CN104274721A - Preparation method of cold heat clearing granules - Google Patents
Preparation method of cold heat clearing granules Download PDFInfo
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- CN104274721A CN104274721A CN201410491233.6A CN201410491233A CN104274721A CN 104274721 A CN104274721 A CN 104274721A CN 201410491233 A CN201410491233 A CN 201410491233A CN 104274721 A CN104274721 A CN 104274721A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
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- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 20
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Classifications
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a preparation method of cold heat clearing granules. The preparation method comprises the following steps: firstly, mixing schizonepeta spike, mint and perilla leaf, grinding and dipping the mixture through an ethanol water solution, percolating, extracting percolate through diethyl ether, decomposing and recovering extract liquor to obtain an extract I; then, mixing divaricate saposhnikovia root, radix bupleuri, root of kudzu vine, platycodon grandiflorum, semen armeniacae amarae, radix angelicae, bunge corydalis herb and rhizoma phragmitis, grinding and decocting the mixture in water, filtering, mixing filtrates, adsorbing the mixed filtrate through macro-porous adsorption resin, eluting through an ethanol water solution, filtering an eluent through an ultrafiltration membrane, condensing and drying to obtain an extract II; and then, adding beta-cyclodextrin to distilled water, wetting and heating to obtain a beta-cyclodextrin water liquid; and finally, adding the extract I and the extract II to the beta-cyclodextrin water liquid, stirring, spray-drying and granulating, mixing and granulating obtained granules with a thinner, a flavoring agent and a wetting agent to obtain the granules. The method disclosed by the invention not only simplifies a technological process and shortens a production cycle, but also improves a recovery rate of active ingredients and stability of the granules.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of preparation method of GANMAO QINGRE KELI.
Background technology
Flu is divided into common cold and influenza.Common cold, the traditional Chinese medical science claims " cold ", is a kind of respiratory tract commonly encountered diseases caused by multiple virus.Though common cold is mainly in early winter, in any season, as spring, summer also can occur, the Causative virus of the flu of Various Seasonal is not just the same.Influenza is the Acute respiratory infectious disease caused by influenza virus.Virus is present in the respiratory tract of patient, gives others when patient's cough, sneeze through droplet infection.Flu is a kind of very common disease extremely harmful again.Ache, myasthenia of limbs, the patient that has a high fever can be called heavy cold from head to foot.
Chinese Pharmacopoeia version in 2010 record: GANMAO QINGRE KELI has expelling wind and cold, the effect of heat clearing away of inducing sweat, and for anemofrigid cold, has a headache and fever, aversion to cold general pain, rhinorrhea with clear discharge, cough dry pharynx.Its prescription is Herba Schizonepetae 200g, Herba Menthae 60g, Radix Saposhnikoviae 100g, Radix Bupleuri 100g, Folium Perillae 60g, Radix Puerariae 100g, Radix Platycodonis 60g, Semen Armeniacae Amarum 80g, Radix Angelicae Dahuricae 60g, Herba Corydalis Bungeanae 200g, Rhizoma Phragmitis 160g.Its preparation method is that Herba Schizonepetae, Herba Menthae, Folium Perillae are extracted volatile oil, and the another device of the aqueous solution after distillation is collected; Eight tastes such as medicinal residues and all the other Radix Saposhnikoviaes decoct with water secondary, collecting decoction, and filter, filtrate and above-mentioned aqueous solution merge; Amalgamation liquid is condensed into the clear paste that relative density is 1.32-1.35 (50 DEG C), with sucrose, dextrin and appropriate amount of ethanol, makes granule, dry, adds above-mentioned volatile oil, and mixing, makes 1600g; Or amalgamation liquid is condensed into the clear paste that relative density is 1.32-1.35 (50 DEG C), add right amount of auxiliary materials, make without sucrose granules, dry, add above-mentioned volatile oil, mixing, makes 800g; Or amalgamation liquid is evaporated to the medicinal liquid that relative density is 1.08-1.10 (55 DEG C), spraying dry, makes dried cream powder, adds lactose appropriate, and mixing, adds above-mentioned volatile oil, and mixing, makes granule 400g, to obtain final product.Adopt decocting method to extract the effective ingredient of medical material in said method, there is the shortcomings such as extraction time is long, Extracting temperature is high, energy consumption is high, heat-sensitive ingredients easily loses, the effective ingredient response rate is low, post processing trouble.
