CN106413751A - 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 - Google Patents

用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Download PDF

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Publication number
CN106413751A
CN106413751A CN201580027437.7A CN201580027437A CN106413751A CN 106413751 A CN106413751 A CN 106413751A CN 201580027437 A CN201580027437 A CN 201580027437A CN 106413751 A CN106413751 A CN 106413751A
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cancer
ser
antibody
ccr4
leu
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CN201580027437.7A
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Chinese (zh)
Inventor
林家扬
陈士浩
李丽芬
S·坡特鲁里
D·希利
M·马歇尔
泽田尚树
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Kyowa Kirin Co Ltd
Pfizer Corp SRL
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Kyowa Hakko Kirin Co Ltd
Pfizer Corp SRL
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CN201580027437.7A 2014-05-21 2015-05-15 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Pending CN106413751A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001534P 2014-05-21 2014-05-21
US62/001,534 2014-05-21
PCT/US2015/031081 WO2015179236A1 (en) 2014-05-21 2015-05-15 Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

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CN106413751A true CN106413751A (zh) 2017-02-15

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US (1) US10023649B2 (enExample)
EP (1) EP3145956A1 (enExample)
JP (1) JP2017517506A (enExample)
KR (1) KR20170004006A (enExample)
CN (1) CN106413751A (enExample)
AU (1) AU2015264528A1 (enExample)
BR (1) BR112016026993A2 (enExample)
CA (1) CA2949214A1 (enExample)
IL (1) IL248540A0 (enExample)
MX (1) MX2016015181A (enExample)
RU (1) RU2016146993A (enExample)
WO (1) WO2015179236A1 (enExample)

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WO2019072274A1 (zh) * 2017-10-12 2019-04-18 瑞阳(苏州)生物科技有限公司 一种激动型4-1bb单克隆抗体
WO2019141268A1 (zh) * 2018-01-22 2019-07-25 江苏恒瑞医药股份有限公司 抗4-1bb抗体、其抗原结合片段及其医药用途
WO2019196868A1 (en) * 2018-04-10 2019-10-17 Wuxi Biologics (Shanghai) Co., Ltd. A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof
CN111278858A (zh) * 2017-07-11 2020-06-12 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
US11365260B2 (en) 2017-10-12 2022-06-21 Reyoung (Suzhou) Biology Science & Technology Co., Ltd Agonistic 4-1BB monoclonal antibody
CN115003691A (zh) * 2020-01-13 2022-09-02 西托戴恩股份有限公司 用于治疗ccr5阳性转移癌的ccr5结合剂

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KR101503341B1 (ko) 2014-03-12 2015-03-18 국립암센터 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법
JP6783312B2 (ja) * 2016-01-25 2020-11-11 ファイザー・インク がんを処置するためのｏｘ４０アゴニストおよび４−１ｂｂアゴニストモノクローナル抗体の組み合わせ
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
CN110234319B (zh) * 2016-11-23 2022-09-27 转化药物开发有限责任公司 苯甲酰胺和活性化合物的组合物及其使用方法
WO2018127787A1 (en) 2017-01-06 2018-07-12 Eutilex Co., Ltd. Anti-human 4-1 bb antibodies and use thereof
PL3431105T3 (pl) * 2017-03-29 2020-11-02 Shionogi & Co., Ltd. Kompozycja lecznicza do leczenia raka
CA3061959A1 (en) 2017-06-09 2018-12-13 Providence Health & Services - Oregon Utilization of cd39 and cd103 for identification of human tumor reactive t cells for treatment of cancer
WO2019025545A1 (en) 2017-08-04 2019-02-07 Genmab A/S BINDING AGENTS BINDING TO PD-L1 AND CD137 AND THEIR USE
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
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WO2019100052A2 (en) 2017-11-20 2019-05-23 Compass Therapeutics Llc Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
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IL277174B2 (en) * 2018-03-13 2025-12-01 Hoffmann La Roche Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies
KR20210035805A (ko) 2018-06-15 2021-04-01 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가
JP7598312B2 (ja) 2018-07-23 2024-12-11 ハイデルベルク ファーマ リサーチ ゲーエムベーハー 同種異系の細胞療法における抗－ｃｄ１３７抗体薬物コンジュゲート（ａｄｃ）の使用
SG11202110287QA (en) 2019-04-24 2021-10-28 Heidelberg Pharma Res Gmbh Amatoxin antibody-drug conjugates and uses thereof
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
AU2020276500A1 (en) 2019-05-10 2021-12-16 Lyvgen Biopharma Holdings Limited Humanized anti-CD137 antibodies and uses thereof
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
WO2021156326A1 (en) * 2020-02-04 2021-08-12 Genmab A/S Antibodies for use in therapy
IL295023A (en) * 2020-02-14 2022-09-01 Jounce Therapeutics Inc Antibodies and fusion proteins that bind to ccr8 and their uses
US20230355804A1 (en) 2020-06-29 2023-11-09 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
US20230406949A1 (en) * 2020-10-13 2023-12-21 Board Of Regents, The University Of Texas System Combinatorial immunotherapeutic methods and compositions for pancreatic ductal adenocarcinoma treatment
CA3214085A1 (en) 2021-03-31 2022-10-06 Darby Rye Schmidt Thanotransmission polypeptides and their use in treating cancer
BR112023022097A2 (pt) 2021-06-07 2023-12-19 Agonox Inc Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso
EP4363059A1 (en) 2021-06-29 2024-05-08 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
CA3224853A1 (en) 2021-07-14 2023-01-19 Gautham GAMPA Anti-c-c motif chemokine receptor 8 (ccr8) antibodies and methods of use
EP4598946A1 (en) 2022-10-05 2025-08-13 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
WO2024151687A1 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent

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US10023649B2 (en) 2018-07-17
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