JP2017517506A - 癌を処置するための抗ccr4抗体および4−1bbアゴニストの併用 - Google Patents
癌を処置するための抗ccr4抗体および4−1bbアゴニストの併用 Download PDFInfo
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- JP2017517506A JP2017517506A JP2016568497A JP2016568497A JP2017517506A JP 2017517506 A JP2017517506 A JP 2017517506A JP 2016568497 A JP2016568497 A JP 2016568497A JP 2016568497 A JP2016568497 A JP 2016568497A JP 2017517506 A JP2017517506 A JP 2017517506A
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462001534P | 2014-05-21 | 2014-05-21 | |
| US62/001,534 | 2014-05-21 | ||
| PCT/US2015/031081 WO2015179236A1 (en) | 2014-05-21 | 2015-05-15 | Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517506A true JP2017517506A (ja) | 2017-06-29 |
| JP2017517506A5 JP2017517506A5 (enExample) | 2018-07-12 |
Family
ID=53284562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568497A Pending JP2017517506A (ja) | 2014-05-21 | 2015-05-15 | 癌を処置するための抗ccr4抗体および4−1bbアゴニストの併用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10023649B2 (enExample) |
| EP (1) | EP3145956A1 (enExample) |
| JP (1) | JP2017517506A (enExample) |
| KR (1) | KR20170004006A (enExample) |
| CN (1) | CN106413751A (enExample) |
| AU (1) | AU2015264528A1 (enExample) |
| BR (1) | BR112016026993A2 (enExample) |
| CA (1) | CA2949214A1 (enExample) |
| IL (1) | IL248540A0 (enExample) |
| MX (1) | MX2016015181A (enExample) |
| RU (1) | RU2016146993A (enExample) |
| WO (1) | WO2015179236A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017507931A (ja) * | 2014-02-05 | 2017-03-23 | シーダーズ−サイナイ メディカル センター | がん及び感染症の治療方法並びに治療用組成物 |
| KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| JP6783312B2 (ja) * | 2016-01-25 | 2020-11-11 | ファイザー・インク | がんを処置するためのox40アゴニストおよび4−1bbアゴニストモノクローナル抗体の組み合わせ |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| CN110234319B (zh) * | 2016-11-23 | 2022-09-27 | 转化药物开发有限责任公司 | 苯甲酰胺和活性化合物的组合物及其使用方法 |
| WO2018127787A1 (en) | 2017-01-06 | 2018-07-12 | Eutilex Co., Ltd. | Anti-human 4-1 bb antibodies and use thereof |
| PL3431105T3 (pl) * | 2017-03-29 | 2020-11-02 | Shionogi & Co., Ltd. | Kompozycja lecznicza do leczenia raka |
| CA3061959A1 (en) | 2017-06-09 | 2018-12-13 | Providence Health & Services - Oregon | Utilization of cd39 and cd103 for identification of human tumor reactive t cells for treatment of cancer |
| BR112020000719A2 (pt) | 2017-07-11 | 2020-07-14 | Compass Therapeutics Llc | anticorpos agonistas que ligam o cd137 humano e seus usos |
| WO2019025545A1 (en) | 2017-08-04 | 2019-02-07 | Genmab A/S | BINDING AGENTS BINDING TO PD-L1 AND CD137 AND THEIR USE |
| CN109651507B (zh) | 2017-10-12 | 2021-11-26 | 瑞阳(苏州)生物科技有限公司 | 一种激动型4-1bb单克隆抗体 |
| WO2019072274A1 (zh) * | 2017-10-12 | 2019-04-18 | 瑞阳(苏州)生物科技有限公司 | 一种激动型4-1bb单克隆抗体 |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| IL274444B2 (en) | 2017-11-06 | 2024-06-01 | Rapt Therapeutics Inc | Chemokine receptor modulators for the treatment of Epstein-Barr virus-positive cancer |
| WO2019100052A2 (en) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| WO2019109238A1 (en) * | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
| KR20200113228A (ko) * | 2018-01-22 | 2020-10-06 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항-4-1bb 항체, 이의 항원-결합 단편 및 이의 의학적 용도 |
| IL277174B2 (en) * | 2018-03-13 | 2025-12-01 | Hoffmann La Roche | Therapeutic combination of 4-1 bb agonists with anti-cd20 antibodies |
| EP3773720A4 (en) * | 2018-04-10 | 2022-01-05 | Wuxi Biologics (Shanghai) Co. Ltd. | MONOCLONAL ANTIBODIES AGAINST HUMAN 4-1BB, METHOD OF MANUFACTURING AND USING THEREOF |
