CN106456643B - 用于trail诱导的药效团 - Google Patents

用于trail诱导的药效团 Download PDF

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Publication number
CN106456643B
CN106456643B CN201580021658.3A CN201580021658A CN106456643B CN 106456643 B CN106456643 B CN 106456643B CN 201580021658 A CN201580021658 A CN 201580021658A CN 106456643 B CN106456643 B CN 106456643B
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compound
cancer
trail
cell derived
compounds
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Chinese (zh)
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CN106456643A (zh
Inventor
基姆·D·扬达
尼古拉斯·T·雅各布
乔纳森·W·洛克纳
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Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580021658.3A 2014-03-31 2015-03-30 用于trail诱导的药效团 Active CN106456643B (zh)

Priority Applications (1)

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CN202010184181.3A CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

Applications Claiming Priority (3)

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US201461972689P 2014-03-31 2014-03-31
US61/972,689 2014-03-31
PCT/US2015/023362 WO2015153468A1 (en) 2014-03-31 2015-03-30 Pharmacophore for trail induction

Related Child Applications (1)

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CN202010184181.3A Division CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

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CN106456643A CN106456643A (zh) 2017-02-22
CN106456643B true CN106456643B (zh) 2020-04-17

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CN202010184181.3A Active CN111499636B (zh) 2014-03-31 2015-03-30 用于trail诱导的药效团

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US (5) US10239877B2 (https=)
EP (3) EP3125898B1 (https=)
JP (4) JP6756435B2 (https=)
KR (2) KR102611067B1 (https=)
CN (2) CN106456643B (https=)
AU (4) AU2015241069B2 (https=)
CA (2) CA2944452C (https=)
CY (1) CY1123093T1 (https=)
DK (2) DK3662910T3 (https=)
ES (2) ES2999685T3 (https=)
FI (1) FI3662910T3 (https=)
HR (2) HRP20241680T1 (https=)
HU (2) HUE069651T2 (https=)
LT (2) LT3125898T (https=)
PL (2) PL3125898T3 (https=)
PT (2) PT3125898T (https=)
RS (2) RS66254B1 (https=)
SI (2) SI3662910T1 (https=)
SM (2) SMT202000219T1 (https=)
WO (1) WO2015153468A1 (https=)

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US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
SI2968294T1 (sl) 2013-03-13 2019-08-30 Oncoceutics, Inc. 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
KR102318238B1 (ko) * 2013-11-15 2021-10-26 온코슈틱스 인코포레이티드 7-벤질-4-(2-메틸벤질)-2,4,6,7,8,9-헥사하이드로이미다조[1,2-a]피리도[3,4-e]피리미딘-5(1H)-온, 이의 염 및 이의 용도
JP6756435B2 (ja) 2014-03-31 2020-09-16 ザ スクリプス リサーチ インスティテュート Ｔｒａｉｌ誘導のためのファーマコフォア
HUE052821T2 (hu) * 2015-01-30 2021-05-28 Oncoceutics Inc 7-benzil-4-(4-trifluormetil)benzil-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4H)-on és sói és azok terápiában történõ alkalmazása
CN104860948B (zh) * 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
RS66519B1 (sr) * 2016-01-29 2025-03-31 Oncoceutics Inc Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona
CA3033667A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
US10172862B2 (en) 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
GB2596010B (en) * 2019-02-11 2023-03-01 Madera Therapeutics Llc Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
CA3131740A1 (en) 2019-02-27 2020-09-03 Madera Therapeutics, LLC Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents
EP4192467A1 (en) 2020-08-06 2023-06-14 Eötvös Loránd Tudományegyetem Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
CN115448921B (zh) * 2021-06-08 2023-08-01 四川大学 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途
CN116751199B (zh) * 2023-06-02 2025-03-18 中国科学院基础医学与肿瘤研究所(筹) 一种线粒体蛋白酶靶向嵌合体、制备方法及用途
EP4684834A1 (de) * 2024-07-26 2026-01-28 BRIU GmbH Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung

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CN102970868A (zh) * 2010-04-16 2013-03-13 柯瑞斯公司 具有k-ras突变的癌症的治疗

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US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
SI2968294T1 (sl) * 2013-03-13 2019-08-30 Oncoceutics, Inc. 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka
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JP6756435B2 (ja) 2014-03-31 2020-09-16 ザ スクリプス リサーチ インスティテュート Ｔｒａｉｌ誘導のためのファーマコフォア

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JP7688245B2 (ja) 2025-06-04
KR20220163533A (ko) 2022-12-09
EP3125898A4 (en) 2017-08-16
DK3125898T3 (da) 2020-03-30
US11891392B2 (en) 2024-02-06
SI3125898T1 (sl) 2020-07-31
US20190284188A1 (en) 2019-09-19
AU2015241069B2 (en) 2020-10-15
JP2023022184A (ja) 2023-02-14
DK3662910T3 (en) 2024-11-04
LT3662910T (lt) 2024-12-27
JP6756435B2 (ja) 2020-09-16
RS66254B1 (sr) 2024-12-31
PT3125898T (pt) 2020-04-01
CN106456643A (zh) 2017-02-22
LT3125898T (lt) 2020-04-10
WO2015153468A1 (en) 2015-10-08
CY1123093T1 (el) 2021-10-29
HUE069651T2 (hu) 2025-03-28
KR20160138513A (ko) 2016-12-05
US10239877B2 (en) 2019-03-26
CA3158795A1 (en) 2015-10-08
ES2779979T3 (es) 2020-08-21
ES2999685T3 (en) 2025-02-26
JP2020002170A (ja) 2020-01-09
AU2015241069A1 (en) 2016-10-20
CA2944452A1 (en) 2015-10-08
HUE049013T2 (hu) 2020-08-28
EP3125898B1 (en) 2019-12-25
US20240190877A1 (en) 2024-06-13
SMT202400497T1 (it) 2025-01-14
US20200283440A1 (en) 2020-09-10
CN111499636B (zh) 2023-01-13
EP3125898A1 (en) 2017-02-08
US20220002300A1 (en) 2022-01-06
AU2022283729A1 (en) 2023-02-02
AU2020286314A1 (en) 2021-01-21
KR102473930B1 (ko) 2022-12-05
EP4470617A2 (en) 2024-12-04
US10633385B2 (en) 2020-04-28
HRP20241680T1 (hr) 2025-02-28
SMT202000219T1 (it) 2020-05-08
JP2021119157A (ja) 2021-08-12
JP6873201B2 (ja) 2021-05-19
SI3662910T1 (sl) 2025-05-30
AU2024204977B2 (en) 2026-04-16
JP2017511321A (ja) 2017-04-20
JP7186256B2 (ja) 2022-12-08
KR102611067B1 (ko) 2023-12-06
PL3125898T3 (pl) 2020-11-16
FI3662910T3 (fi) 2024-10-31
PT3662910T (pt) 2024-11-27
AU2024204977A1 (en) 2024-08-08
EP3662910A1 (en) 2020-06-10
EP4470617A3 (en) 2025-02-26
HRP20200478T1 (hr) 2020-07-24
EP3662910B1 (en) 2024-09-18
PL3662910T3 (pl) 2025-08-11
CN111499636A (zh) 2020-08-07
CA2944452C (en) 2022-07-19
US20170107221A1 (en) 2017-04-20
RS60163B1 (sr) 2020-05-29

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Application publication date: 20170222

Assignee: CHINA RESOURCES SANJIU MEDICAL & PHARMACEUTICAL Co.,Ltd.

Assignor: ONCOCEUTICS, Inc.

Contract record no.: X2021990000006

Denomination of invention: Pharmacophores for trail induction

Granted publication date: 20200417

License type: Exclusive License

Record date: 20210105

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