CN106344450A - Hyaluronic-acid tooth-brushing tablets and preparation method thereof - Google Patents

Hyaluronic-acid tooth-brushing tablets and preparation method thereof Download PDF

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Publication number
CN106344450A
CN106344450A CN201610822843.9A CN201610822843A CN106344450A CN 106344450 A CN106344450 A CN 106344450A CN 201610822843 A CN201610822843 A CN 201610822843A CN 106344450 A CN106344450 A CN 106344450A
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Prior art keywords
hyaluronic acid
acid
tooth piece
mass percent
hyaluronic
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Inventor
贺晓军
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Hangzhou Huidoctor Biotechnology Co Ltd
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Hangzhou Huidoctor Biotechnology Co Ltd
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Priority to CN201610822843.9A priority Critical patent/CN106344450A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention discloses hyaluronic-acid tooth-brushing tablets. The hyaluronic-acid tooth-brushing tablets comprise microcrystalline fiber, sorbitol, xylitol, stevia sugar, sodium lauroyl glutamate, mint, sodium alginate, sodium bicarbonate, ascorbic acid, liquorice, hyaluronic acid, magnesium stearate and essence, wherein the anti-inflammatory activity of the hyaluronic acid is combined with the liquorice and the ascorbic acid to prevent gingival bleeding, eliminate swelling, comprehensively solve tooth hypersensitivity and prevent and treat oral inflammation problems such as gingivitis, periodontitis and oropharyngeal mucositis. When the hyaluronic-acid tooth-brushing tablets are used for a certain period of time, the oral inflammation problems can be prevented effectively, and an evident effect is achieved. The invention further discloses a preparation method of the hyaluronic-acid tooth-brushing tablets. The preparation method is simple, convenient and capable of allow the component particles of the tooth-brushing tablets to be appropriate in size and good in taste.

Description

A kind of hyaluronic acid is brushed teeth tooth piece and preparation method
Technical field
The present invention relates to oral care implement field, brush teeth tooth piece and preparation method more particularly to a kind of hyaluronic acid.
Background technology
Tooth piece of brushing teeth is a kind of polishing, nursing, repairs the dental care products being integrated in one, by microcrystalline cellulose composition pair Tooth is polished making dental surface formation layer protecting film reach fresh breath simultaneously with the auxiliary element containing, prevent staying protection Effect with brilliant white tooth.Widely paid close attention to because its safety is lightly portable.But tooth piece of brushing teeth in the market It is to suppress antibacterial to increase by the sodium bicarbonate in its composition, the acidic materials of neutralization tooth reach and prevent oral ulcer, gingiva The scorching purpose with periodontitis, alleviates the phenomenon of the periodontal allergy inflammation causing because of stimulation, brush teeth tooth piece master by ascorbic acid Effect is wanted to be to clean tooth, prevent staying protection and brilliant white tooth, and to preventing and treating gingival sensitivity, oral ulcer, gingivitiss and periodontal The effect of the oral inflammation problem such as inflammation is simultaneously inconspicuous, and does not have to preventing gingival hemorrhage, eliminates the anti-of the oral problem such as redness Control repair.
Existing hyaluronic acid material, it has anti-inflammatory activity, can be used for preventing gingival hemorrhage, eliminates red and swollen, preventing and treating gingiva The oral problem such as inflammation and oropharyngeal cavity mucous membranes inflammation.Radix Glycyrrhizae has antiinflammatory and anti-allergic effects, and the throat of inflammation and oral cavity can be protected to stick Film.Therefore, develop a kind of can comprehensively solve oral inflammation problem and safely and effectively hyaluronic acid tooth piece of brushing teeth be necessary 's.
Content of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, provides one kind can prevent gingival hemorrhage, disappear Except redness, comprehensively solve hemodia, the hyalomitome of the oral inflammation problem such as preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes inflammation Acid is brushed teeth tooth piece, also provides the preparation method that this brushes teeth tooth piece.
For solving above-mentioned technical problem, the present invention employs the following technical solutions:
A kind of hyaluronic acid is brushed teeth tooth piece, contains ascorbic acid, Radix Glycyrrhizae and the hyaluronic acid with anti-inflammatory activity in its composition.
Above-mentioned ascorbic acid mass percent 0.5-1.5%, above-mentioned Radix Glycyrrhizae mass percent 0.2-1.0%, above-mentioned transparent Matter acid mass percent 0.2-3.0%.
