CN106420500A - Composition containing inonotus obliquus extract and application of composition - Google Patents
Composition containing inonotus obliquus extract and application of composition Download PDFInfo
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- CN106420500A CN106420500A CN201611080672.3A CN201611080672A CN106420500A CN 106420500 A CN106420500 A CN 106420500A CN 201611080672 A CN201611080672 A CN 201611080672A CN 106420500 A CN106420500 A CN 106420500A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a composition containing inonotus obliquus extract and application of composition, and aims to provide a composition which can form a layer of air breathable film on the surface of skin, effectively reducing the pollutant adhering, enhancing the natural barrier function of skin, effectively resisting irritation, allergy and other problems of outside pollutants to skin; the composition is mainly prepared from, by weight, 10-25 parts of inonotus obliquus extract, 8-20 parts of moringa pterygosperma seed extract, 5-15 parts of Bordeaux leaf extract, 3-10 parts of undaria pinnatifida extract. The composition belongs to the field of cosmetics.
Description
Technical field
The present invention relates to a kind of compositionss, specifically, are a kind of skin care compositionss containing Inonqqus obliquus extract, this
Bright further relate to said composition as the application of antipollution skin-protection product additive, belong to cosmetic field.
Background technology
As production and economic express delivery increase, the continuous deterioration of environment, air pollution constantly increases, the pollution of the mankind
Source is constantly increasing, such as the polluter of the physical property such as dust, haze, sandstorm, radiation, PM2.5；As second hand smoking, vehicle exhaust,
The polluter of the chemical such as industrial pollution, waste gas.It is easily caused following skin problem：1. cause skin allergy：In the air is a large amount of
The floating thing allergy of disperse, causes skin pore blocking and allergic symptom, makes one to feel prurituss, plays erythema welt, or even triggering
Urticaria and eczema.Additionally, the polluter of physical property causes, and the particle of in the air is excessive, printing opacity degree reduces, and makes arrival ground
Neighbouring ultraviolet is weakened.Near-earth in the air various virus is so swum in, and antibacterial and funguses become to be not easy by ultraviolet
Kill, poor for body constitution, there is skin allergy, for the people of skin injury, this quasi-microorganism is reached with the dust granules of air
To skin, and skin surface is adhered to, easily cause the infection of skin, such as folliculitises, tinea versicolor, herpes simplex etc., there is erythra
People can increase.2. cause the aging of skin：Pollutants in air, such as haze, vehicle exhaust etc. can make skin produce the pole of excess
Unstable free radical, these free radicals pass through to damage the DNA of cell membrane and human body own health, so as to accelerate organism aging process,
Including the aging of skin, such as dull-looking skin, pigmentation, skin easily relaxes, and microgroove or wrinkle occurs, xerosis cutiss, or even
Cause skin canceration.
Cosmetics on the market are by film forming component or to add ultraviolet attractant, physical property interleaving agent mostly at present,
The pollution of air-isolation and anti-ultraviolet injury is supported, effect is more single, it is impossible to comprehensively resist various polluter, antipollution
Effect not notable.
Content of the invention
For the problems referred to above, the first object of the present invention is to provide one kind to form one layer of breathable films in skin surface,
Effectively reduce the attachment of pollutant, strengthen the natural cover for defense function of skin, effectively resist the thorn that environmental contaminants are caused to skin
The compositionss of the problems such as sharp, allergy.
The second object of the present invention is the application for providing this compositionss as antipollution skin-protection product additive.
For this purpose, first technical scheme that the present invention is provided is such：
A kind of compositionss containing Inonqqus obliquus extract, mainly include following weight parts component：Inonqqus obliquus extract 10-
25 parts；Wing seed Moringa seed extract 8-20 part；Boldo tree leaf extract 5-15 part；Thallus Laminariae extract 3-10 part.
Further, above-mentioned a kind of compositionss containing Inonqqus obliquus extract, described compositionss also include the Flowers of Helichrysum bracteatum
Extract 5-10 part, English walnut seed extract 2-8 part.
Further, above-mentioned a kind of compositionss containing Inonqqus obliquus extract, described compositionss also include short clump tongue
Careless extract 1-5 part.
