CN102319309B - Traditional Chinese medicine preparation for treating chicken coccidiosis - Google Patents
Traditional Chinese medicine preparation for treating chicken coccidiosis Download PDFInfo
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Abstract
A traditional Chinese medicine preparation for treating chicken coccidiosis of the invention comprises antifeverile dichroa root, sweet wormwood, radix bupleuri, Chinese pulsatilla root, uncaria, hairyvein agrimony, and garden burnet, and the preparation method comprises the following steps of material preparation, extraction, condensation, starch addition, drying, and pulverization. The finished medicine is dark yellow powder in appearance, has uniform granularity and bulk density, has strong adhesion when added into feed, has a coordinated color, does not dye or discolor feed, has the efficacy of killing insect and protecting liver, cooling blood and haemostasis, eliminating dampness and relieving dysentery, clearing heat and detoxification, and is applicable to the treatment of chicken coccidiosis and mixed infection of coccidia and bacteria.
Description
Technical field
The present invention relates to the Chinese medicine preparation of a kind of chicken, particularly a kind of Chinese medicine preparation for the treatment of chicken coccidiosis.
Background technology
Chicken coccidiosis is a kind of protozoacide of serious harm poultry husbandry, and primary disease also can cause degradation loss under price of deed reduction, lay eggs minimizing, carcase quality except causing direct economic loss.The anti-primary disease processed of prolonged application antibiotic and chemical synthetic drug not only makes the strain of drug resistance worm constantly occur, and the chemicals that causes poultry product is residual exceeds standard and environmental pollution, the anti-chicken coccidiosis processed of immunity remains deficiency, and therefore, nothing little in the urgent need to a kind of toxic and side effects is harmful to the coccidiostat of drug residue.Studies show that, but Chinese herbal medicine not only has the effect of the worm of killing, and toxic and side effects is low, uses safety, noresidue, coccidiosis is difficult for producing drug resistance, and can also strengthen the immunologic function of chicken, promotes the growth promoter of chicken, improves the advantages such as rate of body weight gain and fertility performance.Therefore, the anti-chicken coccidiosis Chinese medicine of research and development has very large potentiality and wide application prospect to generation and the anticoccidial drug shortage problem that solves the coccidiosis drug resistance.
The artificial vaccination Eimeria mixing egg capsules such as Nie Kui, with middle medicine ball health I (Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis Radix Rehmanniae Preparata, Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, Radix Glycyrrhizae), ball health II (Radix Astragali, the Radix Pulsatillae, Rhizoma Atractylodis Fructus Mume, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Sanguisorbae, Herba Imperatae, Semen Coicis) is carried out curative effect relatively with AC-1, Du's ball, result shows, ball health I group, ball health II group, AC-1 group, Du's set of balls chickling survival rate are respectively 90%, 100%, 100%, 95%; The anticoccidial index is respectively 123.6,179.7,190.9,187.0; Be 0 and inoculate not administration group survival rate, the anticoccidial index is 50.5.Show that the medicine ball health shows prevention effect preferably after strong malicious egg capsule is attacked.The Chinese herbs decoctions such as use Radix Dichroae, Radix Bupleuri, Herba Artemisiae Annuae, Radix Et Rhizoma Rhei such as Liu Yongju are given the meat public young drinking-water of 1 age in days Luo Man and the medicinal residues spice are fed, artificial challenge Eimeria tenella egg capsule, result shows, each administration group (1.0%, 1.5%, 2.0%) all can the utmost point significantly improves chickling survival rate (P＜0.01), and there were significant differences for the pathological changes value (P＜0.05); The egg capsule value infects not administration