CN106389608A - Orally taken traditional Chinese medicine composition for effectively relieving flank pain - Google Patents
Orally taken traditional Chinese medicine composition for effectively relieving flank pain Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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Abstract
The invention discloses an orally taken traditional Chinese medicine composition for effectively relieving flank pain. The traditional Chinese medicine composition comprises 5 to 15 parts of glycyrrhiza uralensis, 5 to 20 parts of astragalus membranaceus, 5 to 10 parts of codonopsis pilosula, 3 to 18 parts of atractylodes macrocephala, 2 to 16 parts of angelica sinensis, 5 to 18 parts of pericarpium citri reticulatae, 4 to 16 parts of radix bupleuri, 20 parts of cyperu srotundus, cimicifugae foetidae and semenpersicae, wherein glycyrrhiza uralensis adopts radix glycyrrhizae. The traditional Chinese medicine composition does not produce adverse effect during use, has an obvious effect on treatment of flank pain, does not have toxic or side effects among the crude drugs, can be used for patients suffering from mild and severe flank pain, has a wide practical range, has the effects of promoting qi to activate blood, dissipating blood stasis and alleviating pain, and has a good curative effect for flank pain caused by sudden lumbar sprain, falling sprain and acute strain.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to a kind of effective oral traditional Chinese medicine composition alleviating flank pain.
Background technology
Lumbago, Chinese medical disease name.Refer to because of diseases caused by exogenous pathogenic factor, internal injury or frustrate sudden strain of a muscle and lead to waist QI-blood circulation not smooth, or lose foster in moistening,
Spinal column or the other tract pain of ridge is caused to be a kind of disease of cardinal symptom.Often with kidney asthenia as the principal aspect, being invaded by exogenous pathogen, tumbling down are frustrated for its morbidity
Dodge for mark.During treatment, excess syndrome focuses on eliminating evil and promotes blood circulation active, and deficiency syndrome focus on righting, and invigorating the liver and kidney, strong waist and knee, spleen invigorating gas are conventional controlling
Method.Lumbago with the passing of time, simulataneous insufficiency and excessive, treatment should grasp specimen deficiency and excess, from the method for eliminating evil and reinforcing.
Treatment pain in the lumbar region uses the Chinese crude drug effect of Chinese tradition more preferably, but the chemical analysis of Chinese medicine are sufficiently complex, existing contains
There are multiple active ingredients, have invalid element again, also comprise toxic substance, how to select raw material of Chinese medicine to be combined formula and become controlling
Treat the important step of pain in the lumbar region.
Content of the invention
It is an object of the invention to provide a kind of can significantly slow pain in the lumbar region symptom, relaxing muscles and tendons to promote blood circulation, improve body immunity
A kind of effective oral traditional Chinese medicine composition alleviating flank pain.
The present invention is achieved through the following technical solutions:A kind of effective oral traditional Chinese medicine composition alleviating flank pain, by weight
Amount part meter, including:Radix Glycyrrhizae 4-16 part, Radix Astragali 3-21 part, Radix Codonopsis 4-15 part, Rhizoma Atractylodis Macrocephalae 3-22 part, Radix Angelicae Sinensis 2-18 part, Pericarpium Citri Reticulatae 5-18
Part, Radix Bupleuri 4-16 part, Rhizoma Cimicifugae 3-23 part, Semen Persicae 5-25 part.
A kind of crude drug pharmacology of oral traditional Chinese medicine composition for alleviating flank pain of the present invention:
Radix Glycyrrhizae:Mild-natured, sweet in the mouth, thoughts of returning home warp, stomach, spleen channel, lung meridian, can be used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and spleen
Insufficiency of stomach-QI, fatigue and weakness etc..
The Radix Astragali:Sweet in the mouth, slightly warm in nature, return lung, spleen, liver and kidney channel, it has enhancing human body immunity function, liver protection, diuresis, anti-ageing
Always, anti-stress, blood pressure lowering and wide antibacterial action.
