CN106539836A - A kind of pharmaceutical composition for treating rhinitis - Google Patents

A kind of pharmaceutical composition for treating rhinitis Download PDF

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CN106539836A
CN106539836A CN201611133130.8A CN201611133130A CN106539836A CN 106539836 A CN106539836 A CN 106539836A CN 201611133130 A CN201611133130 A CN 201611133130A CN 106539836 A CN106539836 A CN 106539836A
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extract
pharmaceutical composition
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不公告发明人
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention discloses a kind of treat pharmaceutical composition of rhinitis and preparation method thereof, pharmaceutical composition of the present invention is with comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish as bulk drug, proportioning is formed, and routinely can make various formulations by preparation process, and treatment rhinitis is evident in efficacy.

Description

A kind of pharmaceutical composition for treating rhinitis
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of treat pharmaceutical composition of rhinitis and preparation method thereof.
Background technology
Treating infant's rhinitis refer to the inflammation of bronchia mucosal and sub-mucosal tissues, can according to the anxious slow degree of course of disease length and morbidity It is divided into allergic rhinitis, acute rhinitis, rhinitis chronic.The clinical manifestation of children with allergic rhinitis for stream clear water sample nasal mucus, nasal obstruction, Rhiocnesmus and paroxysmal sneeze.During the activity of rhinitis chronic infant, nasal obstruction symptom discomfort is particularly evident, and night or the when of sitting quietly nose Plug symptom is obvious, and the nasal mucus of infant is in mucus, while there is also the symptoms such as giddy, headache.Acute rhinitis infant rises Slight fever with aversion to cold is frequently accompanied by when sick, whole body is all uncomfortable, and pharynx nasalis has burning heat sensation, intranasal is dry, itch, afterwards, Infant there is also nasal obstruction, stream clear water sample nasal mucus, and olfactory function declines.Therefore, the disease has a strong impact on the healthy of infant, Greatly reduce the quality of life level of infant.The disease should obtain the great attention of relevant staff.
Treating infant's rhinitis are a kind of clinically relatively conventional pediatric diseases, are divided into rhinitis chronic, acute rhinitis, allergia nose Scorching this 3 type.Wherein, disease most commonly seen in rhinitis chronic is nasosinusitis, mainly in children's cold more than 1 week Occur, clinical manifestation is purulence tears, nasal obstruction and headache etc..Treating infant's rhinitis not only affect the healthy of infant, affect infant Growth and development, while also bringing parents of hospitalized children larger psychological burden.In life, the head of a family to be given rhinitis infant appropriate shield Reason, to reduce the damage that disease brings infant.Further, it requires that clinical workers is furtherd investigate to this disease, look for Treat the effective method of the disease.
Ovate neolepisorus herb：For Polypodiaceae shield Cyclosorus plant ovum leaf shield fern Neolepisorus ovatus (Bedd.) Ching The herb of [Pleopeltis ovata Bedd.].Whole year can harvest, and after excavation, clean, dry.【Nature and flavor】It is bitter；It is cool.【Return Jing】The heart；Lung；Bladder warp.【Indication】Clearing heat and promoting diuresis；Hemostasis；Removing toxic substances.Main heat gonorrhea；Difficult urination；Hematuria；Tuberculosis is spat blood；Tell Blood；Traumatism and bleeding；Carbuncle swells；Scald.【Former phytomorph】The high 15-45cm of plant.Rhizome grows wild, close by ovum shape lanceolar Scale, length are tapering, and there is thin tooth at edge.Ye Yuansheng；The long 10-20cm of petiole, by scale；Blade ground paper matter, ovum shape lanceolar is to ovum Shape Long Circle or nearly triangle, wide 7-12cm, tapering, base portion is wider, circular to circle wedge shape, how many downward in petiole, full edge or How many bottoms divides；Lateral vein is obvious.Sporangiorus is big, circular, lines up irregular 1 to several rows in lateral vein both sides, has shield when young Shape paraphysis is covered.Record in dictionary of medicinal plant.
Comb leaf：This product is Athyriaceae Diplazium donianum (Mett.) Tard. Blet platymiscium Diplazium donianum (Mett.) Tard. Blet Diplazium donianum（Mett.）Tard- Blot. the herb of ［ Asplenium donianum Mett. ］.Whole year can harvest, and clean, dry.【Nature and flavor】Slight bitter；It is cold. 【Indication】Clearing heat and promoting diuresis；Removing pattogenic heat from the blood and toxic material from the body.Main jaundice with damp-heat pathogen；Snake bite；Traumatism and bleeding；Dysmenorrhoea.【Chemical analysis】Containing sieve The Chinese pine sterone (makisterone) A, B and D.【Former phytomorph】The high 30-60cm of plant.Rhizome length and grow wild, sturdy, top It is close with petiole base by black, lanceolar scale, there is little tooth at edge.Ye Jinsheng；The long 15-30cm of petiole, straw color are hard；Leaf Piece ground paper matter, without hair, Long Circle or ovate Long Circle, long 20-40cm, wide 15-20cm, a pinniform；Accessory pinna 2-5 pair is given birth in side, Alternate, obliquely, has short handle, long round shape lanceolar or ovum shape lanceolar, long 10-16cm, wide 2.5-5cm, and top is tapering to be slightly in Shape of tail, base portion wealthy wedge shape, full edge or to top tool dredge sawtooth, basidixed accessory pinna and side life accessory pinna similar shape；Middle arteries substantially, have shallow above Longitudinal furrow, justifies below and swells, lateral vein pinniform bifurcated, slightly obliquely, have scun 3-5 bars per group, and go directly limb.Sporangiorus line Shape, the generally twin both sides up and down in scun, have 1-2 bars on every group of lateral vein, nearly middle arteries are stretched out, several up to limb；Indusium similar shape, Film quality.Record in dictionary of medicinal plant.
