CN106491681A - A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of esophageal carcinoma - Google Patents
A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of esophageal carcinoma Download PDFInfo
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Abstract
A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of esophageal carcinoma.The present invention provides a kind of Chinese medicine composition, including the raw material of following weight portion：10～30 parts of Radix Ginseng, 5～15 parts of Margarita, 2～10 parts of Scorpio, 5～10 parts of Mentholum, 10～20 parts of Radix Panacis Quinquefolii, 5～15 parts of artificial Calculus Boviss, 5～10 parts of Scolopendra, 15～30 parts of Cinnabaris, 15～25 parts of Sal Ammoniacus, 5～10 parts of Fel Ursi powder, 5～15 parts of Herba Asari, 25～40 parts of Radix Notoginseng.The Chinese medicine composition of the present invention is to summarize to obtain through clinical trial for many years, can heat-clearing and toxic substances removing, drying dampness to eliminate phlegm, spleen invigorating qi-regulating, blood circulation promoting and blood stasis dispelling by the reasonable disposition and herb fermenting technique of Chinese medicine ingredients, so as to significantly inhibit growth of cancer cells, enhancing immunity, effectively alleviate the symptom of esophagus tumor, and prescription is simple, cheap, is had no toxic side effect by product obtained in fermentation process, preparation method is simple to operate, can be mass-produced.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, is more particularly to used for the Chinese medicine composition for treating esophageal carcinoma.
Background technology
Esophageal carcinoma is called the esophageal carcinoma, is the common malignant tumor of the mankind, accounts for the 2% of all malignant tumor, account for esophageal neoplasm
More than 90%, occupy the 2nd because esophageal carcinoma died is only second to gastric cancer.Annual about 220,000 people in the whole world die from food according to estimates
Pipe cancer, is one of very harmful modal malignant tumor of the life and health to the people, and China is esophagus high cancer incidence area,
The whole nation has nearly 150,000 people to die from primary disease every year.The generation of esophageal carcinoma is relevant with following factor：1. dietary habit；2. carcinogen；
3. inherited genetic factorss；4. precancerous lesion and other disease factors；5. be deficient in vitamin in nutrition and trace element meals, protein and
Essential fatty acid etc..For a long time, operation, radiotherapy, three big therapy of chemotherapy dominate the dominant position of oncotherapy always.One side
Face, due to the development of three big therapies itself technology and perfect so that oncotherapy has gratifying progress, operation joint more in the past
Chemicotherapy improves the therapeutic effect of tumor to a great extent.On the other hand it is that things turn out contrary to one's wishes for over-treatment, for late period disease
For people, which recurs and the ratio of transfer is remained high always, and therapeutic effect is still undesirable, and five year survival rate is generally relatively low.
Esophageal carcinoma compares the therapeutically effective method of affirmative at present to be had：Operation, radiotherapy and Comprehensive Treatment, wherein preferentially adopt operative treatment,
Though better effects can be obtained, the preferable opportunity of operative treatment has been lost during many patient clinical Accurate Diagnosis, can only have been relied on non-
Operative treatment；But radiotherapy, chemotherapy side effect are larger, the especially harm to Liver and kidney function is bigger, and cure rate and survival rate are low.
It is well known that Chinese medicine plays an important role in the Comprehensive Treatment of tumor, and Chinese patent medicine have dosage into
Divide stable, taking convenience, Small side effects, the convenient advantage of curative effect.Chinese patent literature CN104800585A discloses one kind and controls
The medicine of esophageal carcinoma is treated, raw material includes：Rhizoma Paridis, Bulbus Fritillariae Cirrhosae, Rabdosia rubescens, dried Alumen, the Radix Astragali, Radix Rhodiolae, Rhizoma Dioscoreae, Radix Ginseng, Ganoderma,
SHANZHIZI, Poria, Rhizoma Pinelliae Preparatum, Herba Andrographis, Pseudobulbus Cremastrae Seu Pleioness, Rhizoma Polygoni Cuspidati, lobule buy numb Teng, Radix Tripterygii Wilfordii, Herba euphorbiae lunulatae, Hedyotidis Diffusae.Should
Medicine has certain therapeutic effect to esophageal carcinoma, but formula is complicated, and curative effect is slow, and treatment cost is high.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating esophageal carcinoma, reaches in treatment disease, improves food
Again without any side effects while road cancer survival rate, and body immunity can also be greatly improved comprehensively.