Further, above-mentioned a kind of compositionss containing Inonqqus obliquus extract, described compositionss are by following weight parts
Group be grouped into：Inonqqus obliquus extract 15-20 part；Wing seed Moringa seed extract 10-15 part；Boldo tree leaf extract 10-
13 parts；Thallus Laminariae extract 5-8 part；Helichrysum flower extract 8-10 part；English walnut seed extract 5-8 part；Short clump sedge extract 2-4
Part.
Further, above-mentioned a kind of compositionss containing Inonqqus obliquus extract, under the Inonqqus obliquus extract passes through
State step to be obtained successively：
1) pretreatment：Inonotus obliquus sporophore is placed in 40-50 DEG C of oven for drying to constant weight, is crushed, 100 mesh sieves are crossed, is obtained
To Inonqqus obliquus powder；
2) defat：Inonqqus obliquus powder is placed in supercritical extraction equipment, with CO2For extractant, it is 30-50 DEG C in temperature,
Under conditions of pressure is 20-40Mpa, 1-2h is extracted, obtains Inonqqus obliquus granulated slag；
3) extract：By the Inonqqus obliquus granulated slag distilled water immersion 2-5h of 30-60 times (W/V), in temperature 30-50 DEG C, surpass
Under conditions of acoustical power 300-600W, after extracting 20-30min, filter, repeat above-mentioned distilled water immersion and supersound extraction operation,
Filter, merge the filtrate that extracts twice, obtain extracting solution；
4) digest：It is 5-6 that extracting solution is adjusted pH, controls temperature 20-30 DEG C, adds equivalent to wet mycelium weight 1-
3% papain, digests 1-2h, obtains enzymolysis solution；
5) concentrate：Enzymolysis solution is carried out separating in 5000r/min, isolated supernatant is evaporated to original volume
1/2, obtain concentrated solution；
6) precipitate with ethanol：The concentration of concentrated solution weight 3-5 times amount is added while stirring for the dehydrated alcohol of 70-90%, at 1-3 DEG C
Under conditions of stand 10h, in 10000r/min be centrifuged 10-20min, collect precipitate；
7) dry：By precipitate under conditions of vacuum 0.09MPa, temperature 40-50 DEG C, dry and contain to dried object moisture
Amount 3-8%, that is, obtain Inonqqus obliquus extract.
Last technical scheme that the present invention is provided is this to be contained compositionss of Inonqqus obliquus extract as antipollution
The application of skin-protection product additive.
Compared with prior art, the technical scheme that the present invention is provided has the advantages that：
1st, the Inonqqus obliquus extract that the present invention is provided, using supercritical extraction, supersound extraction and three kinds of sides of enzymatic isolation method
Method combined extracting is obtained, and its main component is polysaccharide, can to form one layer of sugared film in skin surface, and moisturizing water lock, while pass through
Anti-bacterial attachment mechanism, suppression undesired bacteria or pathogen are sticked on skin；Additionally, the polyphenol for containing in the extract is also
The ability that human body removes multiple reactive oxygen free radicals, the antioxidation energy of enhancing body can be lifted together with polysaccharide constituents
Power.
2nd, wing seed Moringa seed extract, the cationic protein (6000-13000 dalton) rich in vitamin, low-molecular-weight
And the mineral such as calcium, ferrum, potassium, meanwhile, the active component containing fabulous flocculating properties in moringa seeds, its water extract substantially can reduce
Bacterial content in mixed water turbidity, hardness and mixed water；It has lotus-effect, reduces pollutant attachment skin surface, protection
Cell, the murder by poisoning to preventing from heavy metal, skin is played a protective role.
3rd, boldo tree leaf extract, can activate a kind of synthesis of skin beta-alexin (Endogenous antimicrobial polypeptide), strengthen flesh
The natural antibacterial system of skin, minimizing bacteria breed, purification skin, suppression inflammatory factor, erythema of dispelling, careful pore, improve oiliness
Skin.
4th, Thallus Laminariae extract is by increasing the natural protection ability of skin resisting rugged environment so that skin from
Free radical and the injury of environmental stimuli, such as waste gas, smoke from cigarette and heavy metal etc., contribute to reducing skin damage, safeguard skin
Health.
