CN106539835A - A kind of pharmaceutical composition for preventing and treating rhinitis - Google Patents

A kind of pharmaceutical composition for preventing and treating rhinitis Download PDF

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CN106539835A
CN106539835A CN201611133106.4A CN201611133106A CN106539835A CN 106539835 A CN106539835 A CN 106539835A CN 201611133106 A CN201611133106 A CN 201611133106A CN 106539835 A CN106539835 A CN 106539835A
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K2236/50—Methods involving additional extraction steps
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a kind of prevent and treat pharmaceutical composition of rhinitis and preparation method thereof, pharmaceutical composition of the present invention is with oyster dish, rib fruit pittosporum tobira, ovate neolepisorus herb, Sisalagenin, hederagenin, mesembranone as bulk drug, proportioning is formed, routinely various formulations can be made by preparation process, prevent and treat rhinitis evident in efficacy.

Description

A kind of pharmaceutical composition for preventing and treating rhinitis
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of prevent and treat pharmaceutical composition of rhinitis and preparation method thereof.
Background technology
The infection of the upper respiratory tract refers to pathogen and invades the upper respiratory tract（Larynx, pharynx, nose etc.）The acute inflammatory reaction for causing, be The common disease of paediatrics, frequently-occurring disease.Clinical symptoms and performance include heating, runny nose, nasal obstruction, cough, it is pharyngeal discomfort, sneeze, receive Difference, chilly, stomachache, diarrhoea etc..Caused by many infection because of virus of upper respiratory tract infection of children, adenovirus, Coxsackie virus, influenza, Parainfluenza virus, Respiratory Syncytial Virus(RSV) etc. are all the common causatives of the infection of the upper respiratory tract.The infection of the upper respiratory tract is annual Morbidity, and with the incidence of disease highest of autumn and winter.
Rhinitis is schneiderian membrance or sub-mucosal tissues because viral infection, courses of infection, stimulant stimulation etc., cause schneiderian membrance Or sub-mucosal tissues are impaired, caused acute or chronic inflammation.Rhinitis causes to produce excessive mucus, generally causes runny nose, nose The symptoms such as plug.Nasosinusitis is often secondary to sense or acute rhinitis, at this moment original exacerbation of symptoms, chilly occurs, heating, and appetite is not Shake, constipation, whole body discomfort etc., children can occur the symptoms such as vomiting, diarrhoea, cough.Ke Chuxian ＆mdash more;Side continuation, it is even Bilateral continuation nasal obstruction can occur.Patient's purulence nasal mucus increases and is difficult to blow to the greatest extent, when such as rearwards into pharyngeal and lower respiratory tract, stimulates Pharynx, larynx mucous membrane cause and itch, and cough and expectoration, or even nausea.Frons aches, light from morning, afternoon weight, it is also possible to have Face and cheek Distending pain or above-listed pain of grinding one's teeth in sleep, are maxillary sinusitis mostly.Frons pain is felt from morning, gradually Zhejiang is increased, it is afternoon to mitigate, all disappear to night Lose, this is probably frontal sinusitis.Headache is relatively light, is confined to endocanthion or nasion portion, it is also possible to be radiated to overhead, and many worm eso-ethmoiditis are drawn Rise.Eyeball depths pain, can emit to overhead, also go out to see morning gently, the occipital headache of afternoon weight, up to possibly sphenoiditis. Chronic nasosinusitis is removed outside the symptoms such as nasal obstruction, runny nose, headache, also following features：(1) headache is relatively light, the vexed pain of general category more, blunt Bitterly.(2) hyposphresia or disappearance.(3) rest, nose drops are had a headache and can be mitigated after steam suction or nasal airflow drainage.(4) cough Cough, bow, bend over, headache when firmly increases.(5) smoking, drinks, and can increase headache when excited.(6) essence can be caused sometimes God is depressed, easily sleepy, dizzy, failure of memory, absent minded etc..
Oyster dish：Frond of this product for Ulvaceae sea lettuce platymiscium oyster dish Ulva conglobata Kjellm..【Nature and flavor】 It is salty；It is cold.【Return through】Kidney；Lung channel.【Indication】It is clearing heat and detoxicating；Diuresis.Main heatstroke；Goitre；Oedema.【Proterties】Oyster dish, Frond drying shrinkage is into lumps.After water logging flattening, thallus green, long 2-4cm are intensive to grow thickly, and slightly extend.Thallus drastic crack, splits Into most slivers or branch, each sliver is overlapped, edge distortion.Thallus top film quality, thick 30-50 μm, bottom thickness 100- 125 μm, base portion is harder, and gas is micro-, lightly seasoned.【Chemical analysis】Frond sulfur-bearing acid polysaccharide (sulfated polysaccharide), Two-α-L- rhamnosides of methyl (methyl di- α-L-rhamnoside).Record in dictionary of medicinal plant.
