The object of the present invention is to provide a kind ofly SHENKANG ZHUSHEYE is changed agent to become injection kidney health glucose injection and preparation technology thereof, can reduce dosing and pollute, easy to use.
The present invention extracts the injection kidney health glucose injection of making by Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the Radix Astragali, Flos Carthami, and its raw material is made up of for 10~20 parts 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes, 40~70 parts of the Radixs Astragali, Flos Carthami.Can obtain by following 6 kinds of process routes during preparation:
Preparation technology 1:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~12 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution, adds ethanol and makes that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70~80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12~48 hours filters filtrate for later use; 40~70 parts of the Radixs Astragali, Flos Carthami is cleaned with distilled water respectively for 10~20 parts, decoct three times with 6~12 times of distilled water, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution and adds ethanol and make that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; Merge above-mentioned reserve liquid, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100~500ml infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 2:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~12 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70~80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol and make that to contain alcohol amount be 70~80%, transfer PH7.5, one night of airtight placement, filter, filtrate recycling ethanol is not to there being the alcohol flavor, contains crude drug 2g, cold preservation 12~48 hours with distilled water diluting to every 1ml, filter filtrate for later use; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there not being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 70~80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12~48 hours filters filtrate for later use; 40~70 parts of the Radixs Astragali, 10~20 parts on Flos Carthami is clean with distilled water, decoct three times with 6~12 times of distilled water respectively, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol again and make that to contain the alcohol amount be 70~80% with distilled water diluting, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use with distilled water diluting to every 1ml; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 3:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~12 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, waving most alcohol does not extremely have the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70~80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; 10~20 parts of 40~70 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 6~12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1~40,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, and filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filters, and filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 4:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~12 times of distilled water respectively, decocting time was respectively 1~2 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there not being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate for later use; 10~20 parts on Flos Carthami is clean with distilled water, use 6~12 times 80 ℃ distilled water warm macerating secondaries respectively, decocting time was respectively 1 hour, merged the secondary decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Flos Carthami concentrated solution adds ethanol makes that to contain the alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter filtrate and Radix Salviae Miltiorrhizae, big yellow filtrate merges, and uses ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40~70 parts of the Radixs Astragali are clean with distilled water, decoct three times with 6~12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 5:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~12 times of distilled water, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70~80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40~70 parts of the Radixs Astragali, 10~20 parts on Flos Carthami is clean with distilled water, decoct three times with 6~12 times of distilled water, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Preparation technology 6:
With 10~20 parts of Radix Et Rhizoma Rhei, 10~20 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 6~42 times of distilled water respectively, decocting time was respectively 1~2 hour, merged three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 70~80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 70~80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 40~70 parts of the Radixs Astragali, 10~20 parts on Flos Carthami is clean with distilled water, decoct three times with 6~12 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 45~70%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
The invention has the advantages that can reduce dosing pollutes, easy to use.
