CN106334044A - Medicament capable of improving central nervous system inflammation - Google Patents
Medicament capable of improving central nervous system inflammation Download PDFInfo
- Publication number
- CN106334044A CN106334044A CN201610668034.7A CN201610668034A CN106334044A CN 106334044 A CN106334044 A CN 106334044A CN 201610668034 A CN201610668034 A CN 201610668034A CN 106334044 A CN106334044 A CN 106334044A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- freeze
- nervous system
- central nervous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a medicament capable of improving central nervous system inflammation, wherein the medicament is prepared from the following raw materials in parts by weight: 20-30 parts of a nostoc commune powder, 25-35 parts of a pine needles baking powder, 15-25 parts of a honeysuckle extract, 6-18 parts of a radix isatidis extract, 6-18 parts of a fructus forsythiae extract, 13-17 parts of a raw mung bean freeze-dried powder, 23-37 parts of cranberry, 26-38 parts of olive leaves, 25-35 parts of a celery seed freeze-dried powder, and 27-33 parts of konjac flour. Through a special process, the pine needle baking powder, the honeysuckle extract, the radix isatidis extract, the fructus forsythiae extract, the raw mung bean freeze-dried powder and the celery seed powder are obtained and are combined together with the cranberry, the olive leaves, the konjac powder and the like according to the optimal ratio, so epidemic cerebrospinal meningitis can be effectively prevented, the body resistance is increased, and no drug resistance is generated.
Description
Technical field
The present invention relates to a kind of field of traditional Chinese is and in particular to a kind of have the medicine improving inflammation of the central nervous system
Agent.
Background technology
Epidemic meningitis is the abbreviation of meningococal meningitis, and it is the purulent inflammation being caused by diplococcus meningitidis, has
Stronger infectiousness.Winter-spring season is the epidemic peak phase, and less than 15 years old children easily suffer from this disease, and the baby of two years old about is ill
Rate is higher.When there is epidemic meningitis, it is the infection of the upper respiratory tract phase at the PD initial stage, infant occurs some similar colds
Symptom such as pharyngalgia, nasal obstruction, runny nose, cough and slight heating etc..
Content of the invention
The present invention there is provided a kind of medicament having and improving inflammation of the central nervous system, can be with effectively preventing stream
Brain, and do not develop immunity to drugs.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of have the medicament improving inflammation of the central nervous system, is prepared from by the raw material of following weight portion:
Nostoc powder 20-30 part, pine needle yeast powder 25-35 part, Honegsukle flower P.E 15-25 part, isatis root extract 6-
18 parts, forsythia suspense extraction 6-18 part, raw mung bean freeze-dried powder 13-17 part, Cranberry 23-37 part, olive leaf 26-38 part, celery seed
Freeze-dried powder 25-35 part, konjaku flour 27-33 part.
Wherein, described Honegsukle flower P.E prepares gained by following steps:
S11, the aqueous solution of Honegsukle flower P.E is first passed through composite polrvinyl chloride milipore filter and carry out UF membrane, collect and pass through
Liquid, then extract is concentrated into the 11% of original volume with the NF membrane of molecular cut off 250, collect concentrate；
S12, by the concentrate obtaining with the flow velocity of 2-6bv/h pass through macroporous resin column, after Dynamic Adsorption saturation, spend from
Sub- water is colourless to efflux with the above-mentioned macroporous resin column of flow velocity drip washing of 3-11bv/h, then is 30%-110%'s with volume fraction
Organic solvent is eluted with the flow velocity of 7-13bv/h, collects organic solvent eluent until no chlorogenic acid flows out, finally will receive
Collection gained eluent reduced pressure concentration, obtains medicinal extract；
S13, will after medicinal extract water dissolves with the flow velocity of 1-5bv/h pass through polyamide column, after Dynamic Adsorption saturation, use 3-
8bv deionized water is with the above-mentioned polyamide column of flow velocity drip washing of 1-10bv/h, then is the organic molten of 20%-100% with volume fraction
The agent aqueous solution is eluted with the flow velocity of 5-10bv/h, collects organic solvent eluent until no chlorogenic acid flows out, is spray-dried,
Obtain Honegsukle flower P.E.