For this purpose, the present invention provides a kind of Chinese medicine composition, it is characterised in that including the raw material of following weight portion：Radix Ginseng 10
～30 parts, 3～15 parts of Margarita, 2～10 parts of Scorpio, 4～10 parts of Mentholum, 6～20 parts of Radix Panacis Quinquefolii, 3～15 parts of artificial Calculus Boviss, Wu
2～10 parts of centipede, 10～30 parts of Cinnabaris, 10～25 parts of Sal Ammoniacus, 3～15 parts of Fel Ursi powder, 5～20 parts of Herba Asari, 25～40 parts of Radix Notoginseng.
Preferred Chinese medicine composition of the present invention, including the raw material of following weight portion：15～25 parts of Radix Ginseng, 5～10 parts of Margarita,
5～8 parts of Scorpio, 6～8 parts of Mentholum, 10～18 parts of Radix Panacis Quinquefolii, 5～10 parts of artificial Calculus Boviss, 3～8 parts of Scolopendra, Cinnabaris 15～25
Part, 12～24 parts of Sal Ammoniacus, 5～10 parts of Fel Ursi powder, 6～18 parts of Herba Asari, 30～35 parts of Radix Notoginseng.
Preferred Chinese medicine composition of the present invention, including the raw material of following weight portion：25 parts of Radix Ginseng, 10 parts of Margarita, Scorpio 8
Part, 8 parts of Mentholum, 18 parts of Radix Panacis Quinquefolii, 10 parts of artificial Calculus Boviss, 8 parts of Scolopendra, 25 parts of Cinnabaris, 24 parts of Sal Ammoniacus, 10 parts of Fel Ursi powder,
18 parts of Herba Asari, 35 parts of Radix Notoginseng.
Optimal Chinese medicine composition of the present invention, including the raw material of following weight portion：20 parts of Radix Ginseng, 8 parts of Margarita, 6 parts of Scorpio,
6.5 parts of Mentholum, 12 parts of Radix Panacis Quinquefolii, 8 parts of artificial Calculus Boviss, 5 parts of Scolopendra, 20 parts of Cinnabaris, 18 parts of Sal Ammoniacus, 8 parts of Fel Ursi powder, Herba Asari
15 parts, 32 parts of Radix Notoginseng.
The Chinese medicine composition makes pharmaceutically acceptable preparation.
The preparation is pill, tablet, granule, capsule, any one in powder.
The invention further relates to the preparation method of the Chinese medicine composition, comprises the following steps：The first step, is weighed by weight
Radix Ginseng, Margarita, Scorpio, Mentholum, Radix Panacis Quinquefolii, artificial Calculus Boviss, Scolopendra, Cinnabaris, Sal Ammoniacus, Fel Ursi powder, Herba Asari, Radix Notoginseng, crush,
Sieve, mix homogeneously obtains fermentation raw material；Second step, strain is added in fermentation raw material, loads fermentation tank after stirring
Fermented；3rd step, at 33～40 DEG C, ferments 8～12 days, and extract at low temperature at 20～60 DEG C obtains moist powder；4th
Step, adds pharmaceutic adjuvant, makes pharmaceutically acceptable preparation.
In second step, the strain is Mel or probiotic bacteria.
Further, the Mel is 1～2 with the part by weight of fermentation raw material：1, the probiotic bacteria and fermentation raw material
Part by weight is 0.05～0.1:1.
Further, the probiotic bacteria be lactic acid bacteria, bacillus bifiduss, one or two in yeast.
In 3rd step, 37 DEG C of fermentation temperature, fermentation time 10 days, at 45 DEG C, extract at low temperature obtains moist powder.
The invention further relates to application of the Chinese medicine composition in treatment esophageal cancer medicine is prepared.
, wherein it is desired to illustrate, for the purpose of the present invention is realized, the Chinese medicine composition of the present invention is not limited to
Above-mentioned preparation method, present invention only provides a kind of specific preparation method.
