CN106540012A - A kind of pharmaceutical composition for treating senile osteoporosis - Google Patents

A kind of pharmaceutical composition for treating senile osteoporosis Download PDF

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CN106540012A
CN106540012A CN201611132993.3A CN201611132993A CN106540012A CN 106540012 A CN106540012 A CN 106540012A CN 201611132993 A CN201611132993 A CN 201611132993A CN 106540012 A CN106540012 A CN 106540012A
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pharmaceutical composition
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Abstract

The invention discloses a kind of treat pharmaceutical composition of senile osteoporosis and preparation method thereof, pharmaceutical composition of the present invention is with little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani as crude drug, proportioning is formed, routinely various dosage forms can be made by preparation process, treatment senile osteoporosis are evident in efficacy.

Description

A kind of pharmaceutical composition for treating senile osteoporosis
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of pharmaceutical composition and its system for treating senile osteoporosis Preparation Method.
Background technology
Senile osteoporosises are to be apt to occur in more than 70 years old old people, with pain, especially lumbago and backache, deformation of spinal column, bone Folding, respiratory function decline etc. are showed for main, and the fear of cold that occurs together is cold, weak, the discomfort such as difficulty of falling asleep.Have a strong impact on the life of patient Bioplasm amount, its main pathological change are that old people's vitamin D activities metabolite is low, secondary hyperparathyroidism, first shape Other hormone secretion increases, and intestinal calcium absorption is reduced, and bone calcium loses caused III.The categories such as category motherland's medical science " atrophic debility of bones " " rheumatism involving the bone ".Suffer from Person is more over seventy-year-old, and internal organs QI and blood is all empty, and liver spleen kidney is write especially, and the first day after tomorrow all damages, and muscles and bones passages through which vital energy circulates is lost and moistens foster, the withered Jing flaccidity bone of muscle Damage, send out then fracture, bow-backed, deformity, dysfunction, pain, anemophobia are cold, knot, wait discomfort.Its pathological change is dirty for the first day after tomorrow Internal organs QI and blood is all lost, muscles and bones passages through which vital energy circulates lose moisten it is foster, it is obstructed not flourish and fall ill.The suitable liver and kidney tonifying of the rule for the treatment of, invigorating the spleen and benefiting QI, blood nourishing acupuncture-stimulating are exempted from Numbness.
Herba sopubiae Trifidae：This product is complete for the short hat grass Sopubia trfida Buch.-Ham.'s of Scrophulariaceae Sopubia plant Grass.Summer, autumn harvesting, dry.【Nature and flavor】Bitter in the mouth；It is puckery；It is warm in nature.【Indication】Expelling wind and removing dampness；Wet inner pain relieving.Main wind and cold is wet Numbness；Stomachache with cool feeling；Lumbago due to renal deficiency.【Former phytomorph】Short hat grass annual herb, high 40-90cm.Root is carefully cylindrical.Stem list One or more numbers, uprightly, top multi-branched, branch have corner angle and striped, by pubescence.Leaf opposite or alternate；The full shape synthesis circle of blade Taper；Luxuriant leave shape；Bennet is about 1cm, has a pair of brill shape squamellas at nearly top；Calyx taper；Bract is lobate；Bennet is about 1cm, There are a pair of brill shape squamellas at nearly top；Calyx bracelet shape, pipe portion 10, rib of tool, calyx tooth 5 are wider than in length, triangle, internal and edge without There is MIAOMAO；Corolla yellow or purple, are about 1cm, manage extremely short, sliver 5, carry out, obovate greatly, and circle is blunt, near equal；Stamen 4, The last two, filigree are born in the top of tube, and flower pesticide Room 1 is degenerated and narrow；Style is single, harbors.Capsule is spherical, and tip is flat And be recessed, it is shorter or isometric than calyx.Shape of the seed is uneven, the reticulate pattern for having elongated hole.The month at florescence 6-7, fruiting period September.Record big in Chinese medicine Dictionary.
Little Hua orrisroots：Rhizome for Iridaceae iris little Hua Rhizoma Iridis Tectori Iris speculatrix Hance and Root.The 9-11 months harvest, and clean cutting, dry.【Nature and flavor】It is pungent；Temperature；It is slightly poisonous.【Indication】Invigorating blood circulation analgesia；Expelling wind and removing dampness.It is main Traumatic injury；Anemofrigid-damp arthralgia；Mad dog is bitten；Snakebite.【Former phytomorph】Little Hua Rhizoma Iridis Tectori perennial herbs, high 30-40cm.Plant Strain base portion is with tan old leaf sheath fiber and the sheath shape leaf by aciculiform.Rhizome grows wild, more sturdy, and link is significant.Basal leaf Sword-shaped or bar shaped, long 10-40cm, wide 3-8mm, tip are tapering, base portion sheath shape, full edge；Stem leaf 3-4 pieces, it is short compared with basal leaf.Flower Stem is flat, has bract 2, lanceolar；Include l-2 flowers；The long 3-5.5cm of bennet, bends after blossom fall；Flower bluish violet or light blue, directly Footpath 5-6cm, foreign steamer sliver cochlear, the annular speckle for having darkviolet, the orange-yellow palpus shape appurtenance of the close tool of middle arteries, lubrication groove sliver drape over one's shoulders pin Shape, inclines；Stamen 3, flower pesticide white；Ovary is the next, and Room 3, style branch are flat, and 3 branches, petal-shaped, tip 2 split, and edge has Tooth.Capsule is oval, long 5-5,5cm, diameter l-1.5cm, and tip has thin styloid beak, and when ripe, lobe is 3 lobes.Seed pears Shape, sepia.The month at florescence 4-5, the fruiting period 7-8 month.Record in dictionary of medicinal plant.
Little Herba Hylotelephii Mingjiniani：For the complete of the little Herba Hylotelephii Mingjiniani Petrocosmea minor Hemsl. of Gesneriaceae Petrocosmea plant Grass.The 7-9 months harvest, and clean, dry.Seed is little, oval, smooth.【Nature and flavor】Taste micro-pungent；It is mild-natured.【Indication】Dissipate wind-heat; Spleen invigorating removing food stagnancy.Main cold, fever；Infantile malnutrition.【Former phytomorph】The perennial Caulis et Folium Polygalae Tenuifoliae of little Herba Hylotelephii Mingjiniani acaulescence.Rhizome is short and thick, to Under close raw fibrous fibrous root.Phyllopodium gives birth to, 15-40 pieces;The leaf tool short handle of inner face or stockless, outside leaf tool handle, up to 4cm, close quilt The pubescence of shape swallowtail;Blade ellipticity whip shape, oval or subcircular, long 1-2.5cm, wide 8-15mm, the micro- point of tip, base portion Wide wedge shape or wedge shape, ellipse, full edge or have unconspicuous wavy little knuckle-tooth, green above leaf, below light green, the close quilt in two sides The pubescence of development.Flower 1-5 bars, have 1 (- 2) flower per inflorescence;The long 3.5-7.5cm of peduncle, is carried out pubescence;Bract is narrow linear, 3mm is about, it is close by pubescence;Calyx 5 is split up to base portion, sliver wire lanceolar, and outside is by pubescence;Corolla purple, outside is by short soft Hair, corolla tube are short, long 2.5-3.5cm, are preced with two lip of mast, upper lip ovate triangle, tip fine fisssure or nearly full edge, and lower lip 3 splits, sliver Near to wait big, tip is circular;Can educate stamen 2, filigree width floss shape, close by brown undercoat, flower pesticide is about 5mm, staminodium 2;Ovary Close to be lied prostrate pubescence by patch, style is about 7mm, and, by short FUMAO, stigma is little, point-like for usual base portion.Capsule Long Circle, up to 10mm, By pubescence, room antiform is 2 lobes.Seed is little, oval, smooth.The month at florescence 8-9, the fruiting period 10-11 month.Record diction big in Chinese medicine Allusion quotation.