Wherein, described pine needle yeast powder prepares gained by following steps:
By fresh pine needle after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, protect
Hold temperature 25-35 DEG C, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, obtain pine needle yeast powder.
Wherein, described microbe leaven is by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 3: 2:
1 mixing gained.
Wherein, described isatis root extract prepares gained by following steps:
The Radix Isatidis being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 and divide
Clock, after separation of solid and liquid, reclaims methyl alcohol or ethanol solution, concentrates so that extract is in paste, then with water-saturated n-butanol to carrying
Take thing to extract 4 times, after recycling design, drying concentrated in vacuo for extract obtains isatis root extract.
Wherein, described forsythia suspense extraction prepares gained by following steps:
The capsule of weeping forsythia being dried is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7-1.3mpa, at explosion
Reason 8-25min；Then being passed through rapidly steam to steam explosion pressure inside the tank is 1.3-1.7mpa, Steam explosion treatment 0.5-2.5min,
Filter, the dregs of a decoction are to add water refluxing extraction 2 time at 1: 10 in mass ratio, each refluxing extraction 1 hour, No. 3 extracts of merging are concentrated into
Relative density 1.10-1.20 (room temperature), is spray-dried concentrate, obtains forsythia suspense extraction.
Wherein, described raw mung bean freeze-dried powder prepares gained by following steps:
By raw mung bean after ultramicro grinding, carry out pre-freeze distillation process, pre-freezing temperature is 20 DEG C, pre-freeze time 6h；Rising
China processes separate explosion and processes, and sublimation temperature is -9.5 DEG C, and vacuum is 260pa, sublimation time 210min.
Wherein, described celery seed freeze-dried powder prepares gained by following steps:
It is placed in steam explosion in steam-explosion jar after celery seed is cleaned to process three times, freeze-drying obtains celery seed freeze-dried powder；Wherein,
Onepull processes and keeps pressure to be 0.6-0.9mpa, temperature 65-95 degree Celsius, time 7-23min, and second explosion treatment is protected
Holding pressure is 0.9-1.1mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and it is 3- that third time explosion treatment keeps pressure
5mpa, temperature 70-90 degree Celsius, time 0.8-2.8min.
Wherein, described nostoc powder is nostoc through ultramicro grinding gained；Described konjaku flour is for konjaku through ultramicro grinding institute
?.
The method have the advantages that
By special technique, obtain pine needle yeast powder, Honegsukle flower P.E, isatis root extract, forsythia suspense extraction,
Raw mung bean freeze-dried powder and celery seed freeze-dried powder, and these raw materials are pressed optimal proportion and the combination such as Cranberry, olive leaf, konjaku flour
Together, the resistance of human body with effectively preventing epidemic meningitis, can be increased, and do not develop immunity to drugs.
Specific embodiment
In order that objects and advantages of the present invention become more apparent, with reference to embodiments the present invention is carried out further
Describe in detail.It should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit this
Bright.
In following examples, the Honegsukle flower P.E that used prepares gained by following steps:
S11, the aqueous solution of Honegsukle flower P.E is first passed through composite polrvinyl chloride milipore filter and carry out UF membrane, collect and pass through
Liquid, then extract is concentrated into the 11% of original volume with the NF membrane of molecular cut off 250, collect concentrate；
S12, by the concentrate obtaining with the flow velocity of 2-6bv/h pass through macroporous resin column, after Dynamic Adsorption saturation, spend from
Sub- water is colourless to efflux with the above-mentioned macroporous resin column of flow velocity drip washing of 3-11bv/h, then is 30%-110%'s with volume fraction
Organic solvent is eluted with the flow velocity of 7-13bv/h, collects organic solvent eluent until no chlorogenic acid flows out, finally will receive
Collection gained eluent reduced pressure concentration, obtains medicinal extract；
S13, will after medicinal extract water dissolves with the flow velocity of 1-5bv/h pass through polyamide column, after Dynamic Adsorption saturation, use 3-
8bv deionized water is with the above-mentioned polyamide column of flow velocity drip washing of 1-10bv/h, then is the organic molten of 20%-100% with volume fraction
The agent aqueous solution is eluted with the flow velocity of 5-10bv/h, collects organic solvent eluent until no chlorogenic acid flows out, is spray-dried,
Obtain Honegsukle flower P.E.
