CN106456787B - Pan-raf激酶抑制剂的医药调配物、其制备方法以及使用方法 - Google Patents

Pan-raf激酶抑制剂的医药调配物、其制备方法以及使用方法 Download PDF

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CN106456787B
CN106456787B CN201580026318.XA CN201580026318A CN106456787B CN 106456787 B CN106456787 B CN 106456787B CN 201580026318 A CN201580026318 A CN 201580026318A CN 106456787 B CN106456787 B CN 106456787B
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cancer
pharmaceutical composition
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pharmaceutically acceptable
tablet
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CN106456787A (zh
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雷切尔·L·布雷克
维维安娜·博宗
荆-国·J·周
詹姆斯·C·迪农齐奥
凯瑟琳·M·加尔文
卡鲁皮亚·卡纳安
勇纪·科多努
徐群立
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Dow Treatment 1
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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    • A61K9/2833—Organic macromolecular compounds
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    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
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CN201580026318.XA 2014-03-26 2015-03-26 Pan-raf激酶抑制剂的医药调配物、其制备方法以及使用方法 Active CN106456787B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201461970595P 2014-03-26 2014-03-26
US61/970,595 2014-03-26
US201462048527P 2014-09-10 2014-09-10
US62/048,527 2014-09-10
PK162/2015 2015-03-25
PK16215 2015-03-25
UY0001036046A UY36046A (es) 2014-03-26 2015-03-25 Formulaciones farmacéuticas, procesos para la preparación y métodos de uso
UY36.046 2015-03-25
PCT/US2015/022792 WO2015148828A1 (en) 2014-03-26 2015-03-26 Pharmaceutical formulations of a pan-raf kinase inhibitor, processes for their preparation, and methods of use

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CN106456787B true CN106456787B (zh) 2020-12-18

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US (1) US10426782B2 (https=)
EP (1) EP3122334B1 (https=)
JP (1) JP6571105B2 (https=)
CN (1) CN106456787B (https=)
BR (1) BR112016022219B1 (https=)
CA (1) CA2943808C (https=)
CO (1) CO2016003340A2 (https=)
CR (1) CR20160483A (https=)
DO (1) DOP2016000254A (https=)
EA (1) EA031190B1 (https=)
EC (1) ECSP16084317A (https=)
ES (1) ES2744298T3 (https=)
GE (1) GEP20186932B (https=)
MA (1) MA39765A (https=)
PE (1) PE20170773A1 (https=)
UY (1) UY36046A (https=)
WO (1) WO2015148828A1 (https=)

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ES2827024T3 (es) * 2014-12-23 2021-05-19 Dot Therapeutics 1 Inc Combinación de inhibidores de Raf y de taxanos
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
WO2017165491A1 (en) * 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Use of a pd-1 antagonist and a raf inhibitor in the treatment of cancer
WO2017165742A1 (en) 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments
MA44483A (fr) 2016-03-24 2019-01-30 Millennium Pharm Inc Procédés pour traiter des événements indésirables gastro-intestinaux d'origine immunitaire dans des traitements oncologiques immunitaires
US12122787B2 (en) 2019-09-20 2024-10-22 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
WO2021108616A1 (en) * 2019-11-27 2021-06-03 Dot Therapeutics-1, Inc. Solid dispersion of pan-raf kinase inhibitor
CN117042772A (zh) * 2020-11-06 2023-11-10 首日生物制药公司 用于治疗低级别胶质瘤的raf抑制剂
AU2021376286A1 (en) * 2020-11-06 2023-06-22 Dana-Farber Cancer Institute, Inc. Raf inhibitor for treating low grade glioma
MX2023009642A (es) * 2021-02-19 2023-10-16 Day One Biopharmaceuticals Inc Combinacion de inhibidor de raf e inhibidor de mek.
WO2023049807A2 (en) * 2021-09-22 2023-03-30 Sirnaomics, Inc. Improved methods for preparing nanoparticle compositions containing histidine-lysine copolymers

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EA201691918A1 (ru) 2017-02-28
CO2016003340A2 (es) 2017-02-17
CA2943808C (en) 2022-08-16
EP3122334B1 (en) 2019-06-26
UY36046A (es) 2015-10-30
EP3122334A1 (en) 2017-02-01
ES2744298T3 (es) 2020-02-24
US10426782B2 (en) 2019-10-01
US20170173033A1 (en) 2017-06-22
WO2015148828A1 (en) 2015-10-01
JP6571105B2 (ja) 2019-09-04
PE20170773A1 (es) 2017-07-04
BR112016022219A2 (pt) 2018-07-10
BR112016022219B1 (pt) 2022-09-27
GEP20186932B (en) 2018-12-10
CA2943808A1 (en) 2015-10-01
CN106456787A (zh) 2017-02-22
MA39765A (fr) 2017-02-01
EA031190B1 (ru) 2018-11-30
JP2017511313A (ja) 2017-04-20
CR20160483A (es) 2017-04-27
DOP2016000254A (es) 2017-02-15
ECSP16084317A (es) 2018-05-31

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