Prior art teaches beta-cyclodextrin inclusion compound technology, it is mainly used in the enclose of chemical drugs and volatile oil on medicament, increase dissolubility and the stability of medicine, improve the bioavailability of medicine, reduce zest, the toxic and side effects of medicine, cover bitterness, and liquid medicine powdered etc., and not yet apply on the enclose of Chinese medicinal material extract.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and the preparation method that a kind of GANMAO QINGRE KELI is provided, the method not only can simplification of flowsheet, significantly shorten the production cycle, energy efficient, and can also effective high effective ingredient the response rate, remove and affect the impurity of main constituent storage stability, the stability of raising granule.
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with ethanol water dipping, percolation speed is 3 ~ 5mL/min, and collect percolate, by extracted with diethyl ether, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin, carry out eluting with ethanol water again, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II;
Step 3, adds beta-schardinger dextrin-in distilled water, and 70 ~ 80 DEG C of heated at constant temperature after infiltrating, obtain beta-schardinger dextrin-aqueous solution;
Step 4, adds extract obtained for step 1 I and step 2 extract obtained II in step 3 gained beta-schardinger dextrin-aqueous solution, and 50 ~ 60 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, obtains GANMAO QINGRE KELI.
The raw material of described GANMAO QINGRE KELI has clearly record at Pharmacopoeia of People's Republic of China (2010 editions) clear granule " medicine composition " of catching a cold: Herba Schizonepetae 200 parts, Herba Menthae 60 parts, Radix Saposhnikoviae 100 parts, Radix Bupleuri 100 parts, Folium Perillae 60 parts, Radix Puerariae 100 parts, Radix Platycodonis 60 parts, Semen Armeniacae Amarum 80 parts, the Radix Angelicae Dahuricae 60 parts, Herba Corydalis Bungeanae 200 parts and Rhizoma Phragmitis 160 parts.
As the further improvement of foregoing invention, in step 1, ethanol water concentration is 90 ~ 95wt.%, and dip time is 24h.
As the further improvement of foregoing invention, percolate extracted with diethyl ether 4 times in step 1.
As the further improvement of foregoing invention, the weight of the water that the process that decocts with water in step 2 adds be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 2 ~ 3 times.
As the further improvement of foregoing invention, in step 2, macroporous adsorbent resin is selected from HDP-100, HDP-722 or HDP-750.
As the further improvement of foregoing invention, in step 2, the concentration of ethanol water is 70 ~ 80wt.%.
As the further improvement of foregoing invention, in step 2, the molecular cut off of ultrafilter membrane is 100000 ~ 200000Da.
As the further improvement of foregoing invention, in step 3, the weight ratio of beta-schardinger dextrin-and distilled water is 10:3 ~ 6.
As the further improvement of foregoing invention, in step 4, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 3 ~ 7:2 ~ 6:1 ~ 4.
As the further improvement of foregoing invention, in step 5, the weight ratio of granule, diluent, correctives, wetting agent is 100:8 ~ 10:2 ~ 5:1 ~ 6.
The preparation method of GANMAO QINGRE KELI provided by the present invention, not only can simplification of flowsheet, significantly shorten the production cycle, energy efficient, and can also effective high effective ingredient the response rate, remove and affect the impurity of main constituent storage stability, the stability of raising granule.