group significant difference (P＜0.05); 1.5%, 2.0% group of anticoccidial index differential extremely significantly (P＜0.01).Liu Ping etc. utilize chicken ball health III, chicken ball health IV to test; the anticoccidial index (ACI) of two compound preparations reaches respectively 181.34,178.71; apparently higher than infecting not administration group (81.57), protective rate both is 100%, higher than infecting not administration group (60%).The pure Chinese medicinal formulae TF-103 that Fei Chenzhong etc. form take the Chinese medicine Radix Pulsatillae as principal agent, on the basis of repeated screening and optimization of orthogonal test prescription, new medicine anticoccidial product toxicity through repeatedly pharmacodynamics and technology research and development is extremely low, and anti-chicken coccidiosis is activity stabilized.Lee causes Baoying County and compares with Chinese medicine (Cortex Phellodendri, Rhizoma Coptidis, the Radix Astragali, Radix Scutellariae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Glycyrrhizae are mixed in proportion) and Western medicine (diclazuril) antagonism chicken coccidiosis curative effect, the anticoccidial index (ACI) of Chinese drug-treated group is 216.5 as a result, chemical group anticoccidial index (ACI) is 182.27, and Chinese drug-treated group the relative weight gain rate (133.05) is higher than chemical group (98.87%) simultaneously; And Du Aifang etc. use the compound Chinese medicinal preparation contrast diclazuril anticoccidials discoveries such as Radix Dichroae, Radix Sophorae Flavescentis, and Chinese drug-treated group (ACI is 174.8,154.5) is but lower than Western medicine group (AC is 183); Li Yunyu also draws similar result, illustrates that different Chinese prescription institute produce an effect is different.
The reports such as Wang Xin are treated by 1% interpolation feedstuff " clean ball is loose " anticoccidial index reached 187 to the Eimeria Tenella disease.Zhang Xichen etc. make an addition to Chinese medicine compound " coccidia powder " in feedstuff by 0.5%, 1% and 2% respectively, find that 1% above addition anticoccidial index can reach more than 180, have efficient anticoccidial effect.The report such as Zhang Tie pure Chinese medicinal preparation ball is rather with 1% additive capacity, and its ACl is 199. 6.The use such as Peng Dewang are from intending Chinese powder medicine ball speed health (being comprised of Chinese medicines such as Herba Artemisiae Annuae, Radix Dichroae, Radix Sophorae Flavescentiss), be mixed in drinking-water after the stewing bubble of ball speed health 1 h with every kg body weight 1 g every day, drunk the same day, be used in conjunction 8 d, its ACI is suitable with speed red (0. 5 g/kg), reach 190.4, and the faster pellet of drug cost is low more than 20%.Pan Zengqiang etc. are with red peppery few (aquatic foods) 2 kg, Herba Acalyphae (aquatic foods) 2 kg, and Herba Portulacae 140 g, Herba Euphorbiae Humifusae 100 g, Herba Ecliptae l00 g, Stenoloma chusana 140 g, Herba Plantaginis 70 g add water 7.5 kg.Fry in shallow oil the soup extracting juice, add water 5 kg, free drink-service is used in conjunction 5 d; 560 badminton insect infection morbidity chickens are treated, and effective percentage is 99. 8%, and case fatality rate is 2.7%.The compound preparation that Du Aifang forms Chinese Medicine Jiaogulan Saponin, java brucea seed (deoiling) etc. is by 0. 1% interpolation, its anticoccidial index reached 169.1 ~ 170.2; Simultaneously the Chinese medicines such as Radix Dichroae, Radix Sophorae Flavescentis, Radix Sanguisorbae, Radix Bupleuri, Herb Gynostemmae Pentaphylli are formed compound recipe, make decoct and be concentrated into every milliliter of medicinal liquid and contain crude drug 1 g.The coccidiosis index of 1 group, the Chinese medicine of every chicken drinking-water administration every day 0.5 mL is l74.8 as a result.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of chicken coccidiosis.
A kind of Chinese medicine preparation for the treatment of chicken coccidiosis of the present invention is flaxen powder, and feeble QI is fragrant, sweet and slightly bitter taste.