| KR20210035805A (ko) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가 |
| JP7598312B2 (ja) | 2018-07-23 | 2024-12-11 | ハイデルベルク ファーマ リサーチ ゲーエムベーハー | 同種異系の細胞療法における抗-cd137抗体薬物コンジュゲート(adc)の使用 |
| SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| AU2020276500A1 (en) | 2019-05-10 | 2021-12-16 | Lyvgen Biopharma Holdings Limited | Humanized anti-CD137 antibodies and uses thereof |
| EP4076434A1 (en) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| CN115003691A (zh) * | 2020-01-13 | 2022-09-02 | 西托戴恩股份有限公司 | 用于治疗ccr5阳性转移癌的ccr5结合剂 |
| WO2021156326A1 (en) * | 2020-02-04 | 2021-08-12 | Genmab A/S | Antibodies for use in therapy |
| IL295023A (en) * | 2020-02-14 | 2022-09-01 | Jounce Therapeutics Inc | Antibodies and fusion proteins that bind to ccr8 and their uses |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| US20230406949A1 (en) * | 2020-10-13 | 2023-12-21 | Board Of Regents, The University Of Texas System | Combinatorial immunotherapeutic methods and compositions for pancreatic ductal adenocarcinoma treatment |
| CA3214085A1 (en) | 2021-03-31 | 2022-10-06 | Darby Rye Schmidt | Thanotransmission polypeptides and their use in treating cancer |
| BR112023022097A2 (pt) | 2021-06-07 | 2023-12-19 | Agonox Inc | Cxcr5, pd-1 e icos expressando células t cd4 reativas de tumor e seu uso |
| EP4363059A1 (en) | 2021-06-29 | 2024-05-08 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| CA3224853A1 (en) | 2021-07-14 | 2023-01-19 | Gautham GAMPA | Anti-c-c motif chemokine receptor 8 (ccr8) antibodies and methods of use |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| CA2352572C (en) | 1998-12-01 | 2010-04-20 | Abbvie Biotherapeutics Inc. | Humanized antibodies to gamma-interferon |
| CN1296960A (zh) * | 1999-11-22 | 2001-05-30 | 上海博容基因开发有限公司 | 一种新的多肽——人ccr4相关蛋白31和编码这种多肽的多核苷酸 |
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- 2015-05-15 MX MX2016015181A patent/MX2016015181A/es unknown
- 2015-05-15 KR KR1020167035347A patent/KR20170004006A/ko not_active Withdrawn
- 2015-05-15 JP JP2016568497A patent/JP2017517506A/ja active Pending
- 2015-05-15 RU RU2016146993A patent/RU2016146993A/ru not_active Application Discontinuation
- 2015-05-15 BR BR112016026993A patent/BR112016026993A2/pt not_active Application Discontinuation
- 2015-05-15 CA CA2949214A patent/CA2949214A1/en not_active Abandoned
- 2015-05-15 US US15/312,515 patent/US10023649B2/en not_active Expired - Fee Related
- 2015-05-15 CN CN201580027437.7A patent/CN106413751A/zh active Pending
- 2015-05-15 EP EP15727159.4A patent/EP3145956A1/en not_active Withdrawn
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2016
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| BLOOD, vol. 117, no. 8, JPN6019006379, 2011, pages 2423 - 2432, ISSN: 0004144381 * |
| CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 61, no. 10, JPN6019006376, 2012, pages 1721 - 1733, ISSN: 0004144379 * |
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| Publication number | Publication date |
|---|---|
| AU2015264528A1 (en) | 2016-11-03 |
| BR112016026993A2 (pt) | 2017-10-31 |
| CN106413751A (zh) | 2017-02-15 |
| WO2015179236A1 (en) | 2015-11-26 |
| IL248540A0 (en) | 2016-12-29 |
| RU2016146993A (ru) | 2018-06-21 |
| CA2949214A1 (en) | 2015-11-26 |
| US10023649B2 (en) | 2018-07-17 |
| MX2016015181A (es) | 2017-05-25 |
| EP3145956A1 (en) | 2017-03-29 |
| KR20170004006A (ko) | 2017-01-10 |
| US20170088627A1 (en) | 2017-03-30 |
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