Above-mentioned hyaluronic acid tooth piece of brushing teeth also contains the composition of following mass percent, 20-30% microcrystalline cellulose, 20- 25% Sorbitol, 20-25% xylitol, 0.1-2% stevioside, 1.0-10% sodium lauroyl glutamate, 0.1-25% Herba Menthae, 0.1-10% sodium alginate, 0.1-10% sodium bicarbonate, 0.5-1.0% magnesium stearate and 0.5-1.0% essence, all the components matter Amount percentage ratio summation is 100%.
Above-mentioned microcrystalline cellulose mass percent 23-26%, described Sorbitol mass percent 22-24%, above-mentioned Herba Menthae Mass percent 17-22%, above-mentioned hyaluronic acid mass percent 0.5-1.5%.
As a total inventive concept, the present invention also provides the preparation method that a kind of above-mentioned hyaluronic acid brushes teeth tooth piece, Comprise the following steps successively:
(1) by microcrystalline cellulose, Sorbitol, xylitol, stevioside, sodium lauroyl glutamate mix homogeneously, grinding；(2) By mixing in Herba Menthae, sodium alginate, sodium bicarbonate, ascorbic acid, Radix Glycyrrhizae, the mixed material of hyaluronic acid addition step (1) all Even, grind；(3) oven drying will be put into after the mixed material sealing of step (2), 40-80 DEG C of baking temperature, drying time 10- 30min/100g；(4) essence, magnesium stearate are added dried mixed material mix homogeneously, grinding；(5) by step (4) Mixed material is put into tablet machine and is compressed into tablet form.
The hyaluronic acid of present invention tooth piece of brushing teeth is repaired effect for the tooth piece that keeps brushing teeth original polishing whitening and is sent out simultaneously Wave the effect that hyaluronic acid solves the problems, such as oral inflammation, reasonable selection appropriate proportioning is carried out to the composition of tooth piece of brushing teeth.Crystallite is fine Dimension is a kind of good filler of disintegrating property, reaches the effect of polishing of teeth whitening decontamination by the friction with tooth；Anti- bad Hematic acid has antioxidation, prevents the effect of gingival hemorrhage and hypertrophy；Radix Glycyrrhizae has antiinflammatory and anti-allergic effects, can protect inflammation Throat and oral mucosa；Hyaluronic acid has anti-inflammatory activity, can eliminate redness, prevents gingival hemorrhage, can comprehensively solve tooth mistake Quick, the oral inflammation problem such as preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes inflammation；Sorbitol is soluble filler, in brush Do conditioning agent in mixed material during the compacting of sound of baby talk piece, and study and show that it is had with hyaluronic acid in terms of solution oral inflammation Synergism；Xylitol is soluble filler, the generation that can prevent dental caries and reduce dental plaque；Herba Menthae is freshener, Ke Yibao Hold breath freshening, comfortable taste；Sodium alginate is gellant, filler, has the effect of moist oral cavity and throat；Lauroyl paddy ammonia Sour sodium is foaming agent；Sodium bicarbonate is mainly acidity adjustment, has suppression antibacterial accretion；Stevioside is sweeting agent；Hard Fat Sour magnesium is lubricant；Essence is used for modulating certain fragrance.
Compared with prior art, it is an advantage of the current invention that:
The hyaluronic acid of the present invention brushes teeth tooth piece reasonable composition ratio properly, goes to decontaminate by microcrystalline cellulose grinding and polishing Form cleaning of teeth film the purpose reaching cleaning oral cavity, taking care of one's teeth while stain, tooth-whitening, then pass through Herba Menthae and Sargassum Sour sodium fresh breath, persistently moist oral cavity and throat；Most importantly Radix Glycyrrhizae and anti-bad is combined by the anti-inflammatory activity of hyaluronic acid Hematic acid, to prevent gingival hemorrhage, eliminates red and swollen, comprehensively solve hemodia, and preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes are scorching Deng oral inflammation problem, after the hyaluronic acid using the present invention brushes teeth one section of process of tooth piece, effectively prevention oral inflammation problem, Effect highlights；The hyaluronic acid of the present invention brushes teeth tooth piece for lamellar, carries easy to use；The hyaluronic acid of the present invention is brushed teeth tooth piece Preparation method it is contemplated that adding size compacting can the be brushed teeth tooth piece result of the order of composition and ingredient granules to impact, Composition is carried out respectively with three mixed grindings to reach mixed material mix homogeneously and to make each ingredient granules be sized for suppressing The purpose of slabbing, carries out cold drying sterilization after grinding at second, the moisture reducing mixed material is easy to it simultaneously It is compressed into tablet form, the brush teeth preparation method of tooth piece of the hyaluronic acid of the present invention not only simple and convenient have the tooth piece that makes to brush teeth simultaneously and becomes Divide granular size suitable, all good advantage of mouthfeel.
