CN106492004A - A kind of Fish Chinese medicine feed additive and preparation method thereof - Google Patents
A kind of Fish Chinese medicine feed additive and preparation method thereof Download PDFInfo
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- CN106492004A CN106492004A CN201610917265.7A CN201610917265A CN106492004A CN 106492004 A CN106492004 A CN 106492004A CN 201610917265 A CN201610917265 A CN 201610917265A CN 106492004 A CN106492004 A CN 106492004A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The invention belongs to feed additive research and development technology field, more particularly to a kind of Fish Chinese medicine feed additive and preparation method thereof.A kind of Fish Chinese medicine feed additive, by being made up of following components by weight：6 15 parts of 20 30 parts of Radix Codonopsis, 10 30 parts of Radix Angelicae Sinensis, 8 20 parts of the Radix Paeoniae Alba, 8 16 parts of Radix Polygoni Multiflori, 8 20 parts of Fructus Schisandrae Chinensis, 9 18 parts of Semen Myristicae, 9 20 parts of Radix Achyranthis Bidentatae, 7 21 parts of Flos Chrysanthemi, 25 35 parts of Herba Schizonepetae, 15 30 parts of Herba Ephedrae, 10 19 parts of Herba Asari, 8 15 parts of Rhizoma Et Radix Notopterygii, 25 35 parts of Rhizoma Imperatae, 25 35 parts of Radix Bupleuri, 8 15 parts of QINGSONG, 10 25 parts of Fructus Aurantii Immaturus and Olibanum.There is synergistic function between each Chinese medicine ingredients of Fish Chinese medicine feed additive of the invention, it is ill that the Chinese medicine feed additive for preparing is prevented from Ctenopharyngodon idellus, Ctenopharyngodon idellus survival rate is improved, improves the activity level of lysozyme, superoxide dismutase, catalase, alkali phosphatase in Ctenopharyngodon idellus body.
Description
Technical field
The invention belongs to feed additive research and development technology field, more particularly to a kind of Fish Chinese medicine feed additive and its system
Preparation Method.
Background technology
Ctenopharyngodon idellus are one of four large Chinese carps of China, and the Freshwater Fish that China is main, Ctenopharyngodon idellus cultivation have feed cost low,
The advantages of economic benefit is obvious.But erythroderma, gill rot, enteritis disease and the bleeding being easily subject in breeding process due to Ctenopharyngodon idellus
Disease is referred to as the infringement of " four disease of Ctenopharyngodon idellus ", and fish production is made a big impact.Problem is prevented and treated in order to solve Ctenopharyngodon idellus " four disease ",
Need the immune function for improving conscientiously Ctenopharyngodon idellus.
Chinese herbal medicine is a kind of preferably natural, environment-friendly medicine, little, safe, residual with efficient, toxic and side effects
Many advantages, such as staying few, and wide material sources, low cost.The immunity of aquatic animal is improved by the administration of Chinese herbal medicine, fish is improved
Class premunition, the sickness rate for reducing aquatic animal is the focus that studied in recent years.In the new shape for advocating healthy aquaculture at present comprehensively
Under gesture, fish immunity function is improved using Chinese herbal medicine, be extremely important.
Application No. 201310630290.3《For improving the immune formulation of Ctenopharyngodon idellus immune function》Patent of invention public
Open a kind of immune formulation for improving Ctenopharyngodon idellus immune function, it is characterised in that：Crude drug is by Polyporus, Radix Et Caulis Acanthopanacis Senticosi, the Rhizoma Atractylodis Macrocephalae, people
Rhizoma panacis majoris, Herba Houttuyniae, the Cortex Eucommiae, Herba Ecliptae, Rhizoma Drynariae, Ramulus Cinnamomi, Radix Isatidis, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, Flos Campsiss, Rhizoma Dioscoreae, Caulis Spatholobi, soap
Fructus Gleditsia acupuncture, Fructus Corni, Ramulus Persicae, Fructus Cnidii, Fructus Jujubae, the Radix Stemonae, Semen Euryaless, Fructus Galangae, Semen Arecae, pittosporm root and Conyza canadensis (L.) Cronq. are constituted.From entirety
See, the formula biases toward spleen reinforcing and supports kidney, adjusts gastrointestinal function, for enteritis disease effect still, but the patent is not given enough
Data illustrate that this kind of immune formulation has ideal effect for the preventing and treating of Ctenopharyngodon idellus viral disease, bacterial disease.
