PE20170773A1 - Formulaciones farmaceuticas, procesos para la preparacion, y metodos de uso - Google Patents
Formulaciones farmaceuticas, procesos para la preparacion, y metodos de usoInfo
- Publication number
- PE20170773A1 PE20170773A1 PE2017000171A PE2017000171A PE20170773A1 PE 20170773 A1 PE20170773 A1 PE 20170773A1 PE 2017000171 A PE2017000171 A PE 2017000171A PE 2017000171 A PE2017000171 A PE 2017000171A PE 20170773 A1 PE20170773 A1 PE 20170773A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- processes
- methods
- pharmaceutical formulations
- pharmaceutically acceptable
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- -1 1- (6-amino-5-chloropyrimidine-4-carboxamido) ethyl Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007962 solid dispersion Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461970595P | 2014-03-26 | 2014-03-26 | |
| US201462048527P | 2014-09-10 | 2014-09-10 | |
| PK16215 | 2015-03-25 | ||
| UY0001036046A UY36046A (es) | 2014-03-26 | 2015-03-25 | Formulaciones farmacéuticas, procesos para la preparación y métodos de uso |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170773A1 true PE20170773A1 (es) | 2017-07-04 |
Family
ID=57215543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017000171A PE20170773A1 (es) | 2014-03-26 | 2015-03-26 | Formulaciones farmaceuticas, procesos para la preparacion, y metodos de uso |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10426782B2 (https=) |
| EP (1) | EP3122334B1 (https=) |
| JP (1) | JP6571105B2 (https=) |
| CN (1) | CN106456787B (https=) |
| BR (1) | BR112016022219B1 (https=) |
| CA (1) | CA2943808C (https=) |
| CO (1) | CO2016003340A2 (https=) |
| CR (1) | CR20160483A (https=) |
| DO (1) | DOP2016000254A (https=) |
| EA (1) | EA031190B1 (https=) |
| EC (1) | ECSP16084317A (https=) |
| ES (1) | ES2744298T3 (https=) |
| GE (1) | GEP20186932B (https=) |
| MA (1) | MA39765A (https=) |
| PE (1) | PE20170773A1 (https=) |
| UY (1) | UY36046A (https=) |
| WO (1) | WO2015148828A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107405348B (zh) * | 2014-12-23 | 2021-06-11 | 点疗法-1公司 | Raf抑制剂与紫杉烷的组合 |
| WO2017066664A1 (en) * | 2015-10-16 | 2017-04-20 | Millennium Pharmaceuticals, Inc. | Combination therapy including a raf inhibitor for the treatment of colorectal cancer |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2017165491A1 (en) * | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Use of a pd-1 antagonist and a raf inhibitor in the treatment of cancer |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| JP7707166B2 (ja) * | 2019-11-27 | 2025-07-14 | デイ ワン バイオファーマシューティカルズ， インコーポレイテッド | Ｐａｎ－ｒａｆキナーゼインヒビターの固体分散物 |
| CN117042772A (zh) * | 2020-11-06 | 2023-11-10 | 首日生物制药公司 | 用于治疗低级别胶质瘤的raf抑制剂 |
| JP2023548600A (ja) * | 2020-11-06 | 2023-11-17 | デイ ワン バイオファーマシューティカルズ， インコーポレイテッド | 低グレード神経膠腫を処置するためのｒａｆインヒビター |
| MX2023009642A (es) * | 2021-02-19 | 2023-10-16 | Day One Biopharmaceuticals Inc | Combinacion de inhibidor de raf e inhibidor de mek. |
| CN118450909A (zh) * | 2021-09-22 | 2024-08-06 | 圣诺制药公司 | 用于制备含有组氨酸-赖氨酸共聚物的纳米颗粒组合物的改善的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| DE19509807A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
