CN102475761B - Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation - Google Patents
Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation Download PDFInfo
- Publication number
- CN102475761B CN102475761B CN 201110326041 CN201110326041A CN102475761B CN 102475761 B CN102475761 B CN 102475761B CN 201110326041 CN201110326041 CN 201110326041 CN 201110326041 A CN201110326041 A CN 201110326041A CN 102475761 B CN102475761 B CN 102475761B
- Authority
- CN
- China
- Prior art keywords
- time
- water
- ethanol
- add
- bright
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Shenkang oral solid compound preparation for treating chronic renal failure, which is characterized by being prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of the red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation; and then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, carrying out secondary ethanol precipitation and water precipitation, and condensing and drying to obtain the oral solid compound preparation. The Shenkang oral solid compound preparation has the advantages of precision in regulating the original ratio, high in content of effective ingredients in the unit volume, few precipitations, small side effect, high acting speed and high bioavailability.
Description
Technical field
The invention belongs to oral preparation of Chinese traditional medicinal, particularly about a kind of kidney health oral administration solid compound preparation for the treatment of chronic kidney hypofunction and preparation method thereof.
Background technology
Former patent 200410039418.X discloses a kind of medicine for treating chronic kidney failure and preparation method thereof; what its prescription was protected is the Chinese medicine scope of application; there is no concrete proportion relation; although also disclose the case of prescription in patent document embodiment; but Radix Astragali input amount is larger; and the Radix Astragali and Radix Et Rhizoma Rhei have precipitation, the Radix Astragali and Radix Salviae Miltiorrhizae also respond, and the Radix Astragali is measured few drug effect that also affects in the compatibility of preparation.Because the proportion relation of Chinese medicine directly has influence on the curative effect of preparation, so the accurate and little side effect of prescription is vital.
Summary of the invention
The objective of the invention is: a kind of kidney health oral administration solid compound preparation for the treatment of chronic kidney hypofunction and preparation method thereof is provided, and it is to have done accurate adjustment on original proportioning, and in unit volume, active constituent content is high, and precipitation is few, and side effect is little, uses convenient.
Technical scheme of the present invention is: a kind of kidney health oral administration solid compound preparation for the treatment of chronic kidney hypofunction is provided, it is characterized in that it is to be made by the crude drug of following proportioning: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.
The preparation method of kidney health oral administration solid compound preparation of the present invention, after crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae are extracted by above-mentioned formula proportion amount, first precipitate with ethanol, tannin-removing, again secondary precipitate with ethanol, water precipitating, repeatedly after time precipitate with ethanol, secondary water precipitating; Again by the Radix Astragali, Flos Carthami by above-mentioned formula proportion amount extract, again precipitate with ethanol, water precipitating, again secondary precipitate with ethanol, water precipitating, ultrafiltration, concentrated, dry, make oral solid formulation.
The preparation method of kidney health oral administration solid compound preparation of the present invention is: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the 7-12 that amount of water is crude drug for the first time doubly measures, after soaking 30min, boil 30min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 30min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add the 4 times amounts of water to medicinal liquid, it is clear and bright and when being concentrated into relative density and being 60 ℃ 1.18～1.25 that cold preservation 38～55h gets supernatant liquid filtering, adding 95% ethanol is 80% to measuring containing alcohol, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, standby, the dosage Flos Carthami, Milkvetch Root, the 7-12 that amount of water is crude drug for the first time doubly measures, soak 30min, boil 45min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 45min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 4 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 38-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, by above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution merges, stir, ultrafiltration, filtrate is concentrated into relative density in the time of 60 ℃ 1.18～1.25, after 60 ℃ of dryings, pulverize, add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill, or concentrated pill.
The preparation method of kidney health oral administration solid compound preparation of the present invention is: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, 10 times of amounts that amount of water is crude drug for the first time, after soaking 30min, boil 30min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 30min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add the 4 times amounts of water for injection to medicinal liquid, cold preservation 42～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.20～1.22, adding 95% ethanol is 80% to measuring containing alcohol, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, standby, the dosage Flos Carthami, Milkvetch Root, 10 times of amounts that amount of water is crude drug for the first time, soak 30min, boil 45min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 45min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add the 4 times amounts of water to medicinal liquid, it is clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22 that cold preservation 42-55h gets supernatant liquid filtering, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 48-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 48～55h, get supernatant liquid filtering clear and bright after, standby, by above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution, mixing and stirring, ultrafiltration, filtrate is concentrated into relative density in the time of 60 ℃ 1.20～1.22, after 60 ℃ of dryings, pulverize, add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill or concentrated pill.
