CN106359470A - Compound traditional Chinese medicine disinfectant and preparation method and application thereof - Google Patents
Compound traditional Chinese medicine disinfectant and preparation method and application thereof Download PDFInfo
- Publication number
- CN106359470A CN106359470A CN201610768226.5A CN201610768226A CN106359470A CN 106359470 A CN106359470 A CN 106359470A CN 201610768226 A CN201610768226 A CN 201610768226A CN 106359470 A CN106359470 A CN 106359470A
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- CN
- China
- Prior art keywords
- chinese medicine
- disinfectant
- extracting solution
- herbal mixture
- purified water
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a compound traditional Chinese medicine disinfectant. The compound traditional Chinese medicine disinfectant is prepared from the following substances in percentages by weight: 5% to 20% of chlorhexidine, 1% to 10% of an organic solvent, 5% to 20% of traditional Chinese medicine and the balance of purified water. The invention also provides a preparation method and application of the compound traditional Chinese medicine disinfectant, and the compound traditional Chinese medicine disinfectant is mainly used for aquacultural environment and breeding appliance sterilization.
Description
Technical field
The invention belongs to disinfectant field, particularly to a kind of herbal mixture disinfectant and its production and use.
Background technology
Chlorhexidine is a kind of biguanide chlorobenzene, has quite wide antimicrobial acivity, its single preparations of ephedrine be 20% ethanol or
Aqueous isopropanol, is mainly used in hand disinfection, the immersion of operating theater instruments and sterilization, skin degerming, rinses wound etc.；But it is current
Related product generally has following effect defect: composition is single, sterilizing ability is not strong, and product contains a large amount of organic solvents, peace
Full property is poor, to spore and virus no killing action, the strengthening of inorganic body autoimmunity and repair function.
Content of the invention
The purpose of the present invention is to propose to a kind of herbal mixture disinfectant and its production and use, from have sterilization and
The Chinese crude drug of bacteriostasis, and it is compounded with chlorhexidine, all there is certain bactericidal action to spore, funguses and virus；Used
Chinese medicine is the aqueous solution of its extract, is not required to add organic solvent, safe；Add Chinese medicine ingredients to be inhaled by body
Receive, participate in physiological metabolism, can play adjust organism physiology function, improve its opposing pathogenic bacteria ability effect.
Based on above-mentioned purpose, realize technical scheme as follows: a kind of herbal mixture disinfectant, it is by following weight
Each material composition of percentage ratio: chlorhexidine 5～20%, organic solvent 1～10%, Chinese medicine 5～20%, balance of purified water.
Preferably, a kind of described herbal mixture disinfectant is by each material composition of following weight percentage ratio: chlorhexidine 10%,
Organic solvent 8%, Chinese medicine 10%, balance of purified water.
Preferably, described chlorhexidine be acetate, hydrochlorate, citrate, at least one in gluconate.
Preferably, described organic solvent be ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol, in n-butyl alcohol at least
A kind of.
Preferably, described Chinese medicine be Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis, Folium Isatidiss, Fructus Gardeniae, Herba Houttuyniae, Radix Gentianae, in Radix Glycyrrhizae extremely
Few two kinds.
Present invention also offers a kind of preparation method of above-mentioned herbal mixture disinfectant, it includes following operating procedure:
Step 1: add 40～44.5 parts of purified water first in Chinese medicine extracting tank, then add 1-10 part in extraction pot
Chinese medicinal raw powder, stirring, mix homogeneously, tank mouth is extracted in then sealing, and is heated to 50～60 DEG C, soaks 6～8h, then will extract
Thing temperature is down to room temperature, releases extracting solution；
Step 2: and then add 40～44.5 parts of purified water, stirring, mix homogeneously in Chinese medicine extracting tank again, then seal
Extract tank mouth, and be heated to 50～60 DEG C, soak 6～8h again, then extract temperature is down to room temperature, release extracting solution；
Step 3: Chinese medicine slag is taken out, after centrifuge dehydration, collects centrifugal liquid, and centrifugal liquid is closed with extracting solution twice
And, prepared extracting solution a；
Step 4: extracting solution a is added in clean extraction pot, and adds 1～3 part of ethanol in extraction pot, stirring is mixed
Even, static more than 24h, takes supernatant, filters, prepared extracting solution b；
Step 5: add 55～89 parts of purified water and 0.1～0.5 part of propylene glycol, mix homogeneously in reactor；
Step 6: and then 0.5～2 part of chlorhexidine salt is added to reactor, stirring makes it all dissolve；
Step 7: finally 0.5～2 part of extracting solution b is added to reactor, mix homogeneously, filters, prepared product.
