CN106511412A - Pharmaceutical composition for preventing and treating arthritis of knee joint - Google Patents
Pharmaceutical composition for preventing and treating arthritis of knee joint Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating arthritis of the knee joint and a preparation method thereof. The pharmaceutical composition is prepared from bulk drugs consisting of Acer grosseri, Gonocarpus micrantha, Ziyuglycoside II, geniposide and water rail in a certain ratio. A variety of dosage forms of the pharmaceutical composition can be prepared by using conventional preparation process. The pharmaceutical composition has substantial curative effect in prevention and treatment of arthritis of the knee joint.
Description
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of pharmaceutical composition of preventing and treating knee joint endoprosthesis inflammation and its system
Preparation Method.
Background technology
Knee joint osteoarthritis abbreviation knee osteoarthritis, articulations digitorum manus cartilage degenerative change causes cartilage to lose, destruction, with
The disease of periarticular hyperosteogeny reaction, is a kind of common diseases of knee joint of middle-aged and elderly people, and clinic often takes nonsteroidal
Drug therapy, but long-term taking frequently results in serious adverse reaction.Knee joint osteoarthritis are closed as clinical common old people
Section degeneration, although expectant treatment patient multipotency receives at present, high recurrence rate.Long-time uses non-steroidal drug not
The disease can not be only effected a radical cure, and long-term taking untoward reaction is serious, and the course of disease can not be changed, or even showing for exacerbation of symptoms occurs
As.Traditional medicine thinks that knee joint osteoarthritis belong to categories such as " arthromyodynias ", " knee joint numbness " of the traditional Chinese medical science, and its etiology and pathogenesis mostly is Liver and kidney two
Void, muscles and bones cervical carcinoma with cachexia, wound, strains or wind-cold damp pathogen invasion and attack is caused in addition, and Therapeutic Principle is based on liver and kidney tonifying, expelling wind and activating blood circulation.
Moth tree：Pueraria lobota trailing plants maple Acer grosseri Pax var.hersii are split for Aceraceae Acer plants length（Rehd.）
Rehd. the twig and fruit of ［ A.hersii Rehd. ］.9-10 month picking fruits, dry；The 6-7 months harvest twig, dry.【Property
Taste】It is bitter；It is salty；It is flat.【Indication】Cough-relieving；Sore.The new chronic cough of master is coughed；Thrush.【Original shape state】It is tall that length splits Pueraria lobota trailing plants maple fallen leaves
Wood, up to 8m.Bark is filbert, smooth；Annual shoot green or purple green, perennial branch lark or taupe, leaf opposite；
The long 2-3cm of petiole, it is thin thin, without hair；Blade papery, avette, long 7-9cm, wide 5-6cm, edge have close and sharp heavy sawtooth, first
Hold sharp point, base portion to be bordering on heart-shaped, often deeper 3 and split, central sliver is larger, and triangular shape is avette, above bottle green, without hair；Under
Face light green, is then come off by faint yellow feathering always in vein base portion when tender；Base goes out 3, arteries and veins, lateral vein pinniform.Flower unisexuality, male and female are different
Strain, often into thin thin sagging raceme；Sepal 5；Petal 5；Stamen 8, without hair, the aplasia in female flower；Floral disc is located at stamen
Inner side；Ovary purple, the aplasia in male flower.The long 3-4mm of bennet.Lavender during Myriopteron extensum (Wight) K. Schum children, ripe rear yellowish-brown；Pyrene is micro- flat
Flat, together with the long 2.5-2.9cm of pyrene, wide about 5mm or is bordering on level at flare up obtuse angle to wing.April at florescence, fruiting period September.Record
In dictionary of medicinal plant.
Herba Haloragidis Micranthae:Haloragaceae seaberry Herba Haloragidis Micranthae Haloragis micrantha
(Thunb.) herb of R.Br.ex Sidb. Et Zucc. [Goniocarpus micranthus Thunb.].Summer harvests
Herb, cleans, dries.【Nature and flavor】Bitter in the mouth；It is puckery；It is cool in nature.【Return through】Return lung；Large intestine；Bladder；It is nontoxic.【Indication】Cough-relieving is put down
Breathe heavily；Clearing away heat-damp and promoting diuresis；Regulating menstruation and activating blood.Main cough；Asthma；Pyretic stranguria；Constipation；Dysentery；Menoxenia；Fall damage fracture；Furuncle；Acute mastitis；
Scald；Venom.【Former phytomorph】Perennial slim and frahile draft, grows thickly, high 20-40cm.Four prismatic of stem, band russet, directly
Vertical, base portion is crawled branch.Leaf is little, has short handle, opposite, and stem upper leaf is alternate sometimes；The usual egg shape or circular shape of blade, long 6-
10cm, wide 4-8mm, tip are short sharp or blunt, and there is a little tooth at edge, basal circular, and two sides is bald net, light green or puce.Circular cone
Inflorescence basidixed, is made up of thin raceme；Spend little, both sexes；Calyx pipe has rib, and sliver 4, triangle are harbored；Petal 4, it is red；
Stamen 8, flower pesticide aubergine；Gynoecium 1；Ovary is the next, has ratio rib, and style 4, the pink hair of the close life of stigma, drupe are subsphaeroidal,
Be about 1mm, it is bald will and it is bright, have 8 ribs.The month at florescence 6-7, the fruiting period 9-10 month.Record in dictionary of medicinal plant.