The described appropriate amount of auxiliary materials that adds is made capsule, be by the said medicine ultrafiltration by the concentration extraction powdered, again by starch 100g, carboxymethylstach sodium 50g, microcrystalline Cellulose 50g, after crossing respectively 80 mesh sieves, evenly mix, and adds appropriate adhesive and make soft material, granulates; Granule is 60 ℃ of dryings.Add carboxymethylstach sodium, micropowder silica gel, magnesium stearate and Pulvis Talci mix homogeneously to measure the content of middle product; With No. 1 capsule dress capsule, prepare 2500, packing.
The described appropriate amount of auxiliary materials that adds is made enteric coated capsule, be by the said medicine ultrafiltration by the concentration extraction powdered, again by starch 20g, carboxymethylstach sodium 10g, after crossing respectively 80 mesh sieves, evenly mix, add appropriate adhesive and make soft material, granulate; Granule is 60 ℃ of dryings.Add carboxymethylstach sodium, micropowder silica gel, magnesium stearate and Pulvis Talci mix homogeneously to measure the content of middle product; With No. 1 enteric coated capsule dress capsule, prepare 2500, packing.
Describedly add the agent of appropriate amount of auxiliary materials granulation, be by the said medicine ultrafiltration by the concentration extraction powdered, then by lactose 250g, microcrystalline Cellulose 100g, magnesium trisilicate 150g, sucrose 500g, add suitable amount of adhesive, makes soft material, granulates; After 60 ℃ of dryings, detect qualified after, be sub-packed in medicinal polyethylene plastic bag, every bag of 10g, make 150 bags altogether, obtains.
The described appropriate amount of auxiliary materials that adds is made powder, is that the said medicine ultrafiltration is become to fine powder by concentration extraction, after crushed, adds appropriate amount of auxiliary materials, is sub-packed in polyethylene plastic bag, is divided into and fills 300 bags, and the moisture barrier bag parcel, obtain.
The described appropriate amount of auxiliary materials that adds is made honeyed pill, is that the said medicine ultrafiltration is made to fine powder by concentration extraction, with Mel 2500g, as binding agent, is rolled onto the 10g pill, makes altogether 300 balls, packing.
The described appropriate amount of auxiliary materials that adds is made the watered pill, is that the said medicine ultrafiltration is made to fine powder by concentration extraction, uses lactose 1000g, adds the pellet shapes pill that suitable amount of adhesive is made, and every bag of packing 5g, make 300 bags altogether.
The invention has the advantages that:
One, its prescription proportioning is the improvement of doing on original patent 96117626.1,03141399.4, ZL03108156.8, ZL200410039420.7, ZL200410004359.2, ZL200410039418 basis, because in former patent, Radix Astragali input amount is high, because the Radix Astragali and Radix Et Rhizoma Rhei have precipitation, the Radix Astragali and Radix Salviae Miltiorrhizae also can react, if Radix Astragali input amount in the compatibility of preparation is few, can affect drug effect again.The proportioning of ZL200410039420.7, ZL200410039418.X embodiment is 1.0: 1.0: 7.0: 1.0 and 1.5: 1.5: 5.5: 1.5, ZL03108156.8,03141399.4 prescription proportioning in an embodiment is 1.5: 1.0: 1.0: 1.5, several patent taste of Chinese medicine proportion relations are fully different.The present invention, through a large amount of experiment contrasts, proves that proportioning effect of the present invention is better, and its experiment Data Comparison is as follows:
Following prescription one consumption: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g, appropriate amount of auxiliary materials.(prescription of the present invention).
Its prescription two consumptions are: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 5500g, Flos Carthami 1500g, appropriate amount of auxiliary materials.
Its prescription three consumptions are: Radix Et Rhizoma Rhei 1667g, Radix Salviae Miltiorrhizae 1667g, Radix Astragali 5000g, Flos Carthami 1666g, appropriate amount of auxiliary materials.
Its prescription four-function amount is: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1500g, Flos Carthami 1000g, appropriate amount of auxiliary materials.
Its prescription five consumptions are: Radix Et Rhizoma Rhei 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 7000g, Flos Carthami 1000g, appropriate amount of auxiliary materials.
Animal experiment study shows: five kinds of prescriptions all can reduce blood urea nitrogen (BUN), creatinine (Cr) level of chronic renal failure (CRF) rat, alleviate the azotemia that carrying out property increases the weight of, rising hemoglobin (Hb), improve anemia, still can improve albumin (ALB) level to adenine CRF rat, renal hypertrophy is alleviated, and the kidney coefficient obviously reduces.And prescription one effect is more obvious, be better than other each prescriptions.Experimental result refers to following table 1-5.