In view of the defect of prior art, a kind of Chinese medicine fodder interpolation for improving Ctenopharyngodon idellus immune function of present invention proposition
Agent, its have efficiently, have no toxic side effect, safe, noresidue many advantages, such as, and wide material sources, low cost, to Fish
Immune system carries out across-the-board regulation, improves the dynamic resistances against diseases of Aquatic product and immune function, so as to preventing and curing of fish disease.
The information for being disclosed in the background section is merely intended to the understanding for increasing the general background to the present invention, and should not
When the prior art for being considered to recognize or imply the information structure in any form well known to persons skilled in the art.
Content of the invention
For above-mentioned deficiency present in prior art, the present invention provides a kind of Fish Chinese medicine feed additive and its preparation
Method, the Chinese medicine feed additive reasonable recipe, prepare simple, effect substantially, have no toxic side effect, have no drug resistance residual with medicine
Stay, Ctenopharyngodon idellus immune function can be effectively improved.
To achieve these goals, the present invention is to employ the following technical solutions realization：
A kind of Fish Chinese medicine feed additive, by being made up of following components by weight：Radix Codonopsis 20-30 parts, Radix Angelicae Sinensis 10-30
Part, Radix Paeoniae Alba 8-20 parts, Radix Polygoni Multiflori 8-16 parts, Fructus Schisandrae Chinensis 8-20 parts, Semen Myristicae 9-18 parts, Radix Achyranthis Bidentatae 9-20 parts, Flos Chrysanthemi 7-21 parts,
Herba Schizonepetae 25-35 parts, Herba Ephedrae 15-30 parts, Herba Asari 10-19 parts, Rhizoma Et Radix Notopterygii 8-15 parts, Rhizoma Imperatae 25-35 parts, Radix Bupleuri 25-35 parts, QINGSONG
8-15 parts, Fructus Aurantii Immaturus 10-25 parts and Olibanum 6-15 parts.
Preferably, described Fish Chinese medicine feed additive, by being made up of following components by weight：25 parts of Radix Codonopsis,
20 parts of Radix Angelicae Sinensis, 12 parts of the Radix Paeoniae Alba, 12 parts of Radix Polygoni Multiflori, 14 parts of Fructus Schisandrae Chinensis, 15 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, 12 parts of Flos Chrysanthemi, Herba Schizonepetae 30
Part, 25 parts of Herba Ephedrae, 15 parts of Herba Asari, 11 parts of Rhizoma Et Radix Notopterygii, 30 parts of Rhizoma Imperatae, 30 parts of Radix Bupleuri, 12 parts of QINGSONG, 20 parts of Fructus Aurantii Immaturus and Olibanum 10
Part.
In addition, present invention also offers the preparation method of described Fish Chinese medicine feed additive, comprises the following steps：
(1) weigh by weight Radix Codonopsis in formula, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Semen Myristicae, Radix Achyranthis Bidentatae,
Flos Chrysanthemi, Herba Schizonepetae, Herba Ephedrae, Herba Asari, Rhizoma Et Radix Notopterygii, Rhizoma Imperatae, Radix Bupleuri, QINGSONG, Fructus Aurantii Immaturus, Olibanum, clean and dry, and in addition to Herba Asari, Herba Schizonepetae, lead to
Cross after pulverizer is pulverized and mixed, add the tap water of its 3-4 times of weight, first boil slow fire again by intense fire and endure 0.5-1h, after filtration
First filtrate, toward the tap water that medicinal residues add its weight 2-3 times, boils rear slow fire by intense fire and endures 0.5h to add Herba Asari, Herba Schizonepetae continuous
10-15min is endured, second filtrate is poured out, after merging filtrate twice, herb liquid study is concentrated to give；
(2) in the herb liquid study of step (1) gained, add the dehydrated alcohol of its volume 3-5 times, stirring and dissolving to dilute,
Flow back at a temperature of 85-95 DEG C 2.5-3.5h, obtains refined herb liquid；
(3) the refined herb liquid of step (2) gained is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 130-150 DEG C, and leaving air temp is 75-90 DEG C,
Powdered rubber is obtained, powdered rubber is crushed to 120 mesh, Chinese medicinal powder is obtained；
(4) Chinese medicinal powder of step (3) gained is admixed the Semen Maydis powder of its quality 2-3 times, is mixed, is carried out expanded, temperature
At 85-90 DEG C, expanded time 1-2min, subsequent pelletize, cooling treat that particulate component is cooled to 20-25 DEG C, pack, obtain final product for control
Fish Chinese medicine feed additive.
