CN101953872B - Method for preparing Chinese medicinal preparation for treating influenza - Google Patents
Method for preparing Chinese medicinal preparation for treating influenza Download PDFInfo
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- CN101953872B CN101953872B CN 200910067296 CN200910067296A CN101953872B CN 101953872 B CN101953872 B CN 101953872B CN 200910067296 CN200910067296 CN 200910067296 CN 200910067296 A CN200910067296 A CN 200910067296A CN 101953872 B CN101953872 B CN 101953872B
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Abstract
The invention relates to a method for preparing a Chinese medicinal preparation for treating influenza, and belongs to the field of medicaments. The method is used for preparing indigowoad root granules and overcomes the defects of high extraction temperature, long time, influenced medicinal potency, high impurity content, potential safety hazards of production, environment pollution and the like in the conventional preparation method. The method of the invention comprises the following steps of: pulverizing the indigowoad root into coarse powder, adding water, extracting by using a high-electric pulse extraction device at the room temperature, filtering extract, performing fine filtering by using a membrane separation device, concentrating to form extractum, and adding a proper amount of auxiliary materials to obtain the Chinese medicinal preparation. The method has the advantages of extracting Chinese medicinal materials by adopting the advanced high-voltage pulse extraction technology, overcoming the defects of high extraction temperature and long time in the conventional decoction method, performing the whole extraction process at the lower temperature of below 30 DEG C, improving medicinal potency, contributing to environmental protection, along with short processing time, no damage of active ingredients, high efficiency, low energy consumption, high transfer rate, and safe production and operation.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of preparation method that is used for the treatment of grippal Chinese medicine preparation.
Background technology
Upper respiratory tract infection, influenza, acute tonsillitis, parotitis are the common clinical frequently-occurring disease, sickness rate is high, and very easily popular, clinical manifestation is fever with chills, headache, dry pharynx, high fever, excessive thirst, coma, tic, has had a strong impact on people's work and life.
For the treatment of above-mentioned disease, doctor trained in Western medicine adopts antiviral drugs and antibiotic therapy more, and toxic and side effects is large, and untoward reaction is many, grievous injury liver and the kidney of human body; The traditional Chinese medical science adopts the treatment by Chinese herbs with antipyretic and antidote functions, and toxic and side effects is little, and curative effect is high.Radix Isatidis has heat-clearing and toxic substances removing, and the effect of removing heat from blood sore-throat relieving is usually used in the treatment of the diseases such as influenza, upper respiratory tract infection, laryngopharynx swelling and pain, acute tonsillitis, parotitis clinically, determined curative effect, and demand is large.
Radix Isatidis preparation commonly used is Radix Isatidis granule in the market, and said preparation adopts traditional preparation technology's preparation, because it is high to extract temperature, the time is long, and quite a few effective ingredient is destroyed, has had a strong impact on the drug effect of preparation; Decoct for a long time and also most of impurity is extracted in the lump, increased great difficulty to subsequent operation, also increased the taking dose of medicine simultaneously; In preparation process, need to use a large amount of ethanol, namely increased the preparation cost, also exist simultaneously serious potential safety hazard, traditional extracting method energy consumption is high, the cycle is long, contaminated environment, namely improved the cost of medicine, increase patient's medical burden, destroyed again the environment that we depend on for existence.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method that is used for the treatment of grippal Chinese medicine preparation, for the preparation of Radix Isatidis granule, overcome the extraction temperature height that existing preparation method is in, time is long, and the part effective ingredient is destroyed, affects drug effect, impurity content is high, increase post-processing difficulty, have potential safety hazard, the deficiencies such as contaminated environment.
Preparation method of the present invention comprises the steps:
(1) Radix Isatidis powder is broken into 30～60 purpose coarse powder, adds the water of 8～15 times of amounts, extract with high electric pulse extraction element, and field intensity 6000～21000V, 1800～18000 of pulse numbers, temperature is below 30 ℃, 1～12 millisecond of processing time;
(2) extracting solution that step (1) obtained filters, and filtrate use the membrane separation device fine straining, and the medicinal liquid of molecular cut off below 10,000 is concentrated into 50 ℃ of survey relative densities and is 1.30～1.40 extractum;
(3) the middle extractum that obtains to step (2) adds appropriate amount of auxiliary materials, granulation, and drying, or film coating are made coated granule, namely get the present invention.