Radix Codonopsis:Mild-natured, sweet in the mouth, returns spleen, lung meridian, there is the effect of invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung, Radix Codonopsis also strengthens immunity
Power, expansion of blood vessels, blood pressure lowering, improve microcirculation, strengthen the effect such as hemopoietic function
The Rhizoma Atractylodis Macrocephalae:Bitter in the mouth, sweet, warm in nature, returns spleen, stomach, the Rhizoma Atractylodis Macrocephalae has an invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect.
Radix Angelicae Sinensis:Sweet in the mouth, pungent, warm in nature, Return liver, the heart, spleen channel, have a benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, anti-
The effect of always prevent old, immune.
Pericarpium Citri Reticulatae:Bitter in the mouth, pungent, warm in nature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.
Radix Bupleuri:Acrid in the mouth, hardship, cold nature, Return liver, gallbladder, lung meridian, there is reconciling superficies and interior, the effect of soothing the liver yang invigorating.
For optimizing the effect of drugs of medicine, further, 11 parts of described Radix Glycyrrhizae, 14 parts of the Radix Astragali, 12 parts of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae 15
Part, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae, 10 parts of Semen Persicae.
Further, in order to improve extraction effect of drugs, present invention additionally comprises:Rhizoma Cyperi 7-23 part.
Further, described Chinese medicine composition includes the raw material of following weight portion:
11 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, 12 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae,
10 parts of Semen Persicae, 20 parts of Rhizoma Cyperi.
Further, described Radix Glycyrrhizae selects Radix Glycyrrhizae.
The Chinese medicine composition of the present invention does not have untoward reaction in use, and the treatment to pain in the lumbar region has obvious effect
Really, the medicine material of selection does not have toxic and side effects from each other, and slight and severe pain in the lumbar region patient can use, usage range
Extensively, promoting flow of QI and blood, scattered silt pain relieving, sudden strain of a muscle being fallen sprain has extraordinary curative effect with pain in the lumbar regions such as acute strains.
Specific embodiment
With reference to embodiment, the present invention is described in further detail, but embodiments of the present invention not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacing
Change and change, all should be included within the scope of the invention.
Embodiment 1:
A kind of effective oral traditional Chinese medicine composition alleviating flank pain described in the present embodiment, by weight, including:Radix Glycyrrhizae 4-16
Part, Radix Astragali 3-21 part, Radix Codonopsis 4-15 part, Rhizoma Atractylodis Macrocephalae 3-22 part, Radix Angelicae Sinensis 2-18 part, Pericarpium Citri Reticulatae 5-18 part, Radix Bupleuri 4-16 part, Rhizoma Cimicifugae 3-23
Part, Semen Persicae 5-25 part.
The preparation method of medicine of the present invention, comprises the following steps:
(1)By above-mentioned whole raw material of Chinese medicine medicines, by weight, configure traditional Chinese medicinal material raw materials;
(2)The traditional Chinese medicinal material raw materials unification that configuration is finished carries out disinfection;
(3)The traditional Chinese medicinal material raw materials that sterilization is completed carry out High Temperature High Pressure extraction, prepared extract;
(4)Ethanol solution using 95% is to step(3)In be obtained extract carry out eluting, and will obtain alcohol eluen mixing;
(5)Concentrate mixed ethanol elution further, obtain the concentrated solution that proportion is 0.6 ~ 0.8, concentrated solution is sprayed
Mist is dried to obtain extract dry powder;
(6)Lyophilization, encapsulation, it is placed in the place of drying and preserves, obtain final product.
Wherein, described step(2)Middle disinfection way adopts high-temperature steam sterilization;Described step(4)Middle ethanol solution dense
Spend for 95%;Described step(5)Using the concentrate bottle of ceramic material in middle concentration process;Described step(5)Middle drying mode adopts
It is spray-dried.
Embodiment 2:
Alleviate the Chinese medicine composition of pain in the lumbar region described in the present embodiment, by weight, including:11 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, Radix Codonopsis 12
Part, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae, 10 parts of Semen Persicae.