Compared with prior art, the present invention has the advantages that：
(1) there is synergistic function between each Chinese medicine ingredients of Fish Chinese medicine feed additive of the invention, in preparing
There is medicine feed additive convergence removing toxic substances, spleen invigorating to support kidney, digestion promoting, the immune system of Fish is adjusted, is improved
The anti-stress ability and immune function of Ctenopharyngodon idellus, is prevented from Ctenopharyngodon idellus illness, improves Ctenopharyngodon idellus survival rate, improve bacteriolyze in Ctenopharyngodon idellus body
Enzyme, superoxide dismutase, catalase, the activity level of alkali phosphatase.
(2) Fish Chinese medicine feed additive raw material of the invention is pure natural raw material, without any chemical classes medicine, system
Preparation Method is simple, and the Chinese medicine feed additive residual rate is low, toxicity is low, does not affect the quality of Ctenopharyngodon idellus, is not detrimental to health.
(3) Fish Chinese medicine feed additive preparation method of the invention is simple, it is easy to large-scale promotion and application.
Specific embodiment
The specific embodiment of the present invention is described in detail with reference to specific embodiment, it is to be understood that of the invention
Protection domain do not limited by specific embodiment.
Embodiment 1：
A kind of Fish Chinese medicine feed additive, by being made up of following components by weight：20 parts of Radix Codonopsis, 10 parts of Radix Angelicae Sinensis, white
8 parts of Chinese herbaceous peony, 8 parts of Radix Polygoni Multiflori, 8 parts of Fructus Schisandrae Chinensis, 9 parts of Semen Myristicae, 9 parts of Radix Achyranthis Bidentatae, 7 parts of Flos Chrysanthemi, 25 parts of Herba Schizonepetae, 15 parts of Herba Ephedrae, Herba Asari
6 parts of 10 parts, 8 parts of Rhizoma Et Radix Notopterygii, 25 parts of Rhizoma Imperatae, 25 parts of Radix Bupleuri, 8 parts of QINGSONG, 10 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of described Fish Chinese medicine feed additive, comprises the following steps：
(1) weigh by weight Radix Codonopsis in formula, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Semen Myristicae, Radix Achyranthis Bidentatae,
Flos Chrysanthemi, Herba Schizonepetae, Herba Ephedrae, Herba Asari, Rhizoma Et Radix Notopterygii, Rhizoma Imperatae, Radix Bupleuri, QINGSONG, Fructus Aurantii Immaturus, Olibanum, clean and dry, and in addition to Herba Asari, Herba Schizonepetae, lead to
Cross after pulverizer is pulverized and mixed, add the tap water of its 3 times of weight, first boil slow fire again by intense fire and endure 0.5h, after filtration for the first time
Filtrate, adds the tap water of 2 times of its weight toward medicinal residues, boils rear slow fire by intense fire and endures 0.5h and adds that Herba Asari, Herba Schizonepetae are continuous to endure
10min, pours out second filtrate, is concentrated to give herb liquid study after merging filtrate twice；
(2) in the herb liquid study of step (1) gained, add the dehydrated alcohol of 3 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 85 DEG C 2.5h, obtains refined herb liquid；
(3) the refined herb liquid of step (2) gained is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 130 DEG C, and leaving air temp is 75 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder of step (3) gained is admixed the Semen Maydis powder of 2 times of its quality, is mixed, is carried out expanded, temperature control
At 85 DEG C, expanded time 1min, subsequent pelletize, cooling treat that particulate component is cooled to 20 DEG C to system, pack, and obtain final product the feeding of Fish Chinese medicine
Feed additives.