Present invention is mainly used for aquatic products field breeding environment and cultivation disinfecting utensils.
The invention has the benefit that
(1) present invention passes through solution addition solubilizing agent, active ingredient of Chinese herbs in chlorhexidine, thus reducing low in product
The dosage of carbon alcohol, improves the bactericidal property of product；
(2) Chinese medicine used by is the aqueous solution of its extract, is not required to add organic solvent, safe；
(3) extraction of active ingredient of Chinese herbs, mainly by the way of water extraction, alcohol are washed, low cost, the easily operated, response rate
High；
(4) production equipment is simple, with short production cycle, energy consumption is little.
Brief description
Fig. 1 is the Chinese medicine extract preparation flow figure of the present invention；
Fig. 2 is the finished product preparation flow figure of the present invention.
Specific embodiment
Embodiment 1 herbal mixture disinfectant products stability test of the present invention
EXPERIMENTAL DESIGN adopts high temperature and two kinds of low temperature；High temperature: at 40 DEG C, continue 30 days；Low temperature: at -10 DEG C and 3～5
DEG C, store 3 days, recover to room temperature, observe whether product characteristics change.
Hot test:
| Detection project | 0d | 10d | 20d | 30d |
| Character | Rufous transparency liquid | Rufous transparency liquid | Rufous transparency liquid | Rufous transparency liquid |
Low-temperature test:
| Storage temperature | 0d | Freezing 3d, after thawing |
| -10℃ | Rufous transparency liquid | Rufous transparency liquid |
| 3～5 DEG C | Rufous transparency liquid | Rufous transparency liquid |
Embodiment 2 herbal mixture disinfectant products toxicity test of the present invention
Experiment equipment: some of various fishes, shrimp (of different sizes, have or not squama)；Stainless steel cask four (more than volume 100l)；
Small-sized oxygen increasing equipment (1 set).
Experimental procedure:
(1) preparation experiment sample solution: precision weigh by optimum proportioning preparation disinfectant sample (3.75g) in 1000ml
In volumetric flask, it is settled to scale with water, shake up；
(2) four rustless steel containers are taken respectively to inject 100kg water；
(3) install oxygen-increasing device additional on four containers, and power-on, oxygenation；
(4) by fish by alepidote, have squama fish, respectively put in four containers；And be numbered: 1～4；Wherein No. 1 bucket conduct
Control sample；
(5) be separately added into 1g, 2g, 10g laboratory sample solution in 2～No. 4 stainless steel casks, observe 4 hours, 10 little
When, fish, the death condition of shrimp in 24 kegs, and carry out itemized record (see table)；
Product toxicity experimental test result:
(6) result shows, this product all no tested fish and shrimp in single times of consumption, double consumption and ten times of amount ranges are dead
Situation it was demonstrated that this product have small toxicity, safe the features such as.
Embodiment described above only have expressed the specific embodiment of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformation can also be made and improve, these broadly fall into the guarantor of the present invention
Shield scope.
Claims (7)
1. a kind of herbal mixture disinfectant it is characterised in that it by following weight percentage ratio each material composition: chlorhexidine 5～
20%, organic solvent 1～10%, Chinese medicine 5～20%, balance of purified water.
2. a kind of herbal mixture disinfectant according to claim 1 is it is characterised in that it is each by following weight percentage ratio
Material composition: chlorhexidine 10%, organic solvent 8%, Chinese medicine 10%, balance of purified water.
3. a kind of herbal mixture disinfectant according to claim 1 is it is characterised in that described chlorhexidine is acetate, salt
At least one in hydrochlorate, citrate, gluconate.
4. a kind of herbal mixture disinfectant according to claim 1 is it is characterised in that described organic solvent is ethanol, different
At least one in propanol, ethylene glycol, propylene glycol, glycerol, n-butyl alcohol.