5th, Helichrysum flower extract, makes skin have well-hydrated effect, the negative effect that counter pressure brings, effective protection
The active component of skin；The side effect that " hydrocortisone " brings can be reduced, the elastic force hydration factor (GAGs) is provided comprehensive
Protection；By reducing the activity of hyaluronidase, increase quantity of the skin to the protective enzyme of free radical resisting, reverse skin aging state
Gesture, provides protection antioxidant defense, provides the protection completely of free radical resisting protective enzyme；Adjust cutaneous nerve system, hence it is evident that
Releive and peaceful skin.
6th, English walnut seed extract, raw material is the Semen Juglandiss for abounding with from French Grenoble, containing phytic acid and polyphenol；The activity
Composition is protected from oxidative pressure and its side effect for causing (cell ageing and inflammation that UV light causes) by making skin
Cellular anti-oxidant source, prevents photochemical aging.While horn cell synthesis propagation and fibroblast albumen resynthesis can be activated,
Play a part of to prevent naturally-aged.
7th, short clump sedge extract energy effective protection skin resists the harmful factors such as environmental pollution, pressure, can promote flesh
Skin oneself generates collagen protein.
In each component above-mentioned, Inonqqus obliquus extract, the collaboration of boldo tree leaf extract are with the natural screen of reinforcement skin
Barrier function, and the counteirritantia effect of antiinflammatory；Wing seed Moringa seed extract, Thallus Laminariae extract and the collaboration of short clump sedge extract
Isolation dust-proof effect is provided, strengthens skin natural protection ability；Inonqqus obliquus extract, Helichrysum flower extract and Semen Juglandiss seed are extracted
The stimulation that environmental contaminants are caused effectively is resisted in thing collaboration to skin.In sum, the present invention passes through Inonqqus obliquus extract, the wing
Seed Moringa seed extract, boldo tree leaf extract, Thallus Laminariae extract, Helichrysum flower extract, English walnut seed extract, short clump tongue
Synergism between the multiple natural active products of careless extract, can form one layer of breathable films in skin surface, effectively reduce dirty
The attachment of dye thing, strengthens the natural cover for defense function of skin, effectively resists stimulation, allergy that environmental contaminants are caused to skin etc. and asks
Topic.
Specific embodiment
With reference to specific embodiment, the claim of the present invention is described in further detail, but do not constitute right
Any restriction of the present invention, the modification of anyone limited number of time for being made in the claims in the present invention protection domain etc, still exist
Within the claims of the present invention.
It should be noted that the raw material employed in the technical scheme of present invention offer, outside non-specified otherwise, all by often
Rule means are prepared or are bought by commercial channel.Wherein：
Wing seed Moringa seed extract is purchased from BASF China；Boldo tree leaf extract is purchased from Guangzhou celestial being
Graceful trade Co., Ltd；Thallus Laminariae extract is purchased from one ball bio tech ltd of Guangzhou；Helichrysum flower extract is purchased from Guangzhou
Nuo Ran bio tech ltd；English walnut seed extract is purchased from Ao Cui trade (Shanghai) Co., Ltd.；Short clump sedge extract purchase
From hundred Hao Bo company limited of Guangzhou.