Specific embodiment
Hyaluronic acid in order to the present invention is described brushes teeth effect of tooth piece and component ratio properly lift following examples do into One step explanation.
Embodiment one: illustrate ascorbic acid, Radix Glycyrrhizae and hyaluronic acid be combined after effect
The hyaluronic acid of the present invention is brushed teeth tooth piece, the hyalomitome containing ascorbic acid, Radix Glycyrrhizae and anti-inflammatory activity in its composition Acid；Ascorbic acid has antioxidation, prevents the effect of gingival hemorrhage and hypertrophy；Radix Glycyrrhizae has antiinflammatory and anti-allergic effects, can protect The scorching throat of hair care and oral mucosa；Hyaluronic acid has anti-inflammatory activity, can prevent gingival hemorrhage, eliminates red and swollen, can solve comprehensively Certainly hemodia, the oral inflammation problem such as preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes inflammation；For illustrating its effect now using people The method of body experiment detects the biologically active human of hyaluronic acid, i.e. anti-inflammatory activity, research ascorbic acid, Radix Glycyrrhizae and hyaluronic acid Preventing gingival hemorrhage and hypertrophy, eliminating red and swollen, the treatment oral inflammation problem such as gingivitiss and oropharyngeal cavity mucous membranes inflammation effect.
The all cases of this experiment are oral inflammation patient, and experimental group 1 adopts ascorbic acid 1.0%+ Radix Glycyrrhizae 0.5%+ saturating Bright matter acid 1.0% tooth piece of brushing teeth chews 2 daily；Experimental group 2 is every using ascorbic acid 1.0%+ hyaluronic acid 1.0% tooth piece of brushing teeth It chews 2；Experimental group 3 chews 2 daily using Radix Glycyrrhizae 0.5%+ hyaluronic acid 1.0% tooth piece of brushing teeth；Positive control adopts 1.0% The tooth piece of brushing teeth of hyaluronic acid chews 2 daily；Negative control chews 2 daily using tooth piece of commonly brushing teeth；Treat 3 days for relatively five groups Sings and symptoms improves situation afterwards.
Gingiva is itched, discomfort, distending pain, halitosis symptom therapeutic evaluation:
Effective: symptom significantly improves or disappears, patient satisfaction；It is effective: symptom has improvement or mitigates, and patient still has discomfort, Require continual cure；Invalid: symptom no substantially mitigates, patient is unsatisfied with.
Sign therapeutic evaluation:
Effective: gingival hemorrhage, gingiva color change, spy is examined 3 signs of bleeding and all improved；Effective: gingival hemorrhage, gingiva 2 signs of color have improvement, and spy is examined bleeding and do not improved；Invalid: gingival hemorrhage, gingiva color, spy are examined 3 signs of bleeding and all no changed Kind.
Statistical method: statistical procedures are carried out using spss12.0 statistics software, compares between metering and enumeration data group Relatively adopt t inspection and x2Inspection, with p < 0.05 for statistically significant difference.
Result is as follows:
As shown in table 1, the 4th day symptom improves situation: effective 10 of experimental group 1, total effective rate 100%；Experimental group 2 is effective 0, effective 8, invalid 2, total effective rate 80%, obvious effective rate compares p < 0.01 with experimental group 1；Effective 0 of experimental group 3, has Effect 10, total effective rate 100%, obvious effective rate compares p < 0.01 with experimental group 1；Effective 3 of positive control, effective 7, always effectively Rate 100%, obvious effective rate compares p < 0.01 with experimental group 1.
