CN106518840B - 一种2-氯噻吩-5-甲酸的合成方法 - Google Patents
一种2-氯噻吩-5-甲酸的合成方法 Download PDFInfo
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- CN106518840B CN106518840B CN201611010695.7A CN201611010695A CN106518840B CN 106518840 B CN106518840 B CN 106518840B CN 201611010695 A CN201611010695 A CN 201611010695A CN 106518840 B CN106518840 B CN 106518840B
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- chlorothiophene
- formic acid
- synthetic method
- bromo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
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CN201611010695.7A CN106518840B (zh) | 2016-11-17 | 2016-11-17 | 一种2-氯噻吩-5-甲酸的合成方法 |
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CN201611010695.7A CN106518840B (zh) | 2016-11-17 | 2016-11-17 | 一种2-氯噻吩-5-甲酸的合成方法 |
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CN106518840A CN106518840A (zh) | 2017-03-22 |
CN106518840B true CN106518840B (zh) | 2019-03-01 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109096245A (zh) * | 2018-09-27 | 2018-12-28 | 上海雅本化学有限公司 | 一种5-氯噻吩-2-甲酸的制备方法 |
CN110759888A (zh) * | 2019-11-19 | 2020-02-07 | 山东省化工研究院 | 一种3-乙酰基-2,5-二氯噻吩的合成方法 |
CR20220294A (es) | 2019-12-20 | 2022-08-03 | Bayer Ag | Tiofenocarboxamidas sustituidas y sus derivados |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1571787A (zh) * | 2001-10-17 | 2005-01-26 | Ucb公司 | 奎宁环衍生物、制备它们的方法和它们作为m2和/或m3毒蕈碱受体抑制剂的用途 |
CN102076677A (zh) * | 2008-06-26 | 2011-05-25 | 石原产业株式会社 | 3-甲基-2-噻吩甲酸的制造方法 |
CN102993164A (zh) * | 2012-11-19 | 2013-03-27 | 连云港宏业化工有限公司 | 一种2-氯-5-噻吩甲酸的制备方法 |
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2016
- 2016-11-17 CN CN201611010695.7A patent/CN106518840B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1571787A (zh) * | 2001-10-17 | 2005-01-26 | Ucb公司 | 奎宁环衍生物、制备它们的方法和它们作为m2和/或m3毒蕈碱受体抑制剂的用途 |
CN102076677A (zh) * | 2008-06-26 | 2011-05-25 | 石原产业株式会社 | 3-甲基-2-噻吩甲酸的制造方法 |
CN102993164A (zh) * | 2012-11-19 | 2013-03-27 | 连云港宏业化工有限公司 | 一种2-氯-5-噻吩甲酸的制备方法 |
Non-Patent Citations (1)
Title |
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Thiophene sulfonamides and their derivatives. II. Reaction of α-thiophene sulfonamides with bromine and chlorine in alkaline medium;Chrzaszczewska, Anna 等;《Lodzkie Towarzystwo Naukowe, Wydzial III, Acta Chimica》;20151231;第12卷;第119-127页 |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: Synthesis of 2-chlorothiophene-5-carboxylic acid Effective date of registration: 20221130 Granted publication date: 20190301 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: Shandong Baoyuan Pharmaceutical Co.,Ltd. Registration number: Y2022980023658 |