A kind of Chinese medicine preparation for the treatment of chicken coccidiosis of the present invention is comprised of Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae and Radix Sanguisorbae, and each shared weight percent of crude drug dry product of distinguishing the flavor of is as follows:
Radix Dichroae 18%～22%, Herba Artemisiae Annuae 13%～17%, Radix Bupleuri 13%～17%, the Radix Pulsatillae 13%～17%, Ramulus Uncariae Cum Uncis 13%～17%, Herba Agrimoniae 8%～12%, Radix Sanguisorbae 8%～12%.
A kind of preparation method for the treatment of the Chinese medicine preparation of chicken coccidiosis of the present invention is characterized in that operating procedure is as follows:
1) get the raw materials ready: the crude drug of 7 flavor oven dry in filling a prescription, press prescription proportioning mixing for standby use;
2) extract: at 55～60 ℃ of temperature, pressure not under the condition higher than 0.05Mpa, be that 70%～75%(V/V) ethanol mixes with above-mentioned raw materials and isopyknic concentration, continuous extraction is 2 times in Multifunctional Chinese medicine extraction unit, each extraction time is all 1h, merges the crude extract of 2 lixiviate gained;
3) concentrated: putting crude extract in concentrator, is that under the condition of 50～55 ℃ of-0.06～0.07Mpa, temperature, being concentrated into proportion is 1.2～1.3, gets extractum in vacuum;
4) add starch: press extractum: the weight ratio of starch=1:1 is added starch in extractum, and stirs;
5) drying: be set up state starch and extractum mixture in the electric heating hot air circulation drying oven, under the condition of 60～80 ℃ of temperature, be dried to moisture content≤8%;
6) pulverize: taking out above-mentioned dry thing, to be crushed to fineness with crushing and pelletizing machine be 50～60 orders; Be finished product.
A kind of Chinese medicine preparation for the treatment of chicken coccidiosis of the present invention is reused Radix Dichroae, Herba Artemisiae Annuae with the preventing the attack (or recurrence) of malaria parasite killing, is principal agent; With heat-clearing and toxic substances removing, treat the heating paresthesia that coccidiosis causes with Radix Bupleuri, the Radix Pulsatillae; Use the Ramulus Uncariae Cum Uncis relieving spasm by subduing liver-wind, auxiliary Radix Dichroae parasite killing; With clearing away heat and cooling blood, treat the bleedings such as hemafecia that coccidiosis causes with Herba Agrimoniae, Radix Sanguisorbae.Prescription meets the Chinese medicinal formulae combination principle, and main symptom, the accompanied symptoms of coccidiosis all had definite curative effect.It is Powdered that finished product is dark yellow in appearance, and granularity and bulk density are even, makes an addition to the feedstuff adhesiveness strong, feedstuff dyeing variable color is coordinated and can not made to color and luster, do not affect the feedstuff primary colors, can add in the chicken coccidiosis stage occurred frequently, prevention and treatment chicken coccidiosis are had original effect; The Chinese medicine preparation of evidence treatment chicken coccidiosis of the present invention can obviously reduce chicken coccidiosis sickness rate, improves daily gain and the feed conversion rate of chicken.
The specific embodiment
In order fully to disclose a kind of Chinese medicine preparation for the treatment of chicken coccidiosis of the present invention, be illustrated below in conjunction with embodiment.
Embodiment: a kind of Chinese medicine preparation for the treatment of chicken coccidiosis----" evergreen anti-ball is loose ".
" evergreen anti-ball is loose " is comprised of Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae and Radix Sanguisorbae, and each shared weight percent of crude drug dry product of distinguishing the flavor of is as follows:
Radix Dichroae 20%, Herba Artemisiae Annuae 15%, Radix Bupleuri 15%, the Radix Pulsatillae 15%, Ramulus Uncariae Cum Uncis 15%, Herba Agrimoniae 10%, Radix Sanguisorbae 10%.
