CN106474216A - A kind of Chinese medicine composition containing pennywort and preparation method thereof - Google Patents
A kind of Chinese medicine composition containing pennywort and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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Abstract
The present invention discloses a kind of Chinese medicine composition containing pennywort, is mainly made up of the raw material of following weight portion：10 25 parts of pennywort, 15 25 parts of loquat flower, 26 parts of pepper, 25 parts of Cynanchum glaucescens, 35 parts of honey.The invention also discloses this contains the preparation method of pennywort Chinese medicinal composition capsules.The present composition effectively plays the effect of moistening lung, cough-relieving, resolving sputum, can be used to coughing, catch a cold, cough that bronchitis etc. causes, cough and asthma, hemoptysis, effect is significant, safe without toxic side effect, be particularly well-suited to the weaker old man of chronic cough or body.
Description
Technical field
The invention belongs to biomedicine technical field, and in particular to a kind of Chinese medicine composition containing pennywort and its preparation side
Method.
Background technology
Chinese medicine is the product of the distinctive traditional Chinese medical theory of China and practice, is the pure natural organic thing of mankind's application earliest
Matter, has the two-way function of nutrition and treatment concurrently.
Cough is a kind of body defenses reflex action that makes to discharge respiratory secretions or foreign matter, throughout the year
Can all occur, easily be sent out when converting in season or weather with elderly and infirm especially, sound is coughed to send, or expectoration sputum is main disease
Shape, is often accompanied by the symptoms such as the miserable, unsmooth breath of nasal obstruction, pharyngalgia, limbs, has a strong impact on rest and daily life.
Though the medicine for being clinically used for cough at present is a lot, majority need to coordinate antibiotics to cure effect to reach
Really, and the problems such as easily causing allergy, suprainfection, resistance of antibiotic, nervous system, kidney, blood are also will result in when serious
Liquid system injury, curative effect are then not fully up to expectations.And China's natural resources of Chinese medicinal materials is abundant, with a long history, and traditional Chinese medicine is comprehensive to cough
The pathology and disease mechanism of venereal disease disease has obvious advantage in terms of having more deep understanding, curative effect, but there is presently no discovery and treating
All relatively have the kind of advantage in effect and market, if the advantage of traditional Chinese medicine on the basis of theory of traditional Chinese medical science, is given full play to, development
Go out the medicine of better efficacy, preferable Social and economic benef@can be obtained.At present treatment disease of cough and asthma class Chinese medicine is had more
Research, but there is not yet pennywort, loquat flower, pepper, Cynanchum glaucescens, the pharmaceutical composition report of honey.
(1) pennywort：For samphire pennywort Hydrocotyle sibthorpioides Lamarck, Hydrocotyle sibthorpioides lam.Var.Batvachium(Hand.- Mazz.) et shan
The complete stool of HydrocotylesibthorpioidesLam.var.batrachium dry herb.【Indication】Heat-clearing solution
Poison, removing dampness through diuresis and removing jaundice, cough-relieving, dispersing swelling and dissipating binds.For jaundice with damp-heat pathogen, cough, pertussis, abscess of throat, hot eyes cloudiness, gonorrhoea are wet
Rash, herpes zoster, sore swollen toxin, beat the stasis of blood swell.
(2) loquat flower：Drying for rosaceous plant loquat Eriobotrya jaPon.ica (Thunb.) I, indl.
Flower.【Indication】Heat-clearing, dissipates wind.For cold, have a headache, thin nasal discharge.
(3) pepper：Drying closely ripe or ripening fruits for Piperaceae plant pepper Piper nigrum L..【Function with
Cure mainly】Warming spleen and stomach for dispelling cold, lower gas, dissolving phlegm.Stomachache is had loose bowels, poor appetite, epilepsy abundant expectoration.
(4) Cynanchum glaucescens：For Luo Mo section plant rhizoma et radix cynanchi stauntoni Cynanchum stazcntonii (Dec-ne.) Schltr.ex
Levl. or leaves of Daphne genkwa Cynanchum glaucescens Cyn, anchum glaucescens (Decne.) Hand.-Mazz. dry rhizome and root.【Work(
Can with cure mainly】Sending down abnormally ascending, dissolving phlegm, cough-relieving.Stop up in fact for lung qi, coughing with a lot of sputum, fullness sensation in chest breathe heavily urgency.
(5) honey：For apidae insect apis cerana Apis ceranaFabricius or apis mellifera Linnaeus Apis
The honey made by melliferaLinnaeus.【Function with cure mainly】Bowl spares, moisturizes, pain relieving, removing toxic substances；External application myogenic sore.For gastral cavity
The empty pain of abdomen, dryness of the lung dry cough, dry constipation of intestines, solution Aconitum medicine poison；Control outward sore not hold back, scald.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition containing pennywort, said composition energy moistening lung, regulating qi-flowing for harmonizing stomach, cough-relieving
Resolving sputum, application effect are good.
