CN106511792A - Traditional Chinese medicine feed additive for grass carp, and preparation method thereof - Google Patents
Traditional Chinese medicine feed additive for grass carp, and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention belongs to the technical field of research and development for feed additives, and specially relates to a traditional Chinese medicine feed additive for grass carp, and a preparation method thereof. The traditional Chinese medicine feed additive for grass carp is prepared from the following components in parts by weight: 20-30 parts of codonopsis pilosula, 8-20 parts of radix paeoniae alba, 8-16 parts of polygonum multiflorum, 9-18 parts of myristica fragrans, 9-20 parts of achyranthes bidentata, 25-35 parts of schizonepeta, 15-30 parts of ephedra, 8-15 parts of notopterygium root, 25-35 parts of lalang grass rhizome, 8-15 parts of artemisia annua, 10-25 parts of immature bitter orange and 6-15 parts of frankincense. Synergetic effects are achieved among the traditional Chinese medicine ingredients of the traditional Chinese medicine feed additive for grass carp, which is disclosed by the invention; and the prepared traditional Chinese medicine feed additive is capable of preventing grass carp from diseases, increasing the survival rate of grass carp, and improving the activity levels of lysozyme, superoxide dismutase, catalase and alkaline phosphatase in the body of grass carp.
Description
Technical field
The invention belongs to feed additive research and development technology field, more particularly to a kind of Chinese medicine feed additive for Ctenopharyngodon idellus
And preparation method thereof.
Background technology
Ctenopharyngodon idellus are one of four large Chinese carps of China, and the Freshwater Fish that China is main, Ctenopharyngodon idellus cultivation with feed cost it is low,
The advantages of economic benefit is obvious.But erythroderma, gill rot, enteritis disease and the bleeding being easily subject in breeding process due to Ctenopharyngodon idellus
Disease is referred to as the infringement of " Ctenopharyngodon idellus four are sick ", and fish production is made a big impact.Problem is prevented and treated in order to solve Ctenopharyngodon idellus " four is sick ",
Need to improve conscientiously the immune function of Ctenopharyngodon idellus.
Chinese herbal medicine is a kind of preferably natural, environment-friendly medicine, little, safe, residual with efficient, toxic and side effects
Many advantages, such as staying few, and wide material sources, low cost.The immunity of aquatic animal is improved by the administration of Chinese herbal medicine, fish is improved
Class premunition, the sickness rate for reducing aquatic animal is the focus studied in recent years.In the new shape for advocating healthy aquaculture at present comprehensively
Under gesture, fish immunity function is improved using Chinese herbal medicine, be extremely important.
Application No. 201310630290.3《For improving the immune formulation of Ctenopharyngodon idellus immune function》Patent of invention it is public
Open a kind of immune formulation for improving Ctenopharyngodon idellus immune function, it is characterised in that：Crude drug is by Polyporus, Radix Et Caulis Acanthopanacis Senticosi, the Rhizoma Atractylodis Macrocephalae, people
Rhizoma panacis majoris, Herba Houttuyniae, the Cortex Eucommiae, Herba Ecliptae, Rhizoma Drynariae, Ramulus Cinnamomi, Radix Isatidis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Flos Campsiss, Rhizoma Dioscoreae, Caulis Spatholobi, soap
Fructus Gleditsia acupuncture, Fructus Corni, Ramulus Persicae, Fructus Cnidii, Fructus Jujubae, the Radix Stemonae, Semen Euryaless, Fructus Galangae, Semen Arecae, pittosporm root and Conyza canadensis (L.) Cronq. are constituted.From entirety
See, the formula biases toward spleen reinforcing and supports kidney, adjusts gastrointestinal function, for enteritis disease effect still, but the patent is not given enough
Data illustrate that this kind of immune formulation has ideal effect for the preventing and treating of Ctenopharyngodon idellus viral disease, bacterial disease.