The 4th day each group patients symptomatic of table 1 improves situation and compares
As shown in table 2, the 4th day clinical sign improves situation: effective 10 of experimental group 1, total effective rate 100%；Experimental group 2 Effective 0, effective 10, total effective rate 100%, obvious effective rate compares p < 0.01 with experimental group 1；Effective 0 of experimental group 3, effective 8 Example, invalid 2, total effective rate 80%, obvious effective rate compares p < 0.01 with experimental group 1；Effective 5 of positive control, effective 5, always Effective percentage 100%, obvious effective rate compares p < 0.01 with experimental group 1.
The 4th day each group patient sign of table 2 improves situation and compares
Conclusion:
Experimental group 1 (ascorbic acid 1.0%+ Radix Glycyrrhizae 0.5%+ hyaluronic acid 1.0%) is substantially than experimental group 2 (ascorbic acid 1.0%+ hyaluronic acid 1.0%), experimental group 3 (Radix Glycyrrhizae 0.5%+ hyaluronic acid 1.0%), positive control effective.The present invention's is saturating Bright matter acid brush teeth tooth piece human experimentation show (1) ascorbic acid and Radix Glycyrrhizae to hyaluronic acid treat oral inflammation curative effect have bright Aobvious synergism；(2) ascorbic acid treats the more remarkable treatment effect of gingival hemorrhage to hyaluronic acid；(3) Radix Glycyrrhizae disappears to hyaluronic acid Except red and swollen more remarkable treatment effect.
Embodiment two: the brush teeth best in quality percentage of tooth piece ascorbic acid, Radix Glycyrrhizae and hyaluronic acid of research hyaluronic acid is joined Than
The experiment of embodiment one shows that ascorbic acid, Radix Glycyrrhizae and hyaluronic acid are red and swollen to eliminating, and prevents gingival hemorrhage and tooth Tooth allergy, the oral inflammation problem such as preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes inflammation has good curative effect, in order to play it Large effect, now research hyaluronic acid brush teeth the best in quality per distribution ratio of tooth piece ascorbic acid, Radix Glycyrrhizae and hyaluronic acid.
Respectively the ascorbic acid of proportioning 0.5%, 1.0%, 1.5% and 0.2%, 0.5%, 1.0% Radix Glycyrrhizae and 0.5%, 1.0%th, 1.5% hyaluronic acid is brushed teeth tooth piece, and other compositions are microcrystalline cellulose, Sorbitol, xylitol, Herba Menthae, alginic acid Sodium, sodium lauroyl glutamate, sodium bicarbonate, stevioside, magnesium stearate and orange flavor, all the components mass percent summation 100%.
The all cases of this experiment are oral inflammation patient, and 1-30 is different with hyaluronic acid with ascorbic acid, Radix Glycyrrhizae for experiment The tooth piece of brushing teeth of concentration chews 2 orthogonal experiments carrying out Three factors-levels daily；31 use, for negative control, tooth of commonly brushing teeth Piece chews 2 treatment oral inflammations, the situation after observation and treatment daily；Positive control 28-30 is respectively adopted 0.5%, 1.0%, The tooth piece of brushing teeth of 1.5% hyaluronic acid chews 2 daily, the situation after observation and treatment；Every group of 5 patients, comparison therapy disease after 3 days Shape and sign improve situation.
Table 3 orthogonal experiment factor meter
Gingiva is itched, discomfort, distending pain, halitosis symptom therapeutic evaluation, sign the standard of curative effect evaluation ibid.
Statistical method: statistical procedures are carried out using spss12.0 statistics software, compares between metering and enumeration data group Relatively adopt t inspection and x2Inspection, with p < 0.05 for statistically significant difference.
The 4th day each group patients symptomatic of table 4 improves situation and compares
As shown in table 4, the 4th day each experimental group patients symptomatic improves situation and compares, p > 0.05, indifference.
The 4th day each group patient sign of table 5 improves situation and compares
As shown in table 5, the 4th day each experimental group patient sign improves situation and compares, p > 0.05, indifference.
Conclusion:
Through human body using experiment, result show using 0.5%, 1.0%, 1.5% ascorbic acid and 0.2%, 0.5%, 1.0% Radix Glycyrrhizae and 0.5%, 1.0%, the 1.5% tooth piece of brushing teeth of hyaluronic acid percent mass proportioning all have to oral inflammation Therapeutic effect, but do not limit to this scope.