The Inonqqus obliquus extract is obtained successively by following step：
1) pretreatment：Inonotus obliquus sporophore is placed in 40-50 DEG C of (preferably 45 DEG C) oven for drying to constant weight, is crushed, mistake
100 mesh sieves, obtain Inonqqus obliquus powder；
2) defat：Inonqqus obliquus powder is placed in supercritical extraction equipment, with CO2For extractant, it is 30-50 DEG C in temperature
(preferably 40 DEG C), under conditions of pressure is 20-40Mpa (preferably 30MPa), extracts 1-2h (preferably 2h), obtain Inonqqus obliquus powder
Slag；
3) extract：By Inonqqus obliquus granulated slag with the distilled water immersion 2-5h of 30-60 times (preferably 50 times) (W/V) (preferably
3h), under conditions of temperature 30-50 DEG C (preferably 40 DEG C), ultrasonic power 300-600W (preferably 500W), 20-30min is extracted
After (preferably 25min), filter, repeat above-mentioned distilled water immersion and supersound extraction operation, filter, merge the filtrate that extracts twice,
Obtain extracting solution；
4) digest：It is 5-6 (preferably pH is 6) that extracting solution is adjusted pH, and control temperature 20-30 DEG C (preferably 25 DEG C) is added
Equivalent to the papain of wet mycelium weight 1-3% (preferably 2%), 1-2h (preferably 1.5h) is digested, obtains enzymolysis solution；
5) concentrate：Enzymolysis solution is carried out separating in 5000r/min, isolated supernatant is evaporated to original volume
1/2, obtain concentrated solution；
6) precipitate with ethanol：The concentration of concentrated solution weight 3-5 times amount (preferably 4 times) is added while stirring for 70-90% (preferably
80%) dehydrated alcohol, stands 10h under conditions of 1-3 DEG C (preferably 2 DEG C), in 10000r/min centrifugation 10-20min (preferably
15min), precipitate is collected；
7) dry：By precipitate under conditions of vacuum 0.09MPa, temperature 40-50 DEG C (preferably 45 DEG C), dry to dry
Dry thing moisture 3-8% (preferably 5%), that is, obtain Inonqqus obliquus extract.
Embodiment 1
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 10g；Wing seed Moringa seed extract 20g；Boldo tree leaf extract 5g；Thallus Laminariae extract 10g.
Embodiment 2
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 25g；Wing seed Moringa seed extract 8g；Boldo tree leaf extract 15g；Thallus Laminariae extract 3g.
Embodiment 3
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 20g；Wing seed Moringa seed extract 15g；Boldo tree leaf extract 10g；Thallus Laminariae extract 5g.
Embodiment 4
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 15g；Wing seed Moringa seed extract 10g；Boldo tree leaf extract 8g；Thallus Laminariae extract 8g；The Flowers of Helichrysum bracteatum is carried
Take thing 5g, English walnut seed extract 8g.
Embodiment 5
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 18g；Wing seed Moringa seed extract 12g；Boldo tree leaf extract 9g；Thallus Laminariae extract 6g；The Flowers of Helichrysum bracteatum is carried
Take thing 10g, English walnut seed extract 2g.
Embodiment 6
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 11g；Wing seed Moringa seed extract 9g；Boldo tree leaf extract 6g；Thallus Laminariae extract 7g；Short clump sedge carries
Take thing 1g.
Embodiment 7
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 22g；Wing seed Moringa seed extract 11g；Boldo tree leaf extract 7g；Thallus Laminariae extract 6g；Short clump sedge
Extract 5g.
Embodiment 8
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 15g；Wing seed Moringa seed extract 15g；Boldo tree leaf extract 13g；Thallus Laminariae extract 5g；The Flowers of Helichrysum bracteatum is carried
Take thing 10g；English walnut seed extract 8g；Short clump sedge extract 2g.
Embodiment 9
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 20g；Wing seed Moringa seed extract 10g；Boldo tree leaf extract 10g；Thallus Laminariae extract 8g；The Flowers of Helichrysum bracteatum is carried
Take thing 8g；English walnut seed extract 5g；Short clump sedge extract 4g.
Embodiment 10
A kind of compositionss containing Inonqqus obliquus extract that the present invention is provided, are grouped into by the group of following mass numbers：Pyropolyporus fomentarius (L.ex Fr.) Teng
Linteus extract 18g；Wing seed Moringa seed extract 13g；Boldo tree leaf extract 12g；Thallus Laminariae extract 7g；The Flowers of Helichrysum bracteatum is carried
Take thing 9g；English walnut seed extract 7g；Short clump sedge extract 3g.
The preparation method of the compositionss containing Inonqqus obliquus extract that the present invention is provided, according to any in embodiment 1 to 10
One group of mass number weighs each component, mix homogeneously.
In order to better illustrate beneficial effects of the present invention, one kind that present invention offer is given below is extracted containing Inonqqus obliquus
The checking test of the compositionss of thing：
First, zest test
In order to verify the zest of the present invention, test sample prepared by embodiment of the present invention 1-10 is sent to third party's detection
Detection skin irritation, to each test sample all with the continuous skin irritation test of 6 Embryo Gallus domesticus, and the going out of the Embryo Gallus domesticus of test group
Blood, blood coagulation and the blood vessel time of melting are above 300 minutes.