Rib fruit pittosporum tobira：This product is Pittosporaceae Chart database plant rib fruit pittosporum tobira Pittosporum The seed of trigonocarpum L é vl [P.glabratum sensu Rehd.].8-9 month harvesting ripe fruits, except removal core, Take out seed to dry.【Nature and flavor】Bitter, micro-puckery, is slightly cold.【Indication】Astringing to arrest diarrhea, clearing heat and relieving fidgetness.Cure mainly diarrhoea, dysentery, pharynx Bitterly, dysphoria and insomnia.【Former phytomorph】, without hair, tender shoots has pubescence for evergreen shrubs, spray, and old branch grey has hole skin.Leafage gives birth to Yu Zhiding, biennial, keratin, obovate or square circle fall lanceolar, long 7-14 centimetre, wide 2.5-4 centimetre, the anxious short point of tip, base The narrow wedge shape in portion, above it is green, shinny, do after breen, below it is light brown, without hair；Lateral vein about 6 pairs, with net vein in upper and lower surface Not substantially, edge is open and flat, and petiole is about 1 centimetre.Umbel 3-5 branch basidixeds, spend majority；Bennet is long 1-2.5 centimetre, fine Carefully, without hair；Sepal is avette, long 2 millimeters, ciliation；1.2 centimetres of petal length, separates, or part combination；8 millimeters of stamen length, it is female Stamen is isometric with stamen, and ovary has pubescence, and parietal placenta 3, ovule 9-15 are individual.Capsule Chang Dansheng, it is oval, dry rear triangle or Circle, long 2.7 centimetres, hairiness, ovary handle are short, long only 2 millimeters, harbor 3 millimeters of style length, and carpopodium is about 1 centimetre, has soft Hair, 3 split, and chankings is thin, keratin, rough surface, have seed 3-5 per piece；Seed is red, is about 5-6 centimetre, seedstalk length 2 Millimeter, flattens, scattered on the placenta of lengthwise.Record in dictionary of medicinal plant.
Ovate neolepisorus herb：For Polypodiaceae shield Cyclosorus plant ovum leaf shield fern Neolepisorus ovatus (Bedd.) Ching The herb of [Pleopeltis ovata Bedd.].Whole year can harvest, and after excavation, clean, dry.【Nature and flavor】It is bitter；It is cool.【Return Jing】The heart；Lung；Bladder warp.【Indication】Clearing heat and promoting diuresis；Hemostasis；Removing toxic substances.Main heat gonorrhea；Difficult urination；Hematuria；Tuberculosis is spat blood；Tell Blood；Traumatism and bleeding；Carbuncle swells；Scald.【Former phytomorph】The high 15-45cm of plant.Rhizome grows wild, close by ovum shape lanceolar Scale, length are tapering, and there is thin tooth at edge.Ye Yuansheng；The long 10-20cm of petiole, by scale；Blade ground paper matter, ovum shape lanceolar is to ovum Shape Long Circle or nearly triangle, wide 7-12cm, tapering, base portion is wider, circular to circle wedge shape, how many downward in petiole, full edge or How many bottoms divides；Lateral vein is obvious.Sporangiorus is big, circular, lines up irregular 1 to several rows in lateral vein both sides, has shield when young Shape paraphysis is covered.Record in dictionary of medicinal plant.
Sisalagenin（Tigogenin）：CAS 77-60-1, molecular formula C27H44O3, molecular weight 416.64.【It is biological living Property】The raw material of synthetic hormone.【Ingredient origin】Sisal hemp Agave sisalana.
Hederagenin（Hederagenin）：CAS 465-99-6, molecular formula C30H48O4, molecular weight 472.70.【It is biological Activity】It is antimycotic.【Ingredient origin】Chinese bulbul Pulsatilla chinensis, teasel Dipsacus asperoides, close Akebi Aristolochia manshuriensis, patrinia scabiosaefolia Fiscs Patrinia scabiosaefolia, honeysuckle Lonicera Japonica, deer grass Rhaponticum carthamoides, akebi Akebia quinata, root of Chinese clematis Clematis chinensis。
Mesembranone（Mesembrine）：CAS 24880-43-1, molecular formula C17H23NO3, molecular weight 289.37.【Medicine Reason is acted on】Anesthetic；Central stimulant.【Ingredient origin】Expansion mesembrianthemum Mesembryanthemum expansum, bright pine needle Chrysanthemum Mesembryanthemum anatomtcum, distort mesembrianthemum Mesembryanthemum tortuosum.
The chemical constitution of 3 bulk drugs：
Hederagenin（Hederagenin）
Sisalagenin（Tigogenin）Mesembranone（Mesembrine）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition for effectively preventing and treating rhinitis and its Preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the bulk drug of the pharmaceutical composition for preventing and treating rhinitis be：
The sub- 50-80 weight portions ovate neolepisorus herb 3500-3700 weight portions sisal hemp saponin(e of oyster dish 4800-4900 weight portion rib fruit pittosporum tobiras First 40-70 weight portions hederagenin 100-110 weight portion mesembranone 60-70 weight portions.
The pharmaceutical composition for preventing and treating rhinitis is preferably used in, is made up of the bulk drug of following weight portion：
4850 weight portion rib fruit pittosporum tobira of oyster dish 65 weight portion ovate neolepisorus herb, 3600 weight portion Sisalagenin, 60 weight portions are normal 65 weight portion of spring 105 weight portion mesembranone of rattan sapogenin.