Embodiment 3:
The present embodiment, on the basis of above-described embodiment, further, also includes 20 parts of Rhizoma Cyperi.It is the Chinese medicine group of this alleviation pain in the lumbar region
Compound, by weight, including:11 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, 12 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae,
15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae, 10 parts of Semen Persicae, 20 parts of Rhizoma Cyperi.
The other parts of the present embodiment are same as the previously described embodiments, repeat no more.
Embodiment 4:
The present embodiment provides the toxicology test of the Chinese medicine composition of this alleviation pain in the lumbar region, specific as follows:
Acute toxicity test:
Experimental observation, because measuring LD50, therefore has carried out the mensure of maximum dosage-feeding.Chinese medicine composition prepared by embodiment 1
Thing is dissolved in sterile saline, is configured to solution gavage mice, and result shows, raw with medicine maximum administration concentration 9.65
Medicine/ml, maximum administered volume 50ml/kg was administered twice to mouse stomach in 24 hours, and mice maximum dosage-feeding is 763.25g
Crude drug/kg, untoward reaction and death in animal, anatomic observation each internal organs no abnormality seen.
Long term toxicity test
SD rat 80 is applied in this test, and Chinese medicine composition prepared by embodiment 1 is dissolved in sterile saline, is configured to
Solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage group, continuous gavage is administered 12 weeks, observes the Chinese medicine of the present invention
The impact to animal indices for the compositionss.Result of the test shows, successive administration 12 weeks, and the Chinese medicine composition of the present invention is to rat
Body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect;Blood biochemical ten binomial
Index determining result, 12 weeks low dose group BiLi values of administration are higher than matched group(P<0.05);Low dose group, middle dose group TP value are high
In matched group(P<0.05), but all within normal physiologic range, other indexs compare no significant difference with matched group.Convalescent period
Each administration group indices measured value compares equal no significant difference with matched group.Each group each internal organs gross examination of skeletal muscle no abnormality seen.
The using method of medicine of the present invention:Directly take orally.
Pain in the lumbar region diagnostic criteria:
Slight pain in the lumbar region:It is unable to strenuous exercise at ordinary times, having heavy burden sense through long-time work back lumbar part, with paroxysmal pain, rest
Have after a period of time and taken a turn for the better.
Moderate pain in the lumbar region:Stand up after sitting to have pain, can take a favorable turn after movable waist, but waist can muscle after suffering from cold
Spasm, has fixing obvious pressure pain point.
Severe pain in the lumbar region:Sitting or lying on bed for a long time back lumbar part muscle rigidity, stand up to have pain it is impossible to normal activity is it is impossible to curved
Waist and turning round, night cannot fall asleep, and lower back has neuropathic pain, waist muscle atrophy.
Recovery from illness standard:Waist no longer has pain, can perform physical exercises, overcast and rainy will not with pain in the lumbar region situation.
Effectively standard:Flank pain sense substantially mitigates, and can carry out appropriate sports, can freely rise after sitting
Body.
Null criterion:Flank pain sense still exists, and sombre sky waist also can pain, sitting back lumbar part muscle is stiff
Firmly, the effect of pain no mitigation.
It is directed to the clinical statisticses data of various pain in the lumbar region patients using medicine of the present invention:
Through the Clinical practice of 200 patients, wherein male patient 127, female patient 73, medication age object 20 ~ 60 years old.Wherein
Minimum 21 years old, maximum 59 years old, 38 years old mean age;Slight pain in the lumbar region 42, moderate pain in the lumbar region 72, severe pain in the lumbar region 36.
Model case:
1st, Zhao, female, 32 years old, slight pain in the lumbar region patient, due to moist south at residence, and it is accustomed to wearing thin, waist mansion mistake shield,
The damp and hot heresy of wind and cold is taken advantage of a weak point in opponent's defence and is invaded, obstruction of meridian, and QI-blood circulation does not freely occur lumbago, often feels like waist in routine work life
Portion's paroxysmal pain, and waist muscle is powerless, and sitting can produce serious feeling of fatigue, sleep nor lie on the back, inconvenience of getting up.Using this
After the prescription of inventive embodiments 2 takes 5 courses for the treatment of orally, can smoothly stand after sitting, not have feeling of fatigue, waist muscle no longer goes out
Existing paroxysmal pain and constriction.