The preparation method of " evergreen anti-ball is loose " comprises the following steps:
1) get the raw materials ready: with the crude drug of 7 flavor oven dry in above-mentioned formula, press prescription proportioning mixing for standby use;
2) extract: under the condition of 55 ℃ of temperature, pressure 0.05Mpa, be that 75% ethanol mixes with above-mentioned raw materials and isopyknic concentration, extract in unit continuous extraction 2 times at Multifunctional Chinese medicine, extraction time is all 1h at every turn, the crude extract of 2 lixiviate gained of merging;
3) concentrated: putting crude extract in concentrator, is that under the condition of 55 ℃ of 0.01Mpa, temperature, being concentrated into proportion is 1.2, gets extractum in vacuum;
4) add starch: press extractum: the weight ratio of starch=1:1 is added starch in extractum, and stirs;
5) drying: be set up state starch and extractum mixture in the electric heating hot air circulation drying oven, under the condition of temperature 70 C, being dried to moisture content is 8%;
6) pulverize: taking out above-mentioned dry thing, to be crushed to fineness with crushing and pelletizing machine be 55 orders; Be finished product.
" evergreen anti-ball is loose " function: parasite killing hemostasis, heat-clearing and toxic substances removing, dampness removing and diarrhea-relieving.
" evergreen anti-ball is loose " cures mainly: the chicken diarrhoea that the treatment coccidiosis causes, hemafecia etc.
" evergreen anti-ball is loose " usage and consumption: spice administration.Every 1000kg feedstuff, dosing 5kg used 5～10 days continuously.
It is below the loose clinical trial to artificial challenge's chicken coccidiosis of evergreen anti-ball.
1 test material
1.1 experimental animal
1 age in days Ai Wei mattress chickling according to conventional method isolated rearing to 10 age in days, after the warming up period of 2 ~ 3 d is observed, is divided into 5 groups at random, and 50 every group, male and female half and half amount to 250.
1.2 trial drug
Evergreen anti-ball is loose, the self-control of this laboratory, and writing out a prescription is: Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae, Radix Bupleuri etc., feed to different tests group chicken mixing spice by 0.25%, 0.5%, 1% concentration.
Three word coccidiosis powder (33% sulfaclozine sodium), Zhengzhou Fu Yuan animal pharmaceutical estate company limited is produced, lot number: 20040601.
1.3 test worm strain
Test is the Eimeria Tenella egg capsule with coccidian oocyst, is provided by animal science institute of University Of Agriculture and Forestry In Fujian parasite laboratory.
2 test groupings
2.1 Chinese medicine test group
1. high dose group: when infecting coccidian oocyst, loose by the treatment of feeding of 1% dosage mixing with evergreen anti-ball.
2. middle dosage group: when infecting coccidian oocyst, loose by the treatment of feeding of 0.5% dosage mixing with evergreen anti-ball.
3. low dose group: when infecting coccidian oocyst, loose by the treatment of feeding of 0.25% dosage mixing with evergreen anti-ball.
2.2 positive controls
When infecting coccidian oocyst, add with three word coccidiosis powder the treatment of feeding, consumption is 1 g/kg.
2.3 negative control group
Infect coccidian oocyst but do not treat.
3 test methods
3.1 artificial challenge
5 groups of chickling whole per os artificial infection chicken Eimeria Tenella Sporulated Oocysts 8.0 * 10 when 15 age in days
4Individual/only.
3.2 Clinical Treatment Test
Infect the same day of coccidian oocyst, immediately each group chicken is carried out the treatment of medicine and control drug, continuous 5 d according to above-mentioned grouping situation.At the 8th d, chicken all to be slaughtered cutd open inspection, survival rate, rate of body weight gain, the caecum lesion that calculates each group scored, hemafecia is scored, caecum egg sac number, egg capsule be than number, egg capsule value and anticoccidial index (ACI).
3.3 index of assessment of curative effect
Index of assessment of curative effect calculates with following formula.
Mortality rate=(every group because infecting chicken sum in the lethal chicken number of coccidiosis/group) * 100%
Feces is scored: with reference to the standard of Morehouse, namely 4d begins to observe the blood stool situation after the artificial challenge, scores by the most serious 1 time of hemafecia, and calculates full cell mean.The normal note of feces 0 minute; Every chicken hemafecia on average occurred how much piling and just remembered respectively what minutes this day.