Detailed description of the invention
Embodiment 1
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with 90wt.% ethanol water dipping 24h, percolation speed is 3mL/min, collects percolate, and by extracted with diethyl ether 4 times, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, the weight of the water added be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 2 times, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin HDP-100, eluting is carried out again with 70wt.% ethanol water, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II, and the molecular cut off of ultrafilter membrane used is 100000Da;
Step 3, adds beta-schardinger dextrin-in distilled water, and the weight ratio of beta-schardinger dextrin-and distilled water is 10:3, infiltrates rear 70 DEG C of heated at constant temperature, obtains beta-schardinger dextrin-aqueous solution;
Step 4, extract obtained for step 1 I and step 2 extract obtained II are added in step 3 gained beta-schardinger dextrin-aqueous solution, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 3:2:1, and 50 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, the weight ratio of granule, diluent, correctives, wetting agent is 100:8:2:1, obtains GANMAO QINGRE KELI.
Embodiment 2
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with 95wt.% ethanol water dipping 24h, percolation speed is 4mL/min, collects percolate, and by extracted with diethyl ether 4 times, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, the weight of the water added be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 3 times, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin HDP-722, eluting is carried out again with 75wt.% ethanol water, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II, and the molecular cut off of ultrafilter membrane used is 150000Da;
Step 3, adds beta-schardinger dextrin-in distilled water, and the weight ratio of beta-schardinger dextrin-and distilled water is 10:4, infiltrates rear 75 DEG C of heated at constant temperature, obtains beta-schardinger dextrin-aqueous solution;
Step 4, extract obtained for step 1 I and step 2 extract obtained II are added in step 3 gained beta-schardinger dextrin-aqueous solution, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 4:3:2, and 55 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, the weight ratio of granule, diluent, correctives, wetting agent is 100:9:4:3, obtains GANMAO QINGRE KELI.
Embodiment 3
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with 95wt.% ethanol water dipping 24h, percolation speed is 5mL/min, collects percolate, and by extracted with diethyl ether 4 times, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, the weight of the water added be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 2 times, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin HDP-750, eluting is carried out again with 80wt.% ethanol water, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II, and the molecular cut off of ultrafilter membrane used is 200000Da;
Step 3, adds beta-schardinger dextrin-in distilled water, and the weight ratio of beta-schardinger dextrin-and distilled water is 10:5, infiltrates rear 80 DEG C of heated at constant temperature, obtains beta-schardinger dextrin-aqueous solution;
Step 4, extract obtained for step 1 I and step 2 extract obtained II are added in step 3 gained beta-schardinger dextrin-aqueous solution, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 7:6:4, and 60 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, the weight ratio of granule, diluent, correctives, wetting agent is 100:10:5:6, obtains GANMAO QINGRE KELI.
Embodiment 4
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with 90wt.% ethanol water dipping 24h, percolation speed is 4mL/min, collects percolate, and by extracted with diethyl ether 4 times, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, the weight of the water added be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 3 times, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin HDP-100, eluting is carried out again with 80wt.% ethanol water, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II, and the molecular cut off of ultrafilter membrane used is 150000Da;
Step 3, adds beta-schardinger dextrin-in distilled water, and the weight ratio of beta-schardinger dextrin-and distilled water is 10:5, infiltrates rear 80 DEG C of heated at constant temperature, obtains beta-schardinger dextrin-aqueous solution;
Step 4, extract obtained for step 1 I and step 2 extract obtained II are added in step 3 gained beta-schardinger dextrin-aqueous solution, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 7:6:4, and 60 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, the weight ratio of granule, diluent, correctives, wetting agent is 100:9:3:5, obtains GANMAO QINGRE KELI.
Embodiment 5
The preparation method of GANMAO QINGRE KELI, comprises the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with 95wt.% ethanol water dipping 24h, percolation speed is 4mL/min, collects percolate, and by extracted with diethyl ether 4 times, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, the weight of the water added be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 3 times, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin HDP-750, eluting is carried out again with 80wt.% ethanol water, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II, and the molecular cut off of ultrafilter membrane used is 200000Da;
Step 3, adds beta-schardinger dextrin-in distilled water, and the weight ratio of beta-schardinger dextrin-and distilled water is 10:5, infiltrates rear 80 DEG C of heated at constant temperature, obtains beta-schardinger dextrin-aqueous solution;
Step 4, extract obtained for step 1 I and step 2 extract obtained II are added in step 3 gained beta-schardinger dextrin-aqueous solution, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 6:4:3, and 60 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, the weight ratio of granule, diluent, correctives, wetting agent is 100:9:3:5, obtains GANMAO QINGRE KELI.