Hydrangea xanthoncura Diels root：This product is Saxifragaceae silk ball platymiscium Huang arteries and veins silk ball Hydrangea xanthoneura The root of Diels.【Nature and flavor】It is pungent, temperature.【Indication】Promoting blood circulation, reunion of bone.Cure mainly fracture, rheumatic lumbago.【Proterties】 Root cylinder, distortion are about 8cm or longer, diameter about 2mm.Surface taupe, has vertical wrinkle and radicula or root trace.Crust is easy Come off, the place that comes off is aobvious faint yellow.Matter is tough, and difficulty fractures, section yellow-white, fibroid.Gas is micro-, taste is pungent.Record in dictionary of medicinal plant.
Tree head dish：This product is Capparidaceae barna platymiscium tree head dish Crateva unilocularis Buch.Ham. The stem of [C.religiosa auct.non Forst.f.], leaf.【Nature and flavor】Bitter；It is cold in nature.【Indication】It is clearing heat and detoxicating；It is strong Stomach.Main acute filthy disease heating；Rotten sore；Snake bite；Stomachache；Rheumatic arthritis.【Former phytomorph】Tree head dish, stingless arbor of falling leaves, Up to more than 10m.Finger-like compound leaf；Tool long handle；3 pieces of leaflet, avette or ovum shape lanceolar, long 7-12cm, wide 3-5cm, tip urgency It is sharp or tapering, carry on the back celadon corymb basidixed；Hua great, polygamy, diameter 5-7cm, just green-yellow, becomes lavender afterwards；Sepal 4, Bottom is bonded with floral disc；Petal 4, avette or square are circular, and tip is blunt or short point, has handle；Stamen is countless, closes with the base portion of podogynium It is raw；Ovary has handle, Room 1.Berry is subsphaeroidal, diameter 2.5-4cm.Seed is most.The month at florescence 3-4, the fruiting period 7-8 month.Record in Medicine voluminous dictionary.
Capillarisin（Capillarisin）：CAS 56365-38-9, molecular formula C16H12O7, molecular weight 316.26. 【Pharmacological action】Cholagogic.【Ingredient origin】Feverfew Artemisia capillaris aerial part.
1 bulk drug chemical constitution：
Capillarisin（Capillarisin）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effectively treatment rhinitis and its Preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the bulk drug of the pharmaceutical composition of the treatment rhinitis be：
Comb leaf 120-160 weight portion Hydrangea xanthoncura Diels root 80-100 weight portion capillarisin 20-30 weight portion ovate neolepisorus herbs 60-80 weight portion tree head dish 40-70 weight portions.
The pharmaceutical composition for the treatment of rhinitis is preferably used in, is made up of the bulk drug of following weight portion：
140 25 weight portion ovate neolepisorus herb of weight portion Hydrangea xanthoncura Diels 90 weight portion capillarisin of root of comb leaf, 70 weight portion tree head 50 weight portion of dish.
A kind of pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy Prepare piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating rhinitis, it is characterised in that the treatment that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Rhinitis medicine.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Comb leaf 120-160 weight portion Hydrangea xanthoncura Diels root 80-100 weight portion oriental wormwood colors Former ketone 20-30 weight portions ovate neolepisorus herb 60-80 weight portions tree head dish 40-70 weight portions；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：140 90 weight portion capillarisin of weight portion Hydrangea xanthoncura Diels root of comb leaf, 25 weight 70 weight portion tree head dish of amount part ovate neolepisorus herb, 50 weight portion；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition can adopt galenic pharmacy Conventional method prepare piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine Composition treatment rhinitis medicine.
Medicine composite for curing rhinitis is evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition for the treatment of rhinitis and preparation method thereof
Treatment rhinitis pharmaceutical composition bulk drug composition and weight portion be：Comb leaf 140g Hydrangea xanthoncura Diels root 90g mattresses Old chromone 25g ovate neolepisorus herbs 70g tree head dish 50g；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition for the treatment of rhinitis and preparation method thereof
Treatment rhinitis pharmaceutical composition bulk drug composition and weight portion be：Comb leaf 160g Hydrangea xanthoncura Diels root 80g mattresses Old chromone 30g ovate neolepisorus herbs 60g tree head dish 70g；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition for the treatment of rhinitis and preparation method thereof
Treatment rhinitis pharmaceutical composition bulk drug composition and weight portion be：Comb leaf 120g Hydrangea xanthoncura Diels root 100g mattresses Old chromone 20g ovate neolepisorus herbs 80g tree head dish 40g；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 24g of Example, adds starch 26g, mixes, and granulation is dried, plus microcrystalline cellulose 12g, stearic acid Magnesium 0.8g, mixes, is pressed into 200, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 26g of Example, adds starch 24g, mixes, and granulation is dried, whole grain, adds appropriate magnesium stearate, Mix, encapsulated 100, obtain final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 183g water-baths and boil molten, add 3 pharmaceutical composition 8g of embodiment, be sufficiently stirred for Uniformly, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 7 DEG C, and drip internal-and external diameter is 7.0/2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed is per dividing 53 drops as optimum condition, to blot the condensation on dripping pill surface with cotton Agent, obtains final product medicament composition dropping pills.