Lesion score: with reference to the standard of Johnson etc., score according to cuing open after inspection the order of severity of caecum intestinal pathological changes.Remember 0 minute without pathological changes; The Minimal change person remembers 1 minute; The caecum wall thickening has little medium hemorrhage note 2 minutes of arriving; In have and much went out clot note 3 minutes, because of the dead note of coccidiosis 4 minutes.
The pathological changes value: with reference to the standard of Merck Sharp, i.e. the average of the lesion score of every group of test chicken * 10.
Egg capsule counting: in the feces by every group of the 7th d excretion after infecting egg capsule, divide multiple spot to choose each 5 g of fresh excreta, then add 10 mL normal saline, with mortar grind gently several under, then add 50 mL saturated brines, use the McMaster counting chamber after mixing, choose at random 5 visuals field and observe counting, average at last.
Egg capsule is than number: egg capsule ratio=(healthy group or test group egg sac number/infect the egg sac number of not administration group) * 100%.
The egg capsule value: the standard of reference angle Sesbania cannabina (Retz.) Pers., when namely egg capsule was 0 ~ 1% than number, the egg capsule value was 0; Be 5 in the time of 2% ~ 25%; Be 10 in the time of 26% ~ 50%; Be 20 in the time of 51% ~ 75%; Be 40 in the time of 76% ~ 100%.
Anticoccidial index (ACI): adopt the standard of Merck ﹠ Co., Inc., i.e. anticoccidial index=(weightening finish percentage rate+survival rate)-(pathological changes value+egg capsule value).
3.4 evaluation of result
With anticoccidial index assessment drug effect.The anticoccidial index〉180 be efficient; 160 ~ 180 is middle effect; Be poor efficiency lower than 160; Be invalid lower than 120.
4 result of the tests
The comprehensive judged result of anticoccidial effect sees Table 1.
Each test group anticoccidial index assessment result of table 1
| ? | Mortality rate % | The relative weight gain rate % | Lesion score | The egg capsule value | ACI |
| The loose group of 1% evergreen anti-ball | 0 | 93.8 | 14 | 5 | 174.8 |
| The loose group of 0.5% evergreen anti-ball | 0 | 89.5 | 17 | 5 | 167.5 |
| The loose group of 0.25% evergreen anti-ball | 10 | 73.5 | 35 | 20 | 108.5 |
| Negative control group | 16 | 72.5 | 38 | 40 | 78.5 |
| Positive controls | 0 | 90.2 | 10 | 5 | 175.2 |
This result of the test shows, the anticoccidial index of the loose group of 1% evergreen anti-ball and the loose group of 0.5% evergreen anti-ball is between 160 ~ 180, be middle effect, two dosage all can well be controlled artificial challenge's eimeria coccidiosis chicken and avoid death, and the loose group of 1% evergreen anti-ball can prevent that rate of body weight gain from reducing.The anticoccidial index of the loose group of 0.25% evergreen anti-ball＜120 are for invalid.Three word coccidiosis treated powder groups are middle effect between 160 ~ 180, suitable with the loose effect of evergreen anti-ball.But evergreen anti-ball is loose, and its toxic and side effects is little, and low-residual is difficult for producing drug resistance, and is therefore even more ideal than three word coccidiosis powder.Evergreen anti-ball is loose has that parasite killing protects the liver, the effect of cooling blood for hemostasis, dampness-eliminating and dysentery-stopping, heat-clearing and toxic substances removing, the mixed infection that is adapted to prevent and treat chicken coccidiosis and coccidiosis and antibacterial, recommended dose be chicken by 0.5% even mixed feeding, be used in conjunction 5 d.
Claims (3)
1. a Chinese medicine preparation for the treatment of chicken coccidiosis, is characterized in that being comprised of Radix Dichroae, Herba Artemisiae Annuae, Radix Bupleuri, the Radix Pulsatillae, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Sanguisorbae, and each shared weight percent of crude drug dry product of distinguishing the flavor of is as follows:
Radix Dichroae 18～22%, Herba Artemisiae Annuae 13～17%, Radix Bupleuri 13～17%, the Radix Pulsatillae 13～17%,
Ramulus Uncariae Cum Uncis 13～17%, Herba Agrimoniae 8～12%, Radix Sanguisorbae 8～12%.