Cucurbitacin C（Cucurbitacin C）：CAS 5988-76-1, molecular formula C32H48O8, molecular weight 560.73.【Into Divide source】Fructus Cucumidis sativi Cucumis sativus, bitter Fructus Cucumidis sativi Cucumis sativus var.hanzil.
1 crude drug chemical constitution：
Cucurbitacin C（Cucurbitacin C）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of medicine group of effectively treatment senile osteoporosis Compound and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the pharmaceutical composition of the treatment senile osteoporosis be：
Little Hua orrisroot 120-160 weight portion little Hua orrisroot 80-100 weight portion cucurbitacin C20-30 weight portions are little to stretch muscle The little Herba Hylotelephii Mingjiniani 40-70 weight portions of careless 60-80 weight portions.
The pharmaceutical composition for the treatment of senile osteoporosis is preferably used in, is made up of the crude drug of following weight portion：
140 weight portion little Hua orrisroots of little Hua orrisroots, 90 weight portion cucurbitacin C25 weight portions Herba sopubiae Trifidae, 70 weight portion 50 weight portion of little Herba Hylotelephii Mingjiniani.
A kind of pharmaceutical composition for treating senile osteoporosis, it is characterised in that pharmaceutical composition can adopt galenic pharmacy Conventional method prepares piece agent or capsule or drop pill.
A kind of pharmaceutical composition for treating senile osteoporosis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine group Into treatment senile osteoporosis medicine.
A kind of preparation method of the pharmaceutical composition for treating senile osteoporosis, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Little Hua orrisroot 120-160 weight portion little Hua orrisroot 80-100 weight portion calabashes The little Herba Hylotelephii Mingjiniani 40-70 weight portions of Lu Su C20-30 weight portion Herba sopubiae Trifidae 60-80 weight portions；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating senile osteoporosis, it is characterised in that as follows Prepare：
The composition and weight portion of crude drug be：140 weight portion little Hua orrisroots of little Hua orrisroots, 90 weight portion cucurbitacin C25 weights Little 50 weight portion of Herba Hylotelephii Mingjiniani of 70 weight portion of amount part Herba sopubiae Trifidae；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating senile osteoporosis, it is characterised in that pharmaceutical composition can be adopted Piece agent or capsule or drop pill are prepared with the conventional method of galenic pharmacy.
A kind of preparation method of the pharmaceutical composition for treating senile osteoporosis, it is characterised in that pharmaceutical composition and chemistry Medicine or Chinese medicine composition treatment senile osteoporosis medicine.