Five kinds of prescriptions of table 1 are on the impact of CRF rat blood serum blood urea nitrogen due to adenine relatively (mmol/L, X ± SD)
Compare * P<0.05, * * P<0.01 with model group
Due to five kinds of prescription Dui Xianpiao ridges of table 2, (μ mol/L, X ± SD) compared in the impact of CRF rat blood serum creatinine
With model group, compare: * P<0.05, * * P<0.01
Experimental result shows: the rats gavaged adenine is after two weeks, and blood BUN, Cr raise, and is significantly higher than normal rat (p<0.01), shows that CRF forms, and grouping is treated.During treatment, continue to the rats gavaged adenine, its blood BUN, Cr continues to rise, after treating 5 weeks, model group rat BUN, Cr rise to respectively 6.5 times of normal rat with 4.3 times, show that this model presents the azotemia that carrying out property increases the weight of, the injection tail vein injection treatment rat made from five kinds of prescriptions respectively, its blood BUN, Cr is along with the blood BUN of model group rat, the rising of Cr also raises gradually, the blood BUN for the treatment of group rat, the Cr rate of climb and amplitude will be lower than model group, treat 3 weeks with after 5 weeks, the blood BUN for the treatment of group, the Cr level is starkly lower than model group (p<0.05 or p<0.01), and the blood BUN of prescription one treatment group rat, the Cr rate of climb and amplitude are still lower than all the other each prescription group treatment groups, show that prescription one reduces the blood BUN of adenine CRF rat, Cr, improve the effect of azotemia, be better than prescription two and prescription three, prescription four, prescription five.
Five kinds of prescriptions of table 3 are on the impact of CRF rat hemoglobin due to adenine relatively (g/L, X ± SD)
With model group, compare: * P<0.05, * * P<0.01
Experimental result shows: the rats gavaged adenine is after two weeks, and the existing institute of Hb level descends, and along with the increase that gives the adenine number of days, Hb also decreases, and after treatment 5 weeks, model group rat Hb level is significantly lower than normal rat (P<0.01).Although injection for treating group rat Hb is also reducing gradually, decrease speed is slower, and in treatment, in the time of 5 weeks, its Hb level is significantly higher than the model group same period (P<0.05), and the successful of prescription one is better than all the other each prescription groups.Show that prescription one can alleviate the Anemia of adenine CRF rat, effect is better than prescription two and prescription three, prescription four, prescription five.
Five kinds of prescriptions of table 4 are on the impact of CRF rat serum albumin due to adenine relatively (g/L, X ± SD)
With model group, compare: * P<0.05, * * P<0.01
Experimental result shows: the model group rat is after treatment 5 weeks, serum albumin obviously reduces (with normal rat, comparing P<0.05), hypoalbuminemia when treatment group can be improved rat CRF, while treating 5 weeks, serum albumin levels is significantly higher than model group (p<0.05).Prescription one effect is significantly better than all the other four groups.
Five kinds of prescriptions of table 5 are on the impact of CRF kidney of rats coefficient due to adenine relatively (mg/100g body weight, X ± SD)
With model group, compare: * P<0.05, * * P<0.01
Experimental result shows: the rat of oral adenine retains right renal hypertrophy, and weight obviously increases, normal 4.4 times of the kidney coefficient average out to of model group.The kidney coefficient of injection for treating group rat all is less than model group, and there were significant differences for the kidney coefficient (p<0.01 and p<0.05), and prescription one kidney coefficient is less than all the other four groups.
Two, the invention has the advantages that medicine is directly oral, easy to use, bioavailability is high, short treating period, and good effect, have QI invigorating and consolidate, and the effect of dissipating stasis and purging turbidity, be applicable to chronic renal failure, especially infringement more than the renal function moderate had to better effects.
Animal experiment study shows: kidney-healing pills agent, granule, powder, pill all can obviously reduce (CRF) rat serum blood urea nitrogen (BUN), creatinine (Cr) level, alleviate the azotemia that carrying out property increases the weight of, rising hemoglobin (Hb), improve anemia, still can improve albumin (ALB) level to 5/6 nephrectomy CRF rat, renal hypertrophy is alleviated, and the kidney coefficient reduces, and experimental result refers to following table 1-5.
The impact (mmol/L, X ± SD) of table 1 kidney health oral administration solid compound preparation on 5/6 nephrectomy CRF rat blood serum blood urea nitrogen
Annotate: with model group, compare: * P<0.05, * * P<0.01
The impact (μ mol/L, X ± SD) of table 2 kidney health oral administration solid compound preparation on 5/6 nephrectomy CRF rat blood serum creatinine
Annotate: with model group, compare: * P<0.05, * * P<0.01
Experimental result shows: after rat is cut 5/6 nephridial tissue, carrying out property of blood BUN, Cr increases, postoperative 5 weeks BUN, Cr rise to respectively 5.6 times of normal rat with 4.2 times, show that CRF forms.During the treatment of kidney health oral administration solid compound preparation, relatively have no obvious rising before the BUN of each treatment group rat, Cr level and self treatment, treat after 5 weeks and also slightly descend, with the same period model group compare, the BUN for the treatment of group, Cr level are all lower, p while treating 5 weeks<0.05.