As a result show, test sample prepared by above-described embodiment is calculated to stimulate scoring to be zero, and this is described
Test sample prepared by bright embodiment 1-10 is nonirritant product.
2nd, efficacy test
(1) with regard to the comparative example of efficacy test
Comparative example 1
Wherein Inonqqus obliquus extract is the product that buys, and remaining is same as Example 8.
Comparative example 2
Only contain 13 parts of wing seed Moringa seed extract；7 parts of Thallus Laminariae extract；3 parts of short clump sedge extract.
Comparative example 3
The a certain commercially available emulsion with antipollution effect that buys.
Comparative example 4
Only contain emulsion matrix.
(2) with regard to the preparation of test sample
First, by embodiment 2,4,6,8, the compositionss of comparative example 1-2, it is added separately in emulsion matrix, makes emulsion.
Wherein：The mass ratio 4 of compositionss and emulsion matrix:96.
The emulsion matrix is emulsion matrix commonly used in the art, based on emulsion matrix gross mass 100g, each component
And its weight percent such as table 1：
Table 1
The preparation method of the emulsion matrix is as follows：
1) A phase is heated with stirring to 80 DEG C or so, standby；
2) first the deionized water in B phase is heated to 80-90 DEG C, is subsequently adding B phase clout, stirring and dissolving homogenizing is to no
Granule, adds the good A phase of pretreatment, after homogenizing 3-5min, insulated and stirred froth breaking, and 45 DEG C or so are cooled to, C phase are added, is stirred
Mix uniformly, be cooled to 35 DEG C and obtain final product emulsion matrix.
(3) adsorbing powder dust test
1st, method of testing：
35 road association duty personnel are selected, is divided into 7 groups, per 5 people are organized, with handwashing liquid, both hands is cleaned up, smeared with napkin
Dry.Each group of people person all smears the emulsion matrix 0.2g of comparative example 4 on about 2 square centimeters of area in left forearm, before the right side
Arm smears the emulsion of the compositionss for adding the preparation of 5% embodiment 2,4,6,8, comparative example 1-2 on about 2 square centimeters of area
0.2g or commercially available emulsion 0.2g with antipollution effect of comparative example 3.Allow their 4 hours 3M on duty on road side
Under dust on forearm is glued by adhesive tape, weigh, average.Result of the test is shown in Table 2.
2 adsorbing powder dust result of the test of table
Above-mentioned test data shows, smear the emulsion for adding embodiment of the present invention compositionss in right forearm after, right forearm powder
Dust quantity reduction reaches more than 55%, hence it is evident that higher than emulsion matrix and the commercially available breast with antipollution effect of comparative example 3 of comparative example 4
The Dust Capacity slip of liquid, illustrates that the compositionss of the present invention can significantly reduce absorption of the dust on skin.
After emulsion using comparative example 1, Dust Capacity slip is significantly lower than the emulsion for preparing using 8 compositionss of embodiment,
The Inonqqus obliquus extract for preparing in this compositions is described, can be with other compositions synergism, hence it is evident that reduce dust in skin
On absorption.
After emulsion using comparative example 2, Dust Capacity slip is significantly lower than the emulsion for preparing using 8 compositionss of embodiment,
Illustrate that individually several extracts in the present composition being added to the effect in emulsion is substantially not so good as the present composition
Seven kinds of compositions are all added to the effect in emulsion, and as the present invention extracts the increase of species, reduce dust in skin
On the effect of absorption also gradually strengthen, it follows that there is synergism between the extract that provides of the present invention.
(4) barrier function test
Normal skin has very strong barrier function, and extraneous harmful substance can be prevented to enter skin.When barrier function damage,
Path just to be formed between horn cell, and moisture is scattered and disappeared from path.Therefore, the moisture percutaneous loss when skin barrier less effective
Increase, otherwise reduce.Protective layer of skin is better, and water content is higher, and the numerical value that skin moisture is lost in TEWL is lower.This survey
Percutaneous moisture loss (TEWL) on probation evaluates the power of skin barrier function, so as to evaluate the antipollution work(of the present composition
Effect.