In view of the defect of prior art, the present invention proposes a kind of Chinese medicine feed additive for Ctenopharyngodon idellus, its have efficiently,
Have no toxic side effect, safe, noresidue many advantages, such as, and wide material sources, low cost are carried out to the immune system of Fish entirely
Face adjusts, and improves the dynamic resistances against diseases of Aquatic product and immune function, so as to preventing and curing of fish disease.
The information for being disclosed in the background section is merely intended to increase the understanding of the general background to the present invention, and should not
When the prior art for being considered to recognize or imply the information structure in any form well known to persons skilled in the art.
The content of the invention
For above-mentioned deficiency present in prior art, the present invention provide a kind of Chinese medicine feed additive for Ctenopharyngodon idellus and
Its preparation method, the Chinese medicine feed additive reasonable recipe, prepare simple, effect substantially, have no toxic side effect, have no drug resistance and medicine
Thing is remained, and can effectively improve Ctenopharyngodon idellus immune function.
To achieve these goals, the present invention is to employ the following technical solutions realization：
A kind of Chinese medicine feed additive for Ctenopharyngodon idellus, by being made up of following components by weight：It is Radix Codonopsis 20-30 parts, white
Chinese herbaceous peony 8-20 parts, Radix Polygoni Multiflori 8-16 parts, Semen Myristicae 9-18 parts, Radix Achyranthis Bidentatae 9-20 parts, Herba Schizonepetae 25-35 parts, Herba Ephedrae 15-30 parts, Rhizoma Et Radix Notopterygii
8-15 parts, Rhizoma Imperatae 25-35 parts, QINGSONG 8-15 part, Fructus Aurantii Immaturus 10-25 parts and Olibanum 6-15 parts.
Preferably, the described Chinese medicine feed additive for Ctenopharyngodon idellus, by being made up of following components by weight：Radix Codonopsis
25 parts, it is 12 parts of the Radix Paeoniae Alba, 13 parts of Radix Polygoni Multiflori, 15 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, 30 parts of Herba Schizonepetae, 25 parts of Herba Ephedrae, 12 parts of Rhizoma Et Radix Notopterygii, white
12 parts of 30 parts of Rhizoma Imperatae, 12 parts of QINGSONG, 20 parts of Fructus Aurantii Immaturus and Olibanum.
Present invention also offers the preparation method of the described Chinese medicine feed additive for Ctenopharyngodon idellus, comprises the following steps：
(1) Radix Codonopsis in formula, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Semen Myristicae, Radix Achyranthis Bidentatae, Herba Schizonepetae, Herba Ephedrae, Qiang is weighed by weight
Work, Rhizoma Imperatae, QINGSONG, Fructus Aurantii Immaturus and Olibanum, are cleaned and are dried, in addition to Rhizoma Et Radix Notopterygii, Herba Schizonepetae, after being pulverized and mixed by pulverizer, add which
The tap water of 3-4 times of weight, first boils again slow fire by intense fire and endures 0.5-1h, obtains first filtrate, add its weight toward medicinal residues after filtration
2-3 times of tap water, boils rear slow fire by intense fire and endures 0.5h and add that Rhizoma Et Radix Notopterygii, Herba Schizonepetae are continuous to endure 10-15min, pours out second filtrate,
Herb liquid study is concentrated to give after merging filtrate twice；
(2) in the herb liquid study obtained by step (1), add the dehydrated alcohol of its volume 3-5 times, stirring and dissolving to dilute,
Flow back at a temperature of 85-95 DEG C 2.5-3.5h, obtains refined herb liquid；
(3) the refined herb liquid obtained by step (2) is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 130-150 DEG C, and leaving air temp is 75-90 DEG C,
Powdered rubber is obtained, powdered rubber is crushed to into 120 mesh, Chinese medicinal powder is obtained；
(4) Chinese medicinal powder obtained by step (3) is admixed the Semen Maydis powder of its quality 2-3 times, is mixed, is carried out expanded, temperature
At 85-90 DEG C, expanded time 1-2min, subsequent pelletize, cooling treat that particulate component is cooled to 20-25 DEG C, pack, obtain final product for control
For the Chinese medicine feed additive of Ctenopharyngodon idellus.