The impact (g/L, X ± SD) of table 3 kidney health oral administration solid compound preparation on 5/6 nephrectomy CRF rat hemoglobin
Annotate: with model group, compare: * P<0.05, * * P<0.01
The impact (g/L, X ± SD) of table 4 kidney health oral administration solid compound preparation on 5/6 nephrectomy CRF rat serum albumin
Annotate: with model group, compare: * P<0.05, * * P<0.01
Experimental result shows: after the nephrectomy 8 weeks, obvious anemia and hypoproteinemia have appearred in rat, and put off in time and continue to increase the weight of, kidney health oral administration solid compound preparation is improved the effect of its anemia, than model group, rebound significantly (p<0.05) is arranged when treating 5 weeks.To hypoalbuminemia, kidney health oral administration solid compound preparation also has some improvement.
The impact (mg/100g body weight, X ± SD) of table 5 kidney health oral administration solid compound preparation on 5/6 nephrectomy CRF kidney of rats coefficient
Annotate: with model group, compare: * P<0.05, * * P<0.01
Experimental result shows: treat after 5 weeks and put to death rat and cut open and get kidney, visible residual kidney obviously increases (1.7 times that the average kidney coefficient of model group is normal group) while performing the operation.The kidney coefficient of kidney health oral administration solid compound preparation treatment group rat is less than model group.Show that treatment group can alleviate the glomerule hypertrophy, suppress mesangial cell and matrix secreted, obviously reduce the hardening ratio of glomerule, alleviate renal tubules overdistension and epithelial damage, alleviate interstitial fibrosis, promote reparation and the mitochondrial hyperplasia of renal cells.
Three, the preparation method of described kidney health oral administration solid compound preparation and the contrast of 96117626.1 preparation methoies are as follows
1, in patent 96117626.1 preparation methoies, the medicinal material extract water consumption is 7 times of medical material amount, and existing preparation method water consumption is 7-12 times; 7 times of water consumptions of former preparation method, after medical material soaks 30min, most of water that extracts is absorbed by medical material, and extraction efficiency reduces, and causes part medical material active substance not to be fully extracted, and after being increased to 10 times, most of working substance mass-energy extracts fully, but surpasses 14 times, and the impurity extracted amount also increases, the effective ingredient content back has the decline phenomenon, and has greatly increased energy consumption.Amount of water is 10 times for the first time, and 8 times for the second time, 7 times of effects are best for the third time.
2, the present invention adds 95% ethanol, and to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, and this time precipitate with ethanol effect is better than the 12h of patent 96117626.1, and active constituent content is high after testing, precipitate fully and completely, but the overlong time production cost is higher.
3, reclaim ethanol in patent 96117626.1 preparation methoies to without the alcohol flavor, the not concrete index of controlling, the bad control of production process, the present invention 1.20～1.25 as detecting, facilitates the production control procedure quality during now by 60 ℃ of relative densities.
4, under agitation in condensed cream, slowly add 4% gelatin solution in patent 96117626.1 preparation methoies, and the present invention adds 5% gelatin solution tannin-removing; Add 95% ethanol, patent 96117626.1 is to add 250ml to calculate containing the alcohol amount to be approximately 60%, to be difficult to remove tannin, and that the present invention adds to containing alcohol amount 75% its tannin-removing effect is better, and the quality of production is easily controlled.
As the gelatin by variable concentrations to Radix Et Rhizoma Rhei, after Radix Salviae Miltiorrhizae extracts, the tannin-removing effect of medicinal liquid relatively, best with gelatin 5%, 4% gelatin is because concentration is rarer, in the tannin-removing process, the gelatin solution use amount is excessive, increased the volume of medicinal liquid, reduced the concentration of medicinal liquid, not only the tannin-removing effect is poor, also strengthened man-hour simultaneously, improved energy consumption, 6% gelatin solution, because gelatin solution concentration is excessive, effective ingredient easily is wrapped and loses, cause active constituent content to reduce, therefore through test of many times, 5% gelatin solution tannin-removing effect is better and medicinal liquid extraction component content is higher, after tannin-removing, alcohol precipitation concentration confirms through overtesting, when alcohol precipitation concentration is 60%, gelatin in medicinal liquid is difficult to eliminate, and 75% alcohol precipitation concentration can remove the unnecessary gelatin after tannin-removing fully, form gradient with one, two, three precipitate with ethanol again, be conducive to the extraction of effective ingredient and the removal of invalid components, and the high consumption of ethanol content is relatively few, not only capable of reducing energy consumption but also can reduce work hours.