Embodiment 2：
A kind of Fish Chinese medicine feed additive, by being made up of following components by weight：30 parts of Radix Codonopsis, 30 parts of Radix Angelicae Sinensis, white
20 parts of Chinese herbaceous peony, 16 parts of Radix Polygoni Multiflori, 20 parts of Fructus Schisandrae Chinensis, 18 parts of Semen Myristicae, 20 parts of Radix Achyranthis Bidentatae, 21 parts of Flos Chrysanthemi, 35 parts of Herba Schizonepetae, Herba Ephedrae 30
15 parts of part, 19 parts of Herba Asari, 15 parts of Rhizoma Et Radix Notopterygii, 35 parts of Rhizoma Imperatae, 35 parts of Radix Bupleuri, 15 parts of QINGSONG, 25 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of described Fish Chinese medicine feed additive, comprises the following steps：
(1) weigh by weight Radix Codonopsis in formula, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Semen Myristicae, Radix Achyranthis Bidentatae,
Flos Chrysanthemi, Herba Schizonepetae, Herba Ephedrae, Herba Asari, Rhizoma Et Radix Notopterygii, Rhizoma Imperatae, Radix Bupleuri, QINGSONG, Fructus Aurantii Immaturus, Olibanum, clean and dry, and in addition to Herba Asari, Herba Schizonepetae, lead to
Cross after pulverizer is pulverized and mixed, add the tap water of its 4 times of weight, first boil slow fire again by intense fire and endure 1h, after filtration filter for the first time
Liquid, adds the tap water of 3 times of its weight toward medicinal residues, boils rear slow fire by intense fire and endures 0.5h and adds that Herba Asari, Herba Schizonepetae are continuous to endure 15min,
Second filtrate is poured out, after merging filtrate twice, herb liquid study is concentrated to give；
(2) in the herb liquid study of step (1) gained, add the dehydrated alcohol of 5 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 95 DEG C 3.5h, obtains refined herb liquid；
(3) the refined herb liquid of step (2) gained is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 150 DEG C, and leaving air temp is 90 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder of step (3) gained is admixed the Semen Maydis powder of 3 times of its quality, is mixed, is carried out expanded, temperature control
At 90 DEG C, expanded time 2min, subsequent pelletize, cooling treat that particulate component is cooled to 25 DEG C to system, pack, and obtain final product the feeding of Fish Chinese medicine
Feed additives.
Embodiment 3：
A kind of Fish Chinese medicine feed additive, by being made up of following components by weight：25 parts of Radix Codonopsis, 20 parts of Radix Angelicae Sinensis, white
12 parts of Chinese herbaceous peony, 12 parts of Radix Polygoni Multiflori, 12 parts of Fructus Schisandrae Chinensis, 15 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, 14 parts of Flos Chrysanthemi, 30 parts of Herba Schizonepetae, Herba Ephedrae 25
9 parts of part, 15 parts of Herba Asari, 12 parts of Rhizoma Et Radix Notopterygii, 30 parts of Rhizoma Imperatae, 30 parts of Radix Bupleuri, 12 parts of QINGSONG, 20 parts of Fructus Aurantii Immaturus and Olibanum.
The preparation method of described Fish Chinese medicine feed additive, comprises the following steps：
(1) weigh by weight Radix Codonopsis in formula, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Semen Myristicae, Radix Achyranthis Bidentatae,
Flos Chrysanthemi, Herba Schizonepetae, Herba Ephedrae, Herba Asari, Rhizoma Et Radix Notopterygii, Rhizoma Imperatae, Radix Bupleuri, QINGSONG, Fructus Aurantii Immaturus, Olibanum, clean and dry, and in addition to Herba Asari, Herba Schizonepetae, lead to
Cross after pulverizer is pulverized and mixed, add the tap water of its 3.5 times of weight, first boil slow fire again by intense fire and endure 0.8h, after filtration just
Secondary filtrate, adds the tap water of 2.5 times of its weight toward medicinal residues, boils rear slow fire by intense fire and endures 0.5h and adds that Herba Asari, Herba Schizonepetae are continuous to endure
12min, pours out second filtrate, is concentrated to give herb liquid study after merging filtrate twice；
(2) in the herb liquid study of step (1) gained, add the dehydrated alcohol of 4 times of its volume, stirring and dissolving to dilute,
Flow back at a temperature of 90 DEG C 3.0h, obtains refined herb liquid；
(3) the refined herb liquid of step (2) gained is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape is obtained
Middle medicinal substances, glue milky substance are put in drying machine and are dried, and inlet temperature is 140 DEG C, and leaving air temp is 80 DEG C, obtains powder
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by material；
(4) Chinese medicinal powder of step (3) gained is admixed the Semen Maydis powder of 2.5 times of its quality, is mixed, is carried out expanded, temperature
At 88 DEG C, expanded time 1-2min, subsequent pelletize, cooling treat that particulate component is cooled to 22 DEG C, pack, obtain final product in Fish for control
Medicine feed additive.