Carnis Rallus aquaticuss：This product is the meat that Rallidae Carnis Rallus aquaticuss belong to animal Carnis Rallus aquaticuss Rallus apuaticus (Linnaeus).The four seasons are equal
Can catch, after catching, remove feather and internal organs, take meat.【Nature and flavor】Sweet in the mouth；It is warm in nature.【Return through】Large intestine channel.【Indication】Removing toxic substances
Parasite killing；Invigorating the spleen and replenishing QI.Main ant fistula；Weakness of the spleen and stomach；Inappetence.【Former zoomorphism】Carnis Rallus aquaticuss, body are about 30cm.It is little；Neck
It is long.Upper body feather taupe, band black speckle, head speckle are particularly significant.The more than half ash of two wing surfaces is brown.Lower body brown, two
Axil has white macula；Crissum is identical with lower tall coverts black and white, plumage end white.Shin plumage is black and has white horizontal speckle.Mouth is dark brown, lower mouth base portion compared with
It is light.Foot sepia.Record in dictionary of medicinal plant.
Ziyuglycoside I I（Ziyuglycoside II）：CAS 35286-59-0, molecular formula C35H56O8, molecular weight
604.81.【Biological activity】Removing heat from blood, hemostasis.【Ingredient origin】Radix Sanguisorbae Sanguisorba officinalis.
Jasminoidin（Gardenoside）：CAS 24512-62-7, molecular formula C17H24O11, molecular weight 404.37.【It is biological
Activity】Discharge function, choleretic effect.【Ingredient origin】Fructus Gardeniae Gardenia jasminoides [Syn.Gardenia
florida)。
2 crude drug chemical constitutions：
Jasminoidin（Gardenoside）Ziyuglycoside I I（Ziyuglycoside II）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of scorching medicine group of effective preventing and treating knee joint endoprosthesis
Compound and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the scorching pharmaceutical composition of the preventing and treating knee joint endoprosthesis be：
Moth tree 262-268 weight portion Herba Haloragidis Micranthae 234-238 weight portion Ziyuglycoside I I13-16 weight portion jasminoidin 5-8
Weight portion Carnis Rallus aquaticuss 195-200 weight portions.
The scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis is preferably used in, is made up of the crude drug of following weight portion：
265 weight portion Herba Haloragidis Micranthae of moth tree, 236 weight portion Ziyuglycoside I I15 weight portion jasminoidin, 6 weight portion Carnis Rallus aquaticuss
198 weight portions.
The scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that pharmaceutical composition can be using galenic pharmacy
Conventional method prepares piece agent or capsule or drop pill.
The scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine group
Into preventing and treating knee joint endoprosthesis inflammation medicine.
The preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Moth tree 262-268 weight portion Herba Haloragidis Micranthae 234-238 weight portion sanguisorbins
II13-16 weight portion jasminoidin 5-8 weight portion Carnis Rallus aquaticuss 195-200 weight portions；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of the scorching pharmaceutical composition of preferred a kind of preventing and treating knee joint endoprosthesis, it is characterised in that as follows
Prepare：
The composition and weight portion of crude drug be：265 weight portion Herba Haloragidis Micranthae of moth tree, 236 weight portion Ziyuglycoside I I15 weight
6 weight portion Carnis Rallus aquaticuss of part jasminoidin, 198 weight portion；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
The preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that pharmaceutical composition can be adopted
Piece agent or capsule or drop pill are prepared with the conventional method of galenic pharmacy.
The preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that pharmaceutical composition and chemistry
Medicine or Chinese medicine composition preventing and treating knee joint endoprosthesis inflammation medicine.
Pharmaceutical composition preventing and treating knee joint endoprosthesis inflammation is evident in efficacy.