5, in patent 96117626.1 preparation methoies, secondary precipitate with ethanol extracting solution uses distilled water diluting 14 to 84ml, and the feasibility of operation is not strong, and scope is crossed the large-scale production process difficult quality and controlled.So adopting, the present invention adds 4 times of water gagings so that control quality and operation in production process.
Four, the preparation method of described kidney health oral administration solid compound preparation and patent 03141399.4 contrast are as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.The prescription of patent 03141399.4 is a scope, and the present invention is not in its scope, and the proportioning in embodiment is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1500g, Flos Carthami 1000g.
2. in patent 03141399.4 preparation method, 100mL * 50mL, not clearly stating is what, does not also know what the content of statement is, does not possess operability.And the present invention clear and definite the water yield of extracting, decoct with water three times, there is operability.
3. in patent 03141399.4 preparation method, there is no the process of water soaking, medicinal liquid extracts not exclusively; The clear and definite soak time 30min of the present invention, extraction time 30min is more complete to the extraction of effective ingredient.Contrast as follows.
4. in patent 03141399.4 preparation method, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae extract are concentrated into 1: 1.5 (mL: g); Flos Carthami, Radix Astragali extractive solution are concentrated into 1: 2.2, and (mL: g), operability is not strong, and process is difficult to control; The present invention is concentrated into 60 ℃ of relative densities 1.20～1.23, workable, can control concentration process.
5. in patent 03141399.4 preparation method, reclaim ethanol to nothing alcohol flavor, not concrete detection index, the bad control of production process; The present invention is concentrated into 60 ℃ of relative densities 1.20～1.22 as detecting index, can effectively control the product quality in drug production process.
Five, the preparation method of described kidney rehabilitation side injection and ZL 03108156.8 contrast are as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.
The prescription of ZL 03108156.8 is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: Flos Carthami: the Radix Astragali 1.5: 1: 1: 1.5, and this ratio does not comprise prescription of the present invention.
2.ZL 03108156.8 preparation method Chinese medicine is prescription in proportion, not concrete formula, and the not concrete mode of operation of extracting, do not possess operability yet.
3.ZL in 03108156.8 preparation method, there is no the process of water soaking, medicinal liquid extracts not exclusively, the clear and definite soak time 30min of the present invention, extraction time 30min is more complete to the extraction of effective ingredient.Contrast as follows
4.ZL, in 03108156.8 preparation method, the precipitate with ethanol time, the precipitate with ethanol temperature is all not clear and definite, does not possess operability.
5.ZL in 03108156.8 preparation method, filtrate is concentrated into 5 gram dries/mL filtrate, after 80% precipitate with ethanol, adds again water to be diluted to 5 gram dries/mL solution, can't be operated.
Six, the preparation method of described kidney health oral administration solid compound preparation and ZL200410039420.7 contrast are as follows
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g; In ZL200410039420.7, be ratio, not concrete formula, and the proportioning in embodiment is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: the Radix Astragali: Flos Carthami is 15: 15: 55: 15, and different with formula proportion of the present invention.
2.ZL200410039420.7 in preparation method, decocting time is 1-2h, overlong time, and energy consumption is excessive, and the impurity level of extraction also increases relatively; Decocting time of the present invention is 30min, and energy consumption is suitable, and in effective component extracting preferably, the impurity level of extraction is also relatively less.
3.ZL200410039420.7 after precipitate with ethanol, reclaim ethanol to distinguishing the flavor of without alcohol in preparation method, fuzzyyer, the present invention is concentrated into the regulation relative density, workable.
Seven, the preparation method of described kidney health oral administration solid compound preparation and ZL200410004359.2 contrast are as follows:
1, there is no the medical material immersion process in the ZL200410004359.2 preparation method, and decocting time 1-2h, the time is longer, and extraction efficiency is lower; And the present invention soaks 30min, decoct 30min more reasonable.
2, be concentrated into relative density 1.00-1.15 after collecting decoction in the ZL200410004359.2 preparation method, alcohol adding amount is larger, and expends man-hour; 1.20-1.23 when the present invention is concentrated into 60 ℃ of relative densities, can enhance productivity preferably.
Eight, the preparation method of described kidney health oral administration solid compound preparation and ZL200410039418.X contrast are as follows:
1. the prescription proportioning is different, and prescription of the present invention is Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.In ZL200410039418.X, be ratio, not concrete formula, and the proportioning in embodiment is Radix Et Rhizoma Rhei: Radix Salviae Miltiorrhizae: the Radix Astragali: Flos Carthami is 10: 10: 70: 10 and 15: 15: 55: 15,20: 20: 40: 40, and different with formula proportion of the present invention.
2.ZL200410039418.X 1.20-1.23 while being concentrated into 80 ℃-90 ℃ of relative densities in preparation method, operability is poor; When the present invention is concentrated into relative density and is 60 ℃ 1.20～1.23, more easy to operate and control quality.