The Chinese medicine composition of the present invention, selected Radix Ginseng sweet in the mouth, slight bitter are warm in nature, with strongly invigorating primordial QI, invigorating the spleen to benefit the lung, calm the nerves
Effect of Fructus Alpiniae Oxyphyllae, can control lack of appetite, asthenia, regurgitation and tell food, stool lingering diarrhea, empty cough with asthma and the symptom such as promote, quench one's thirst；Margarita taste raw meat, have
Calm the nerves arresting convulsion, heat clearing away YIN nourishing, improving eyesight, Detoxication can improve body immunity, slow down aging, freckle removing and whitening, supplement calcium；
Scorpio acrid in the mouth, poisonous, return liver warp, for spasm of twitching, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache
Deng；Mentholum external can with antiinflammatory, pain relieving, antipruritic, blood circulation promoting, mitigate edema etc., for oral administration can alleviate local inflammation and
Treatment flu, and have stomach invigorating, wind dispelling effect；Radix Panacis Quinquefolii mildly bitter flavor, sweet, with CNS regulation function, protection cardiovascular system
The effects such as system, enhance immunity antitumor, promotion blood vigor；Artificial Calculus Boviss' bitter in the mouth, micro-sweet, cure mainly heat-clearing and toxic substances removing, and resolving sputum is fixed
Frightened, for the hot delirium of expectorant, coma in silence, pediatric acute convulsion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle swells furunculosis；Scolopendra acrid in the mouth, warm in nature,
Return liver warp, the effect of with Inflammation Zhijing, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain；Cinnabaris sweet in the mouth, be slightly cold, slightly poisonous, thoughts of returning home warp, mainly
Clear away heart-fire relieving convulsion, Detoxication of calming the nerves；Sal Ammoniacus saline taste is bitter, pungent, warm, is mainly used in treating the esophageal carcinoma, skin carcinoma, nasopharyngeal carcinoma；Bearss
Gallbladder powder heat clearing away, suppressing the hyperactive liver, improving eyesight, for convulsion with spasms, external treatment conjunctival congestion and swelling pain, laryngopharynx swelling and pain；Herba Asari be mainly used in wind-dispelling, cold expelling,
Water-filling, have one's ideas straightened out, with expelling wind and cold, sensible pain relieving, effect of warming the lung to resolve fluid-retention；Radix Notoginseng sweet in the mouth, slight bitter, warm in nature, can stop blooding, fixed
Bitterly, cure mainly to fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen, blood stasis is through closing.Said medicine compatibility plays heat-clearing and toxic substances removing, drying dampness to eliminate phlegm, spleen invigorating altogether
The effect of qi-regulating, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, so as to suppress or kill cancerous cell, eliminate cancer and make, improve immunity of organisms, face
Bed can be used to treat esophageal carcinoma.
Chinese medicine composition of the present invention has advantages below：
Chinese medicine composition of the present invention, including Radix Ginseng, Margarita, Scorpio, Mentholum, Radix Panacis Quinquefolii, artificial Calculus Boviss, Wu
Centipede, Cinnabaris, Sal Ammoniacus, Fel Ursi powder, Herba Asari, Radix Notoginseng, side in all medicine compatibilities play altogether heat-clearing and toxic substances removing, spleen invigorating qi-regulating, removing toxic substances of calming the nerves, from
And suppress or kill cancerous cell, eliminating cancer makes, and improves immunity of organisms, is the good medicine for treating esophageal carcinoma.Above-mentioned formula is not only passed through
Experiment proves, to drenching esophageal carcinoma, there is good therapeutic effect, and prescription is simple, cheap, be suitable for industrialized production, benefits food
Road cancer patient.In addition, Chinese medicine composition of the present invention becomes small molecule through solid fermentation by macromole, can be with 100% by people
Body absorbs；Using solid fermentation, the effective ingredient for obtaining is improved, and clinical efficacy is improved significantly.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.
Embodiment 1
The first step, weigh Radix Ginseng 10g, Margarita 3g, Scorpio 2g, Mentholum 4g, Radix Panacis Quinquefolii 6g, artificial Calculus Boviss 3g, Scolopendra 2g,
Cinnabaris 10g, Sal Ammoniacus 10g, Fel Ursi powder 3g, Herba Asari 5g, Radix Notoginseng 25g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second
Step, Mel 83g is added in fermentation raw material, loads fermentation tank and fermented after stirring；3rd step, at 33 DEG C, sends out
Ferment 12 days, extract at low temperature at 20 DEG C obtain moist powder；4th step, moist powder is dried, and is added starch, is made pill.