The present invention takes technical scheme below:
A kind of Chinese medicine composition containing pennywort, is mainly made up of the raw material of following weight portion：Pennywort 10-25 part, loquat
Flower 15-25 part, pepper 2-6 part, Cynanchum glaucescens 2-5 part, honey 3-5 part.
Preferably, the above Chinese medicine composition containing pennywort, is mainly made up of the raw material of following weight portion：Pennywort 20
Part, 20 parts of loquat flower, 4 parts of pepper, 3 parts of Cynanchum glaucescens, 4 parts of honey.
The above Chinese medicine composition containing pennywort, can be prepared into pharmaceutically acceptable any preparation, be preferably prepared to
Powder, granule, pill, tablet, capsule, decoction, soft extracts, mixture, oral liquid or syrup etc., are wherein most preferably preferably made glue
Capsule.
More than one described preparation methods containing pennywort Chinese medicinal composition capsules, comprise the following steps：
S1：Raw material is weighed by following weight portion：Pennywort 5-20 part, loquat flower 10-20 part, pepper 2-8 part, Cynanchum glaucescens 2-5
Part, honey 3-6 part；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 6-8 times amount water, heating and refluxing extraction 2-3 time, each 1-3 hour, filter
Cross, merging filtrate, concentrate, obtain thick paste；
S3：Pepper is taken, is crushed, 60-100 mesh sieve is crossed, obtains pepper powder；
S4：In thick paste, starch, honey is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, magnesium stearate, mix, load capsule, obtain final product.
The above preparation method containing pennywort Chinese medicinal composition capsules, step S1 are preferably claimed by following weight portion
Take raw material：20 parts of pennywort, 20 parts of loquat flower, 4 parts of pepper, 3 parts of Cynanchum glaucescens, 4 parts of honey.
The above preparation method containing pennywort Chinese medicinal composition capsules, the thick paste that step S2 is obtained are preferably 60
DEG C when relative density for 1.28-1.35 thick paste.
The above preparation method containing pennywort Chinese medicinal composition capsules, in step S3, pepper preferably crosses 80 mesh
Sieve.
The above preparation method containing pennywort Chinese medicinal composition capsules, in step S4, baking temperature is 60-65
℃.
The above application containing pennywort Chinese medicine composition, the composition can be used for the breathing for causing of coughing, catch a cold
Road catches.It is particularly well-suited to the weaker old man of chronic cough, the patient of prolonged illness or body.
The beneficial effect that the present invention is obtained：
1. the present invention, is closed with loquat flower, Cynanchum glaucescens, pepper in conjunction with medication experience among the people with the peculiar Chinese medicine pennywort in Guangxi
With, the honey with moistening lung effect being added, is formulated with modern scientific theory, the Chinese medicine composition being combined into effectively rises
To moistening lung, cough-relieving, resolving sputum effect, the respiratory infection diseases caused for coughing, catching a cold etc., such as cough, flu, cough and asthma,
The treatment of bronchitis, pulmonary tuberculosis etc., efficient up to 98%, safe without toxic side effect, it is particularly well-suited to the disease of chronic cough, prolonged illness
The weaker old man of people or body.
2. the pennywort Traditional Chinese medicine composition formula science of the present invention, preparation process is simple, low cost, application effect are notable,
It is easily achieved industrialization.
3. pennywort Chinese medicinal composition capsules of the present invention, in preparation method using honey adhesive effect, in step 4
Prepare and be not required to add adhesive in softwood operation, reduce auxiliary material and use, reduce production cost；Conventional food materials pepper is using crushing
Directly it is used as medicine afterwards, the loss of pepper effective active composition can be reduced.The pennywort Chinese medicinal composition capsules of the present invention are using existing
Foundry skill by scientific process is formed, and is easy to preserve, easy to carry.
Specific embodiment
For ease of more fully understanding the present invention, it is illustrated by following examples, these embodiments belong to the present invention's
Protection domain, but do not limit the scope of the invention.
First, the preparation containing pennywort Chinese medicinal composition capsules
Embodiment 1
A kind of preparation method containing pennywort Chinese medicinal composition capsules, comprises the following steps：
S1：Raw material is weighed by following weight portion：Pennywort 10kg, loquat flower 15kg, pepper 2kg, Cynanchum glaucescens 2kg, honey
3kg；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 6 times amount water, heating and refluxing extraction 2 times, 3 hours every time, filtration, merge
Filtrate, concentrates, and when obtaining 60 DEG C, relative density is 1.28 thick paste；
S3：Pepper is taken, is crushed, 60 mesh sieves are crossed, obtains pepper powder；
S4：In thick paste, honey, appropriate amount of starch is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, appropriate magnesium stearate, mix, load capsule, obtain final product.