Embodiment three: different taste hyaluronic acid is brushed teeth the compound prescription of tooth piece and preparation method
Compound prescription one: Fructus Citri sinensiss taste is brushed teeth tooth piece
This compound prescription is that Fructus Citri sinensiss taste is brushed teeth tooth piece, and its component ratio is as follows:
Microcrystalline cellulose 26%, Sorbitol 24%, xylitol 24%, stevioside 0.25%, sodium lauroyl glutamate 1.0%th, Herba Menthae 17%, sodium alginate 2.8%, sodium bicarbonate 1.0%, ascorbic acid 0.5%, Radix Glycyrrhizae 0.2%, hyaluronic acid 1.5%th, magnesium stearate 1.0% and orange flavor 0.75%, all percents are mass percent, and each composition quality summation is 100%, this compound prescription gross mass is 100g.
This compound prescription is prepared by following processing step:
(1) by microcrystalline cellulose, Sorbitol, xylitol, stevioside, sodium lauroyl glutamate mix homogeneously, grinding；
(2) Herba Menthae, sodium alginate, sodium bicarbonate, ascorbic acid, Radix Glycyrrhizae and hyaluronic acid are added the mixing of step (1) Mix homogeneously in material, grinds；
(3) the mixed material sealing of step (2) is put in 60 DEG C of oven drying 20min；
(4) orange flavor, magnesium stearate are added dried mixed material mix homogeneously, grinding；
(5) mixed material is put into tablet machine to be compressed into tablet form.
Compound prescription two: lemon is brushed teeth tooth piece
This compound prescription is that lemon is brushed teeth tooth piece, and its component ratio is as follows:
Microcrystalline cellulose 25.5%, Sorbitol 24%, xylitol 24%, stevioside 0.25%, sodium lauroyl glutamate 1.0%th, Herba Menthae 17%, sodium alginate 3.0%, sodium bicarbonate 1.0%, ascorbic acid 1.0%, Radix Glycyrrhizae 0.5%, hyaluronic acid 1.0%th, magnesium stearate 1.0% and Fructus Citri Limoniae essence 0.75%, all percents are mass percent, and each composition quality summation is 100%, this compound prescription gross mass is 100g.
This compound prescription is prepared by following processing step:
(1) by microcrystalline cellulose, Sorbitol, xylitol, stevioside, sodium lauroyl glutamate mix homogeneously, grinding；
(2) Herba Menthae, sodium alginate, sodium bicarbonate, ascorbic acid, Radix Glycyrrhizae and hyaluronic acid are added step (1) mixture Mix homogeneously in material, grinds；
(3) the mixed material sealing of step (2) is put in 50 DEG C of oven drying 15min；
(4) Fructus Citri Limoniae essence, magnesium stearate are added dried mixed material mix homogeneously, grinding；
(5) mixed material is put into tablet machine to be compressed into tablet form.
Compound prescription three: hot Herba Menthae is brushed teeth tooth piece
This compound prescription is that hot Herba Menthae is brushed teeth tooth piece, and its component ratio is as follows:
Microcrystalline cellulose 23%, Sorbitol 22%, xylitol 22%, stevioside 0.25%, sodium lauroyl glutamate 2.0%th, Herba Menthae 22%, sodium alginate 2.0%, sodium bicarbonate 1.0%, ascorbic acid 1.5%, Radix Glycyrrhizae 1.0%, hyaluronic acid 1.5%th, magnesium stearate 1.0% and Mint Essence 0.75%, all percents are mass percent, and each composition quality summation is 100%, this compound prescription gross mass is 100g.
This compound prescription is prepared by following processing step:
(1) by microcrystalline cellulose, Sorbitol, xylitol, stevioside, sodium lauroyl glutamate mix homogeneously, grinding；
(2) Herba Menthae, sodium alginate, sodium bicarbonate, ascorbic acid, Radix Glycyrrhizae and hyaluronic acid are added the mixing of step (1) Mix homogeneously in material, grinds；
(3) the mixed material sealing in step (2) is put in 45 DEG C of oven drying 10min；
(4) Mint Essence, magnesium stearate are added dried mixed material mix homogeneously, grinding；
(5) mixed material is put into tablet machine to be compressed into tablet form.