Embodiment 2
The first step, weighs Radix Ginseng 30g, Margarita 15g, Scorpio 10g, Mentholum 10g, Radix Panacis Quinquefolii 20g, artificial Calculus Boviss 15g, Wu
Centipede 10g, Cinnabaris 30g, Sal Ammoniacus 25g, Fel Ursi powder 15g, Herba Asari 20g, Radix Notoginseng 40g, crush, sieve, and mix homogeneously is fermented
Raw material；Second step, Mel 480g is added in fermentation raw material, loads fermentation tank and fermented after stirring；3rd step,
At 35 DEG C, ferment 11 days, extract at low temperature at 35 DEG C obtains moist powder；4th step, moist powder is dried, and adds dextrin, pressure
Piece, makes tablet.
Embodiment 3
The first step, weighs Radix Ginseng 20g, Margarita 8g, Scorpio 6g, Mentholum 6.5g, Radix Panacis Quinquefolii 12g, artificial Calculus Boviss 8g, Scolopendra
5g, Cinnabaris 20g, Sal Ammoniacus 18g, Fel Ursi powder 8g, Herba Asari 15g, Radix Notoginseng 32g, crush, sieve, and mix homogeneously obtains fermentation raw material；
Second step, Mel 200g is added in fermentation raw material, loads and fermented in fermentation tank after stirring；3rd step, 37
At DEG C, ferment 10 days, extract at 40 DEG C, obtain moist powder；4th step, adds dextrin, and granule is made in drying of pelletizing, subpackage
Agent.
Embodiment 4
The first step, weighs Radix Ginseng 25g, Margarita 10g, Scorpio 8g, Mentholum 8g, Radix Panacis Quinquefolii 18g, artificial Calculus Boviss 10g, Scolopendra
8g, Cinnabaris 25g, Sal Ammoniacus 24g, Fel Ursi powder 10g, Herba Asari 18g, Radix Notoginseng 35g, crush, sieve, and mix homogeneously obtains proferment
Material；Second step, Mel 280g is added in fermentation raw material, loads and fermented in fermentation tank after stirring；3rd step,
At 37 DEG C, ferment 10 days, extract at 45 DEG C, obtain moist powder；4th step, moist powder is dried, and is added starch, is made ball
Agent.
Embodiment 5
The first step, weighs Radix Ginseng 15g, Margarita 5g, Scorpio 5g, Mentholum 6g, Radix Panacis Quinquefolii 10g, artificial Calculus Boviss 5g, Scolopendra
3g, Cinnabaris 15g, Sal Ammoniacus 12g, Fel Ursi powder 5g, Herba Asari 6g, Radix Notoginseng 30g, crush, sieve, and mix homogeneously obtains fermentation raw material；
Second step, Mel 180g is added to load after stirring in fermentation raw material and is fermented in fermentation tank；3rd step, at 40 DEG C
Under, ferment 8 days, extract at 55 DEG C and obtain moist powder；4th step, moist powder is dried, and is added starch, is made powder.
Embodiment 6
The first step, weighs Radix Ginseng 18g, Margarita 6g, Scorpio 6g, Mentholum 8g, Radix Panacis Quinquefolii 20g, artificial Calculus Boviss 12g, Scolopendra
8g, Cinnabaris 25g, Sal Ammoniacus 18g, Fel Ursi powder 8g, Herba Asari 15g, Radix Notoginseng 35g, crush, sieve, and mix homogeneously obtains fermentation raw material；
Second step, Mel 300g is added in fermentation raw material, loads and fermented in fermentation tank after stirring；3rd step, 38
At DEG C, ferment 9 days, obtain moist powder；4th step, moist powder is dried, filling dress capsule, makes capsule.
In embodiment 1-6, using Mel as strain raw material, the addition of Mel can improve Chinese medicine taste.
