CN106421263A - Cold-dispelling traditional Chinese medicine formula for rheumatoid low back pain - Google Patents

Abstract

The invention discloses a cold-dispelling traditional Chinese medicine formula for rheumatoid low back pain. The formula contains the following raw materials in parts by weight: 5-23 parts of Szechuan lovage rhizome, 7-19 parts of largehead atractylodes rhizome, 5-15 parts of Chinese angelica, 8-17 parts of tangerine peel, 6-17 parts of Chinese thorowax root, 3-23 parts of largetrifoliolious bugbane rhizome, 5-25 parts of peach seeds, 5-15 parts of ground beetles, 4-19 parts of trogopterus dung, and 7-20 parts of nutgrass galingale rhizome, wherein the Szechuan lovage rhizome is raw Szechuan lovage rhizome. The traditional Chinese medicinal composition provided by the invention does not have untoward effects in use, and has an obvious effect of treating the low back pain; the selected raw medicinal materials have no toxic or side effects among one another; and the traditional Chinese medicinal composition can be used by mild and severe low back pain patients, is wide in application range, achieves the effects of promoting circulation of qi and blood and dissipating blood stasis to relieve pain, and has a very good curative effect on low back pains caused by flash fall sprains and acute strains.

Description

A kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain

Technical field

The present invention relates to technical field of traditional Chinese medicines, specifically refer to a kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain.

Background technology

Pain in the back, Chinese medical disease name.Refer to because of diseases caused by external factors, internal injury or frustrate sudden strain of a muscle and lead to waist QI-blood circulation not smooth, or lose foster in moistening, Spinal column or the other tract pain of ridge is caused to be a kind of disease of cardinal symptom.Its morbidity, often with kidney asthenia as the principal aspect, being invaded by exogenous pathogen,invasion of exogenous pathogen, is fallen servant and is frustrated Dodge for mark.During treatment, real example focuses on eliminating evil and promotes blood circulation active, and asthenic symptoms focus on righting, and filling liver kidney, strong waist and knee, invigorating the spleen gas are conventional controlling Method.Pain in the back with the passing of time, simulataneous insufficiency and excessive, treatment should grasp sample actual situation, from the method for eliminating evil and reinforcing.

Treatment Low Back Pain uses the Chinese medicine effect of Chinese tradition more preferably, but the chemical analysis of Chinese medicine is sufficiently complex, existing contains There are multiple effective ingredients, have invalid element again, also comprise toxic substance, how to select Chinese medicine material to be combined formula and become controlling Treat the important step of Low Back Pain.

Content of the invention

It is an object of the invention to provide a kind of can significantly slow Low Back Pain symptom, relax the muscles and stimulate the blood circulation, improve body immunity A kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain.

The present invention is achieved through the following technical solutions：A kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain, by weight Meter, including：Ligusticum wallichii 5-23 part, bighead atractylodes rhizome 7-19 part, Radix Angelicae Sinensis 5-15 part, dried orange peel 8-17 part, radix bupleuri 6-17 part, rattletop 3-23 part, peach Benevolence 5-25 part, eupolyphage sece steleophaga 5-15 part, excrementum pteropi 4-19 part, rhizoma cyperi 7-20 part.

A kind of bulk drug pharmacology of Chinese medicine preparation of dispeling cold for rheumatic low back pain of the present invention：

Ligusticum wallichii：Mild-natured, bitter, pungent.Return stomach, Liver Channel, gallbladder channel, wines used as antirheumatic, reducing the asthenic fever, relaxing muscles and tendons relieve the pain, be that treatment rheumatism is closed One of main ingredients of disease such as section pain.

The bighead atractylodes rhizome：Bitter, sweet, warm in nature, returns spleen, stomach, the bighead atractylodes rhizome has a strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive work( Effect.

Radix Angelicae Sinensis：Sweet, pungent, warm in nature, Return liver, the heart, the spleen channel, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, anti- The effect of always prevent old, immune.