The pine needle yeast powder being used prepares gained by following steps:
By fresh pine needle after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, protect
Hold temperature 25-35 DEG C, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, obtain pine needle yeast powder.Wherein, described microorganism
Leavening mixes gained by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 3: 2: 1.
The isatis root extract being used prepares gained by following steps:
The Radix Isatidis being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 and divide
Clock, after separation of solid and liquid, reclaims methyl alcohol or ethanol solution, concentrates so that extract is in paste, then with water-saturated n-butanol to carrying
Take thing to extract 4 times, after recycling design, drying concentrated in vacuo for extract obtains isatis root extract.
The forsythia suspense extraction being used prepares gained by following steps:
The capsule of weeping forsythia being dried is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7-1.3mpa, at explosion
Reason 8-25min；Then being passed through rapidly steam to steam explosion pressure inside the tank is 1.3-1.7mpa, Steam explosion treatment 0.5-2.5min,
Filter, the dregs of a decoction are to add water refluxing extraction 2 time at 1: 10 in mass ratio, each refluxing extraction 1 hour, No. 3 extracts of merging are concentrated into
Relative density 1.10-1.20 (room temperature), is spray-dried concentrate, obtains forsythia suspense extraction.
The raw mung bean freeze-dried powder being used prepares gained by following steps:
By raw mung bean after ultramicro grinding, carry out pre-freeze distillation process, pre-freezing temperature is 20 DEG C, pre-freeze time 6h；Rising
China processes separate explosion and processes, and sublimation temperature is -9.5 DEG C, and vacuum is 260pa, sublimation time 210min.
The celery seed freeze-dried powder being used prepares gained by following steps:
It is placed in steam explosion in steam-explosion jar after celery seed is cleaned to process three times, freeze-drying obtains celery seed freeze-dried powder；Wherein,
Onepull processes and keeps pressure to be 0.6-0.9mpa, temperature 65-95 degree Celsius, time 7-23min, and second explosion treatment is protected
Holding pressure is 0.9-1.1mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and it is 3- that third time explosion treatment keeps pressure
5mpa, temperature 70-90 degree Celsius, time 0.8-2.8min.
The nostoc powder being used is nostoc through ultramicro grinding gained；The konjaku flour being used is konjaku through ultramicro grinding
Gained.
Embodiment 1
A kind of have the medicament improving inflammation of the central nervous system, is prepared from by the raw material of following weight portion:
20 parts of nostoc powder, 25 parts of pine needle yeast powder, 15 parts of Honegsukle flower P.E, 6 parts of isatis root extract, the capsule of weeping forsythia extract
6 parts of thing, 13 parts of raw mung bean freeze-dried powder, 23 parts of Cranberry, 26 parts of olive leaf, 25 parts of celery seed freeze-dried powder, 27 parts of konjaku flour.
Embodiment 2
A kind of have the medicament improving inflammation of the central nervous system, is prepared from by the raw material of following weight portion:
30 parts of nostoc powder, 35 parts of pine needle yeast powder, 25 parts of Honegsukle flower P.E, 18 parts of isatis root extract, the capsule of weeping forsythia carry
Take 18 parts of thing, 17 parts of raw mung bean freeze-dried powder, 37 parts of Cranberry, 38 parts of olive leaf, 35 parts of celery seed freeze-dried powder, 33 parts of konjaku flour.