Compared with prior art, the present invention has the advantages that：
(1) there is between each Chinese medicine ingredients of Chinese medicine feed additive of the invention synergistic function, the Chinese medicine prepared is raised
Feed additives have functions that kidney, digestion promoting are supported in convergence removing toxic substances, spleen invigorating, and the immune system of Fish is adjusted, Ctenopharyngodon idellus are improved
Anti-stress ability and immune function, it is ill to be prevented from Ctenopharyngodon idellus, improves Ctenopharyngodon idellus survival rate, improves lysozyme in Ctenopharyngodon idellus body, super
Superoxide dismutase, catalase, the activity level of alkali phosphatase.
(2) Chinese medicine feed additive raw material of the invention is pure natural raw material, without any chemical classes medicine, preparation side
Method is simple, and the Chinese medicine feed additive residual rate is low, toxicity is low, does not affect the quality of Ctenopharyngodon idellus, is not detrimental to health.
(3) Chinese medicine feed additive preparation method of the invention is simple, it is easy to large-scale promotion and application.
Specific embodiment
The specific embodiment of the present invention is described in detail with reference to specific embodiment, it is to be understood that of the invention
Protection domain do not limited by specific embodiment.
Embodiment 1：
A kind of Chinese medicine feed additive for Ctenopharyngodon idellus, by being made up of following components by weight：20 parts of Radix Codonopsis, the Radix Paeoniae Alba 8
Part, 8 parts of Radix Polygoni Multiflori, 9 parts of Semen Myristicae, 9 parts of Radix Achyranthis Bidentatae, 25 parts of Herba Schizonepetae, 15 parts of Herba Ephedrae, 8 parts of Rhizoma Et Radix Notopterygii, 25 parts of Rhizoma Imperatae, QINGSONG 8
6 parts of part, 10 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of the described Chinese medicine feed additive for Ctenopharyngodon idellus, comprises the following steps：
(1) Radix Codonopsis in formula, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Semen Myristicae, Radix Achyranthis Bidentatae, Herba Schizonepetae, Herba Ephedrae, Qiang is weighed by weight
Work, Rhizoma Imperatae, QINGSONG, Fructus Aurantii Immaturus and Olibanum, clean dry, in addition to Rhizoma Et Radix Notopterygii, Herba Schizonepetae, after being pulverized and mixed by pulverizer, add its 3
The tap water of times weight, first boils again slow fire by intense fire and endures 0.5h, after filtration first filtrate, add 2 times of its weight toward medicinal residues
Tap water, boils rear slow fire by intense fire and endures 0.5h and add that Rhizoma Et Radix Notopterygii, Herba Schizonepetae are continuous to endure 10min, pours out second filtrate, and merging is filtered twice
Herb liquid study is concentrated to give after liquid；
(2) in the herb liquid study obtained by step (1), add the dehydrated alcohol of 3 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 85 DEG C 2.5h, obtains refined herb liquid；
(3) the refined herb liquid obtained by step (2) is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 130 DEG C, and leaving air temp is 75 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder obtained by step (3) is admixed the Semen Maydis powder of 2 times of its quality, is mixed, is carried out expanded, temperature control
At 85 DEG C, expanded time 1min, subsequent pelletize, cooling treat that particulate component is cooled to 20 DEG C to system, pack, obtain final product for Ctenopharyngodon idellus
Chinese medicine feed additive.