Specific embodiment
Embodiment 1：Scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis and preparation method thereof
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：Moth tree 265g Herba Haloragidis Micranthae
236g Ziyuglycoside I I15g jasminoidin 6g Carnis Rallus aquaticuss 198g；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis and preparation method thereof
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：Moth tree 262g Herba Haloragidis Micranthae
238g Ziyuglycoside I I13g jasminoidin 8g Carnis Rallus aquaticuss 195g；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis and preparation method thereof
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：Moth tree 268g Herba Haloragidis Micranthae
234g Ziyuglycoside I I16g jasminoidin 5g Carnis Rallus aquaticuss 200g；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 177g of Example, adds starch 426g, mixes, and granulation is dried, plus Microcrystalline Cellulose 130g, Hard Fat
Sour magnesium 7g, mixes, is pressed into 1800, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 167g of Example, adds starch 310g, mixes, and granulation is dried, granulate, adds appropriate stearic acid
Magnesium, mixes, encapsulated 1300, obtains final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 314g water-baths and boil molten, add 3 pharmaceutical composition 12g of embodiment, fully stir
Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is 3 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip are 2.4cm away from liquid level, and drop speed is per dividing 53 drops as optimum condition, to blot the cold of drop pill surface with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：
250 weight portion jasminoidin of Herba Haloragidis Micranthae, 5 weight portion Carnis Rallus aquaticuss, 260 weight portion.
Embodiment 8：The scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：
10 weight portion Carnis Rallus aquaticuss of Ziyuglycoside I I15 weight portion jasminoidin, 250 weight portion.
Embodiment 9：The scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis
The composition and weight portion of the crude drug of the scorching pharmaceutical composition of preventing and treating knee joint endoprosthesis be：
5 weight portion Carnis Rallus aquaticuss of Ziyuglycoside I I10 weight portion jasminoidin, 150 weight portion.
Experimental example 1：The scorching experimental study of preventing and treating knee joint endoprosthesis
1 data and method
1.1 physical data
The object of study medical knee joint osteoarthritis of Orthopaedics Clinic that are hospital of the city during in the June, 2012 in July, 2013
The clinical data of patient, all patients check all in accordance with clinical diagnosises and x-ray plain film, meet American Rheumatism Association in 1986 and push away
The standard of the diagnosis knee joint osteoarthritis recommended, is randomly divided into matched group and matched group by consultation time order.
Matched group 30, wherein male 15, women 15；Age at 50～75 years old, average 60.2 years old；The course of disease exists
2 months～12.2, average 2.5 years.
Treatment group 30, wherein male 15, women 15；Age at 50～75 years old, average 60.5 years old；The course of disease exists
3 months～12.1, average 2.4 years.
Constant pain etc. is shown as 2 groups of clinical symptoms more.The aspects such as 2 groups of Genders, age, the course of disease and clinical symptoms are entered
Row contrast, no significant difference (P>0.05), data has comparability.
1.2 Therapeutic Method
1.2.1 matched group
This group of patient takes and takes dorsal positions, and with patella, as point of puncture, after the routine disinfection of local, implantation glass is sour for lower edge recess
Sodium injection 2ml, after injection, under the guidance of doctor, bend and stretch joint carries out reconditioning.Inject weekly 1 time, treat for 1 within 1 month
Journey, efficacy after 3 courses for the treatment of.
1.2.2 treatment group
Massage manipulation is taken to coordinate oral medicinal herb treatment.During massage, patient lies supine is advised, doctor is from thigh to shank with brisk soft
Maneuver be affectedly bashful and loosen suffering limb 2～5min of muscle, press Heding cave, Xiyan, each 3min in Dubi cave successively, sp 9, gb 34,
Liangqiu, tsu san li, each cave 1min of the sea of blood, are then rubbed Ipsilateral patella with the palm of the hand and are defined by knee joint heating, hip in the wrong of finally going down on one's knees,
Inside and outside rotation shank, bends and stretches knee joint repeatedly, is finally pulled out in committee with bullet and completes a whole set of massage.Once a day, about 30min every time,
1 month be 1 course for the treatment of, efficacy after 3 courses for the treatment of.Oral medicament composition (1 pharmaceutical composition of embodiment), orally, every time
1.2g, respectively takes 1 time sooner or later.1 month be 1 course for the treatment of, efficacy after 3 courses for the treatment of.
2 results
2.1 criterion of therapeutical effect
The clinical symptoms of patient, sign all disappear, and locally without tenderness, activity is clinical recovery freely；
Patient clinical symptom disappears substantially, and sign has clear improvement, and pain substantially mitigates, though there is mild pain when movable not
Activist is affected to be effective；
Patient clinical symptom, sign make moderate progress, and when light during pain, severe one is effective；
The symptom of patient, sign are not improved or have the person that increases sign for invalid.
2.2 statistical method
Measurement data is checked with t, and ranked data rank test, all processes are counted in SPSS 12.0.2.3 2 groups
The curative effect of patient is contrasted
The results are shown in Table 1.