| US20050220865A1 (en) | 2004-04-02 | 2005-10-06 | Koleng John J | Compressed composition comprising magnesium salt |
| ZA200806138B (en) | 2005-12-16 | 2009-11-25 | Hanmi Pharm Ind Co Ltd | Solid dispersion comprising an active ingredient having a low melting point and tablet for oral administration comprising same |
| KR100767349B1 (ko) * | 2006-08-01 | 2007-10-17 | 삼천당제약주식회사 | 페노피브레이트를 함유하는 경구용 약제 조성물 및 그의제조방법 |
| US20100143481A1 (en) | 2006-11-08 | 2010-06-10 | Dinesh Shenoy | Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions |
| JPWO2008114859A1 (ja) * | 2007-03-22 | 2010-07-08 | アステラス製薬株式会社 | ピラゾール誘導体を含有する医薬組成物 |
| CL2008001933A1 (es) * | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| AU2009292615B2 (en) | 2008-09-17 | 2015-12-03 | Mylan Inc. | Granulates, process for preparing them and pharmaceutical products containing them |
| US20130172375A1 (en) * | 2011-12-13 | 2013-07-04 | Hoffmann-La Roche Inc. | Pharmaceutical composition |
| CA2868954A1 (en) * | 2012-03-30 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma |
-
2015
- 2015-03-25 UY UY0001036046A patent/UY36046A/es not_active Application Discontinuation
- 2015-03-26 ES ES15716288T patent/ES2744298T3/es active Active
- 2015-03-26 EA EA201691918A patent/EA031190B1/ru not_active IP Right Cessation
- 2015-03-26 BR BR112016022219-9A patent/BR112016022219B1/pt active IP Right Grant
- 2015-03-26 CN CN201580026318.XA patent/CN106456787B/zh active Active
- 2015-03-26 WO PCT/US2015/022792 patent/WO2015148828A1/en not_active Ceased
- 2015-03-26 US US15/128,714 patent/US10426782B2/en active Active
- 2015-03-26 CR CR20160483A patent/CR20160483A/es unknown
- 2015-03-26 MA MA039765A patent/MA39765A/fr unknown
- 2015-03-26 CA CA2943808A patent/CA2943808C/en active Active
- 2015-03-26 PE PE2017000171A patent/PE20170773A1/es unknown
- 2015-03-26 EP EP15716288.4A patent/EP3122334B1/en active Active
- 2015-03-26 GE GEAP201514304A patent/GEP20186932B/en unknown
- 2015-03-26 JP JP2016558714A patent/JP6571105B2/ja active Active
-
2016
- 2016-09-23 DO DO2016000254A patent/DOP2016000254A/es unknown
- 2016-10-24 CO CONC2016/0003340A patent/CO2016003340A2/es unknown
- 2016-10-26 EC ECIEPI201684317A patent/ECSP16084317A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2943808A1 (en) | 2015-10-01 |
| CN106456787B (zh) | 2020-12-18 |
| BR112016022219B1 (pt) | 2022-09-27 |
| UY36046A (es) | 2015-10-30 |
| ES2744298T3 (es) | 2020-02-24 |
| CR20160483A (es) | 2017-04-27 |
| EP3122334B1 (en) | 2019-06-26 |
| MA39765A (fr) | 2017-02-01 |
| GEP20186932B (en) | 2018-12-10 |
| EA201691918A1 (ru) | 2017-02-28 |
| BR112016022219A2 (pt) | 2018-07-10 |
| CA2943808C (en) | 2022-08-16 |
| EP3122334A1 (en) | 2017-02-01 |
| US10426782B2 (en) | 2019-10-01 |
| JP6571105B2 (ja) | 2019-09-04 |
| JP2017511313A (ja) | 2017-04-20 |
| DOP2016000254A (es) | 2017-02-15 |
| ECSP16084317A (es) | 2018-05-31 |
| US20170173033A1 (en) | 2017-06-22 |
| WO2015148828A1 (en) | 2015-10-01 |
| CO2016003340A2 (es) | 2017-02-17 |
| EA031190B1 (ru) | 2018-11-30 |
| CN106456787A (zh) | 2017-02-22 |
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