Embodiment 2：
A kind of Chinese medicine feed additive for Ctenopharyngodon idellus, by being made up of following components by weight：30 parts of Radix Codonopsis, the Radix Paeoniae Alba 20
Part, 16 parts of Radix Polygoni Multiflori, 18 parts of Semen Myristicae, 20 parts of Radix Achyranthis Bidentatae, 35 parts of Herba Schizonepetae, 30 parts of Herba Ephedrae, 15 parts of Rhizoma Et Radix Notopterygii, 35 parts of Rhizoma Imperatae, green grass or young crops
15 parts of high 15 parts, 25 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of the described Chinese medicine feed additive for Ctenopharyngodon idellus, comprises the following steps：
(1) Radix Codonopsis in formula, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Semen Myristicae, Radix Achyranthis Bidentatae, Herba Schizonepetae, Herba Ephedrae, Qiang is weighed by weight
Work, Rhizoma Imperatae, QINGSONG, Fructus Aurantii Immaturus and Olibanum, clean dry, in addition to Rhizoma Et Radix Notopterygii, Herba Schizonepetae, after being pulverized and mixed by pulverizer, add its 4
The tap water of times weight, first boils again slow fire by intense fire and endures 1h, after filtration first filtrate, toward medicinal residues add 3 times of its weight from
Water, boils rear slow fire by intense fire and endures 0.5h and add that Rhizoma Et Radix Notopterygii, Herba Schizonepetae are continuous to endure 15min, pours out second filtrate, merges filtrate twice
After be concentrated to give herb liquid study；
(2) in the herb liquid study obtained by step (1), add the dehydrated alcohol of 5 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 95 DEG C 3.5h, obtains refined herb liquid；
(3) the refined herb liquid obtained by step (2) is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 150 DEG C, and leaving air temp is 90 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder obtained by step (3) is admixed the Semen Maydis powder of 3 times of its quality, is mixed, is carried out expanded, temperature control
At 90 DEG C, expanded time 2min, subsequent pelletize, cooling treat that particulate component is cooled to 25 DEG C to system, pack, obtain final product for Ctenopharyngodon idellus
Chinese medicine feed additive.
Embodiment 3：
A kind of Chinese medicine feed additive for Ctenopharyngodon idellus, by being made up of following components by weight：25 parts of Radix Codonopsis, the Radix Paeoniae Alba 15
Part, 12 parts of Radix Polygoni Multiflori, 13 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, 30 parts of Herba Schizonepetae, 25 parts of Herba Ephedrae, 10 parts of Rhizoma Et Radix Notopterygii, 30 parts of Rhizoma Imperatae, green grass or young crops
9 parts of high 12 parts, 20 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of the described Chinese medicine feed additive for Ctenopharyngodon idellus, comprises the following steps：
(1) Radix Codonopsis in formula, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Semen Myristicae, Radix Achyranthis Bidentatae, Herba Schizonepetae, Herba Ephedrae, Qiang is weighed by weight
Work, Rhizoma Imperatae, QINGSONG, Fructus Aurantii Immaturus and Olibanum, are cleaned and are dried, in addition to Rhizoma Et Radix Notopterygii, Herba Schizonepetae, after being pulverized and mixed by pulverizer, add which
The tap water of 3.5 times of weight, first boils again slow fire by intense fire and endures 0.8h, obtains first filtrate, add its weight 2.5 toward medicinal residues after filtration
Times tap water, boil rear slow fire by intense fire and endure 0.5h and add that Rhizoma Et Radix Notopterygii, Herba Schizonepetae are continuous to endure 12min, pour out second filtrate, merge two
Herb liquid study is concentrated to give after secondary filtrate；
(2) in the herb liquid study obtained by step (1), add the dehydrated alcohol of 4 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 90 DEG C 3.0h, obtains refined herb liquid；
(3) the refined herb liquid obtained by step (2) is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 140 DEG C, and leaving air temp is 80 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder obtained by step (3) is admixed the Semen Maydis powder of 2.5 times of its quality, is mixed, is carried out expanded, temperature
At 88 DEG C, expanded time 1.5min, subsequent pelletize, cooling treat that particulate component is cooled to 23 DEG C, pack, obtain final product for grass for control
The Chinese medicine feed additive of fish.