The hyaluronic acid of the present invention above-mentioned three kinds of compound gradation composition rational proportions of tooth piece of brushing teeth are suitable, through embodiment one, The anti-inflammatory activity of two checking hyaluronic acid to prevent gingival hemorrhage with reference to Radix Glycyrrhizae and ascorbic acid, eliminates red and swollen, comprehensively solve Hemodia, the oral inflammation problem such as preventing and treating gingivitiss, periodontitis and oropharyngeal cavity mucous membranes inflammation, in the hyaluronic acid using the present invention After one section of process of tooth piece of brushing teeth, effectively prevention oral inflammation problem, effect highlights；The hyaluronic acid of the present invention brushes teeth tooth piece for piece Shape, can add different essence proportioning difference tastes, carry easy to use；The hyaluronic acid of the present invention is brushed teeth the preparation side of tooth piece It is contemplated that the order of addition composition and the size of ingredient granules can be brushed teeth to compacting, tooth piece result impacts method, and composition is divided Do not carry out 3 mixed grindings to reach mixed material mix homogeneously and to make each ingredient granules be sized for the mesh being compressed into tablet form , carry out cold drying sterilization at second after grinding, the moisture of minimizing mixed material is easy to it and is compressed into tablet form simultaneously, The hyaluronic acid of the present invention brush teeth tooth piece preparation method not only simple and convenient have simultaneously make tooth piece ingredient granules size of brushing teeth Suitably, all good advantage of mouthfeel.
Above-mentioned simply presently preferred embodiments of the present invention, not makees any pro forma restriction to the present invention.Although the present invention Disclosed above with preferred embodiment, but it is not limited to the present invention.Any those of ordinary skill in the art, are not taking off In the case of technical solution of the present invention scope, all can be utilized the technology contents of the disclosure above that technical solution of the present invention is made perhaps How possible variation and modification, or the Equivalent embodiments being revised as equivalent variations.Therefore, every without departing from technical solution of the present invention Content, according to the technology of the present invention essence to any simple modification made for any of the above embodiments, equivalent variations and modification, all should fall In the range of technical solution of the present invention protection.

Claims (5)

1. a kind of hyaluronic acid brush teeth tooth piece it is characterised in that: contain ascorbic acid, Radix Glycyrrhizae and there is anti-inflammatory activity in its composition Hyaluronic acid.
2. the hyaluronic acid described in a kind of claim 1 brush teeth tooth piece it is characterised in that: described ascorbic acid mass percent 0.5-1.5%, described Radix Glycyrrhizae mass percent 0.2-1.0%, described hyaluronic acid mass percent 0.2-3.0%.
3. the hyaluronic acid described in a kind of claim 1 or 2 brush teeth tooth piece it is characterised in that: described hyaluronic acid is brushed teeth tooth piece Also comprise the composition of following mass percent, 20-30% microcrystalline cellulose, 20-25% Sorbitol, 20-25% xylitol, 0.1- 2% stevioside, 1.0-10% sodium lauroyl glutamate, 0.1-25% Herba Menthae, 0.1-10% sodium alginate, 0.1-10% bicarbonate Sodium, 0.5-1.0% magnesium stearate and 0.5-1.0% essence, all the components mass percent summation is 100%.
4. the hyaluronic acid described in a kind of claim 3 brush teeth tooth piece it is characterised in that: described microcrystalline cellulose mass percent 23-26%, described Sorbitol mass percent 22-24%, described Herba Menthae mass percent 17-22%, described hyaluronic acid Mass percent 0.5-1.5%.
5. the hyaluronic acid described in a kind of claim 3 is brushed teeth the preparation method of tooth piece, comprises the following steps that successively:
(1) by microcrystalline cellulose, Sorbitol, xylitol, stevioside, sodium lauroyl glutamate mix homogeneously, grinding；
(2) Herba Menthae, sodium alginate, sodium bicarbonate, ascorbic acid, Radix Glycyrrhizae, hyaluronic acid are added in the mixed material of step (1) Mix homogeneously, grinds；
(3) oven drying will be put into after the mixed material sealing of step (2), 40-80 DEG C of baking temperature, drying time 10- 30min/100g；
(4) essence, magnesium stearate are added dried mixed material mix homogeneously, grinding；
(5) mixed material of step (4) is put into tablet machine to be compressed into tablet form.
CN201610822843.9A 2016-09-14 2016-09-14 Hyaluronic-acid tooth-brushing tablets and preparation method thereof Withdrawn CN106344450A (en)

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Application publication date: 20170125