Medicine composite for curing senile osteoporosis are evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition for the treatment of senile osteoporosis and preparation method thereof
Treatment senile osteoporosis pharmaceutical composition crude drug composition and weight portion be：Little Hua orrisroot 140g little Hua The little Herba Hylotelephii Mingjiniani 50g of orrisroot 90g cucurbitacin C25g Herba sopubiae Trifidae 70g；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition for the treatment of senile osteoporosis and preparation method thereof
Treatment senile osteoporosis pharmaceutical composition crude drug composition and weight portion be：Little Hua orrisroot 160g little Hua The little Herba Hylotelephii Mingjiniani 70g of orrisroot 80g cucurbitacin C30g Herba sopubiae Trifidae 60g；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition for the treatment of senile osteoporosis and preparation method thereof
Treatment senile osteoporosis pharmaceutical composition crude drug composition and weight portion be：Little Hua orrisroot 120g little Hua The little Herba Hylotelephii Mingjiniani 40g of orrisroot 100g cucurbitacin C20g Herba sopubiae Trifidae 80g；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
1 pharmaceutical composition 27g of Example, adds starch 29g, mixes, and granulation is dried, plus Microcrystalline Cellulose 19g, stearic acid Magnesium 0.6g, mixes, is pressed into 230, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
2 pharmaceutical composition 22g of Example, adds starch 26g, mixes, and granulation is dried, granulate, adds appropriate magnesium stearate, Mix, encapsulated 210, obtain final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 182g water-baths and boil molten, add 3 pharmaceutical composition 9.5g of embodiment, fully stir Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is 5 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip are 2.3cm away from liquid level, and drop speed is per dividing 54 drops as optimum condition, to blot the cold of drop pill surface with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：The experimental study for the treatment of senile osteoporosis
1. clinical data
38 are city hospital outpatient, and Western medicine diagnose meets the suggestion diagnostic criteria of Chinese's osteoporosis.At random It is divided into 2 groups, treatment group 19, matched group 19.2 groups of case sexes, age, the course of disease, state of an illness etc. compare, and difference is without statistics Meaning（P>0.05）.Two groups give inspection blood, routine urinalysis, anti-chain " O ", CRP, ESR, hepatic and renal function, lumbar X line positive side position Piece, bone densitometry etc. check that as a result equal showed different osteoporosises and 2 vertebral body pathologisch Bruch of merging breast 11- waists, arrange Except other diseases are secondary and combination type osteoporosis.Tcm diagnosis standard is with reference to reference《Chinese medical disease Standardization of diagnosis and curative effect》, Symptom weight grade scale reference《New Chinese medicine guideline of clinical investigations》Formulate.
2. Therapeutic Method
2.1 matched group
Give Calcium Carbonate D3 piece (Beijing Kangyuan Pharmaceutical Co., Ltd., Chinese medicines quasi-word：H20093675), 1 time 1, day 2 times, mouth Clothes.Salmon calcitonin see calcimar nasal drop (Beijing Yin Gu pharmaceutical Co. Ltds, Chinese medicines quasi-word：H20030905), day 1 time, sleeps front collunarium.4 All l courses for the treatment of, 2 courses for the treatment of of continuous treatment.
2.2 treatment group
Add pharmaceutical composition on the basis of matched group medicine（1 pharmaceutical composition of embodiment）.Pharmaceutical composition 5g, with water 1000mL, decocts to 400mL, and point morning and evening decoction being taken warmly, medicinal residues temperature apply affected part.2 groups of patients treat 8 weeks, and treatment phase asks that disabling other controls Treat the disease to take orally and external used medicine.Coordinate suitable motion, daily life rule to shine sunlight, high calcareous diet more.
3. observation of curative effect
3.1 efficacy assessment standard
With reference to《Chinese medical disease Standardization of diagnosis and curative effect》.Draft.Clinical recovery：Cardinal symptom, sign disappear or basic disappearance, function Recovering state is normal or normal, and concomitant symptom recovers normal or normal；It is effective：Cardinal symptom, sign substantially mitigate, Functional statuses substantially recover, and concomitant symptom is obviously improved；Effectively：Cardinal symptom, sign, functional statuses part are alleviated or are improved, Concomitant symptom makes moderate progress；It is invalid：Symptom, sign are unchanged.
3.2 therapeutic outcome
Treatment group 19, clinical recovery 7, effective 6, effective 5, invalid 1, total effective rate 94.74%；Matched group 19 Example, clinical recovery 4, effective 6, effective 4, invalid 5, total effective rate 73.68%.2 groups of total effective rates compare, Jing Ridit analyzes P<0.05, difference has statistical significance, and treatment group's curative effect is better than matched group.
3.3 untoward reaction
There is untoward reaction 3 in matched group, shows as that big loose stool is thin, decreased food intake of receiving is few, and Jing after symptomatic treatment, disease disappears；Treatment group does not go out Existing toxicity person.