Experimental example 1：The experimental study for the treatment of rhinitis
One. data and method
1 data and method
1.1 physical data
Using in July, -2013 in July, 2012 city's hospital for treatment 52 rhinitis infants as this research object, press Experimental group and control group are classified as according to the method being randomly assigned, each 26.The male sex 13 in experimental group, women 13, age - 5 years old 3 months, average age（3.24±0.51）Year, the course of disease 2 months ~ 1 year, average age（0.66±0.35）Year；It is acute Rhinitis infant 11, rhinitis chronic infant 15.Man 13, female 13,3 months ~ 5 years old age, average age in control group （3.34±0.52）Year, the course of disease 2 months ~ 1 year, average course of disease（0.62±0.36）Year；Acute rhinitis infant 11, chronic nose Scorching infant 15.The basic document of two groups of infants compares, and difference is not statistically significant（P ＞ 0.05）, with comparativity.
1.2 treatment method
1.2.1 control group simple western medicine is treated
The key agents of infant are two generation cynnematin pins, give infant drip-feed, and local adds with 0.25 % furacillin solutions 3mg and dexamethasone pin, daily injection 5 times.Then nose is sprayed using Flixonase outside nasal cavity, daily spray 2 times.Observation infant Dense tears amount, reapply nasal sinus negative pressure give displacement attraction carry out auxiliary treatment.Inform that parents of hospitalized children carrys out weekly hospital's check 1 Secondary, every month is checked to the nasal cavity of infant using CT and hysteroscope.The time for treating 1 course for the treatment of is 1 month.
1.2.2 experimental group adds taste Cang'erzi San to treat
Prescription is：Pharmaceutical composition（1 pharmaceutical composition of embodiment）2.5g, and carry out adding to the ill according to the different symptoms of infant Subtract：The infant of allergic symptom weight adds cicada slough, plays both sides of the street；Infant more than purulence tears adds grass-leaved sweetflag, root of Chinese trichosanthes；The infant of headache adds river Rhizome of chuanxiong, bletilla striata lamb's-quarters；The infant of nosebleed epistaxis adds the dried rhizome of rehmannia, the root bark of tree peony.Medicine is decocted per agent 2 times, decocted good by the 1st time and the 2nd time Concoction mixes, and is divided into 4 times and takes.The time for treating 1 course for the treatment of is 1 month.
1.3 criterion
This experimental effect is divided into effective, effective and invalid.It is effective：After treatment, infant nasal obstruction, rhinorrhea and headache etc. Clinical manifestation thoroughly disappears, and the mucous membrane in infant nasal cavity recovers normal color, does not have purulent secretion at nasal meatus and olfactory cleft； CT scanning results show that the nasosinusitis mucous membrane of infant is normal；Nasal meatus inspection result shows that the aeration status of infant intranasal are preferable. Effectively：After treatment, the nasal obstruction of infant, rhinorrhea and headache syndromes are improved, infant nasal meatus and olfactory cleft Place's purulent secretion has been reduced；In infant nasal cavity, the color and luster of mucous membrane recovers normal；CT scanning results show, infant nasosinusitis Interior mucous membrane does not also disappear still in the trend for thickening, and soft tissue.It is invalid：After treatment, the nasal obstruction of infant, rhinorrhea with And headache syndromes are not changed in even aggravation, CT scanning results show that infant sinus mucosa does not have any improvement.Control Treatment total effective rate=（Effective number of cases+effective number of cases）/ total number of cases × 100%.The quality of life situation of infant is commented by quality of life Quantitative table（The shortform health survey questionnaire, SF-36）Scale is evaluated, and scale is divided into For 8 dimensions, total score is 100 points.The fraction of infant is higher, represents its quality of life level higher.Scoring is by professional people Member is investigated to infant, the life quality scores before investigating two groups of patient's treatments and after treatment, and control time is half an hour.
1.4 statistical method
Data processing is carried out using 18.0 softwares of SPSS, measurement data is represented with x ± s, checked using t, enumeration data is used Percentage represents that, using Chi-square Test, P ＜ 0.05 have statistical significance for difference.
2 results
The comparison of 2.1 two groups of infant therapeutic effects
Experimental group treatment total effective rate is 92.31%, and treatment of control group total effective rate is 69.23 %, is compared between group, and difference has Statistical significance（P ＜ 0.05）, it is shown in Table 1.
The comparison (n=25) of 1 two groups of infant therapeutic effects of table
Group It is effective Effectively It is invalid Total effective rate (%)
Control group 7 11 8 69.23
Experimental group 14 10 2 92.31*
Compare with control group, * P ＜ 0.05.
The comparison of 2.2 two groups of infant life quality scores
Life quality scores of the experimental group with control group before the treatment compare, no significant difference（P ＞ 0.05）；And treat Afterwards, the life quality scores of experimental group and control group are significantly improved, and difference has statistical significance（P ＜ 0.05）；Experimental group is compared with the life quality scores after treatment of control group, and difference has statistical significance（P ＜ 0.05）, it is shown in Table 2。
The comparison of 2 two groups of infant life quality scores of table（N=25, point）
Group Before treatment After treatment
Control group 65.44±4.12 73.48±6.48*
Experimental group 65.55±4.17 85.24±7.42*#
Compare before treating with same group, * P ＜ 0.05；Compare with after treatment of control group, #P ＜ 0.05.