A kind of pharmaceutical composition for preventing and treating rhinitis, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy Prepare piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating rhinitis, it is characterised in that the preventing and treating that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Rhinitis medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The sub- 50-80 weight portions ovate neolepisorus herb of oyster dish 4800-4900 weight portion rib fruit pittosporum tobiras 3500-3700 weight portion Sisalagenin 40-70 weight portion hederagenin 100-110 weight portion mesembranone 60-70 Weight portion；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：4850 weight portion rib fruit pittosporum tobira of oyster dish 65 weight portion ovate neolepisorus herb, 3600 weight portion 60 weight portion hederagenin of Sisalagenin, 105 weight portion mesembranone, 65 weight portion；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis, it is characterised in that pharmaceutical composition can adopt galenic pharmacy Conventional method prepare piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine Composition prevents and treats rhinitis medicine.
It is notable that pharmaceutical composition prevents and treats rhinitis effect.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of rhinitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of rhinitis be：The sub- 65g great Jin of oyster dish 4850g rib fruit pittosporum tobiras Knife 3600g Sisalagenin 60g hederagenin 105g mesembranone 65g；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of rhinitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of rhinitis be：The sub- 80g great Jin of oyster dish 4800g rib fruit pittosporum tobiras Knife 3500g Sisalagenin 70g hederagenin 100g mesembranone 70g；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of rhinitis and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of rhinitis be：The sub- 50g great Jin of oyster dish 4900g rib fruit pittosporum tobiras Knife 3700g Sisalagenin 40g hederagenin 110g mesembranone 60g；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 540g of Example, adds starch 910g, mixes, and granulation is dried, plus microcrystalline cellulose 170g, stearic Sour magnesium 8g, mixes, is pressed into 8000, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 95g of Example, adds starch 120g, mixes, and granulation is dried, whole grain, adds appropriate magnesium stearate, Mix, encapsulated 500, obtain final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 200g water-baths and boil molten, add 3 pharmaceutical composition 11g of embodiment, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 8 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip are 2.5cm away from liquid level, and drop speed is per dividing 45 drops as optimum condition, to blot the cold of dripping pill surface with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：Prevent and treat the experimental study of rhinitis
1 data and method
1.1 physical data
58 infection of the upper respiratory tract rhinitis infants that selection this city hospital accepts for medical treatment in April, -2013 in June, 2012 are right as studying As all infants meet infection of the upper respiratory tract rhinitis diagnostic criteria.Using random digits table by infant be divided into seminar and Control group, per group each 29.Seminar, wherein man 14, female 15；1～12 years old age, average age（5.3±1. 6）Year； 4～11d of the course of disease, average course of disease（4.6±1.4）d.Control group, wherein man 14, female 15；10 months～11 years old age, averagely Age（5.4±1.8）Year；4～12d of the course of disease, average course of disease（5.3±1.7）d.
The physical data such as 2 groups of infant sexes, age, courses of disease compare, no significant difference（P>0.05）, with comparable Property.
1.2 treatment method
Control group gives Moroxydine Hydrochloride, and orally, dosage is 10mg/kg, and one time a day；VITAMIN C TABLET, orally, administration Dosage is 100mg/ time, and 3 times a day.Seminar gives pharmaceutical composition（1 pharmaceutical composition of embodiment）, orally, 1.2g/ time, 3 times a day.2 groups of equal continued treatments 2 weeks.
1.3 therapeutic evaluation
Cure：After medication 1 week, the clinical symptoms such as runny nose, pharyngalgia, nasal obstruction all disappear, and congestion of throat disappears；Take a turn for the better：Treat 2 weeks Afterwards, the clinical symptoms such as runny nose, pharyngalgia, nasal obstruction are significantly improved, and congestion of throat mitigates；It is invalid：After treating 2 weeks, clinical symptoms without Improve, and get along with.
1.4 statistical procedures
19.0 statistical software processing datas of statistical procedures application SPSS, measurement data represent that with x ± s enumeration data is examined with t Test and Chi-square Test, it is statistically significant as difference with P ＜ 0.05.
2 results
2.1 clinical efficacy
Control group cure rate, total effective rate are respectively 55.17%, 93.10%, and seminar's cure rate, total effective rate are respectively 31.03%th, 68.97%, 2 groups are compared, and difference is statistically significant（P ＜ 0.05）.During treatment, 2 groups of infants do not occur bright Aobvious bad reaction.It is shown in Table 1.
12 groups of infant Clinical efficacy comparisons of table（n=29）
Group Cure Take a turn for the better It is invalid Total effective rate (%)
Control group 16 11 2 93.10*
Seminar 9 11 9 68.97
Compare * P ＜ 0.05 with control group.
2.2 symptom extinction times
The body temperature of seminar, nasal obstruction, pharyngalgia, cough, congestion of throat symptom extinction time are considerably shorter than control group（P ＜ 0.05）.