Optimum extraction condition of the present invention is: Radix Isatidis powder is broken into 40 purpose coarse powder, adds the water of 12 times of amounts, extracts field intensity 10000V, 12000 of pulse numbers, 17 ℃ of temperature, 8 milliseconds of processing times with high electric pulse extraction element.
Good effect of the present invention is: adopt advanced potential pulse extraction technology to extract Chinese crude drug, overcome the traditional decoction method and extracted the temperature height, the shortcoming that time is long, whole leaching process carries out under the low temperature environment below 30 ℃, processing time is 1～12 millisecond, effective ingredient contained in the Chinese crude drug without any destruction, has completely been kept effective ingredient contained in the Chinese crude drug; Application of high voltages DISCHARGE PULSES EXTRACTION technology is extracted, efficient is high, energy consumption is low, the rate of transform is high, its energy consumption only is 1/10th of traditional extraction process, and the rate of transform reaches more than 99 percent, has greatly improved drug effect, the application of potential pulse extraction technology greatly reduces the production cost of Radix Isatidis granule, makes it have larger competitive advantage in like product; The potential pulse extraction technology, handling safety, environmental protection has the at present existing incomparable superiority of extractive technique.The present invention adopts again membrane separation technique that extracting solution is carried out separation and purification, most impurity have been removed, substituted the precipitate with ethanol step in the former technique, a large amount of ethanol have been saved, reduce production cost, stopped the potential safety hazard of using ethanol to bring because of a large amount of, improved medicine purity, reduce the taking dose of medicine, guaranteed the quality of medicine
The present invention adopts film-coated technique that preparation is carried out coating, and it is moist effectively to have reduced drawing of medicine, has strengthened the stability of preparation, has improved product quality.
The Radix Isatidis granule of the present invention's preparation and the Radix Isatidis granule of traditional handicraft preparation are pressed " new Chinese medicine guideline of clinical investigations ", respectively choose patient's 120 examples, adopt multicenter, the experimental technique of two the region between the heart and the diaphragms, dual analog, masculine parallel comparison carries out clinical trial at random, the tcm clinical practice curative effect is as follows:
Clinical research is the result show, adopts the Radix Isatidis granule of the present invention's preparation to compare with the Radix Isatidis granule of traditional handicraft preparation, and drug effect obviously improves.
The specific embodiment
Embodiment 1:
1. get Radix Isatidis 1.4kg, be ground into 30 purpose coarse powder, add 21kg water, extract field intensity 6500V, 1800 of pulse numbers, 20 ℃ of temperature, 12 milliseconds of processing times with the potential pulse extraction device;
2. extracting solution filters in will be 1., and filtrate use the membrane separation device fine straining, and the medicinal liquid of molecular cut off below 10,000 is concentrated into 50 ℃ of survey relative densities and is 1.30 extractum;
3. extractum adds an amount of dextrin, sucrose in 2., granulation, and drying is made the 1000g granule, and coating namely gets the present invention.
Embodiment 2:
1. get Radix Isatidis 1.4kg, be ground into 60 purpose coarse powder, add 11kg water, extract field intensity 21000V, 18000 of pulse numbers, 21 ℃ of temperature, 2 milliseconds of processing times with high electric pulse extraction element;
2. extracting solution filters in will be 1., and filtrate use the membrane separation device fine straining, and the medicinal liquid of molecular cut off below 5000 is concentrated into 50 ℃ of survey relative densities and is 1.35 extractum;
3. extractum adds an amount of soluble starch, aspartame in 2., granulation, and drying is made the 600g granule, and coating namely gets the present invention.
Embodiment 3:
1. get Radix Isatidis 1.4kg, be ground into 40 purpose coarse powder, add 17kg water, extract field intensity 10000V, 12000 of pulse numbers, 17 ℃ of temperature, 8 milliseconds of processing times with high electric pulse extraction element;
2. extracting solution filters in will be 1., and filtrate use the membrane separation device fine straining, and the medicinal liquid of molecular cut off below 8000 is concentrated into 50 ℃ of survey relative densities and is 1.40 extractum;
3. extractum adds an amount of dextrin, aspartame in 2., granulation, and drying is made the 600g granule, and coating namely gets the present invention.