Claims (8)

1. a kind of pharmaceutical composition for treating rhinitis, it is characterised in that make the composition and weight of the bulk drug of the pharmaceutical composition Part it is：
Comb leaf 120-160 weight portion Hydrangea xanthoncura Diels root 80-100 weight portion capillarisin 20-30 weight portion ovate neolepisorus herbs 60-80 weight portion tree head dish 40-70 weight portions.
2. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that make the pharmaceutical composition The composition and weight portion of bulk drug be：
140 25 weight portion ovate neolepisorus herb of weight portion Hydrangea xanthoncura Diels 90 weight portion capillarisin of root of comb leaf, 70 weight portion tree head 50 weight portion of dish.
3. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition can be adopted The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
4. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition and chemical drugs Or the treatment rhinitis medicine of Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Comb leaf 120-160 weight portion Hydrangea xanthoncura Diels root 80-100 weight portion oriental wormwood colors Former ketone 20-30 weight portions ovate neolepisorus herb 60-80 weight portions tree head dish 40-70 weight portions；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that by following step It is rapid to prepare：
The composition and weight portion of bulk drug be：140 90 weight portion capillarisin of weight portion Hydrangea xanthoncura Diels root of comb leaf, 25 weight 70 weight portion tree head dish of amount part ovate neolepisorus herb, 50 weight portion；
Preparation method：
（1）Comb leaf, Hydrangea xanthoncura Diels root, capillarisin, ovate neolepisorus herb, tree head dish are taken by bulk drug proportioning, is mixed, with weight hundred Divide 33.5% ethanol of specific concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 17 times, and each extraction time is 36 little When, 54 times for bulk drug gross weight of each solvent load, filtration obtain dregs of a decoction A and extract A, and extract A reclaims ethanol, dense Relative density 1.08 is reduced to, is filtered, liquid is first washed with water by XAD-3 large pore resin absorption columns, then dense with percentage by weight 18% ethanol solution wash-out XAD-3 large pore resin absorption columns are spent, 18% ethanol eluate of weight percent concentration is collected, is reclaimed second Alcohol, concentrate drying obtain final product extract A；
（2）Take step（1）Dregs of a decoction A, with 43% ethanol of weight percent concentration as solvent, heating and refluxing extraction 17 times, is carried every time The time is taken for 0.3 hour, 30 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.12 is concentrated into, is filtered, liquid is first washed with water, then used by XAD-16 large pore resin absorption columns 58% ethanol solution of weight percent concentration elutes XAD-16 large pore resin absorption columns, collects 58% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that drug regimen Thing can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or dripping pill.
8. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that drug regimen Thing and chemical drugs or Chinese medicine composition treatment rhinitis medicine.
CN201611133130.8A 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating rhinitis Withdrawn CN106539836A (en)

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Application publication date: 20170329