Embodiment 4：The Chinese medicine feed additive of the present invention is tested to survival rate and resistances against diseases
Experimental animal：Test Ctenopharyngodon idellus are purchased from Nanning City fish farm, are juvenile fish, body weight 80-86g/ tail, selected test fry
Number is 4000 tails, and healthy strong, male and female have.4000 tail Ctenopharyngodon idellus are randomly divided into into four groups：Test group 1-3 and matched group, per group
Containing 1000 tail of juvenile fish.
Test feed：Chinese medicine feed additive mixed fodder prepared by test group 1-3 difference feeding embodiment of the present invention 1-3
(will 150g above-described embodiments 1-3 prepare Chinese medicine feed additive, 80g soybean cakes, 350g wheat flours, 35g crab shell powders, 60g shrimps
Powder, 10g Sal, 160g Semen Maydis powder, 30g fish oil, 15g glycine betaines, 2g dalcium biphosphates, 2g ferric citrates, 40g compound vitamines
B, 30g yeast, 20g threonine, 20g lysines, mix homogeneously)；The feedstuff of matched group feeding with the difference of test group is：Make
The Chinese medicine feed additive for replacing the present invention to use with bambermycin 20mg/kg.
Feeding method：Date of test is 8 days-October 22 May in 2015.Ctenopharyngodon idellus are cultivated in fish pond, stocking density 1
Bar/20L.Fish pond area 1500m2(long 50m × wide 30m), deep 80cm, with bamboo fence, (water can pass through, and fish can not be by being mark
It is accurate) separate and block into 375m24 blockages；Fish pond coolant-temperature gage it is whole it is average 16 DEG C (wherein 24-29 DEG C of summer, average 25.5
DEG C), pH value 6.5 ± 0.2, water quality meet fishery standard.
Feedstuff day feeding volume by fry weight 3-5% it is quantitative it is of fixed place and time feed, feed 2 times/d, every 10d dosages 1 time.Adjust
Look into the survival rate of Ctenopharyngodon idellus.
Fish is put to death, with buffer (pH value 7.5,0.25mol/ sucrose, 0.025mol/L Tris-HCL,
0.1mmol/L EDTA-2Na solution) rinse, then surface moisture is sucked with absorbent paper, remove bone parts, stay
The tissue homogenates such as heart, liver and gonad.Tissue 0.30g is accurately weighed, 9 times of buffer ice bath homogenate, 3000r/min is added
Low-temperature and high-speed centrifuge 10-15min, takes supernatant 2mL and determines lysozyme and superoxide dismutase vigor.
Test data represents that using means standard deviation (x ± s) two sample averages compare to be checked with t, and two samples constitute ratio
With chi-square criterion, P<0.05 has significance for difference.
As a result：Impact of the Chinese medicine feed additive to Ctenopharyngodon idellus survival rate, is shown in Table 1；Chinese medicine feed additive to lysozyme and
The impact of superoxide dismutase vigor, the results are shown in Table 2.
Impact of the Chinese medicine feed additive of 1 present invention of table to Ctenopharyngodon idellus survival rate
| Group | Survival number (tail) | Death toll (tail) | Survival rate (%) |
| Test group 1 | 989 | 11 | 98.9 |
| Test group 2 | 986 | 14 | 98.6 |
| Test group 3 | 990 | 10 | 99.0 |
| Matched group | 800 | 200 | 80.0 |
As it can be seen from table 1 the Chinese medicine feed additive feeding Ctenopharyngodon idellus prepared using the present invention, its ill probability drop
Low, survival rate is significantly higher than matched group.