Embodiment 3
A kind of have the medicament improving inflammation of the central nervous system, is prepared from by the raw material of following weight portion:
25 parts of nostoc powder, 30 parts of pine needle yeast powder, 20 parts of Honegsukle flower P.E, 12 parts of isatis root extract, the capsule of weeping forsythia carry
Take 12 parts of thing, 15 parts of raw mung bean freeze-dried powder, 30 parts of Cranberry, 32 parts of olive leaf, 30 parts of celery seed freeze-dried powder, 30 parts of konjaku flour.
The above is only the preferred embodiment of the present invention it is noted that ordinary skill people for the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of there is the medicament improving inflammation of the central nervous system it is characterised in that by following weight portion raw material prepare and
Become:
Nostoc powder 20-30 part, pine needle yeast powder 25-35 part, Honegsukle flower P.E 15-25 part, isatis root extract 6-18 part,
Forsythia suspense extraction 6-18 part, raw mung bean freeze-dried powder 13-17 part, Cranberry 23-37 part, olive leaf 26-38 part, celery seed freeze-dried powder
25-35 part, konjaku flour 27-33 part.
2. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described gold and silver
Flower extract prepares gained by following steps:
S11, the aqueous solution of Honegsukle flower P.E is first passed through composite polrvinyl chloride milipore filter and carries out UF membrane, collect permeate,
Extract is concentrated into the 11% of original volume with the NF membrane of molecular cut off 250 again, collects concentrate；
S12, by the concentrate obtaining with the flow velocity of 2-6bv/h pass through macroporous resin column, after Dynamic Adsorption saturation, deionized water
Colourless to efflux with the above-mentioned macroporous resin column of flow velocity drip washing of 3-11bv/h, then be the organic of 30%-110% with volume fraction
Solvent is eluted with the flow velocity of 7-13bv/h, collects organic solvent eluent until no chlorogenic acid flows out, finally will collect institute
Obtain eluent reduced pressure concentration, obtain medicinal extract；
S13, will after medicinal extract water dissolves with the flow velocity of 1-5bv/h pass through polyamide column, after Dynamic Adsorption saturation, gone with 3-8bv
Ionized water is with the above-mentioned polyamide column of flow velocity drip washing of 1-10bv/h, then the organic solvent being 20%-100% with volume fraction is water-soluble
Liquid is eluted with the flow velocity of 5-10bv/h, collects organic solvent eluent until no chlorogenic acid flows out, is spray-dried, obtains gold and silver
Flower extract.
3. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described pine needle
Yeast powder prepares gained by following steps:
By fresh pine needle after ultramicro grinding, according to the ratio microbe inoculation leavening of inoculum concentration 1.5-1.7%, keep temperature
25-35 DEG C of degree, after fermentation 48-54 hour, high-temperature inactivation, low temperature drying, obtain pine needle yeast powder.
4. a kind of as claimed in claim 3 have the medicament improving inflammation of the central nervous system it is characterised in that described micro- life
Thing leavening mixes gained by Bacillus acidi lactici, bacillus licheniformis, Corynebacterium glutamicum in mass ratio 3: 2: 1.
5. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described plate is blue
Root extract prepares gained by following steps:
The Radix Isatidis being dried is placed in 90% methyl alcohol or the ethanol solution that flash extracter adds 6 times of volumes, processes 1-3 minute,
After separation of solid and liquid, reclaim methyl alcohol or ethanol solution, concentrate so that extract is in paste, then with water-saturated n-butanol to extraction
Thing extracts 4 times, after recycling design, drying concentrated in vacuo for extract obtains isatis root extract.
6. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that the described capsule of weeping forsythia
Extract prepares gained by following steps:
The capsule of weeping forsythia being dried is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7-1.3mpa, explosion treatment 8-
25min；Then being passed through rapidly steam to steam explosion pressure inside the tank is 1.3-1.7mpa, Steam explosion treatment 0.5-2.5min, filters,
The dregs of a decoction add water refluxing extraction 2 times for 1: 10 in mass ratio, and each refluxing extraction 1 hour merges No. 3 extracts, is concentrated into relatively
Density 1.10-1.20 (room temperature), is spray-dried concentrate, obtains forsythia suspense extraction.
7. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described life is green
Beans freeze-dried powder prepares gained by following steps:
By raw mung bean after ultramicro grinding, carry out pre-freeze distillation process, pre-freezing temperature is 20 DEG C, pre-freeze time 6h；At distillation
Reason separate explosion is processed, and sublimation temperature is -9.5 DEG C, and vacuum is 260pa, sublimation time 210min.
8. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described celery
Seed freeze-dried powder prepares gained by following steps:
It is placed in steam explosion in steam-explosion jar after celery seed is cleaned to process three times, freeze-drying obtains celery seed freeze-dried powder；Wherein, for the first time
It is 0.6-0.9mpa, temperature 65-95 degree Celsius, time 7-23min that explosion treatment keeps pressure, and second explosion treatment keeps pressure
Power is 0.9-1.1mpa, temperature 95-115 degree Celsius, time 0.8-1.2min, and it is 3- that third time explosion treatment keeps pressure
5mpa, temperature 70-90 degree Celsius, time 0.8-2.8min.
9. a kind of as claimed in claim 1 have the medicament improving inflammation of the central nervous system it is characterised in that described Ge Xian
Ground rice is nostoc through ultramicro grinding gained；Described konjaku flour is konjaku through ultramicro grinding gained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610668034.7A CN106334044A (en) | 2016-08-16 | 2016-08-16 | Medicament capable of improving central nervous system inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610668034.7A CN106334044A (en) | 2016-08-16 | 2016-08-16 | Medicament capable of improving central nervous system inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106334044A true CN106334044A (en) | 2017-01-18 |
Family
ID=57825014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610668034.7A Pending CN106334044A (en) | 2016-08-16 | 2016-08-16 | Medicament capable of improving central nervous system inflammation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106334044A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110419741A (en) * | 2018-08-07 | 2019-11-08 | 湖南炎帝生物工程有限公司 | Nostoc composition and its application in improvement diarrhea, mitigation intestinal inflammatory |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940727A (en) * | 2009-07-03 | 2011-01-12 | 王学文 | Chinese medicinal preparation for treating epidemic meningitis |
| CN102258556A (en) * | 2010-05-29 | 2011-11-30 | 宫怀恒 | Oral liquid for preventing epidemic meningitis |
| CN104189644A (en) * | 2014-09-14 | 2014-12-10 | 洪满 | Combined traditional Chinese medicine for treating purulent meningitis |
| CN105535286A (en) * | 2016-01-17 | 2016-05-04 | 新乡医学院第一附属医院 | Traditional Chinese medicine composition for resisting tumors in internal medicine |
| CN105535116A (en) * | 2015-12-23 | 2016-05-04 | 辽宁科技学院 | Natural medicinal material extract and preparation method thereof |
| CN105709209A (en) * | 2016-01-17 | 2016-06-29 | 新乡医学院第一附属医院 | Medicine for treating tumor and preparation method thereof |
| CN105727015A (en) * | 2016-02-06 | 2016-07-06 | 济南市第三人民医院 | Composition for regulating blood lipid and blood pressure and preparation method thereof |
| CN105748764A (en) * | 2016-03-12 | 2016-07-13 | 华北理工大学 | Traditional Chinese medicine composition with antibacterial and anti-inflammation effects and preparation method of composition |
-
2016
- 2016-08-16 CN CN201610668034.7A patent/CN106334044A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940727A (en) * | 2009-07-03 | 2011-01-12 | 王学文 | Chinese medicinal preparation for treating epidemic meningitis |
| CN102258556A (en) * | 2010-05-29 | 2011-11-30 | 宫怀恒 | Oral liquid for preventing epidemic meningitis |