Embodiment 4：The Fish Chinese medicine feed additive of the present invention is tested to survival rate and resistances against diseases
Experimental animal：Test Ctenopharyngodon idellus are purchased from Nanning City fish farm, are juvenile fish, body weight 80-86g/ tail, selected test fry
Number is 4000 tails, and healthy strong, male and female have.4000 tail Ctenopharyngodon idellus are randomly divided into four groups：Test group 1-3 and matched group, per group
Containing 1000 tail of juvenile fish.
Test feed：Chinese medicine feed additive mixed fodder prepared by test group 1-3 difference feeding embodiment of the present invention 1-3
(will 150g above-described embodiments 1-3 prepare Chinese medicine feed additive, 80g soybean cakes, 350g wheat flours, 35g crab shell powders, 60g shrimps
Powder, 10g Sal, 160g Semen Maydis powder, 30g fish oil, 15g glycine betaines, 2g dalcium biphosphates, 2g ferric citrates, 40g compound vitamines
B, 30g yeast, 20g threonine, 20g lysines, mix homogeneously)；The feedstuff of matched group feeding is with the difference of test group：Make
The Chinese medicine feed additive for replacing the present invention to use with bambermycin 20mg/kg.
Feeding method：Date of test is 8 days-October 22 May in 2015.Ctenopharyngodon idellus are cultivated in fish pond, stocking density 1
Bar/20L.Fish pond area 1500m2(long 50m × wide 30m), deep 80cm, with bamboo fence, (water can pass through, and fish can not pass through as mark
Accurate) separate and block into 375m24 blockages；Fish pond coolant-temperature gage whole average 16 DEG C (wherein 24-29 DEG C of summer, average 25.5
DEG C), pH value 6.5 ± 0.2, water quality meet fishery standard.
3-5% is quantitatively of fixed place and time feeds by fry weight for feedstuff day feeding volume, feeds 2 times/d, every 10d dosages 1 time.Adjust
Look into the survival rate of Ctenopharyngodon idellus.
Fish is put to death, with buffer (pH value 7.5,0.25mol/ sucrose, 0.025mol/L Tris-HCL, 0.1mmol/L
EDTA-2Na solution) rinse, then surface moisture is sucked with absorbent paper, remove bone parts, leave the groups such as heart, liver and gonad
Knit homogenate.Tissue 0.30g is accurately weighed, 9 times of buffer ice bath homogenate, 3000r/min low-temperature and high-speed centrifuges is added
10-15min, takes supernatant 2mL and determines lysozyme and superoxide dismutase vigor.
Test data represents that using means standard deviation (x ± s) two sample averages compare to be checked with t, and two samples constitute ratio
With chi-square criterion, P<0.05 has significance for difference.
As a result：Impact of the Chinese medicine feed additive to Ctenopharyngodon idellus survival rate, is shown in Table 1；Chinese medicine feed additive to lysozyme and
The impact of superoxide dismutase vigor, the results are shown in Table 2.
Impact of the Fish Chinese medicine feed additive of 1 present invention of table to Ctenopharyngodon idellus survival rate
| Group | Survival number (tail) | Death toll (tail) | Survival rate (%) |
| Test group 1 | 985 | 15 | 98.5 |
| Test group 2 | 988 | 12 | 98.8 |
| Test group 3 | 982 | 18 | 98.2 |
| Matched group | 800 | 200 | 80.0 |
As it can be seen from table 1 the Chinese medicine feed additive feeding Ctenopharyngodon idellus prepared using the present invention, its ill probability drop
Low, survival rate is significantly higher than matched group.
The Fish Chinese medicine feed additive of 2 present invention of table is to lysozyme, superoxide dismutase, catalase, alkalescence
The impact of Phosphatase Activity
From table 2 it can be seen that adopting the Ctenopharyngodon idellus of the Fish Chinese medicine feed additive feeding of the present invention relative to matched group, body
Interior lysozyme, superoxide dismutase, catalase, alkaline phosphatase levels are significantly improved, so as to prove the fish of the present invention
Class Chinese medicine feed additive has preferably defence disease, antiviral and antibacterial ability, can significantly improve the immunization machine of Ctenopharyngodon idellus
Energy.