Claims (8)

1. a kind of pharmaceutical composition for treating senile osteoporosis, it is characterised in that make the group of the crude drug of the pharmaceutical composition Into with weight portion it is：
Little Hua orrisroot 120-160 weight portion little Hua orrisroot 80-100 weight portion cucurbitacin C20-30 weight portions are little to stretch muscle The little Herba Hylotelephii Mingjiniani 40-70 weight portions of careless 60-80 weight portions.
2. a kind of pharmaceutical composition for treating senile osteoporosis according to claim 1, it is characterised in that make the medicine The composition and weight portion of the crude drug of compositionss be：
140 weight portion little Hua orrisroots of little Hua orrisroots, 90 weight portion cucurbitacin C25 weight portions Herba sopubiae Trifidae, 70 weight portion 50 weight portion of little Herba Hylotelephii Mingjiniani.
3. a kind of pharmaceutical composition for treating senile osteoporosis according to claim 1, it is characterised in that pharmaceutical composition The conventional method of galenic pharmacy can be adopted to prepare piece agent or capsule or drop pill.
4. a kind of pharmaceutical composition for treating senile osteoporosis according to claim 1, it is characterised in that pharmaceutical composition The treatment senile osteoporosis medicine constituted with chemical drugs or Chinese medicine.
5. a kind of preparation method of the pharmaceutical composition for treating senile osteoporosis, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Little Hua orrisroot 120-160 weight portion little Hua orrisroot 80-100 weight portion calabashes The little Herba Hylotelephii Mingjiniani 40-70 weight portions of Lu Su C20-30 weight portion Herba sopubiae Trifidae 60-80 weight portions；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating senile osteoporosis according to claim 5, it is characterised in that Prepare as follows：
The composition and weight portion of crude drug be：140 weight portion little Hua orrisroots of little Hua orrisroots, 90 weight portion cucurbitacin C25 weights Little 50 weight portion of Herba Hylotelephii Mingjiniani of 70 weight portion of amount part Herba sopubiae Trifidae；
Preparation method：
（1）Little Hua orrisroots, little Hua orrisroots, cucurbitacin C, Herba sopubiae Trifidae, little Herba Hylotelephii Mingjiniani are taken by crude drug proportioning, is mixed, used 18.5% ethanol of weight percent concentration is extracted in 36.5 DEG C of warm macerating as solvent, and extraction time is 10 times, each extraction time For 0.8 hour, 47 times for crude drug gross weight of each solvent load, filtration obtained medicinal residues A and extracting solution A, and extracting solution A is reclaimed Ethanol, is concentrated into relative density 1.09, and filtration, medicinal liquid are first washed with water by D280 macroporous adsorptive resins, then with weight hundred Divide 48% ethanol solution eluting D280 macroporous adsorptive resins of specific concentration, collect 48% ethanol elution of weight percent concentration, return Ethanol is received, concentrate drying obtains final product extract A；
（2）Take step（1）Medicinal residues A, with 59% ethanol of weight percent concentration as solvent, heating and refluxing extraction 10 times, is carried every time The time is taken for 0.3 hour, 90 times for medicinal residues A weight of each solvent load, filtration obtain medicinal residues B and extracting solution B, and extracting solution B is returned Ethanol is received, relative density 1.11 is concentrated into, is filtered, medicinal liquid is first washed with water, then used by XAD-16 macroporous adsorptive resins 76% ethanol solution eluting XAD-16 macroporous adsorptive resins of weight percent concentration, collect 76% ethanol of weight percent concentration Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating senile osteoporosis according to claim 5, it is characterised in that Pharmaceutical composition can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or drop pill.
8. a kind of preparation method of the pharmaceutical composition for treating senile osteoporosis according to claim 5, it is characterised in that Pharmaceutical composition and chemical drugs or Chinese medicine composition treatment senile osteoporosis medicine.
CN201611132993.3A 2016-12-10 2016-12-10 A kind of pharmaceutical composition for treating senile osteoporosis Withdrawn CN106540012A (en)

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