With specific embodiment the present invention is elaborated below:
Embodiment 1:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution, adds ethanol and makes that to contain the alcohol amount be 60%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12~48 hours filters filtrate for later use; 55 parts of the Radixs Astragali, Flos Carthami is cleaned with distilled water respectively for 15 parts, decoct three times with 8 times of distilled water, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, merges concentrated solution and adds ethanol and make that to contain the alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; Merge above-mentioned reserve liquid, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100~500ml infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 2:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol and make that to contain alcohol amount be 80%, transfer PH7.5, one night of airtight placement, filter, filtrate recycling ethanol is not to there being the alcohol flavor, contains crude drug 2g, cold preservation 12~48 hours with distilled water diluting to every 1ml, filter filtrate for later use; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there not being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol and make that to contain the alcohol amount be 80% with distilled water diluting, transfer PH7.5, one night of airtight placement filters, and filtrate recycling ethanol is to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, cold preservation 12~48 hours filters filtrate for later use; 55 parts of the Radixs Astragali, 15 parts on Flos Carthami is clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add ethanol again and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use to every 1ml with distilled water diluting; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, add ethanol again and make that to contain the alcohol amount be 80% with distilled water diluting, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g, filtrate for later use with distilled water diluting to every 1ml; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate being sub-packed in is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 3:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, waving most alcohol does not extremely have the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there not being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; 10~20 parts of 40~70 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, and with 8 times of distilled water decoctions three times, decocting time was respectively 1 hour respectively, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter, filtrate is with 1~40,000 fenestra ultrafiltration, and ultrafiltrate is standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, and filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, filters, and filtrate is with 1~20,000 fenestra ultrafiltration, and ultrafiltrate is standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 4:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1~2 hour, merged three times decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there not being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filtration, filtrate for later use; 15 parts on Flos Carthami is clean with distilled water, use 8 times 80 ℃ distilled water warm macerating secondaries respectively, decocting time was respectively 1 hour, merged the secondary decocting liquid, after leaving standstill 12~48 hours, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Flos Carthami concentrated solution adds ethanol makes that to contain the alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, filter filtrate and Radix Salviae Miltiorrhizae, big yellow filtrate merges, and uses ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 55 parts of the Radixs Astragali are clean with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 5:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 15 parts of 55 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 8 times of distilled water, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned reserve liquid, add glucose 100g heating for dissolving, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours, filter, filtrate adds injection and is diluted with water to about 50% concentration, transfers PH7.5 with sodium hydroxide, add injection water to 1000ml, filter, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, and filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.
Embodiment 6:
With 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Salviae Miltiorrhizaes are clean with distilled water, decoct three times with 8 times of distilled water respectively, and decocting time was respectively 1~2 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, and the Radix Salviae Miltiorrhizae concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contains crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, to there being the tannin reaction, placed 2~4 hours after fully stirring, add ethanol and make that to contain that alcohol measures be 80%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Radix Et Rhizoma Rhei concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours filters filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, add 3~5% gelatin solution, after fully stirring to there being the tannin reaction, placed 2~4 hours, add ethanol and make that to contain alcohol amount be 80%, cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with ethyl acetate extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; 15 parts of 55 parts of the Radixs Astragali, Flos Carthami are cleaned with distilled water, decoct three times with 8 times of distilled water respectively, decocting time was respectively 1 hour, merge three times decocting liquid, leave standstill 12~48 hours after, filter, it is 1.00-1.15 that filtrate is concentrated into 60 ℃ of relative densities, Radix Astragali concentrated solution adds ethanol makes that to contain alcohol amount be 60%, and cold preservation 12~48 hours filters, filtrate recycling ethanol, wave most alcohol to there not being the alcohol flavor, contain crude drug 2g to every 1ml, with water saturated n-butanol extraction 2~6 times with distilled water diluting, combining extraction liquid, reclaim n-butyl alcohol, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; The Flos Carthami concentrated solution adds ethanol makes that to contain alcohol amount be 60%, cold preservation 12~48 hours, filter, filtrate recycling ethanol is waved most alcohol to there not being the alcohol flavor, contain crude drug 2g with distilled water diluting to every 1ml, with ethyl acetate extraction 2~6 times, combining extraction liquid, reclaim ethyl acetate, add the injection water and contain crude drug 1g crude drug to every 1ml, standby; Merge above-mentioned all reserve liquids, add the injection water and contain crude drug 1g, adding glucose 100g heating for dissolving to every 1ml, added 0.2~0.5% active carbon heated and boiled 15~30 minutes, cold preservation 12 hours filters, filtrate adds injection and is diluted with water to about 50% concentration, transfer PH7.5 with sodium hydroxide, add injection water, filter to 1000ml, the microporous filter membrane that filtrate is crossed 0.2 μ m filters, filtrate is sub-packed in 100~500ml and is sub-packed in the infusion bottle, 115 ℃ of pressure sterilizings 30 minutes, promptly.