Aforementioned to the present invention specific illustrative embodiment description illustrate that and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, much can be changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should
With so that those skilled in the art can realize and using the present invention a variety of exemplaries and
A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (3)
1. a kind of Fish Chinese medicine feed additive, it is characterised in that by being made up of following components by weight：Radix Codonopsis 20-30 parts,
Radix Angelicae Sinensis 10-30 parts, Radix Paeoniae Alba 8-20 parts, Radix Polygoni Multiflori 8-16 parts, Fructus Schisandrae Chinensis 8-20 parts, Semen Myristicae 9-18 parts, Radix Achyranthis Bidentatae 9-20 parts, chrysanthemum
Flower 7-21 parts, Herba Schizonepetae 25-35 parts, Herba Ephedrae 15-30 parts, Herba Asari 10-19 parts, Rhizoma Et Radix Notopterygii 8-15 parts, Rhizoma Imperatae 25-35 parts, Radix Bupleuri 25-
35 parts, QINGSONG 8-15 part, Fructus Aurantii Immaturus 10-25 parts and Olibanum 6-15 parts.
2. Fish Chinese medicine feed additive according to claim 1, it is characterised in that by by weight by following components system
Into：25 parts of Radix Codonopsis, 20 parts of Radix Angelicae Sinensis, 12 parts of the Radix Paeoniae Alba, 12 parts of Radix Polygoni Multiflori, 14 parts of Fructus Schisandrae Chinensis, 15 parts of Semen Myristicae, 15 parts of Radix Achyranthis Bidentatae, chrysanthemum
Spend 12 parts, 30 parts of Herba Schizonepetae, 25 parts of Herba Ephedrae, 15 parts of Herba Asari, 11 parts of Rhizoma Et Radix Notopterygii, 30 parts of Rhizoma Imperatae, 30 parts of Radix Bupleuri, 12 parts of QINGSONG, Fructus Aurantii Immaturus
20 parts and 10 parts of Olibanum.
3. the preparation method of Fish Chinese medicine feed additive according to claim 1 and 2, it is characterised in that including following
Step：
(1) weigh by weight Radix Codonopsis in formula, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Fructus Schisandrae Chinensis, Semen Myristicae, Radix Achyranthis Bidentatae, Flos Chrysanthemi,
Herba Schizonepetae, Herba Ephedrae, Herba Asari, Rhizoma Et Radix Notopterygii, Rhizoma Imperatae, Radix Bupleuri, QINGSONG, Fructus Aurantii Immaturus, Olibanum, clean and dry, in addition to Herba Asari, Herba Schizonepetae, by powder
The tap water of its 3-4 times of weight after broken machine is pulverized and mixed, is added, slow fire again is first boiled by intense fire and is endured 0.5-1h, obtained for the first time after filtration
Filtrate, adds the tap water of its weight 2-3 times toward medicinal residues, boils rear slow fire by intense fire and endures 0.5h and add Herba Asari, Herba Schizonepetae and continue and endures 10-
15min, pours out second filtrate, is concentrated to give herb liquid study after merging filtrate twice；
(2) in the herb liquid study of step (1) gained, add the dehydrated alcohol of its volume 3-5 times, stirring and dissolving to dilute,
Flow back at a temperature of 85-95 DEG C 2.5-3.5h, obtains refined herb liquid；
(3) the refined herb liquid of step (2) gained is taken, after decompression recycling ethanol, by herb liquid low-temperature evaporation, latex shape Chinese medicine is obtained
Material, glue milky substance is put in drying machine and is dried, and inlet temperature is 130-150 DEG C, and leaving air temp is 75-90 DEG C, obtains
Powdered rubber is crushed to 120 mesh, obtains Chinese medicinal powder by powdered rubber；
(4) Chinese medicinal powder of step (3) gained is admixed the Semen Maydis powder of its quality 2-3 times, is mixed, is carried out expanded, temperature control
At 85-90 DEG C, expanded time 1-2min, subsequent pelletize, cooling treat that particulate component is cooled to 20-25 DEG C, pack, obtain final product Fish
Chinese medicine feed additive.
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