The Comparison of therapeutic of 12 groups of patients of table
| Group | Number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate (%) |
| Matched group | 30 | 6 | 9 | 6 | 9 | 70.0 |
| Treatment group | 30 | 13 | 10 | 5 | 2 | 93.3 |
Note:2 groups of total effective rates compare P<0.05, difference has significant.
Claims (8)
1. it is a kind of to prevent and treat the scorching pharmaceutical composition of knee joint endoprosthesis, it is characterised in that to make the group of the crude drug of the pharmaceutical composition
Into with weight portion it is：
Moth tree 262-268 weight portion Herba Haloragidis Micranthae 234-238 weight portion Ziyuglycoside I I13-16 weight portion jasminoidin 5-8
Weight portion Carnis Rallus aquaticuss 195-200 weight portions.
2. it is a kind of according to claim 1 to prevent and treat the scorching pharmaceutical composition of knee joint endoprosthesis, it is characterised in that to make the medicine
The composition and weight portion of the crude drug of compositionss be：
265 weight portion Herba Haloragidis Micranthae of moth tree, 236 weight portion Ziyuglycoside I I15 weight portion jasminoidin, 6 weight portion Carnis Rallus aquaticuss
198 weight portions.
3. it is a kind of according to claim 1 to prevent and treat the scorching pharmaceutical composition of knee joint endoprosthesis, it is characterised in that pharmaceutical composition
Piece agent or capsule or drop pill can be prepared using the conventional method of galenic pharmacy.
4. it is a kind of according to claim 1 to prevent and treat the scorching pharmaceutical composition of knee joint endoprosthesis, it is characterised in that pharmaceutical composition
The preventing and treating knee joint endoprosthesis inflammation medicine constituted with chemical drugs or Chinese medicine.
5. the preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Moth tree 262-268 weight portion Herba Haloragidis Micranthae 234-238 weight portion sanguisorbins
II13-16 weight portion jasminoidin 5-8 weight portion Carnis Rallus aquaticuss 195-200 weight portions；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. the preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis according to claim 5, it is characterised in that
Prepare as follows：
The composition and weight portion of crude drug be：265 weight portion Herba Haloragidis Micranthae of moth tree, 236 weight portion Ziyuglycoside I I15 weight
6 weight portion Carnis Rallus aquaticuss of part jasminoidin, 198 weight portion；
Preparation method：
（1）Moth tree, Herba Haloragidis Micranthae, Ziyuglycoside I I, jasminoidin, Carnis Rallus aquaticuss are taken by crude drug proportioning, is mixed, is used percentage by weight
Used as solvent, 30 DEG C of warm macerating are extracted 14% ethanol of concentration, and extraction time is 13 times, and each extraction time is 19.5 hours, molten every time
73.5 times for crude drug gross weight of agent consumption, filtration obtain medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, are concentrated into relative
Density 1.08, filtration, medicinal liquid are first washed with water by X-5 macroporous adsorptive resins, then with 47% ethanol of weight percent concentration
Eluant solution X-5 macroporous adsorptive resins, collection 47% ethanol elution of weight percent concentration, recovery ethanol, concentrate drying,
Obtain final product extract A；
（2）Take step（1）Medicinal residues A, with 66% ethanol of weight percent concentration as solvent, heating and refluxing extraction 8 times, is carried every time
The time is taken for 0.2 hour, 67 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned
Ethanol is received, relative density 1.12 is concentrated into, is filtered, medicinal liquid is first washed with water, then uses weight by SP70 macroporous adsorptive resins
79% ethanol solution eluting SP70 macroporous adsorptive resins of percent concentration, collect 79% ethanol elution of weight percent concentration,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. the preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis according to claim 5, it is characterised in that
Pharmaceutical composition can prepare piece agent or capsule or drop pill using the conventional method of galenic pharmacy.
8. the preparation method of the scorching pharmaceutical composition of a kind of preventing and treating knee joint endoprosthesis according to claim 5, it is characterised in that
Pharmaceutical composition and chemical drugs or Chinese medicine composition preventing and treating knee joint endoprosthesis inflammation medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132940.1A CN106511412A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for preventing and treating arthritis of knee joint |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611132940.1A CN106511412A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for preventing and treating arthritis of knee joint |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511412A true CN106511412A (en) | 2017-03-22 |
Family
ID=58343047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611132940.1A Withdrawn CN106511412A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for preventing and treating arthritis of knee joint |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106511412A (en) |
-
2016
- 2016-12-10 CN CN201611132940.1A patent/CN106511412A/en not_active Withdrawn
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Application publication date: 20170322 |