Comparative example 1
With reference to Pharmacopoeia of People's Republic of China version in 2010 first, the preparation method of GANMAO QINGRE KELI is that Herba Schizonepetae, Herba Menthae, Folium Perillae are extracted volatile oil, and the another device of the aqueous solution after distillation is collected; Eight tastes such as medicinal residues and all the other Radix Saposhnikoviaes decoct with water secondary, collecting decoction, and filter, filtrate and above-mentioned aqueous solution merge; Amalgamation liquid is condensed into the clear paste that relative density is 1.32-1.35 (50 DEG C), with sucrose, dextrin and appropriate amount of ethanol, makes granule, dry, adds above-mentioned volatile oil, and mixing, makes 1600g; Or amalgamation liquid is condensed into the clear paste that relative density is 1.32-1.35 (50 DEG C), add right amount of auxiliary materials, make without sucrose granules, dry, add above-mentioned volatile oil, mixing, makes 800g.
Experimental example
Carry out study on the stability to above-described embodiment and comparative example, content assaying method is with reference to Pharmacopoeia of People's Republic of China version in 2010 first.
Chromatographic condition and system suitability take octadecylsilane chemically bonded silica as filler; With acetonitrile-water (11:89) for mobile phase; Determined wavelength is 250nm.Number of theoretical plate calculates should be not less than 4500 by puerarin.
The preparation of reference substance solution gets puerarin reference substance in right amount, accurately weighed, adds 30% ethanol and makes the solution of every 1mL containing 16 μ g, to obtain final product.
This product content under content uniformity item is got in the preparation of need testing solution, and porphyrize, gets about 0.4g, accurately weighed, put in tool plug conical flask, precision adds 30% ethanol 50mL, close plug, weighed weight, supersound process (power 250W, frequency 33kHz) 20 minutes, let cool, more weighed weight, supply the weight of less loss with 30% ethanol, shake up, filter, get subsequent filtrate, to obtain final product.
Algoscopy is accurate respectively draws reference substance solution and each 10 μ L of need testing solution, injection liquid chromatography, measures, to obtain final product.
To carry out long-term stable experiment under the terms of packing that goes on the market, temperature 25 DEG C ± 2 DEG C, relative humidity, 60% ± 5%, samples detection level respectively at 0,3,6,9,12,18,24 the end of month.Testing result is as shown in the table:
Puerarin result of laboratory test (the content mg in every 6g finished product)
| ? | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Comparative example 1 |
| 0 month | 15.4 | 14.9 | 16.1 | 15.8 | 14.6 | 10.6 |
| 3 months | 15.4 | 14.9 | 16.0 | 15.8 | 14.6 | 10.1 |
| 6 months | 15.3 | 14.9 | 16.0 | 15.7 | 14.5 | 9.7 |
| 9 months | 15.2 | 14.7 | 15.9 | 15.6 | 14.5 | 9.4 |
| 12 months | 15.1 | 14.6 | 15.8 | 15.5 | 14.3 | 9.0 |
| 18 months | 15.0 | 14.6 | 15.7 | 15.5 | 14.2 | 8.7 |
| 24 months | 14.9 | 14.6 | 15.5 | 15.4 | 14.2 | 8.5 |
| Degradation rate after 24 months | 3.25％ | 2.01％ | 3.73％ | 2.53％ | 2.74％ | 19.8％ |
Compare as can be seen from embodiment with comparative example 1, by the improvement to Chinese medicine component extracting process, and adopt macroporous adsorbent resin to adsorb, not only can simplification of flowsheet, significantly shorten the production cycle, effectively can also remove impurity, extract obtained employing beta-cyclodextrin inclusion compound technology, the degraded of main constituent can be prevented, improve the stability of granule.