The Chinese medicine feed additive of 2 present invention of table is to lysozyme, superoxide dismutase, catalase, alkaline phosphatase
Enzyme
The impact of vigor
From table 2 it can be seen that using the Ctenopharyngodon idellus of Chinese medicine feed additive feeding of the present invention relative to matched group, internal bacteriolyze
Enzyme, superoxide dismutase, catalase, alkaline phosphatase levels are significantly improved, so as to prove the Chinese medicine fodder of the present invention
Additive has preferably defence disease, antiviral and antibacterial ability, can significantly improve the immune function of Ctenopharyngodon idellus.
It is aforementioned to the present invention specific illustrative embodiment description be in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, much can be changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should
With so that those skilled in the art can realize and using the present invention a variety of exemplaries and
A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (3)
1. a kind of Chinese medicine feed additive for Ctenopharyngodon idellus, it is characterised in that by being made up of following components by weight：Radix Codonopsis
20-30 parts, Radix Paeoniae Alba 8-20 parts, Radix Polygoni Multiflori 8-16 parts, Semen Myristicae 9-18 parts, Radix Achyranthis Bidentatae 9-20 parts, Herba Schizonepetae 25-35 parts, Herba Ephedrae 15-
30 parts, Rhizoma Et Radix Notopterygii 8-15 parts, Rhizoma Imperatae 25-35 parts, QINGSONG 8-15 part, Fructus Aurantii Immaturus 10-25 parts and Olibanum 6-15 parts.
2. the Chinese medicine feed additive for Ctenopharyngodon idellus according to claim 1, it is characterised in that by by weight by following
Component is made：25 parts of Radix Codonopsis, 12 parts of the Radix Paeoniae Alba, 13 parts of Radix Polygoni Multiflori, 15 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, 30 parts of Herba Schizonepetae, Herba Ephedrae 25
12 parts of part, 12 parts of Rhizoma Et Radix Notopterygii, 30 parts of Rhizoma Imperatae, 12 parts of QINGSONG, 20 parts of Fructus Aurantii Immaturus and Olibanum.
3. the preparation method of the Chinese medicine feed additive for Ctenopharyngodon idellus according to claim 1 and 2, it is characterised in that bag
Include following steps：
(1) Radix Codonopsis in the formula, Radix Paeoniae Alba, Radix Polygoni Multiflori, Semen Myristicae, Radix Achyranthis Bidentatae, Herba Schizonepetae, Herba Ephedrae, Rhizoma Et Radix Notopterygii, white is weighed by weight
Rhizoma Imperatae, QINGSONG, Fructus Aurantii Immaturus and Olibanum, are cleaned and are dried, in addition to Rhizoma Et Radix Notopterygii, Herba Schizonepetae, after being pulverized and mixed by pulverizer, add its 3-4 times
The tap water of weight, first boils again slow fire by intense fire and endures 0.5-1h, obtains first filtrate, add its weight 2-3 times toward medicinal residues after filtration
Tap water, boil rear slow fire by intense fire and endure 0.5h and add that Rhizoma Et Radix Notopterygii, Herba Schizonepetae are continuous to endure 10-15min, pour out second filtrate, merge
It is concentrated to give herb liquid study twice after filtrate；
(2) in the herb liquid study obtained by step (1), add the dehydrated alcohol of its volume 3-5 times, stirring and dissolving to dilute,
Flow back at a temperature of 85-95 DEG C 2.5-3.5h, obtains refined herb liquid；
(3) the refined herb liquid obtained by step (2) is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape Chinese medicine is obtained
Material, glue milky substance is put in drying machine and is dried, and inlet temperature is 130-150 DEG C, and leaving air temp is 75-90 DEG C, is obtained
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by powdered rubber；
(4) Chinese medicinal powder obtained by step (3) is admixed the Semen Maydis powder of its quality 2-3 times, is mixed, is carried out expanded, temperature control
At 85-90 DEG C, expanded time 1-2min, subsequent pelletize, cooling, treat that particulate component is cooled to 20-25 DEG C, pack, obtain final product for
The Chinese medicine feed additive of Ctenopharyngodon idellus.
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Application publication date: 20170322 |