Embodiment 7
The first step, weighs Radix Ginseng 15g, Margarita 5g, Scorpio 5g, Mentholum 6g, Radix Panacis Quinquefolii 10g, artificial Calculus Boviss 5g, Scolopendra
3g, Cinnabaris 15g, Sal Ammoniacus 12g, Fel Ursi powder 5g, Herba Asari 6g, Radix Notoginseng 30g, crush, sieve, and mix homogeneously obtains fermentation raw material；
Second step, 5.85g lactic acid bacterias is added to load after stirring in fermentation raw material and is fermented in fermentation tank；3rd step,
At 40 DEG C, ferment 8 days, extract at 55 DEG C and obtain moist powder；4th step, moist powder is dried, and is added starch, is made scattered
Agent.
Embodiment 8
The first step, weighs Radix Ginseng 25g, Margarita 10g, Scorpio 8g, Mentholum 8g, Radix Panacis Quinquefolii 18g, artificial Calculus Boviss 10g, Scolopendra
8g, Cinnabaris 25g, Sal Ammoniacus 24g, Fel Ursi powder 10g, Herba Asari 18g, Radix Notoginseng 35g, crush, sieve, and mix homogeneously obtains proferment
Material；Second step, 11.94g yeast is added in fermentation raw material, loads and fermented in fermentation tank after stirring；3rd
Step, at 37 DEG C, ferments 10 days, extracts, obtain moist powder at 45 DEG C；4th step, moist powder is dried, and adds starch,
Make pill.
Embodiment 9
The first step, weighs Radix Ginseng 20g, Margarita 8g, Scorpio 6g, Mentholum 6.5g, Radix Panacis Quinquefolii 12g, artificial Calculus Boviss 8g, Scolopendra
5g, Cinnabaris 20g, Sal Ammoniacus 18g, Fel Ursi powder 8g, Herba Asari 15g, Radix Notoginseng 32g, crush, sieve, and mix homogeneously obtains fermentation raw material；
Second step, 15.85g bacillus bifiduss are added in fermentation raw material, load and fermented in fermentation tank after stirring；3rd
Step, at 37 DEG C, ferments 10 days, extracts, obtain moist powder at 40 DEG C；4th step, adds dextrin, drying of pelletizing, subpackage, system
Into granule.
Embodiment 10
The first step, weighs Radix Ginseng 30g, Margarita 15g, Scorpio 10g, Mentholum 10g, Radix Panacis Quinquefolii 20g, artificial Calculus Boviss 15g, Wu
Centipede 10g, Cinnabaris 30g, Sal Ammoniacus 25g, Fel Ursi powder 15g, Herba Asari 20g, Radix Notoginseng 40g, crush, sieve, and mix homogeneously is fermented
Raw material；Second step, lactic acid bacteria, the common 12g of yeast are added in fermentation raw material, and loading fermentation tank after stirring carries out sending out
Ferment；3rd step, at 35 DEG C, ferments 11 days, and extract at low temperature at 35 DEG C obtains moist powder；4th step, moist powder is done
Dry, add dextrin, tabletting to make tablet.
Experimental example：
In order to show clinical therapeutic efficacy of the Chinese medicine composition of the present invention to esophageal carcinoma, the following research approach of present invention design
Carry out efficacy experiment.
1st, clinical data
200 patients for being diagnosed as esophageal carcinoma are carried out with clinical observation treatment, wherein matched group 100, treatment group 100
Example.
2nd, Therapeutic Method
Matched group gives the medicine prepared by 1 method of Chinese patent literature CN104800585A embodiment, one daily, and one
Agent is taken in two times, serve on one month；Treatment group gives the granule of the preparation of the embodiment of the present invention 3, every time oral 10g, daily
Twice, one month is serve on.
3rd, curative effect determinate standard
Cure：Symptom is wholly absent；
Effectively：Symptom part is alleviated, and tumor area reduces, life cycle 1-3；
Invalid：Symptom is without any improvement or trend that have deterioration, and the even short time is death.
4th, clinical effectiveness
Matched group cures 50, and effective 28, invalid 22, total effective rate is 78%；Treatment group cures 78, and effective 18
Example, invalid 4, total effective rate is 96%, and toxic and side effects do not occur during treatment.
According to clinical verification, the medicine that prepared by other embodiments of the invention also has the effect of embodiment 3.
