EA030604B1 - Соединения, применимые в качестве ингибиторов s100 - Google Patents

Соединения, применимые в качестве ингибиторов s100 Download PDF

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Publication number
EA030604B1
EA030604B1 EA201692405A EA201692405A EA030604B1 EA 030604 B1 EA030604 B1 EA 030604B1 EA 201692405 A EA201692405 A EA 201692405A EA 201692405 A EA201692405 A EA 201692405A EA 030604 B1 EA030604 B1 EA 030604B1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxo
trifluoromethyl
dodeca
triazatricyclo
tetraen
Prior art date
Application number
EA201692405A
Other languages
English (en)
Russian (ru)
Other versions
EA201692405A1 (ru
Inventor
Ульф Веллмар
Давид Либерг
Мария Экблад
Мэри Бейнбридж
Стивен Ист
Джонатан Харгрейв
Наташа Превост
Original Assignee
Эктив Байотек Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эктив Байотек Аб filed Critical Эктив Байотек Аб
Publication of EA201692405A1 publication Critical patent/EA201692405A1/ru
Publication of EA030604B1 publication Critical patent/EA030604B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
EA201692405A 2014-05-23 2015-05-22 Соединения, применимые в качестве ингибиторов s100 EA030604B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14169757 2014-05-23
PCT/EP2015/061468 WO2015177367A1 (en) 2014-05-23 2015-05-22 Novel compounds useful as s100-inhibitors

Publications (2)

Publication Number Publication Date
EA201692405A1 EA201692405A1 (ru) 2017-06-30
EA030604B1 true EA030604B1 (ru) 2018-08-31

Family

ID=50774707

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692405A EA030604B1 (ru) 2014-05-23 2015-05-22 Соединения, применимые в качестве ингибиторов s100

Country Status (12)

Country Link
US (1) US9771372B2 (enExample)
EP (1) EP2991990B1 (enExample)
JP (1) JP6580074B2 (enExample)
KR (1) KR20170005868A (enExample)
CN (1) CN106414448B (enExample)
AU (1) AU2015261775B2 (enExample)
BR (1) BR112016024749A2 (enExample)
CA (1) CA2948436A1 (enExample)
EA (1) EA030604B1 (enExample)
ES (1) ES2620751T3 (enExample)
MX (1) MX2016014483A (enExample)
WO (1) WO2015177367A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019208290A1 (ja) 2018-04-27 2019-10-31 国立大学法人 岡山大学 抗s100a8/a9抗体とその用途
US11197908B2 (en) 2018-07-17 2021-12-14 The Board Of Trustees Of The University Of Arkansas Peptoids and methods for attenuating inflammatory response
EP4052725A4 (en) 2019-10-30 2024-07-17 National University Corporation Okayama University PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY LUNG DISEASE
WO2023209141A1 (en) 2022-04-29 2023-11-02 Westfälische Wilhelms-Universität Münster Benzo[d]imidazo[1,2-a]imidazoles and their use in diagnosis
WO2025132458A1 (en) 2023-12-18 2025-06-26 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2002069965A1 (en) * 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
US20090186879A1 (en) * 2008-01-22 2009-07-23 Takeda Pharmaceutical Company Limited Tricyclic compounds and use thereof

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US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
DE60125373T2 (de) 2000-07-26 2007-10-18 Smithkline Beecham P.L.C., Brentford Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
GB0117506D0 (en) 2001-07-18 2001-09-12 Bayer Ag Imidazopyridinones
SE0104331D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Novel compounds
CN101597262A (zh) * 2002-03-05 2009-12-09 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
US20060111416A1 (en) 2004-11-24 2006-05-25 Lane Charlotte A L Octahydropyrrolo[3,4-C]pyrrole derivatives
CA2663856A1 (en) 2006-09-28 2008-04-10 Exelixis, Inc. Jak-2 modulators and methods of use
AU2008231384B2 (en) 2007-03-23 2011-09-15 Amgen Inc. Heterocyclic compounds and their use
EP1986009A1 (en) * 2007-04-26 2008-10-29 Active Biotech AB Screening method
BRPI0812521A2 (pt) 2007-06-13 2015-06-23 Glaxosmithkline Llc Composto, composição farmacêutica, método para o tratamento de doença em um mamífero, processo para a preparação de um composto, e, uso de um composto
TW201004941A (en) 2008-07-16 2010-02-01 Wyeth Corp Alpha7 nicotinic acetylcholine receptor inhibitors
MX2011009213A (es) 2009-03-02 2011-12-14 Sirtris Pharmaceuticals Inc Quinolinas 8-sustituidas y analogos relacionados como moduladores de sirtuina.
BR112014010391A2 (pt) 2011-11-03 2017-04-18 Hoffmann La Roche composto, composição farmacêutica, processo de produção de uma composição farmacêutica, método de tratamento, kit e uso de uma composição farmacêutica
GB201321728D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069965A1 (en) * 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
US20090186879A1 (en) * 2008-01-22 2009-07-23 Takeda Pharmaceutical Company Limited Tricyclic compounds and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DESCOURS DENIS; FESTAL DIDIER: "Reactions of N-(.omega.-Chloroalkanoyl)-carbonimidic Dichlorides: A New Synthesis of 2-Oxo-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles, 2-Oxo-2, 3-dihydro-1H-imidazo[1,2-a]benzimidazoles, and 2-Oxo-2,3,5,10-tetrahydro-1H-imidazo[1,2-b][2,4]benzodiazepines", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 1983, no. 12, 1 December 1983 (1983-12-01), STUTTGART, DE., pages 1033 - 1036, XP002727411, ISSN: 0039-7881, DOI: 10.1055/s-1983-30617 *
IVANO MESSINA , IGOR POPA , VÍTĚZSLAV MAIER , AND MIROSLAV SOURAL: "Solid-Phase Synthesis of 5-Noranagrelide Derivatives", ACS COMBINATORIAL SCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 1, 1 January 2014 (2014-01-01), US, pages 33 - 38, XP002727412, ISSN: 2156-8952, DOI: 10.1021/co40013151 *
TROXLER FRANZ., WEBER HANS PETER: "Synthese von Pyrimido[1,2-a]benzimidazolen durch Umsetzung von 2-Aminobenzimidazol mit Acetylendicarbonsäure-dimethylester und ihre Überführung in Imidazol[1,2-a]benzimidazole.", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., CH, vol. 57, no. 8, 1 August 1974 (1974-08-01), CH, pages 2356 - 2364, XP002727410, ISSN: 0018-019X, DOI: 10.1002/hlca.19740570807 *

Also Published As

Publication number Publication date
MX2016014483A (es) 2017-01-23
ES2620751T3 (es) 2017-06-29
BR112016024749A2 (pt) 2017-08-15
AU2015261775A1 (en) 2016-12-08
HK1221463A1 (en) 2017-06-02
EA201692405A1 (ru) 2017-06-30
AU2015261775B2 (en) 2019-07-11
WO2015177367A1 (en) 2015-11-26
EP2991990B1 (en) 2017-02-01
US9771372B2 (en) 2017-09-26
JP2017516772A (ja) 2017-06-22
JP6580074B2 (ja) 2019-09-25
CA2948436A1 (en) 2015-11-26
CN106414448A (zh) 2017-02-15
US20170204098A1 (en) 2017-07-20
KR20170005868A (ko) 2017-01-16
CN106414448B (zh) 2019-04-19
EP2991990A1 (en) 2016-03-09

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM