CN1823722A - Medicinal tooth paste and its processing method - Google Patents
Medicinal tooth paste and its processing method Download PDFInfo
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- CN1823722A CN1823722A CN 200610017325 CN200610017325A CN1823722A CN 1823722 A CN1823722 A CN 1823722A CN 200610017325 CN200610017325 CN 200610017325 CN 200610017325 A CN200610017325 A CN 200610017325A CN 1823722 A CN1823722 A CN 1823722A
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Abstract
A medicinal tooth-paste for preventing periodontitis, gingivitis, oral ulcer, foul breath, decayed tooth, etc is prepared from the raw materials used by original tooth-paste, and additional cactus, berberine hydrochloride and metronidazole.
Description
Technical field
The invention belongs to the toothpaste technical field, be specifically related to a kind of medicated toothpaste that periodontitis, gingivitis, gingival hemorrhage, oral ulcer, halitosis, dental caries is had remarkable preventive effect.
Background technology
Periodontal disease, oral ulcer and dental caries, and pathogen that should disease is due to the infection of a class anaerobe and other harmful bacterium, these floras form bacterial plaque, calculus, etch various focusing depths represented, swelling, hemorrhage, pain, halitosis occurs on tooth, the long-term gingiva that destroys makes gingival atrophy, frontal resorption causes odontoseisis, very then comes off, infect oral mucosa, form oral ulcer.
Control to above-mentioned disease, existing mainly is that the health-care toothpaste that cleans the teeth preventing decayed tooth, anti-inflammation hemostasia, adopted has antiinflammatory tooth protection class, deodorization hemostasis class, fluorine-containing enzyme, the desensitization class of containing, in case oral pathology has taken place, the multipurpose apparatus tool combines with Drug therapy, and mechanotherapy effectively is the oral cavity oral prophylaxis, and endo-medicine is many with Tetracyclines and metronidazole class, it is main mainly advocating precautions now, strengthens oral cavity health consciousness, in case odontopathy has taken place, even cure, tooth health has been subjected to infringement.
Health toothpaste on the existing market is not ideal enough to the prevention effect of above-mentioned disease, be that produce effects is slow, weak effect, the rehabilitation rate is low, the life-time service preventive effect is undesirable, and mostly to be that the conventional formulation of toothpaste is added Chinese medicine or fluoridize enzyme-added etc., if do not take the measure of oral cavity resistance against diseases, then can form new bacterial plaque over time.
Summary of the invention
Therefore, still there is demand in people to preventive effect better medicament toothpaste, up to now, also do not find the report of any relevant pharmaceutical composition of the present invention, the present invention suffers from periodontitis gingival hemorrhage, halitosis the inventor, after failing to respond to any medical treatment through several different methods, abandon the routine treatment of textbook, the inventor has found preventive effect better medicament toothpaste finally, thereby has finished the present invention through research repeatedly.
The purpose of this invention is to provide a kind of decontamination that cleans the teeth, the sterilization antiinflammatory is used to prevent and treat the medicated toothpaste of periodontal disease, oral ulcer and dental caries.
The technical scheme that the present invention takes is to have increased Radix et Caulis Opuntiae Dillenii, berberine and metronidazole on the basis of original formulation of tooth-paste.
The present invention is made up of following material, and its percentage by weight is respectively calcite in powder 48-55%, formaldehyde 0.5 ‰, CMC 0.7-1.2%, glycerol 14-28%, saccharin sodium 0.4-0.45%, spice 0.9-1.2%, lauric aldehyde sodium sulfate 1.6-2.5%, cactus extraction 15-20%, metronidazole 2.0-2.8%, berberine hydrochloride 1.5-1.8%, water 5.0-10.0%.
Processing method of the present invention is as follows:
1, earlier with Radix et Caulis Opuntiae Dillenii deburring unhairing, cleaning and sterilizing, pulverizing, centrifugal 20 order filter clothes, suction pressurization coarse filtration; Centrifugal 200 order filter clothes pressurization suction fine filtering, filtrate (containing Radix et Caulis Opuntiae Dillenii active ingredient and colloid);
2, again CMC and glycerol are mixed into the wetting agent of colloidal sol by described percentage by weight, after binding agent is disperseed uniformly, the water that adds described percentage by weight, make binding agent expansion peptization, the glucide that adds the described percentage by weight of soluble substance again, metronidazole and berberine hydrochloride, stir the cactus extraction that the back adds described percentage by weight, fully stir, the Radix et Caulis Opuntiae Dillenii colloid is fully mixed with glue, add the calcite powder and the spice of described percentage by weight then, the limit edged stirs, add the lauric aldehyde sodium sulfate and the formaldehyde of described percentage by weight at last, stir, grind with colloid mill, display about 12 hours, the bottling of bleeding gets final product.
The present invention is that the newtype drug toothpaste that combines of a kind of Chinese medicine and western medicine, flavor are slightly bitter, and the decontamination that cleans the teeth, is used to prevent and treat periodontal disease, oral ulcer and dental caries at the sterilization antiinflammatory; The contained Chinese medicine of the present invention partly is extracting solution and berberine from Radix et Caulis Opuntiae Dillenii, and Radix et Caulis Opuntiae Dillenii has heat-clearing and toxic substances removing, the effect of removing heat from blood; Active ingredient is glycoside, triterpene, chlorophyll and natural gum and phlegmatic temperament; The former cooperates Rhizoma Coptidis to have anti-inflammation protection ulcer and promotes cell new life's effect; Natural gum and phlegmatic temperament viscosity are very high, can replace a part of CMC as a kind of novel toothpaste jointing material, have the effect of antiinflammatory, protection ulcer; Western medicine part metronidazole is effective anti-anaerobism medicine, uses in the saccharin sodium and the bitterness of metronidazole.Other basic composition is general in the world now component; Principal agent of the present invention is Radix et Caulis Opuntiae Dillenii, berberine and metronidazole, the adsorptivity of CMC (carboxymethyl cellulose) in the general toothpaste is very strong, and the activity of drug molecule is lowered, and the contained natural gum of this product and to be stained with the viscosity of liquid matter very strong, can be as a kind of natural gum compound, thus the consumption of CMC reduced; Natural gum and chlorophyll have affinity and permeability to soft tissue and protection ulcer are arranged and impel epithelial cell new life; Thereby strengthened antibacterial activity, and metronidazole has very strong inhibitory action to the anaerobe in the oral cavity, and oral mucosa absorbs seldom this medicine, has no side effect, and does not meet quick reaction in the life-time service process.
Based on prevention and health care, often use this product for oral disease, preventable disease is in possible trouble, advantage be protection effect obviously reliable, be difficult for forming Drug resistance, have no side effect and easy to use.
The specific embodiment
The present invention is made up of following material, and its percentage by weight is respectively calcite in powder 48-55%, formaldehyde 0.5 ‰, CMC 0.7-1.2%, glycerol 14-28%, saccharin sodium 0.4-0.45%, spice 0.9-1.2%, lauric aldehyde sodium sulfate 1.6-2.5%, cactus extraction 15-20%, metronidazole 2.0-2.8%, berberine hydrochloride 1.5-1.8%, water 5.0-10.0.
Embodiment 1:
The present invention is made up of following material, and its percentage by weight is respectively calcite in powder 48%, formaldehyde 0.5 ‰, CMC 0.9%, glycerol 18%, saccharin sodium 0.4%, spice 1.1%, lauric aldehyde sodium sulfate 1.8%, cactus extraction 20%, metronidazole 2.0%, berberine hydrochloride 1.6%, water 6.2%.
Embodiment 2:
The present invention is made up of following material, and its percentage by weight is respectively calcite in powder 50%, formaldehyde 0.5 ‰, CMC 1.0%, glycerol 20%, saccharin sodium 0.42%, spice 1.0%, lauric aldehyde sodium sulfate 2.0%, cactus extraction 16%, metronidazole 2.2%, berberine hydrochloride 1.68%, water 5.7%.
Embodiment 3:
The present invention is made up of following material, and its percentage by weight is respectively calcite in powder 54%, formaldehyde 0.5 ‰, CMC 1.1%, glycerol 16.66%, saccharin sodium 0.44%, spice 1.2%, lauric aldehyde sodium sulfate 2.4%, cactus extraction 15%, metronidazole 2.4%, berberine hydrochloride 1.8%, water 5.0%.
Processing method of the present invention is as follows:
1, earlier with Radix et Caulis Opuntiae Dillenii deburring unhairing, cleaning and sterilizing, pulverizing, centrifugal 20 order filter clothes, suction pressurization coarse filtration; Centrifugal 200 order filter clothes pressurization suction fine filtering, filtrate (containing Radix et Caulis Opuntiae Dillenii active ingredient and colloid);
2, again CMC and glycerol are mixed into the wetting agent of colloidal sol by described percentage by weight, after binding agent is disperseed uniformly, the water that adds described percentage by weight, make binding agent expansion peptization, the glucide that adds the described percentage by weight of soluble substance again, metronidazole and berberine hydrochloride, stir the cactus extraction that the back adds described percentage by weight, fully stir, the Radix et Caulis Opuntiae Dillenii colloid is fully mixed with glue, add the calcite powder and the spice of described percentage by weight then, the limit edged stirs, add the lauric aldehyde sodium sulfate and the formaldehyde of described percentage by weight at last, stir, grind with colloid mill, display about 12 hours, the bottling of bleeding gets final product.
Calcite in powder is filler and abrasive in the present invention, adopts with CaCO more
3Or CaHPO
4Two kinds, general fineness is moderate, and pH value is 7.5-9, free from admixture; CMC is primary raw material, adhesion-molded dose, and pH value is generally 8, and its consumption is directly proportional with the calcite in powder consumption; Glycerol is wetting agent, have the suction antifreeze and guarantee mastic display the back indeformable effect; Synthetic foaming agent is used lauric aldehyde sodium sulfate more, and the foaming decontamination is arranged; Spice is many with mint aroma or Herba Menthae Rotundifoliae type, the major ingredient of pleasant sensation sense of taste; Sweeting agent is used saccharin sodium more, strengthens sense of taste, eliminates bitterness, and consumption does not have influence to mastic, but the excessive bitter in the mouth of consumption; Water is used ionized water more, main dispersing medium in the one-tenth glue of toothpaste; Radix et Caulis Opuntiae Dillenii is given birth to the product extracting solution, and the effect of antiinflammatory, detoxifcation, removing heat from blood is arranged, but the part of colloid wherein instead of part CMC, and the hydrone of cholla gum body portion can form adsorbed water with the powder surface in the mastic, makes colloid and solid material form stable network structure; Metronidazole is for effectively killing the medicine of the anaerobe in the oral cavity; Content of formaldehyde is 5/10000ths, for making the habitual antiseptic of toothpaste in the world; Berberine hydrochloride has inhibitory action to be difficult in the oral cavity absorbing to multiple bacillus, coccus.
Radix et Caulis Opuntiae Dillenii is at water content height in summer, winter and arid season water content are few, therefore, the viscosity differences of its extracting solution is very big, directly influence the hardness and the effect of toothpaste, this is amount of water debugging as the case may be just, adds 2/3rds water when being preferably in glue, add remaining water at last as required, it is moderate that the limit edged is stirred to mastic hardness.
The metronidazole bitter in the mouth entangles flavor with glucide, but glucide adds flavor change hardship at most, and because of medicine and glucide place of production mass discrepancy, therefore, with the glucide lapping-in, in the molten water that takes a morsel, directly mouthfeel is sweet in slightly spending metronidazole in elder generation.
The clinical observation of medicine of the present invention
1, physical data
Accept out-patient's 337 examples for medical treatment, the patient is divided into two groups at random, 240 examples are organized in treatment, give toothpaste prophylactic treatment of the present invention, matched group 97 examples give existing as toothpaste prophylactic treatment such as " Radix Zanthoxyli ", " Crest ", " Luclean ", " blue sky six must be controlled "; Minimum 16 years old of age wherein, maximum 76 years old, the longest 5 years the course of disease the shortest half a year, clinical treatment observation, the shortest 2 months, the longest 5 years.51 examples below 40 years old in the treatment group, 40--49 year 103 examples, 50--59 year 52 examples, 34 examples more than 60 years old; The course of disease is 55 examples below 1 year, 2--3 94 examples, 3--4 55 examples, 36 examples more than 4 years; 15 examples below 40 years old in the matched group, 40--49 year 40 examples, 50--59 year 30 examples, 12 examples more than 60 years old; The course of disease is 18 examples below 1 year, 2--3 31 examples, 3--4 26 examples, 22 examples more than 4 years; Two groups of patients are aspect mean age, the course of disease, the state of an illness, and are in a basic balance, have comparability.
2, paired observation
Use the present inventor after 2 years with use other toothpaste person synopsis after 2 years
| Before using the present invention | Use the present invention after 2 years | Before using other toothpaste | Use other toothpaste after 2 years | |
| Periodontitis (example) | 34 | 1 | 18 | 12 |
| Gingival hemorrhage (example) | 27 | 0 | 9 | 6 |
| Dental caries (example) | 29 | 6 | 32 | 27 |
| Halitosis (example) | 68 | 2 | 26 | 23 |
| Oral ulcer (example) | 82 | 2 | 12 | 14 |
| Add up to (example) | 240 | 11 | 97 | 82 |
| Total effective rate (%) | 95.41 | 15.46 |
The curative effect of treatment group as can be seen from the above table obviously is better than matched group, and its total effective rate (95.41%) is all apparently higher than matched group (15.46%).
The product that the present invention combines for Chinese medicine and western medicine, used Chinese medicine partly are without chemically treated protoplasm Chinese medicine, Western medicine part no side effects.To the prevention of oral pathology, the rehabilitation produce effects is fast, and medicine is strong to the permeability of lesion portion, result of use is satisfied, bacterium (tooth) speckle is eliminated, can be obtained long especially preventive effect simultaneously, and easy to use, can prevent and can be used as general articles for daily use, price is low, to gingivitis, gingival hemorrhage, halitosis, oral ulcer, brushes teeth for three times on the one with this product, symptom is obviously improved after one week, does not generally recur after the rehabilitation.