| CN104189644A (en) * | 2014-09-14 | 2014-12-10 | 洪满 | Combined traditional Chinese medicine for treating purulent meningitis |
| CN105535116A (en) * | 2015-12-23 | 2016-05-04 | 辽宁科技学院 | Natural medicinal material extract and preparation method thereof |
| CN105535286A (en) * | 2016-01-17 | 2016-05-04 | 新乡医学院第一附属医院 | Traditional Chinese medicine composition for resisting tumors in internal medicine |
| CN105709209A (en) * | 2016-01-17 | 2016-06-29 | 新乡医学院第一附属医院 | Medicine for treating tumor and preparation method thereof |
| CN105727015A (en) * | 2016-02-06 | 2016-07-06 | 济南市第三人民医院 | Composition for regulating blood lipid and blood pressure and preparation method thereof |
| CN105748764A (en) * | 2016-03-12 | 2016-07-13 | 华北理工大学 | Traditional Chinese medicine composition with antibacterial and anti-inflammation effects and preparation method of composition |
Non-Patent Citations (3)
| Title |
|---|
| 刘基柱 主编: "《中草药识别与应用 上册》", 31 May 2010, 广东人民出版社 * |
| 周德生 等主编: "《中医验方全书（珍藏本）》", 31 January 2011, 湖南科学技术出版社 * |
| 韦桂宁 等主编: "《小偏方胜名医 独特偏方祛百病》", 30 September 2015, 军事医学科学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110419741A (en) * | 2018-08-07 | 2019-11-08 | 湖南炎帝生物工程有限公司 | Nostoc composition and its application in improvement diarrhea, mitigation intestinal inflammatory |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101518558B (en) | Artemisia extract containing high content of eupatilin | |
| CN105796892A (en) | Traditional Chinese medicine extractive composition and preparation method thereof | |
| CN112870236B (en) | Flavone effective part of abelmoschus manihot and preparation method and application thereof | |
| CN107303303B (en) | Prepare Tongkat Ali active ingredient and combination application | |
| CN104140403B (en) | A kind of separation purifying technique of rographolide | |
| CN103623075B (en) | The preparation method of Flos Trollii extract | |
| CN104274721A (en) | Preparation method of cold heat clearing granules | |
| CN106334044A (en) | Medicament capable of improving central nervous system inflammation | |
| CN100434093C (en) | 'Kidney-Benefiting' glucose injection and its preparing process | |
| CN105943569A (en) | Method for extracting effective ingredients of green plums | |
| CN102228488A (en) | Preparation of Lysimachia capillipes Hemsl total saponin | |
| CN108066501A (en) | A kind of Lignum Aquilariae Resinatum extract and its application with effect of lowering blood sugar | |
| CN104127471A (en) | Preparation method and quality control method for honeysuckle flower formula granule | |
| CN106478419B (en) | Separation prepares the method and its application of Rosmarinic acid from dracocephalum heterophyllum | |
| CN103251908B (en) | Hair-restorer and preparation method thereof | |
| CN108403732A (en) | A kind of industrial process of green plum total extract | |
| CN106421545A (en) | Poultry antiviral traditional Chinese veterinary medicine | |
| CN102362949B (en) | Medicine for treating chronic pelvic inflammation and preparation method thereof | |
| CN101953872B (en) | Method for preparing Chinese medicinal preparation for treating influenza | |
| CN102423371A (en) | Chinese medicinal drug withdrawal cigarette and preparation process thereof | |
| CN102631583B (en) | External nasal delivery preparation for preventing and treating influenza | |
| CN103141844A (en) | Food capable of increasing immunity and preparation method thereof | |
| CN101389344A (en) | Synthesized medicament and method for treating HIV | |
| CN110917264B (en) | Preparation method of oral liquid for treating infantile common cold | |
| CN107823912A (en) | A kind of method that Chinese herbal and crude drugs preparations is extracted using membrane separation technique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170118 |
|
| RJ01 | Rejection of invention patent application after publication |