CN106413751A - 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 - Google Patents

用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Download PDF

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Publication number
CN106413751A
CN106413751A CN201580027437.7A CN201580027437A CN106413751A CN 106413751 A CN106413751 A CN 106413751A CN 201580027437 A CN201580027437 A CN 201580027437A CN 106413751 A CN106413751 A CN 106413751A
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cancer
ser
antibody
ccr4
leu
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CN201580027437.7A
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Chinese (zh)
Inventor
林家扬
陈士浩
李丽芬
S·坡特鲁里
D·希利
M·马歇尔
泽田尚树
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Kyowa Kirin Co Ltd
Pfizer Corp SRL
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Kyowa Hakko Kirin Co Ltd
Pfizer Corp SRL
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CN201580027437.7A 2014-05-21 2015-05-15 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Pending CN106413751A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001534P 2014-05-21 2014-05-21
US62/001,534 2014-05-21
PCT/US2015/031081 WO2015179236A1 (en) 2014-05-21 2015-05-15 Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

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CN106413751A true CN106413751A (zh) 2017-02-15

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US (1) US10023649B2 (enExample)
EP (1) EP3145956A1 (enExample)
JP (1) JP2017517506A (enExample)
KR (1) KR20170004006A (enExample)
CN (1) CN106413751A (enExample)
AU (1) AU2015264528A1 (enExample)
BR (1) BR112016026993A2 (enExample)
CA (1) CA2949214A1 (enExample)
IL (1) IL248540A0 (enExample)
MX (1) MX2016015181A (enExample)
RU (1) RU2016146993A (enExample)
WO (1) WO2015179236A1 (enExample)

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WO2019141268A1 (zh) * 2018-01-22 2019-07-25 江苏恒瑞医药股份有限公司 抗4-1bb抗体、其抗原结合片段及其医药用途
WO2019196868A1 (en) * 2018-04-10 2019-10-17 Wuxi Biologics (Shanghai) Co., Ltd. A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof
CN111278858A (zh) * 2017-07-11 2020-06-12 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
US11365260B2 (en) 2017-10-12 2022-06-21 Reyoung (Suzhou) Biology Science & Technology Co., Ltd Agonistic 4-1BB monoclonal antibody
CN115003691A (zh) * 2020-01-13 2022-09-02 西托戴恩股份有限公司 用于治疗ccr5阳性转移癌的ccr5结合剂

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KR101503341B1 (ko) 2014-03-12 2015-03-18 국립암센터 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법
EP3408294A1 (en) * 2016-01-25 2018-12-05 Pfizer Inc. Combination of an ox40 agonist and a 4-1bb agonist monoclonal antibody for treating cancer
BR112018076260A2 (pt) 2016-06-20 2019-03-26 Kymab Limited anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
IL300095A (en) * 2016-11-23 2023-03-01 Translational Drug Dev Llc Benzamide and tumor necrosis factor receptor superfamily agonist compositions and uses thereof
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EP3431105B1 (en) 2017-03-29 2020-01-01 Shionogi&Co., Ltd. Medicinal composition for treating cancer
JP7657023B2 (ja) 2017-06-09 2025-04-04 プロビデンス ヘルス アンド サービシーズ－オレゴン がんの処置のための腫瘍反応性ヒトｔ細胞の同定のためのｃｄ３９およびｃｄ１０３の使用
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
WO2019090272A1 (en) 2017-11-06 2019-05-09 Flx Bio, Inc. Chemokine receptor modulators for treatment of epstein barr virus positive cancer
US11851497B2 (en) 2017-11-20 2023-12-26 Compass Therapeutics Llc CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
WO2019109238A1 (en) * 2017-12-05 2019-06-13 Lyvgen Biopharma Co., Ltd. Anti-cd137 antibodies and uses thereof
MX2020009468A (es) * 2018-03-13 2020-10-22 Hoffmann La Roche Terapias de combinacion de agonistas de 4-1bb con anticuerpos anti-cd20.
KR20210035805A (ko) 2018-06-15 2021-04-01 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가
AU2019312200B2 (en) 2018-07-23 2024-11-14 Heidelberg Pharma Research Gmbh Use of anti-CD137 antibody drug conjugate (ADC) in allogeneic cell therapy
WO2020216947A1 (en) 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
JP7682102B2 (ja) 2019-05-10 2025-05-23 リビジェン バイオファーマ ホールディングス リミテッド ヒト化抗ｃｄ１３７抗体およびその使用
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
CN115135344A (zh) * 2020-02-04 2022-09-30 健玛保 在疗法中使用的抗体
BR112022014623A2 (pt) * 2020-02-14 2022-09-13 Jounce Therapeutics Inc Anticorpos e proteínas de fusão que se ligam a ccr8 e usos dos mesmos
US20230355804A1 (en) 2020-06-29 2023-11-09 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
EP4228627A4 (en) * 2020-10-13 2024-11-06 Board of Regents, The University of Texas System COMBINATORIAL IMMUNOTHERAPEUTIC METHODS AND COMPOSITIONS FOR THE TREATMENT OF PANCREATIC DUCT ADENOCARCINOMA
CA3214085A1 (en) 2021-03-31 2022-10-06 Darby Rye Schmidt Thanotransmission polypeptides and their use in treating cancer
CA3218590A1 (en) 2021-06-07 2022-12-15 Providence Health & Services - Oregon Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
KR20240026507A (ko) 2021-06-29 2024-02-28 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
IL309856A (en) 2021-07-14 2024-02-01 Genentech Inc Antibodies anti-C-C motif receptor 8 (CCR8) and methods of use
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
WO2024151687A1 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent

Citations (4)

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CA2949214A1 (en) 2015-11-26
AU2015264528A1 (en) 2016-11-03
BR112016026993A2 (pt) 2017-10-31
US20170088627A1 (en) 2017-03-30
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