Dried orange peel：Bitter, pungent, warm in nature, return lung, the spleen channel, have a regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.

Radix bupleuri：Taste is pungent, hardship, cold nature, Return liver, courage, lung channel, in having and inducing sweat, soothing the liver rise sun the effect of.

Rattletop：Cold nature, taste is pungent, micro-sweet.Return lung warp, the spleen channel, stomach, large intestine channel, have deliver promoting eruption, clearing heat and detoxicating, Rise the effect lifting yang-energy.

Peach kernel：Mild-natured, bitter, sweet.Thoughts of returning home warp, Liver Channel, large intestine channel, have functions that activating blood circulation and dissipating phlegm, relax bowel.

Eupolyphage sece steleophaga：Cold in nature, taste is salty, return liver warp, broken stasis of blood blood, continuous muscles and bones, with controlling injured bone, blood stasis closed, lump in the abdomen lump in the abdomen.

Excrementum pteropi：Warm in nature, taste is salty, sweet, return liver warp, and promoting blood circulation and stopping pain, removing blood stasis and hemostasis, disappear long-pending removing toxic substances, all with controlling trusted subordinate's vim and vigour Bitterly.

Rhizoma cyperi：Mild-natured, taste is pungent, slight bitter, micro-sweet, return liver warp, tri-jiao channel, promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.

For optimizing the effect of drugs of medicine, further, 15 parts of described Ligusticum wallichii, 18 parts of the bighead atractylodes rhizome, 15 parts of Radix Angelicae Sinensis, dried orange peel 14 Part, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, 10 parts of ground bettle, 15 parts of excrementum pteropi, 13 parts of rhizoma cyperi.

Further, in order to improve extraction effect of drugs, present invention additionally comprises：Official osmanthus 5-17 part.

Further, described Chinese medicine composition includes the raw material of following weight portion：

15 parts of Ligusticum wallichii, 18 parts of the bighead atractylodes rhizome, 15 parts of Radix Angelicae Sinensis, 14 parts of dried orange peel, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, eupolyphage sece steleophaga 10 Part, 15 parts of excrementum pteropi, 13 parts of rhizoma cyperi, 11 parts of official osmanthus.

Further, dam rhizome of chuanxiong selected by described Ligusticum wallichii.

The Chinese medicine composition of the present invention does not have bad reaction in use, and the treatment to Low Back Pain has obvious effect Really, the medicine material of selection does not have toxic and side effect from each other, and slight and severe Low Back Pain patient can use, usage range Extensively, the promoting flow of qi and blood circulation, scattered silt pain relieving, there is extraordinary curative effect to rheumatic low back pain.

Specific embodiment

With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this, Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacing Change and change, all should be included within the scope of the invention.

Embodiment 1：

A kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain described in the present embodiment, by weight, including：Ligusticum wallichii 5-23 part, Bighead atractylodes rhizome 7-19 part, Radix Angelicae Sinensis 5-15 part, dried orange peel 8-17 part, radix bupleuri 6-17 part, rattletop 3-23 part, peach kernel 5-25 part, eupolyphage sece steleophaga 5-15 Part, excrementum pteropi 4-19 part, rhizoma cyperi 7-20 part.

The preparation method of medicine of the present invention, comprises the following steps：

（1）By above-mentioned whole Chinese medicine material medicines, by weight, configure traditional Chinese medicinal material raw materials；

（2）The traditional Chinese medicinal material raw materials unification that configuration is finished carries out disinfection；

（3）The traditional Chinese medicinal material raw materials that sterilization is completed carry out HTHP extraction, prepared extract；

（4）Ethanol solution using 95% is to step（3）In be obtained extract eluted, and will obtain alcohol eluen mixing；

（5）Concentrate mixed ethanol eluate further, obtain the concentrate that proportion is 0.6 ~ 0.8, concentrate is sprayed Mist is dried to obtain extract dry powder；

（6）Freeze-drying, encapsulation, it is placed in the place of drying and preserves, obtain final product.

Wherein, described step（2）Middle disinfection way adopts high-temperature steam sterilization；Described step（4）Middle ethanol solution dense Spend for 95%；Described step（5）Using the concentrate bottle of ceramic material in middle concentration process；Described step（5）Middle drying mode adopts It is spray-dried.

Embodiment 2：

Low Back Pain Chinese medicine preparation promoting blood circulation and removing blood stasis described in the present embodiment, by weight, including：15 parts of Ligusticum wallichii, 18 parts of the bighead atractylodes rhizome, Radix Angelicae Sinensis 15 parts, 14 parts of dried orange peel, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, 10 parts of ground bettle, 15 parts of excrementum pteropi, 13 parts of rhizoma cyperi.

Embodiment 3：

The present embodiment, on the basis of above-described embodiment, further, also includes official osmanthus 5-17 part.It is this Chinese medicine preparation, by weight Amount part meter, including：11 parts of dam rhizome of chuanxiong, 18 parts of the bighead atractylodes rhizome, 15 parts of Radix Angelicae Sinensis, 14 parts of dried orange peel, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, soil 10 parts of worm, 15 parts of excrementum pteropi, 13 parts of rhizoma cyperi, 11 parts of official osmanthus.

The other parts of the present embodiment are same as the previously described embodiments, repeat no more.

Embodiment 4：

The present embodiment provides this Chinese medicine preparation toxicology test, specific as follows：

Acute toxicity test：

Experimental observation, because measuring LD50, therefore has carried out the mensure of maximum dosage-feeding.Chinese traditional medicine composition prepared by embodiment 1 Thing is dissolved in sterile saline, is configured to solution gavage mouse, and result shows, raw with medicine maximum administration concentration 9.65 Medicine/ml, maximum administered volume 50ml/kg was administered twice to mouse stomach in 24 hours, and mouse maximum dosage-feeding is 763.25g Crude drug/kg, bad reaction and death in animal, anatomic observation each internal organs no abnormality seen.

Long term toxicity test

SD rat 80 is applied in this test, and Chinese medicine composition prepared by embodiment 1 is dissolved in sterile saline, is configured to Solution gavage, if control group and 24g, 35g, 49g crude drug/kg dosage group, continuous gavage is administered 12 weeks, observes the Chinese medicine of the present invention The impact to animal indices for the composition.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to rat Body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect；Blood biochemical ten binomial Index determining result, 12 weeks low dose group BiLi values of administration are higher than control group（P<0.05)；Low dose group, middle dose group TP value are high In control group（P<0.05), but all within normal physiologic range, other indexs compare no significant difference with control group.Convalescence Each administration group indices measured value compares equal no significant difference with control group.Each group each internal organs gross examination of skeletal muscle no abnormality seen.

The using method of medicine of the present invention：Directly take orally.

Low Back Pain diagnostic criteria：

Slight Low Back Pain：It is unable to strenuous exercise at ordinary times, having heavy burden sense through long-time work rear waist, with throe, rest Have after a period of time and taken a turn for the better.

Moderate Low Back Pain：Stand up after sitting to have pain, can take a favorable turn after movable waist, but waist can muscle after suffering from cold Spasm, has fixing obvious tender point.

Severe Low Back Pain：Sitting or the rear waist muscle rigidity that crouches long, stand up to have pain it is impossible to normal activity is it is impossible to curved Waist and turning round, night cannot fall asleep, and the small of the back has neuropathic pain, waist muscle atrophy.

Recovery from illness standard：Waist no longer has pain, can perform physical exercises, overcast and rainy will not with Low Back Pain situation.

Effectively standard：Flank pain sense substantially mitigates, and can carry out appropriate sports, can freely rise after sitting Body.

Null criterion：Flank pain sense still exists, and sombre sky waist also can pain, sitting rear waist muscle is stiff Firmly, the effect of pain no mitigation.