5. a kind of herbal mixture disinfectant according to claim 1 is it is characterised in that described Chinese medicine is Cortex Phellodendri, Radix Scutellariae, Huang
Company, Folium Isatidiss, Fructus Gardeniae, Herba Houttuyniae, Radix Gentianae, in Radix Glycyrrhizae at least two.
6. a kind of preparation method of herbal mixture disinfectant described in claim 1 to 5 any one it is characterised in that: it includes
Following operating procedure:
Step 1: add 40～44.5 parts of purified water first in Chinese medicine extracting tank, in then adding 1～10 part in extraction pot
The former powder of medicine, stirring, mix homogeneously, tank mouth is extracted in sealing, and is heated to 50～60 DEG C, soaks 6～8h, then by extract temperature
It is down to room temperature, release extracting solution；
Step 2: add 40～44.5 parts of purified water, stirring, mix homogeneously in Chinese medicine extracting tank again, tank mouth is extracted in sealing, and
It is heated to 50～60 DEG C, soak 6～8h again, then extract temperature is down to room temperature, release extracting solution；
Step 3: Chinese medicine slag is taken out, after centrifuge dehydration, collects centrifugal liquid, and centrifugal liquid is merged with extracting solution twice, system
Obtain extracting solution a；
Step 4: extracting solution a is put in clean extraction pot, and adds 1～3 part of ethanol in extraction pot, stirring and evenly mixing, quiet
Only more than 24h, takes supernatant, filters, prepared extracting solution b；
Step 5: add 55～89 parts of purified water and 0.1～0.5 part of propylene glycol, mix homogeneously in reactor；
Step 6: and then 0.5～2 part of chlorhexidine salt is added to reactor, stirring makes it all dissolve；
Step 7: finally 0.5～2 part of extracting solution b is added to reactor, mix homogeneously, filters, prepared product.
7. described in claim 1 to 5 any one, a kind of herbal mixture disinfectant is preparing culture environment of aquatic products disinfectant and water
Produce the purposes of cultivation utensil disinfectant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610768226.5A CN106359470A (en) | 2016-08-30 | 2016-08-30 | Compound traditional Chinese medicine disinfectant and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610768226.5A CN106359470A (en) | 2016-08-30 | 2016-08-30 | Compound traditional Chinese medicine disinfectant and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106359470A true CN106359470A (en) | 2017-02-01 |
Family
ID=57901622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610768226.5A Pending CN106359470A (en) | 2016-08-30 | 2016-08-30 | Compound traditional Chinese medicine disinfectant and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106359470A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107646881A (en) * | 2017-10-10 | 2018-02-02 | 广州市澳米环保科技有限公司 | A kind of disinfectant and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
| CN1488258A (en) * | 2002-10-08 | 2004-04-14 | 谢永军 | Air sterilizing disinfectant |
| CN103493853A (en) * | 2013-09-25 | 2014-01-08 | 合肥智上农业开发有限公司 | Disinfectant |
| CN103891784A (en) * | 2013-09-11 | 2014-07-02 | 安徽亿人安有限公司 | Bacteriostatic agent for sterilization and disinfection, skin mucosa disinfection fluid and preparation method thereof |
| CN104920499A (en) * | 2015-05-15 | 2015-09-23 | 金维元 | Compound disinfectant, and preparation method and application thereof |
-
2016
- 2016-08-30 CN CN201610768226.5A patent/CN106359470A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397168A (en) * | 2001-07-13 | 2003-02-19 | 周茜 | Composite disinfectant |
| CN1488258A (en) * | 2002-10-08 | 2004-04-14 | 谢永军 | Air sterilizing disinfectant |
| CN103891784A (en) * | 2013-09-11 | 2014-07-02 | 安徽亿人安有限公司 | Bacteriostatic agent for sterilization and disinfection, skin mucosa disinfection fluid and preparation method thereof |
| CN103493853A (en) * | 2013-09-25 | 2014-01-08 | 合肥智上农业开发有限公司 | Disinfectant |
| CN104920499A (en) * | 2015-05-15 | 2015-09-23 | 金维元 | Compound disinfectant, and preparation method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107646881A (en) * | 2017-10-10 | 2018-02-02 | 广州市澳米环保科技有限公司 | A kind of disinfectant and preparation method thereof |
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| PB01 | Publication | ||
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Application publication date: 20170201 |