Embodiment 2
A kind of preparation method containing pennywort Chinese medicinal composition capsules, comprises the following steps：
S1：Raw material is weighed by following weight portion：Pennywort 25kg, loquat flower 25kg, pepper 6kg, Cynanchum glaucescens 5kg, honey
5kg；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 8 times amount water, heating and refluxing extraction 3 times, 1 hour every time, filtration, merge
Filtrate, concentrates, and when obtaining 60 DEG C, relative density is 1.35 thick paste；
S3：Pepper is taken, is crushed, 100 mesh sieves are crossed, obtains pepper powder；
S4：In thick paste, honey, appropriate amount of starch is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, appropriate magnesium stearate, mix, load capsule, obtain final product.
Embodiment 3
A kind of preparation method containing pennywort Chinese medicinal composition capsules, comprises the following steps：
S1：Raw material is weighed by following weight portion：Pennywort 20kg, loquat flower 20kg, pepper 4kg, Cynanchum glaucescens 3kg, honey
4kg；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 7 times amount water, heating and refluxing extraction 2 times, 2 hours every time, filtration, merge
Filtrate, concentrates, and when obtaining 60 DEG C, relative density is 1.30 thick paste；
S3：Pepper is taken, is crushed, 80 mesh sieves are crossed, obtains pepper powder；
S4：In thick paste, honey, appropriate amount of starch is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, appropriate magnesium stearate, mix, load capsule, obtain final product.
Embodiment 4
A kind of preparation method containing pennywort Chinese medicinal composition capsules, comprises the following steps：
S1：Raw material is weighed by following weight portion：Pennywort 22kg, loquat flower 18kg, pepper 4kg, Cynanchum glaucescens 5kg, honey
3kg；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 6 times amount water, heating and refluxing extraction 3 times, 2 hours every time, filtration, merge
Filtrate, concentrates, and when obtaining 60 DEG C, relative density is 1.26 thick paste；
S3：Pepper is taken, is crushed, 200 mesh sieves are crossed, obtains pepper powder；
S4：In thick paste, honey, appropriate amount of starch is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, appropriate magnesium stearate, mix, load capsule, obtain final product.
2nd, application test
1. subjects selection standard
Primary symptom：Cough, nothing phlegm or expectoration；
Secondary disease：Pharynx is itched or pain；Dry throat；；Pharyngeal portion flare, nasal obstruction, runny nose；Out of breath pant；Bronchitis；Pneumonia；Pulmonary tuberculosis；
White or yellow thin fur；Floating and tense pulse or cunning.
Possess 2 in above primary symptom and secondary disease, the age is in 15-85 year person, you can.
2. application scheme
Test group：By above-mentioned 3 sample of embodiment for preparing, for above-mentioned subjects.It is administered orally, every time 4 (0.5g/
Grain), 3 times a day.Time of Administration：5 day are continuously taken.
Control group：Chuanbei pipa syrup, is administered orally, each 10ml, and 3 times a day.Time of Administration：5 day are continuously taken.
3. effect criterion
Recovery from illness：Cough symptom, sign disappear or basic disappearance, and integration reduces more than 95%.
Effective：Cough symptom, sign are obviously improved, and integration is reduced between 70%-94%.
Effectively：Cough symptom, sign all take a favorable turn, and integration is reduced in 30%-<69%.
Invalid：Cough symptom is not improved, and very then increases, and integration is reduced<30%.
Computing formula is：[integration before (integrating after integration-treatment before treatment) ÷ treatment] × 100%
4. result is applied
By present invention Chinese medicinal composition capsules containing pennywort and the chuanbei pipa syrup of certain company's production commercially available, once it was applied to
88 patients (man 42, female 46).The results detailed in Table 1.
1 application effect of products investigation result table of table
Application test result shows：Using present invention Chinese medicine composition containing pennywort, cough recovery from illness 76%, efficient reach
98%, occur without bad reaction, its application effect is better than control group, illustrates that the present invention has good effect to cough, has
Moistening lung, cough-relieving, the effect of resolving sputum, the respiratory infection diseases for causing such as can be used to coughing, catch a cold, such as cough, flu, cough and asthma,
The treatment of bronchitis, pulmonary tuberculosis etc., safe without toxic side effect, it is particularly well-suited to chronic cough, the patient of prolonged illness or body weaker
Old man.
3rd, typical case
In addition to above-mentioned application test, the embodiment 1-4 sample also by the present invention containing pennywort Chinese medicinal composition capsules is used for
Other patients, all obtain good result, are several typical cases below：
Case 1：Sieve ××, man, 15 years old, cardinal symptom was：Cough, dry cough without phlegm, nasal obstruction, runny nose, tongue are thin white, floating pulse
Tightly.Take the capsule (embodiment 4) that present invention Chinese medicine composition containing pennywort is made, 2 every time (0.5g/ grain), 3 times a day,
3 are serve on, symptom eliminates, recovery from illness.