2. a kind of Chinese medicine preparation for the treatment of chicken coccidiosis according to claim 1, the shared weight percent of crude drug that it is characterized in that respectively distinguishing the flavor of is as follows:
Radix Dichroae 20%, Herba Artemisiae Annuae 15%, Radix Bupleuri 15%, the Radix Pulsatillae 15%,
Ramulus Uncariae Cum Uncis 15%, Herba Agrimoniae 10%, Radix Sanguisorbae 10%.
One kind treat chicken coccidiosis the preparation method of Chinese medicine preparation, it is characterized in that comprising the following steps:
1) get the raw materials ready: 7 flavor crude drug of oven dry as claimed in claim 1 or 2, by its prescription proportioning mixing for standby use;
2) extract: at 55～60 ℃ of temperature, pressure not under the condition higher than 0.05Mpa, be that 70%～75% ethanol mixes with above-mentioned raw materials medicine and isopyknic concentration, continuous extraction is 2 times in Multifunctional Chinese medicine extraction unit, and each extraction time is all 1h, merges the crude extract of 2 lixiviate gained;
3) concentrated: putting crude extract in concentrator, is that under the condition of 50～55 ℃ of-0.06～0.07Mpa, temperature, being concentrated into proportion is 1.2～1.3, gets extractum in vacuum;
4) add starch: press extractum: the weight ratio of starch=1:1 is added starch in extractum, and stirs;
5) drying: be set up state starch and extractum mixture in the electric heating hot air circulation drying oven, under the condition of 60～80 ℃ of temperature, be dried to moisture content≤8%;
6) pulverize: taking out above-mentioned dry thing, to be crushed to fineness with crushing and pelletizing machine be 50～60 orders; Get final product.
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| CN102319309B true CN102319309B (en) | 2013-06-19 |
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| CN102621052A (en) * | 2012-03-01 | 2012-08-01 | 塔里木大学 | Method for efficiently and accurately determining quantity of worm eggs in excrements of plant-eating animals |
| CN102805266B (en) * | 2012-08-21 | 2013-09-25 | 山东新希望六和集团有限公司 | Feed for improving digestive and immunologic ability of chicken |
| CN103349718B (en) * | 2013-07-31 | 2015-02-25 | 华南农业大学 | Livestock and poultry cryptozoite infection prevention and treatment compound traditional Chinese medicine, preparation method and application thereof |
| CN103417654B (en) * | 2013-08-12 | 2016-02-10 | 河南惠通天下生物工程有限公司 | A kind ofly prevent and treat Chinese medicine composition of Avian Coccidia disease and preparation method thereof |
| CN103585462B (en) * | 2013-11-13 | 2016-01-13 | 河南牧翔动物药业有限公司 | A kind of anticoccidial herb mixture and preparation method thereof |
| CN105031245B (en) * | 2015-08-27 | 2018-09-28 | 山东恩康药业有限公司 | A kind of Chinese medicine composition of anti-Eimeria Tenella |
| CN106615920A (en) * | 2016-11-18 | 2017-05-10 | 遵义市吉贵乐生态养殖场 | Native chicken fodder |
| CN109588555A (en) * | 2018-12-26 | 2019-04-09 | 北京爱绿生物科技有限公司 | A kind of water-soluble natural plants anticoccidial feed addictive and preparation method thereof |
| CN110100950A (en) * | 2019-06-19 | 2019-08-09 | 山东省农业科学院家禽研究所 | A kind of composite feed additive of substitute antibiotics prevention and treatment chicken coccidiasis |
| CN112674231A (en) * | 2020-12-28 | 2021-04-20 | 江门市旺海饲料实业有限公司 | Fast-growing chicken complete feed and preparation method and application thereof |
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