3.ZL200410039418.X there is no the tannin-removing preparation method in preparation method, Impurity removal is incomplete.
4.ZL200410039418.X in preparation method, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae and the Radix Astragali, Flos Carthami all only carry out one time precipitate with ethanol; The present invention, through precipitate with ethanol repeatedly, removes impurity more thorough.
The specific embodiment
Embodiment 1
Kidney health oral administration solid compound preparation of the present invention, it is made by the crude drug of following proportioning; Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.Its preparation method is: after crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae are extracted by above-mentioned formula proportion amount, first precipitate with ethanol, tannin-removing, again secondary precipitate with ethanol, water precipitating, repeatedly after time precipitate with ethanol, secondary water precipitating; Again by the Radix Astragali, Flos Carthami by above-mentioned formula proportion amount extract, precipitate with ethanol, water precipitating, secondary precipitate with ethanol, water precipitating more again, ultrafiltration, concentrated, make oral solid formulation.
Embodiment 2
Kidney health oral administration solid compound preparation of the present invention, its preparation method is: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the 7-12 that amount of water is crude drug for the first time doubly measures, after soaking 30min, boil 30min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 30min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 4 times of amounts of medicinal liquid, cold preservation 38～55h gets that supernatant liquid filtering is clear and bright and to be concentrated into relative density be 60 ℃ 1.18～1.25, adding 95% ethanol is 80% to measuring containing alcohol, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, standby, the dosage Flos Carthami, Milkvetch Root, the 7-12 that amount of water is crude drug for the first time doubly measures, soak 30min, boil 45min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 45min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 4 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 38-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, by above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution merges, stir, ultrafiltration, filtrate is concentrated into relative density in the time of 60 ℃ 1.18～1.25, after 60 ℃ of dryings, pulverize.Add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill, concentrated pill.
Embodiment 3
Kidney health oral administration solid compound preparation its preparation method of the present invention is: get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, 10 times of amounts that amount of water is crude drug for the first time, after soaking 30min, boil 30min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 30min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add the 4 times amounts of water to medicinal liquid, it is clear and bright and when being concentrated into relative density and being 60 ℃ 1.20～1.22 that cold preservation 42～55h gets supernatant liquid filtering, adding 95% ethanol is 80% to measuring containing alcohol, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, standby, the dosage Flos Carthami, Milkvetch Root, 10 times of amounts that amount of water is crude drug for the first time, soak 30min, boil 45min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 45min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 4 times of amounts of medicinal liquid, it is clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22 that cold preservation 42-55h gets supernatant liquid filtering, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 48-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 48～55h, get supernatant liquid filtering clear and bright after, standby, by above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution, mixing and stirring, ultrafiltration, filtrate is concentrated into relative density and after 1.20～1.22,60 ℃ of dryings, pulverizes in the time of 60 ℃.Add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill, concentrated pill.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made the kidney-healing pills preparation method and is: by the said medicine ultrafiltration by the concentration extraction powdered, again by starch 100g, carboxymethylstach sodium 50g, microcrystalline Cellulose 50g, after crossing respectively 80 mesh sieves, evenly mix, add appropriate adhesive and make soft material, granulate; Granule is 60 ℃ of dryings.Add carboxymethylstach sodium, micropowder silica gel, magnesium stearate and Pulvis Talci mix homogeneously to measure the content of middle product; With No. 1 capsule dress capsule, prepare 2500, after the assay was approved, packing.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made kidney health enteric coated capsule preparation method and is: by the said medicine ultrafiltration by the concentration extraction powdered, again by starch 20g, carboxymethylstach sodium 10g, after crossing respectively 80 mesh sieves, evenly mix, add appropriate adhesive and make soft material, granulate; Granule is 60 ℃ of dryings.Add carboxymethylstach sodium, micropowder silica gel, magnesium stearate and Pulvis Talci mix homogeneously to measure the content of middle product; With No. 1 enteric coated capsule dress capsule, prepare 2500, after the assay was approved, packing.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made the Shenkang granule preparation method and is: be by the said medicine ultrafiltration by the concentration extraction powdered, then by lactose 250g, microcrystalline Cellulose 100g, magnesium trisilicate 150g, sucrose 500g, add suitable amount of adhesive, make soft material, granulate; After 60 ℃ of dryings, detect qualified after, be sub-packed in medicinal polyethylene plastic bag, every bag of 10g, make 150 bags altogether, obtains.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made Shenkangsan-medicine for treating nephrosis agent preparation method and is: be that the said medicine ultrafiltration is become to fine powder by concentration extraction, after crushed, add appropriate amount of auxiliary materials, be sub-packed in polyethylene plastic bag, after the assay was approved, be divided into and fill 300 bags, the moisture barrier bag parcel.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made kidney health honeyed pill preparation method and is: the said medicine ultrafiltration made to fine powder by concentration extraction, with Mel 500g, as binding agent, is rolled onto the 10g pill, make altogether 300 balls, after the assay was approved, packing.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made kidney health watered pill preparation method and is: is that the said medicine ultrafiltration is made to fine powder by concentration extraction, with Mel 2500g, as binding agent, is rolled onto the 10g pill, make altogether 300 balls, after the assay was approved, packing.