2nd, field, female, 26 years old, moderate pain in the lumbar region patient, because not looked after well in puerperal and being nursed, by wind,
Wet, cold invasion and attack, lead to the long bony spur of vertebra to induce lumbago, after keeping a posture for a long time, action can feel waist spinosity
Pain, and waist can not be descended and turn round faster.Taken orally after 4 courses for the treatment of using the prescription of the embodiment of the present invention 3, in sitting or long
After sleeping, the paroxysmal pain sense of action significantly mitigates, and somatosensory is lightly more a lot of than in the past, can turn round faster.
3rd, week certain, man, 52 years old, severe pain in the lumbar region patient, with advancing age, the false vertebra that causes because of degeneration
Post slips, lumbar spinal stenosises, oppresses spinal cord and nerve root, leads to lumbago and lower limb rediating pain, simultaneously also with persistence lumbago.
Take orally after 10 courses for the treatment of using the prescription of the embodiment of the present invention 3, the pain in activity for the waist has obvious mitigation, and holds
Continuous pain disappears, can be voluntarily movable, and waist no longer has heavy burden sense.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that:Not
Multiple changes, modification, replacement and modification can be carried out to these embodiments under the principle of the disengaging present invention and objective, the present invention's
Scope is limited by claim and its equivalent.
Claims (5)
1. a kind of effective oral traditional Chinese medicine composition alleviating flank pain is it is characterised in that by weight, including:Radix Glycyrrhizae 4-
16 parts, Radix Astragali 3-21 part, Radix Codonopsis 4-15 part, Rhizoma Atractylodis Macrocephalae 3-22 part, Radix Angelicae Sinensis 2-18 part, Pericarpium Citri Reticulatae 5-18 part, Radix Bupleuri 4-16 part, Rhizoma Cimicifugae 3-
23 parts, Semen Persicae 5-25 part.
2. a kind of effective oral traditional Chinese medicine composition alleviating flank pain according to claim 1 is it is characterised in that described
11 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, 12 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae, Semen Persicae
10 parts.
3. according to claim 1 and 2 a kind of effective alleviate flank pain oral traditional Chinese medicine composition it is characterised in that
By weight, also include:Rhizoma Cyperi 7-23 part.
4. a kind of effective oral traditional Chinese medicine composition alleviating flank pain according to claim 3 is it is characterised in that in this
Drug composition includes the raw material of following weight portion:
11 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, 12 parts of Radix Codonopsis, 15 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Angelicae Sinensis, 11 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Bupleuri, 20 parts of Rhizoma Cimicifugae,
10 parts of Semen Persicae, 20 parts of Rhizoma Cyperi.
5. according to claim 1 and 2 a kind of effective alleviate flank pain oral traditional Chinese medicine composition it is characterised in that
Described Radix Glycyrrhizae selects Radix Glycyrrhizae.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103893653A (en) * | 2014-04-01 | 2014-07-02 | 朱鹏 | Traditional Chinese medicine for treating lumbar interveterbral disc protrusion |
CN104069226A (en) * | 2014-07-12 | 2014-10-01 | 范巧兰 | Medicament for treating lumbar muscle scleredema with strain and preparation method thereof |
CN104147264A (en) * | 2014-07-14 | 2014-11-19 | 贾富平 | Pharmaceutical formula for treating lumbago and preparation method thereof |
-
2016
- 2016-11-07 CN CN201610974986.1A patent/CN106389608A/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103893653A (en) * | 2014-04-01 | 2014-07-02 | 朱鹏 | Traditional Chinese medicine for treating lumbar interveterbral disc protrusion |
CN104069226A (en) * | 2014-07-12 | 2014-10-01 | 范巧兰 | Medicament for treating lumbar muscle scleredema with strain and preparation method thereof |
CN104147264A (en) * | 2014-07-14 | 2014-11-19 | 贾富平 | Pharmaceutical formula for treating lumbago and preparation method thereof |
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