It is directed to the clinical statisticses data of various Low Back Pain patients using medicine of the present invention：

Through the Clinical practice of 200 patients, wherein male patient 127, female patient 73, medication age object 20 ~ 60 years old.Wherein Minimum 21 years old, maximum 59 years old, average age 38 years old；Slight Low Back Pain 42, moderate Low Back Pain 72, severe Low Back Pain 36.

Model case：

1st, Zhao, female, 32 years old, slight Low Back Pain patient, due to moist south at residence, and it is accustomed to wearing thin, waist mansion mistake shield, The damp and hot heresy of chill is taken advantage of a weak point in opponent's defence and is invaded, obstruction of meridian, and QI-blood circulation does not freely occur pain in the back, often feels like waist in routine work life Portion's throe, and waist muscle is powerless, and sitting can produce serious sense of fatigue, sleep nor lie on the back, inconvenience of getting up.Using this After the prescription of inventive embodiments 2 takes 5 courses for the treatment of orally, can smoothly stand after sitting, not have sense of fatigue, waist muscle no longer goes out Existing throe and girdle sensation.

2nd, field, female, 26 years old, moderate Low Back Pain patient, because not looked after well in postpartum and being nursed, by wind, Wet, cold invasion and attack, lead to the long spur of vertebra to induce pain in the back, after keeping a posture for a long time, action can feel waist spinosity Pain, and waist can not be descended and turn round faster.Taken orally after 4 courses for the treatment of using the prescription of the embodiment of the present invention 3, in sitting or long After sleeping, the throe sense of action significantly mitigates, and somatosensory is lightly more a lot of than in the past, can turn round faster.

3 Wang, man, 24 years old, slight Low Back Pain patient, the school-days has received and has wounded in school's waist of playing soccer, and leads to waist Muscle damage, and custom blower fan and air-conditioning after moving, lead to waist run into sombre weather or rainy day will pain, and Waist chance is cool will pain.Prescription using the embodiment of the present invention 2 takes 3 courses for the treatment of orally, and Low Back Pain symptom significantly mitigates, overcast and rainy Also will not obvious pain, and being capable of freely activity.

Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not Multiple changes, modification, replacement and modification can be carried out to these embodiments under the principle of the disengaging present invention and objective, the present invention's Scope is limited by claim and its equivalent.

Claims (5)

1. a kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain is it is characterised in that by weight, including：Ligusticum wallichii 5-23 part, Bighead atractylodes rhizome 7-19 part, Radix Angelicae Sinensis 5-15 part, dried orange peel 8-17 part, radix bupleuri 6-17 part, rattletop 3-23 part, peach kernel 5-25 part, eupolyphage sece steleophaga 5-15 Part, excrementum pteropi 4-19 part, rhizoma cyperi 7-20 part.

2. a kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain according to claim 1 is it is characterised in that described Ligusticum wallichii 15 parts, 18 parts of the bighead atractylodes rhizome, 15 parts of Radix Angelicae Sinensis, 14 parts of dried orange peel, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, 10 parts of ground bettle, excrementum pteropi 15 parts, 13 parts of rhizoma cyperi.

3. according to claim 1 and 2 a kind of for rheumatic low back pain dispel cold Chinese medicine preparation it is characterised in that by weight Amount part meter, also includes：Official osmanthus 5-17 part.

4. a kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain according to claim 3 is it is characterised in that this Chinese medicine group Compound includes the raw material of following weight portion：

15 parts of Ligusticum wallichii, 18 parts of the bighead atractylodes rhizome, 15 parts of Radix Angelicae Sinensis, 14 parts of dried orange peel, 17 parts of radix bupleuri, 13 parts of rattletop, 10 parts of peach kernel, eupolyphage sece steleophaga 10 Part, 15 parts of excrementum pteropi, 13 parts of rhizoma cyperi, 11 parts of official osmanthus.

5. a kind of Chinese medicine preparation of dispeling cold for rheumatic low back pain according to claim 1 and 2 is it is characterised in that described Dam rhizome of chuanxiong selected by Ligusticum wallichii.