The appropriate amount of auxiliary materials that adds described in above-described embodiment is made kidney health method for preparing concentrated pill and is: the said medicine ultrafiltration is made to fine powder by concentration extraction, use lactose 1000g, add the pellet shapes pill that suitable amount of adhesive is made, after the assay was approved, every bag of packing 5g, make 300 bags altogether.
Claims (4)
1. a kidney health oral administration solid compound preparation for the treatment of chronic kidney hypofunction, is characterized in that it is to be made by the crude drug of following proportioning: Radix Et Rhizoma Rhei 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 4500g, Flos Carthami 1500g.
2. the preparation method of kidney health oral administration solid compound preparation claimed in claim 1, it is characterized in that: crude drug Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae are pressed to above-mentioned formula proportion amount with after water extraction, first precipitate with ethanol, tannin-removing, again secondary precipitate with ethanol, water precipitating, repeatedly after time precipitate with ethanol, secondary water precipitating, get supernatant liquid filtering, standby; Again by the Radix Astragali, Flos Carthami by above-mentioned formula proportion water extraction for amount, precipitate with ethanol, water precipitating, secondary precipitate with ethanol, water precipitating more again, get supernatant liquid filtering, standby; Above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution are merged, ultrafiltration, concentrated, drying, make oral solid formulation.
3. the preparation method of kidney health oral administration solid compound preparation claimed in claim 1 is characterized in that:
(1) get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the 7-12 that amount of water is crude drug for the first time doubly measures, after soaking 30min, boil 30min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 30min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 4 times of amounts of medicinal liquid, it is clear and bright and when being concentrated into relative density and being 60 ℃ 1.18～1.25 that cold preservation 38～55h gets supernatant liquid filtering, adding 95% ethanol is 80% to measuring containing alcohol, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, standby,
(2) dosage Flos Carthami, Milkvetch Root, the 7-12 that amount of water is crude drug for the first time doubly measures, soak 30min, boil 45min, filter, the 7-12 that amount of water is crude drug for the second time doubly measures, boil 45min, filter, the 7-12 that amount of water is crude drug for the third time doubly measures, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 38-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 4 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright and be concentrated into relative density in the time of 60 ℃ 1.18～1.25, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 38-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.18～1.25, add water to 2 times of amounts of medicinal liquid, cold preservation 38～55h, get supernatant liquid filtering clear and bright after, standby,
(3) above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution are merged, stir, ultrafiltration, filtrate is concentrated into relative density and after 1.18～1.25,60 ℃ of dryings, pulverizes in the time of 60 ℃; Add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill or concentrated pill.
4. the preparation method of kidney health oral administration solid compound preparation according to claim 1 is characterized in that:
(1) get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, 10 times of amounts that amount of water is crude drug for the first time, after soaking 30min, boil 30min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 30min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 30min, filter, merge three times water extraction liquid, while being concentrated into 60 ℃ of relative densities 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering to clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add 5% gelatin solution, tannin-removing, add 95% ethanol, to measuring containing alcohol, be 75%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 4 times of amounts of medicinal liquid, it is clear and bright and when being concentrated into relative density and being 60 ℃ 1.20～1.22 that cold preservation 42～55h gets supernatant liquid filtering, adding 95% ethanol is 80% to measuring containing alcohol, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 42～55h, get supernatant liquid filtering clear and bright after, standby,
(2) dosage Flos Carthami, Milkvetch Root, 10 times of amounts that amount of water is crude drug for the first time, soak 30min, boil 45min, filter, 8 times of amounts that amount of water is crude drug for the second time, boil 45min, filter, 7 times of amounts that amount of water is crude drug for the third time, boil 45min, filter, merge three times water extraction liquid, be concentrated into relative density in the time of 60 ℃ 1.20～1.22, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 70%, standing 48-60h, get supernatant liquid filtering clear and bright, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add the 4 times amounts of water to medicinal liquid, it is clear and bright and be concentrated into relative density in the time of 60 ℃ 1.20～1.22 that cold preservation 42-55h gets supernatant liquid filtering, add 95% ethanol, to medicinal liquid, containing alcohol, measuring is 80%, it is clear and bright that standing 48-60h gets supernatant liquid filtering, reclaim ethanol to relative density 60 ℃ the time 1.20～1.22, add water to 2 times of amounts of medicinal liquid, cold preservation 48～55h, get supernatant liquid filtering clear and bright after, standby,