Prove that by above-mentioned experiment the Chinese medicine composition of the present invention has good effect to esophageal carcinoma, with control drug phase
Than the prescription of the present composition is simple, cheap, can be widely used in the treatment of esophageal carcinoma.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.Right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change, and thus extended obvious change or change still in protection scope of the present invention within.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that including the raw material of following weight portion：10～30 parts of Radix Ginseng, Margarita 3～15
Part, 2～10 parts of Scorpio, 4～10 parts of Mentholum, 6～20 parts of Radix Panacis Quinquefolii, 3～15 parts of artificial Calculus Boviss, 2～10 parts of Scolopendra, Cinnabaris 10
～30 parts, 10～25 parts of Sal Ammoniacus, 3～15 parts of Fel Ursi powder, 5～20 parts of Herba Asari, 25～40 parts of Radix Notoginseng.
2. Chinese medicine composition according to claim 1, it is characterised in that including the raw material of following weight portion：Radix Ginseng 15～
25 parts, 5～10 parts of Margarita, 5～8 parts of Scorpio, 6～8 parts of Mentholum, 10～18 parts of Radix Panacis Quinquefolii, 5～10 parts of artificial Calculus Boviss, Scolopendra 3
～8 parts, 15～25 parts of Cinnabaris, 12～24 parts of Sal Ammoniacus, 5～10 parts of Fel Ursi powder, 6～18 parts of Herba Asari, 30～35 parts of Radix Notoginseng.
3. Chinese medicine composition according to claim 2, it is characterised in that including the raw material of following weight portion：20 parts of Radix Ginseng,
8 parts of Margarita, 6 parts of Scorpio, 6.5 parts of Mentholum, 12 parts of Radix Panacis Quinquefolii, 8 parts of artificial Calculus Boviss, 5 parts of Scolopendra, 20 parts of Cinnabaris, Sal Ammoniacus 18
Part, 8 parts of Fel Ursi powder, 15 parts of Herba Asari, 32 parts of Radix Notoginseng.
4. the Chinese medicine composition according to any one of claims 1 to 3, it is characterised in that the Chinese medicine composition makes medicine
Acceptable preparation on.
5. Chinese medicine composition according to claim 4, it is characterised in that the preparation be capsule, tablet, granule,
Any one in powder, membrane or pill.
6. the preparation method of the Chinese medicine composition described in a kind of claim 4, it is characterised in that comprise the following steps：The first step,
Radix Ginseng, Margarita, Scorpio, Mentholum, Radix Panacis Quinquefolii, artificial Calculus Boviss, Scolopendra, Cinnabaris, Sal Ammoniacus, Fel Ursi powder, thin is weighed by weight
Pungent, Radix Notoginseng, crushes, sieves, and mix homogeneously obtains fermentation raw material；Second step, strain is added in fermentation raw material, is stirred
Load fermentation tank afterwards to be fermented；3rd step, at 33～40 DEG C, ferments 8～12 days, and extract at low temperature at 20～60 DEG C is obtained
Moist powder；4th step, adds pharmaceutic adjuvant, makes pharmaceutically acceptable preparation.
7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in second step, the strain is honeybee
Honey or probiotic bacteria.
8. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that the weight of the Mel and fermentation raw material
Amount ratio is 1～2：1, the probiotic bacteria is 0.05～0.1 with the part by weight of fermentation raw material:1.
9. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that in the 3rd step, fermentation temperature
37 DEG C of degree, fermentation time 10 days, at 45 DEG C, extract at low temperature obtains moist powder.
10. application of the arbitrary Chinese medicine composition of claims 1 to 3 in treatment esophageal cancer medicine is prepared.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655692A (en) * | 2012-08-30 | 2014-03-26 | 陕西欧珂药业有限公司 | Pure traditional Chinese medicine preparation capable of tonifying qi and removing stasis, removing toxicity and eliminating stagnation and preparation method thereof |
| CN103908475A (en) * | 2014-03-26 | 2014-07-09 | 深圳市新华南方生物科技股份有限公司 | Traditional Chinese medicine preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655692A (en) * | 2012-08-30 | 2014-03-26 | 陕西欧珂药业有限公司 | Pure traditional Chinese medicine preparation capable of tonifying qi and removing stasis, removing toxicity and eliminating stagnation and preparation method thereof |
| CN103908475A (en) * | 2014-03-26 | 2014-07-09 | 深圳市新华南方生物科技股份有限公司 | Traditional Chinese medicine preparation method |
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