removing residual cot, impurity;

(10) Radix Puerariae: pick decontamination, cleans, is soaked in water, pulls out, run through, cut into slices in time, dry;

(11) Radix Rubiae: removing impurity, cleans, runs through, cut sheet or section, and dry, sieve removes chip;

(12) Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;

(13) Rhizoma Paridis: removing fibrous root, cleaning, drying;

(14) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;

(15) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(16) Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;

(17) Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into equal greatly rectangular after moistening, then stripping and slicing or shredding, dry;

(18) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

(19) Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

(20) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

(21) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

(22) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(23) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

(24) Radix Isatidis: pick clean impurity, cleans, runs through, and section, dries;

(25) Folium Isatidis: pick decontamination and dead leaf, cleans, slightly moistens, cutting, dry;

(26) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(27) Gypsum Fibrosum: remove assorted stone, cleans earth, is broken into fritter;

(28) Rhizoma Atractylodis: pick decontamination, with blister to seven, most probably thoroughly, pull out, run through rear section, dry;

(29) Radix Trichosanthis: pick decontamination, size block is separately, saturating with blister about sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, pull out, shine extremely dry, be pounded fritter;

(30) Flos Lonicerae: sieve removes silt, picks clean impurity;

(31) Cortex Mori: brush away ash bits, clean, run through rear shredding, dry;

(2) prepare

(1) Fructus Xanthii will cooked, the Rhizoma Pinelliae, Flos Chrysanthemi Indici, Flos Magnoliae, Fructus Viticis, Herba Centipedae, Herba Pogostemonis, Rhizoma Drynariae, Semen Coicis, Radix Puerariae, Radix Rubiae, Herba Houttuyniae, Rhizoma Paridis, the Rhizoma Anemarrhenae, Radix Codonopsis, Cortex Lycii, Cortex Albiziae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Scrophulariae, Radix Platycodonis, Semen Persicae, Rhizoma Cimicifugae, Radix Isatidis, Folium Isatidis, Radix Saposhnikoviae, Gypsum Fibrosum, Rhizoma Atractylodis, Radix Trichosanthis, Flos Lonicerae, Cortex Mori puts into decocting container, add water 8 times amount, soak after 100 minutes, intense fire decocts boiling, use slow fire boiling again 20 minutes, filter first time decoction liquor, first time decoction liquor is poured in container,

(2) add water the medicinal residues of filtration 6 times amount, and intense fire boils, then uses slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

(3) by twice decoction liquor mixing and stirring and get final product, 4 doses are divided into take.