Claims (10)
1. the preparation method of GANMAO QINGRE KELI, is characterized in that: comprise the following steps:
Step 1, by Herba Schizonepetae, Herba Menthae and Folium Perillae mixing, is ground into coarse powder, and with ethanol water dipping, percolation speed is 3 ~ 5mL/min, and collect percolate, by extracted with diethyl ether, extract reclaim under reduced pressure obtains extract I;
Step 2, by Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis mixing, be ground into coarse powder, decoct with water, filter, merging filtrate, filtrate is adsorbed by macroporous adsorbent resin, carry out eluting with ethanol water again, eluent is concentrated, dry after ultrafiltration membrance filter obtains extract II;
Step 3, adds beta-schardinger dextrin-in distilled water, and 70 ~ 80 DEG C of heated at constant temperature after infiltrating, obtain beta-schardinger dextrin-aqueous solution;
Step 4, adds extract obtained for step 1 I and step 2 extract obtained II in step 3 gained beta-schardinger dextrin-aqueous solution, and 50 ~ 60 DEG C of constant temperature stir, and puts spray-drying process after 4 DEG C of refrigerator cold-storages;
Step 5, by step 4 gained granule and diluent, correctives, wetting agent mixing granulation, obtains GANMAO QINGRE KELI.
2. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 1, ethanol water concentration is 90 ~ 95wt.%, and dip time is 24h.
3. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: percolate extracted with diethyl ether 4 times in step 1.
4. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: the weight of the water that the process that decocts with water in step 2 adds be Radix Saposhnikoviae, Radix Bupleuri, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae and Rhizoma Phragmitis gross weight 2 ~ 3 times.
5. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 2, macroporous adsorbent resin is selected from HDP-100, HDP-722 or HDP-750.
6. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 2, the concentration of ethanol water is 70 ~ 80 wt.%.
7. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 2, the molecular cut off of ultrafilter membrane is 100000 ~ 200000Da.
8. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 3, the weight ratio of beta-schardinger dextrin-and distilled water is 10:3 ~ 6.
9. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 4, the weight ratio of extract I, extract II, beta-schardinger dextrin-aqueous solution is 3 ~ 7:2 ~ 6:1 ~ 4.
10. the preparation method of GANMAO QINGRE KELI according to claim 1, is characterized in that: in step 5, the weight ratio of granule, diluent, correctives, wetting agent is 100:8 ~ 10:2 ~ 5:1 ~ 6.
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| CN105727020A (en) * | 2016-02-28 | 2016-07-06 | 南京正亮医药科技有限公司 | Preparation method and application of granules for treating cold and clearing heat |
| CN106236990A (en) * | 2016-08-29 | 2016-12-21 | 河南鑫远洋动物药业有限公司 | A kind of preparation method of the Chinese medicine preparation treating chicken diarrhea |
| CN108607047A (en) * | 2016-12-09 | 2018-10-02 | 内蒙古天奇中蒙制药股份有限公司 | A kind of preparation method of GANMAO QINGRE KELI |
| CN109331076A (en) * | 2018-11-26 | 2019-02-15 | 广东新峰药业股份有限公司 | A kind of Ganmaoling Granules and its production technology |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104998143A (en) * | 2015-06-17 | 2015-10-28 | 蚌埠市天星树脂有限责任公司 | Resin used for extracting of active compound of medicine relieving fever and preparation method thereof |
| CN105727020A (en) * | 2016-02-28 | 2016-07-06 | 南京正亮医药科技有限公司 | Preparation method and application of granules for treating cold and clearing heat |
| CN106236990A (en) * | 2016-08-29 | 2016-12-21 | 河南鑫远洋动物药业有限公司 | A kind of preparation method of the Chinese medicine preparation treating chicken diarrhea |
| CN108607047A (en) * | 2016-12-09 | 2018-10-02 | 内蒙古天奇中蒙制药股份有限公司 | A kind of preparation method of GANMAO QINGRE KELI |
| CN109331076A (en) * | 2018-11-26 | 2019-02-15 | 广东新峰药业股份有限公司 | A kind of Ganmaoling Granules and its production technology |
| CN109331076B (en) * | 2018-11-26 | 2021-03-19 | 广东新峰药业股份有限公司 | Ganmaoling granules and production process thereof |
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