Case 1：Liao's ××, female, 38 years old, with cough, expectoration, pharyngeal portion flare as cardinal symptom.The present invention is taken containing day Hu
The capsule (embodiment 1) that Sui Chinese medicine composition is made, 4 every time (0.5g/ grain), 3 times a day, and after 2 days, cough symptom mitigates,
Expectoration amount is reduced, then serve on 3, symptom eliminates, recovery from illness.
Case 3：Wei ××, female, 72 years old, chronic bronchitis patient, weather turned cold outbreak, and cough, expectoration, pharynx are itched, gas
Short pant.Take the capsule (embodiment 2) that present invention Chinese medicine composition containing pennywort is made, 4 every time (0.5g/ grain), daily 3
Secondary, 5 are serve on, symptom mitigation, then continuously take 5, recovery from illness, nothing recurrence is paid a return visit after 1 year.
Above-described be only the present invention preferred embodiment, it is noted that for the ordinary skill people of this area
For member, without departing from the concept of the premise of the invention, some deformation and improvement can also be made, these belong to this
Bright protection domain.
Claims (10)
1. a kind of Chinese medicine composition containing pennywort, it is characterised in that be mainly made up of the raw material of following weight portion：Pennywort 10-
25 parts, loquat flower 15-25 part, pepper 2-6 part, Cynanchum glaucescens 2-5 part, honey 3-5 part.
2. as claimed in claim 1 Chinese medicine composition containing pennywort, it is characterised in that mainly by the raw material group of following weight portion
Become：20 parts of pennywort, 20 parts of loquat flower, 4 parts of pepper, 3 parts of Cynanchum glaucescens, 4 parts of honey.
3. as claimed in claim 1 Chinese medicine composition containing pennywort, it is characterised in that the composition make powder, granule,
Pill, tablet, capsule, decoction, soft extracts, mixture, oral liquid or syrup.
4. as claimed in claim 1 Chinese medicine composition containing pennywort, it is characterised in that the composition makes capsule.
5. a kind of preparation method as claimed in claim 4 containing pennywort Chinese medicinal composition capsules, it is characterised in that including following
Step：
S1：Raw material is weighed by following weight portion：Pennywort 10-25 part, loquat flower 15-25 part, pepper 2-6 part, Cynanchum glaucescens 2-5 part,
Honey 3-5 part；
S2：Take pennywort, loquat flower, Cynanchum glaucescens, plus 6-8 times amount water, heating and refluxing extraction 2-3 time, each 1-3 hour, filtration, conjunction
And filtrate, concentrate, obtain thick paste；
S3：Pepper is taken, is crushed, 60-100 mesh sieve is crossed, obtains pepper powder；
S4：In thick paste, starch, honey is added, mix, granulation, dry, obtain dry particl；
S5：By dry particl, pepper powder, magnesium stearate, mix, load capsule, obtain final product.
6. the preparation method of pennywort Chinese medicinal composition capsules is contained as claimed in claim 5, it is characterised in that step S1 is pressed
Following weight portion weighs raw material：20 parts of pennywort, 20 parts of loquat flower, 4 parts of pepper, 3 parts of Cynanchum glaucescens, 4 parts of honey.
7. the preparation method of pennywort Chinese medicinal composition capsules is contained as claimed in claim 5, it is characterised in that step S2 is obtained
To thick paste be 60 DEG C when relative density for 1.28-1.35 thick paste.
8. the preparation method of pennywort Chinese medicinal composition capsules is contained as claimed in claim 5, it is characterised in that in step S3
Pepper crosses 80 mesh sieves.
9. the preparation method of pennywort Chinese medicinal composition capsules is contained as claimed in claim 5, it is characterised in that in step S4
Baking temperature is 60-65 DEG C.
10. a kind of application containing pennywort Chinese medicine composition, it is characterised in that the composition causes for coughing, catching a cold
Respiratory infection diseases.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107373142A (en) * | 2017-08-10 | 2017-11-24 | 田东雄桂牧业有限公司 | A kind of flu-prevention pig feed |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972441A (en) * | 2010-10-11 | 2011-02-16 | 王蔚 | Medicament for treating cough and asthma and preparation method thereof |
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2016
- 2016-12-31 CN CN201611269991.9A patent/CN106474216A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972441A (en) * | 2010-10-11 | 2011-02-16 | 王蔚 | Medicament for treating cough and asthma and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 李建松: "鲜天胡荽治疗干咳效好", 《新中医》 * |
| 杨建峰: "《中草药大典》", 31 January 2015, 江西科学技术出版社 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107373142A (en) * | 2017-08-10 | 2017-11-24 | 田东雄桂牧业有限公司 | A kind of flu-prevention pig feed |
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