Test method：Select face skin that 70 female subjects of hydropenia are more dry, age 20-45 year, be divided into 7
Group, per 10 people are organized, detects first three day, and face determines the 1st day not using the facial TEWL value before product not using any cosmetics
(during detection, popped one's head in the TEWL of CK MPA580, detect by inspection skin, test 5 times, read meansigma methodss on computers).Receive per group
Examination person will take equivalent emulsion respectively and be applied on skin of face, and wherein left face smears the emulsion matrix 0.2g of comparative example 4, and right face is smeared
Emulsion 0.2g of compositionss prepared by embodiment 2,4,6,8, comparative example 1-2 or comparative example 3 commercially available with antipollution effect
Emulsion 0.2g, sooner or later once, continuous use 28 days, disable within the 29th, 30 days product, the 31st day measurement TEWL.The results are shown in Table 3.
3 barrier function test result of table
Above-mentioned test data shows, after the emulsion using interpolation embodiment of the present invention compositionss, its skin moisture is lost in
TEWL value illustrates the group of the present invention less than emulsion matrix and the commercially available emulsion with antipollution effect of comparative example 3 of comparative example 4
Compound has the effect for strengthening skin barrier function.
After emulsion using comparative example 1, TEWL value is relatively higher than the emulsion for preparing using 8 compositionss of embodiment, and this is described
The Inonqqus obliquus extract for preparing in compositionss, can effectively supplement skin moisture, reduce moisture loss, preferably increase skin
Barrier function.
After emulsion using comparative example 2, TEWL value is relatively higher than the emulsion for preparing using 8 compositionss of embodiment, instruction sheet
Solely the effect that several extracts in the present composition are added in emulsion is substantially not so good as the present composition seven kinds to become
Divide the effect being all added in emulsion, and as the present invention extracts the increase of species, strengthen skin barrier function, reduce
The lost effect of moisture of skin also gradually strengthens, it follows that there is synergism between the extract of present invention offer.
(5) stimulus object toleration is tested
Skin is stimulated by xenobiotic pollutants, often can cause redness, prurituss, rise erythema welt situations such as, in the course of time
Cutaneous autoimmune function can be reduced sensitivity skin is formed, seriously skin health be damaged, so repairing impaired and strengthening skin
Immunity is to resist the most basic mode of external source pollution, tests antipollution effect of compositionss by skin irritation efficacy assessment.
Experimental technique：Using 3%SLS solution and 5% fruit acid as stimulus, stimulate left and right forearm flexor skin respectively
Until red and swollen, the emulsion of the compositionss containing 5% embodiment of the present invention 2 is then smeared in left front arm region, is applied in right forearm region
The emulsion of the compositionss containing 5% embodiment of the present invention 8 is smeared, test observation red swelling of the skin regression degree after 2 days.
Test result：3%SLS stimulates left front arm region 1, and skin is substantially red and swollen, smears containing 2 groups of 5% embodiment of the present invention
The emulsion of compound is after 2 days, and the redness of left front arm region 1 substantially disappears；After 5% fruit acid stimulates right forearm region 2, skin is bright
Aobvious redness, after the emulsion that smears containing 5% embodiment of the present invention, 8 compositionss 2 days, the swollen also obvious regression in right forearm region 2.Say
The compositionss of the bright present invention have the anti-redness effect of obvious irritation.
In sum, the present invention passes through Inonqqus obliquus extract, wing seed Moringa seed extract, boldo tree by the present invention
Leaf extract, Thallus Laminariae extract, Helichrysum flower extract, English walnut seed extract, short seven kinds of natural active products of clump sedge extract
Between synergism, one layer of breathable films can be formed in skin surface, effectively reduce the attachment of pollutant, strengthen the day of skin
Right barrier function, the problems such as effectively resist stimulation, the allergy that environmental contaminants are caused to skin, reaches resistant to pollution effect.
Claims (6)
1. a kind of compositionss containing Inonqqus obliquus extract, it is characterised in that mainly include following weight parts component：Inonqqus obliquus
Extract 10-25 part；Wing seed Moringa seed extract 8-20 part；Boldo tree leaf extract 5-15 part；Thallus Laminariae extract 3-10
Part.
2. a kind of compositionss containing Inonqqus obliquus extract according to claim 1, it is characterised in that described compositionss
Also include Helichrysum flower extract 5-10 part, English walnut seed extract 2-8 part.
3. a kind of compositionss containing Inonqqus obliquus extract according to claim 1, it is characterised in that described compositionss
Also include short clump sedge extract 1-5 part.
4. a kind of compositionss containing Inonqqus obliquus extract according to claim 1, it is characterised in that described compositionss
It is made up of following components in parts by weight：Inonqqus obliquus extract 15-20 part；Wing seed Moringa seed extract 10-15 part；Boldo tree
Leaf extract 10-13 part；Thallus Laminariae extract 5-8 part；Helichrysum flower extract 8-10 part；English walnut seed extract 5-8 part；Short clump tongue
Careless extract 2-4 part.
5. a kind of compositionss containing Inonqqus obliquus extract according to claim 1, it is characterised in that the Inonqqus obliquus
Extract is obtained successively by following step：
1) pretreatment：Inonotus obliquus sporophore is placed in 40-50 DEG C of oven for drying to constant weight, is crushed, 100 mesh sieves are crossed, obtains birch
Brown pore fungi powder；
2) defat：Inonqqus obliquus powder is placed in supercritical extraction equipment, with CO2For extractant, it is 30-50 DEG C in temperature, pressure is
Under conditions of 20-40Mpa, 1-2h is extracted, obtains Inonqqus obliquus granulated slag；
3) extract：By Inonqqus obliquus granulated slag with 30-60 times of distilled water immersion 2-5h, in temperature 30-50 DEG C, ultrasonic power 300-
Under conditions of 600W, after extracting 20-30min, filter, repeat above-mentioned distilled water immersion and supersound extraction operation, filter, merge two
The filtrate of secondary extraction, obtains extracting solution；
4) digest：It is 5-6 that extracting solution is adjusted pH, controls temperature 20-30 DEG C, adds equivalent to wet mycelium weight 1-3%
Papain, digests 1-2h, obtains enzymolysis solution；
5) concentrate：Enzymolysis solution is carried out separating in 5000r/min, isolated supernatant is evaporated to the 1/ of original volume
2, obtain concentrated solution；
6) precipitate with ethanol：The concentration of concentrated solution weight 3-5 times amount is added while stirring for the dehydrated alcohol of 70-90%, in 1-3 DEG C of bar
10h being stood under part, is centrifuged 10-20min in 10000r/min, collects precipitate；
7) dry：By precipitate under conditions of vacuum 0.09MPa, temperature 40-50 DEG C, dry to dried object moisture 3-
8%, that is, obtain Inonqqus obliquus extract.
6. a kind of compositionss containing Inonqqus obliquus extract described in claim 1 as antipollution skin-protection product additive should
With.
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| CN107095842A (en) * | 2017-05-04 | 2017-08-29 | 广州诺胜化妆品有限公司 | A kind of moringa seeds elite antipollution facial mask and preparation technology |
| IT201700115753A1 (en) * | 2017-10-13 | 2019-04-13 | Cristalfarma S R L | Supplement to alleviate the problems caused by aging in women |
| CN109875931A (en) * | 2019-03-19 | 2019-06-14 | 广东芭薇生物科技股份有限公司 | It is a kind of to have effects that the cosmetic additive agent of antipollution and its cosmetics |
| WO2020084259A1 (en) * | 2018-10-26 | 2020-04-30 | Basf Beauty Care Solutions France Sas | Novel cosmetic and dermatological uses of an extract from the fungus inonotus obliquus |
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| IT201700115753A1 (en) * | 2017-10-13 | 2019-04-13 | Cristalfarma S R L | Supplement to alleviate the problems caused by aging in women |
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| FR3087658A1 (en) * | 2018-10-26 | 2020-05-01 | Basf Beauty Care Solutions France Sas | NEW COSMETIC AND DERMATOLOGICAL USES OF A MUSHROOM EXTRACT INONOTUS OBLIQUUS |
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| CN112409503A (en) * | 2020-11-09 | 2021-02-26 | 广东省微生物研究所（广东省微生物分析检测中心） | Inonotus obliquus anti-allergic polysaccharide extract and preparation method and application thereof |
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