Claims (8)

1. a kind of pharmaceutical composition for preventing and treating rhinitis, it is characterised in that make the composition and weight of the bulk drug of the pharmaceutical composition Part it is：
The sub- 50-80 weight portions ovate neolepisorus herb 3500-3700 weight portions sisal hemp saponin(e of oyster dish 4800-4900 weight portion rib fruit pittosporum tobiras First 40-70 weight portions hederagenin 100-110 weight portion mesembranone 60-70 weight portions.
2. a kind of pharmaceutical composition for preventing and treating rhinitis according to claim 1, it is characterised in that make the pharmaceutical composition The composition and weight portion of bulk drug be：
4850 weight portion rib fruit pittosporum tobira of oyster dish 65 weight portion ovate neolepisorus herb, 3600 weight portion Sisalagenin, 60 weight portions are normal 65 weight portion of spring 105 weight portion mesembranone of rattan sapogenin.
3. a kind of pharmaceutical composition for preventing and treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition can be adopted The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
4. a kind of pharmaceutical composition for preventing and treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition and chemical drugs Or Chinese medicine composition prevent and treat rhinitis medicine.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The sub- 50-80 weight portions ovate neolepisorus herb of oyster dish 4800-4900 weight portion rib fruit pittosporum tobiras 3500-3700 weight portion Sisalagenin 40-70 weight portion hederagenin 100-110 weight portion mesembranone 60-70 Weight portion；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis according to claim 5, it is characterised in that by following step It is rapid to prepare：
The composition and weight portion of bulk drug be：4850 weight portion rib fruit pittosporum tobira of oyster dish 65 weight portion ovate neolepisorus herb, 3600 weight portion 60 weight portion hederagenin of Sisalagenin, 105 weight portion mesembranone, 65 weight portion；
Preparation method：
（1）Rib fruit pittosporum tobira, ovate neolepisorus herb, oyster dish, Sisalagenin, hederagenin, mesembranone are taken by bulk drug proportioning, Mix, with 29% ethanol of weight percent concentration as solvent, take in 27.5 DEG C of temperature extractions, extraction time is 20 times, is extracted every time Time is 19 hours, 24 times for bulk drug gross weight of each solvent load, and filtration obtains dregs of a decoction A and extract A, and extract A is returned Ethanol is received, relative density 1.04 is concentrated into, is filtered, liquid is first washed with water by DM-7HP large pore resin absorption columns, then with again Amount percent concentration 37% ethanol solution wash-out DM-7HP large pore resin absorption columns, collect 37% ethanol elution of weight percent concentration Liquid, reclaims ethanol, and concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with 48% ethanol of weight percent concentration as solvent, heating and refluxing extraction 9 times, is carried every time The time is taken for 0.3 hour, 50 times for dregs of a decoction A weight of each solvent load, filtration obtain dregs of a decoction B and extract B, and extract B is returned Ethanol is received, relative density 1.02 is concentrated into, is filtered, liquid is first washed with water, then used by GDX-501 large pore resin absorption columns 57% ethanol solution of weight percent concentration elutes GDX-501 large pore resin absorption columns, collects 57% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis according to claim 5, it is characterised in that drug regimen Thing can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or dripping pill.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating rhinitis according to claim 5, it is characterised in that drug regimen Thing prevents and treats rhinitis medicine with chemical drugs or Chinese medicine composition.
CN201611133106.4A 2016-12-10 2016-12-10 A kind of pharmaceutical composition for preventing and treating rhinitis Withdrawn CN106539835A (en)

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Application publication date: 20170329