Claims (2)
1. a preparation method that is used for the treatment of grippal Chinese medicine preparation is characterized in that comprising the steps:
(1) Radix Isatidis powder is broken into 30～60 purpose coarse powder, adds the water of 8～15 times of Radix Isatidis weight, extract with high electric pulse extraction element, and field intensity 6000～21000V, 1800～18000 of pulse numbers, temperature is below 30 ℃, 1～12 millisecond of processing time;
(2) extracting solution that step (1) obtained filters, and filtrate use the membrane separation device fine straining, and the medicinal liquid of molecular cut off below 10,000 is concentrated into 50 ℃ of survey relative densities and is 1.30～1.40 extractum;
(3) extractum that obtains to step (2) adds appropriate amount of auxiliary materials, granulation, and drying, coating namely gets the present invention.
2. the preparation method of Radix Isatidis granule according to claim 1, it is characterized in that: Radix Isatidis powder is broken into 40 purpose coarse powder, adds the water of 12 times of Radix Isatidis weight, extract field intensity 10000V, 12000 of pulse numbers with high electric pulse extraction element, 17 ℃ of temperature, 8 milliseconds of processing times.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910067296 CN101953872B (en) | 2009-07-21 | 2009-07-21 | Method for preparing Chinese medicinal preparation for treating influenza |
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| CN 200910067296 CN101953872B (en) | 2009-07-21 | 2009-07-21 | Method for preparing Chinese medicinal preparation for treating influenza |
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| CN101953872A CN101953872A (en) | 2011-01-26 |
| CN101953872B true CN101953872B (en) | 2013-04-24 |
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| CN 200910067296 Active CN101953872B (en) | 2009-07-21 | 2009-07-21 | Method for preparing Chinese medicinal preparation for treating influenza |
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| CN107875138B (en) * | 2016-09-30 | 2021-11-16 | 天士力医药集团股份有限公司 | Preparation method of spherical formula particles and related products |
| CN106511400B (en) * | 2016-12-15 | 2019-12-06 | 湖南中健欣元生物科技有限公司 | Cell wall breaking method for preparing medicinal material wall breaking powder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682763A (en) * | 2005-02-21 | 2005-10-19 | 吉林大学 | Method for extracting bone calcium from animal bone powder |
| CN101138686A (en) * | 2007-07-23 | 2008-03-12 | 沈军 | Method for extracting active ingredient of natural product and uses thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682763A (en) * | 2005-02-21 | 2005-10-19 | 吉林大学 | Method for extracting bone calcium from animal bone powder |
| CN101138686A (en) * | 2007-07-23 | 2008-03-12 | 沈军 | Method for extracting active ingredient of natural product and uses thereof |
Non-Patent Citations (8)
| Title |
|---|
| 卢敏等.高压电脉冲提取小麦胚谷胱苷肽.《食品科学》.2005,第26卷(第8期), |
| 吴小辉.高压脉冲电场在食品加工及天然产物提取中的研究现状和前景展望.《安徽农学通报》.2008,第14卷(第24期), |
| 张铁华等.高压脉冲电场(PEF)非热处理的加工原理与安全控制.《食品科学》.2006,第27卷(第12期), |
| 金哲雄.高压脉冲电场常温快速提取动植物成分工艺及机理研究.《吉林大学博士学位论文》.2008, |
| 高压电脉冲提取小麦胚谷胱苷肽;卢敏等;《食品科学》;20051231;第26卷(第8期);205-207 * |
| 高压脉冲电场(PEF)非热处理的加工原理与安全控制;张铁华等;《食品科学》;20061231;第27卷(第12期);881-885 * |
| 高压脉冲电场在食品加工及天然产物提取中的研究现状和前景展望;吴小辉;《安徽农学通报》;20081231;第14卷(第24期);24-26 * |
| 高压脉冲电场常温快速提取动植物成分工艺及机理研究;金哲雄;《吉林大学博士学位论文》;20081231;摘要、第19、33-52页 * |
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Effective date of registration: 20160802 Address after: 130012 No. 2426 Qianjin Street, Changchun hi tech Development Zone, Jilin, China Patentee after: Xiuzheng Pharmaceutical Group HoIding Co., Ltd. Patentee after: Jilin Changbaishan Pharmaceutical Group Co., Ltd. Address before: 130012 No. 2426 Qianjin Street, Changchun hi tech Development Zone, Jilin, China Patentee before: Xiuzheng Pharmaceutical Group HoIding Co., Ltd. |
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Denomination of invention: Preparation method of Chinese medicine preparation for treating influenza Effective date of registration: 20211223 Granted publication date: 20130424 Pledgee: Tonghua Xinhua sub branch of Bank of Jilin Co.,Ltd. Pledgor: Xiuzheng Pharmaceutical Group Co.,Ltd. Registration number: Y2021220000108 |