The present invention has light bitterness, and first the use has sense of discomfort, and just be accustomed to a couple of days; Because the present invention contains bioactive ingredients,, be generally under the room temperature 6-8 month so the shelf-life is shorter.
The present invention mainly is a cleaning oral cavity, owing to having added medicine, antiinflammatory is arranged, having prevented and treated the effect of oral pathology.Periodontitis, gingivitis, gingival hemorrhage, oral ulcer, halitosis, dental caries are all had significant preventive effect, can be used for keeping oral cavity cleaning, pre-preventing tooth diseases takes place, and impels dental health.By observation statistics, show that its strong tooth effect of diseases prevention is better than toothpaste such as existing " Radix Zanthoxyli ", " Crest ", " Luclean ", " blue sky six must be controlled " to 337 routine user.
Claims (3)
1, medicated toothpaste mainly is made up of calcite in powder, formaldehyde, CMC, glycerol, saccharin sodium, spice, lauric aldehyde sodium sulfate, water, it is characterized in that also including cactus extraction, metronidazole and berberine hydrochloride in above-mentioned composition.
2, medicated toothpaste according to claim 1, it is characterized in that being made up of following material, its percentage by weight is respectively calcite in powder 48-55%, formaldehyde 0.5 ‰, CMC0.7-1.2%, glycerol 14-28%, saccharin sodium 0.4-0.45%, spice 0.9-1.2%, lauric aldehyde sodium sulfate 1.6-2.5%, cactus extraction 15-20%, metronidazole 2.0-2.8%, berberine hydrochloride 1.5-1.8%, water 5.0-10.0.
3, according to the processing method of the described medicated toothpaste of claim 2, its processing method is as follows:
A, first with Radix et Caulis Opuntiae Dillenii deburring unhairing, cleaning and sterilizing, pulverizing, centrifugal 20 order filter clothes, suction pressurization coarse filtration; Centrifugal 200 order filter clothes pressurization suction fine filtering, filtrate wherein contains Radix et Caulis Opuntiae Dillenii active ingredient and colloid;
B, again CMC and glycerol are mixed into the wetting agent of colloidal sol by described percentage by weight, after binding agent is disperseed uniformly, the water that adds described percentage by weight, make binding agent expansion peptization, the glucide that adds the described percentage by weight of soluble substance again, metronidazole and berberine hydrochloride, stir the cactus extraction that the back adds described percentage by weight, fully stir, the Radix et Caulis Opuntiae Dillenii colloid is fully mixed with glue, add the calcite powder and the spice of described percentage by weight then, the limit edged stirs, add the lauric aldehyde sodium sulfate and the formaldehyde of described percentage by weight at last, stir, grind with colloid mill, display about 12 hours, the bottling of bleeding gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610017325 CN1823722A (en) | 2006-01-09 | 2006-01-09 | Medicinal tooth paste and its processing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610017325 CN1823722A (en) | 2006-01-09 | 2006-01-09 | Medicinal tooth paste and its processing method |
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| Publication Number | Publication Date |
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| CN1823722A true CN1823722A (en) | 2006-08-30 |
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| CN 200610017325 Pending CN1823722A (en) | 2006-01-09 | 2006-01-09 | Medicinal tooth paste and its processing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013091139A1 (en) * | 2011-12-21 | 2013-06-27 | Colgate-Palmolive Company | Heatiness and salivary secretory immunoglobulin |
| AU2011384378B2 (en) * | 2011-12-21 | 2014-09-18 | Colgate-Palmolive Company | Methods and products to diagnose and treat heatiness |
| CN109303730A (en) * | 2018-11-23 | 2019-02-05 | 谢树群 | It is a kind of to eliminate bad breath the good formulation of tooth-paste of effect |
-
2006
- 2006-01-09 CN CN 200610017325 patent/CN1823722A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013091139A1 (en) * | 2011-12-21 | 2013-06-27 | Colgate-Palmolive Company | Heatiness and salivary secretory immunoglobulin |
| AU2011384378B2 (en) * | 2011-12-21 | 2014-09-18 | Colgate-Palmolive Company | Methods and products to diagnose and treat heatiness |
| AU2011384377B2 (en) * | 2011-12-21 | 2014-09-18 | Colgate-Palmolive Company | Heatiness and salivary secretory immunoglobulin |
| CN109303730A (en) * | 2018-11-23 | 2019-02-05 | 谢树群 | It is a kind of to eliminate bad breath the good formulation of tooth-paste of effect |
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