CN106414448B - 可用作s100-抑制剂的新型化合物 - Google Patents

可用作s100-抑制剂的新型化合物 Download PDF

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Publication number
CN106414448B
CN106414448B CN201580026356.5A CN201580026356A CN106414448B CN 106414448 B CN106414448 B CN 106414448B CN 201580026356 A CN201580026356 A CN 201580026356A CN 106414448 B CN106414448 B CN 106414448B
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CN
China
Prior art keywords
oxo
tetraen
trifluoromethyl
dodeca
triazatricyclo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201580026356.5A
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English (en)
Chinese (zh)
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CN106414448A (zh
Inventor
U.维尔马
D.利贝里
M.埃克布拉德
M.拜因布里奇
S.伊斯特
J.哈格拉夫
N.普雷沃斯特
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Active Biotech AB
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Active Biotech AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
CN201580026356.5A 2014-05-23 2015-05-22 可用作s100-抑制剂的新型化合物 Expired - Fee Related CN106414448B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14169757.3 2014-05-23
EP14169757 2014-05-23
PCT/EP2015/061468 WO2015177367A1 (en) 2014-05-23 2015-05-22 Novel compounds useful as s100-inhibitors

Publications (2)

Publication Number Publication Date
CN106414448A CN106414448A (zh) 2017-02-15
CN106414448B true CN106414448B (zh) 2019-04-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580026356.5A Expired - Fee Related CN106414448B (zh) 2014-05-23 2015-05-22 可用作s100-抑制剂的新型化合物

Country Status (12)

Country Link
US (1) US9771372B2 (enExample)
EP (1) EP2991990B1 (enExample)
JP (1) JP6580074B2 (enExample)
KR (1) KR20170005868A (enExample)
CN (1) CN106414448B (enExample)
AU (1) AU2015261775B2 (enExample)
BR (1) BR112016024749A2 (enExample)
CA (1) CA2948436A1 (enExample)
EA (1) EA030604B1 (enExample)
ES (1) ES2620751T3 (enExample)
MX (1) MX2016014483A (enExample)
WO (1) WO2015177367A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019208290A1 (ja) 2018-04-27 2019-10-31 国立大学法人 岡山大学 抗ｓ１００ａ８／ａ９抗体とその用途
US11197908B2 (en) 2018-07-17 2021-12-14 The Board Of Trustees Of The University Of Arkansas Peptoids and methods for attenuating inflammatory response
JP7675440B2 (ja) 2019-10-30 2025-05-13 国立大学法人 岡山大学 炎症性肺疾患の予防及び／又は治療剤
WO2023209141A1 (en) 2022-04-29 2023-11-02 Westfälische Wilhelms-Universität Münster Benzo[d]imidazo[1,2-a]imidazoles and their use in diagnosis
WO2025132458A1 (en) 2023-12-18 2025-06-26 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors

Citations (3)

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EP1986009A1 (en) * 2007-04-26 2008-10-29 Active Biotech AB Screening method
CN101597262A (zh) * 2002-03-05 2009-12-09 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
CN101981031A (zh) * 2008-01-22 2011-02-23 武田药品工业株式会社 具有促肾上腺皮质激素释放因子拮抗活性的三环化合物和含有它们的药物组合物

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US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
JP2004504397A (ja) 2000-07-26 2004-02-12 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー 抗菌活性を有するアミノピペリジンキノリン類およびそれらのアザイソステリックアナログ類
WO2002069965A1 (en) 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
GB0117506D0 (en) 2001-07-18 2001-09-12 Bayer Ag Imidazopyridinones
SE0104331D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Novel compounds
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
WO2008042282A2 (en) 2006-09-28 2008-04-10 Exelixis, Inc. Imidazole-4, 5-dicarboxamide derivatives as jak-2 modulators
US7919498B2 (en) 2007-03-23 2011-04-05 Amgen Inc. Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors
BRPI0812521A2 (pt) 2007-06-13 2015-06-23 Glaxosmithkline Llc Composto, composição farmacêutica, método para o tratamento de doença em um mamífero, processo para a preparação de um composto, e, uso de um composto
TW201004941A (en) 2008-07-16 2010-02-01 Wyeth Corp Alpha7 nicotinic acetylcholine receptor inhibitors
EA201171098A1 (ru) 2009-03-02 2012-04-30 Сертрис Фармасьютикалз, Инк. 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина
US8722676B2 (en) 2011-11-03 2014-05-13 Genentech, Inc. Bicyclic piperazine compounds
GB201321728D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101597262A (zh) * 2002-03-05 2009-12-09 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
EP1986009A1 (en) * 2007-04-26 2008-10-29 Active Biotech AB Screening method
CN101981031A (zh) * 2008-01-22 2011-02-23 武田药品工业株式会社 具有促肾上腺皮质激素释放因子拮抗活性的三环化合物和含有它们的药物组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthese von Pyrimido[1,2-a]benzimidazolen durch Umsetzung von 2-aminobenzimidazol mit Acetylendicarbonsaure-dimethylester und ihre Uberfuhrung in Imidazo[l,2-a]benzimidazole;Franz Troxler et al.;《HELVETICA CHIMICA ACTA》;19740801;第57卷(第8期);第2356-2364页 *

Also Published As

Publication number Publication date
EA201692405A1 (ru) 2017-06-30
US20170204098A1 (en) 2017-07-20
MX2016014483A (es) 2017-01-23
AU2015261775B2 (en) 2019-07-11
WO2015177367A1 (en) 2015-11-26
EP2991990A1 (en) 2016-03-09
JP6580074B2 (ja) 2019-09-25
US9771372B2 (en) 2017-09-26
CA2948436A1 (en) 2015-11-26
ES2620751T3 (es) 2017-06-29
JP2017516772A (ja) 2017-06-22
KR20170005868A (ko) 2017-01-16
CN106414448A (zh) 2017-02-15
HK1221463A1 (en) 2017-06-02
EP2991990B1 (en) 2017-02-01
BR112016024749A2 (pt) 2017-08-15
AU2015261775A1 (en) 2016-12-08
EA030604B1 (ru) 2018-08-31

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