(3) by above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae group Flos Carthami, Radix Astragali group solution, mixing and stirring, ultrafiltration, filtrate is concentrated into relative density in the time of 60 ℃ 1.20～1.22, after 60 ℃ of dryings, pulverize, add appropriate amount of auxiliary materials and make capsule, enteric coated capsule, granule, powder, honeyed pill, the watered pill or concentrated pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110326041 CN102475761B (en) | 2010-11-30 | 2011-10-24 | Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010581975 | 2010-11-30 | ||
| CN201010581975.X | 2010-11-30 | ||
| CN 201110326041 CN102475761B (en) | 2010-11-30 | 2011-10-24 | Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102475761A CN102475761A (en) | 2012-05-30 |
| CN102475761B true CN102475761B (en) | 2013-12-18 |
Family
ID=46088619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110326041 Active CN102475761B (en) | 2010-11-30 | 2011-10-24 | Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102475761B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146358A (en) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | Shengkang injection solution (for nephrosis) and preparation technology |
| CN1654058A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Medicine for treating chronic kidney failure and its preparing process |
| CN1654060A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | 'Kidney-Benefiting' glucose injection and its preparing process |
| CN1654059A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat diabetic nephropathy |
| CN1654061A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome |
| CN1657060A (en) * | 2004-02-17 | 2005-08-24 | 吴芳 | Shenkang freeze-dried powder injection for injection and its preparation technology |
-
2011
- 2011-10-24 CN CN 201110326041 patent/CN102475761B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146358A (en) * | 1996-07-16 | 1997-04-02 | 成都中医药大学附属医院 | Shengkang injection solution (for nephrosis) and preparation technology |
| CN1654058A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Medicine for treating chronic kidney failure and its preparing process |
| CN1654060A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | 'Kidney-Benefiting' glucose injection and its preparing process |
| CN1654059A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat diabetic nephropathy |
| CN1654061A (en) * | 2004-02-11 | 2005-08-17 | 吴芳 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome |
| CN1657060A (en) * | 2004-02-17 | 2005-08-24 | 吴芳 | Shenkang freeze-dried powder injection for injection and its preparation technology |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102475761A (en) | 2012-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579667B (en) | Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles | |
| US10124032B2 (en) | Seven-star tea without excipient and method of preparing the same | |
| CN107259564A (en) | deficiency of yang health composition and preparation method thereof | |
| CN102475762B (en) | Shenkang oral liquid compound preparation for treating chronic renal failure and preparation method of Shenkang oral liquid compound preparation | |
| CN102000172A (en) | Oral liquid, granules and powder for preventing and treating chronic allergic rhinitis | |
| CN102475761B (en) | Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation | |
| CN102233091A (en) | Nutritional and health-care Chinese medicine for treating liver diseases | |
| CN102475753B (en) | Kidney-health patch for treating chronic renal failure and preparation method thereof | |
| CN102475758B (en) | Shenkang tablet for treating chronic renal failure and preparation method of Shenkang tablet | |
| CN106177416B (en) | A kind of traditional Chinese medicinal composition with effect of reducing blood sugar and preparation method thereof | |
| CN106511414A (en) | Pharmaceutical composition for treating tumor and preparation method and application thereof | |
| CN106581352A (en) | Blood pressure lowering medicine and production method thereof | |
| CN102475754B (en) | Shenkang soft capsule for treating chronic renal failure and preparation method of Shenkang soft capsule | |
| CN102475763B (en) | Shenkang dripping pill for treating chronic renal failure and preparation method thereof | |
| CN102475755B (en) | Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol | |
| CN107929512A (en) | A kind of method that LONGMU ZHUANGGU KELI is prepared using ultra high pressure extraction | |
| CN106728640A (en) | It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy | |
| CN102475757B (en) | Kidney-strengthening externally applied compound preparation for treating chronic renal failure and preparation method of compound preparation | |
| CN107320665A (en) | Treat precocious pharmaceutical composition of child and preparation method thereof | |
| CN107596065B (en) | A kind of pharmaceutical composition treated the hypertension of pregnancy and merge preeclampsia | |
| CN106860687A (en) | One kind treats alcoholism and liver-protecting medicine composition | |
| CN107029081B (en) | Compound Chinese medicine prepn for treating anemia caused by kidney deficiency and hemophthisis and its prepn process | |
| CN105687365A (en) | Traditional Chinese medicine composition for treating polymyositis and preparation method and application of traditional Chinese medicine composition for treating polymyositis | |
| CN107596318A (en) | Treat uremic Chinese medicine composition, medicine and its preparation method and application | |
| CN102475759A (en) | Shenkang sodium chloride injection for treating chronic renal failure and preparation method of Shenkang sodium chloride injection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |