CN106279110B - 杂环化合物、含有所述化合物的药物及其用途和其制备方法 - Google Patents

杂环化合物、含有所述化合物的药物及其用途和其制备方法 Download PDF

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CN106279110B
CN106279110B CN201610685839.2A CN201610685839A CN106279110B CN 106279110 B CN106279110 B CN 106279110B CN 201610685839 A CN201610685839 A CN 201610685839A CN 106279110 B CN106279110 B CN 106279110B
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alkyl
phenyl
amino
acid
hydrogen
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CN106279110A (zh
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A·赫克尔
S·弗拉蒂尼
D·哈姆普里克特
J·克雷
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Boehringer Ingelheim International GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Hydrogenated Pyridines (AREA)
CN201610685839.2A 2011-11-02 2012-10-29 杂环化合物、含有所述化合物的药物及其用途和其制备方法 Active CN106279110B (zh)

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EP11187553.0 2011-11-02
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CN201280065806.8A Active CN104024244B (zh) 2011-11-02 2012-10-29 杂环化合物、含有所述化合物的药物及其用途和其制备方法

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CA2635581C (en) 2005-12-28 2017-02-28 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
PT2773633T (pt) * 2011-11-02 2017-11-14 Boehringer Ingelheim Int Compostos heterocíclicos, medicamentos contendo os referidos compostos, sua utilização e processos para a sua preparação
JP2016525508A (ja) * 2013-07-02 2016-08-25 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ 嚢胞性線維症の処置のための化合物
EP3019492B1 (en) * 2013-07-08 2017-09-06 Boehringer Ingelheim International GmbH Amiloride-type compounds as inhibitors in epithelial sodium channels for the treatment of diseases of the lungs and airways
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе
MX373603B (es) * 2014-10-24 2020-05-26 Ono Pharmaceutical Co Activador de canales de kcnq2-5.
CN107405505A (zh) * 2015-01-07 2017-11-28 加州生物医学研究所 用于治疗囊性纤维化的化合物
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds
GB201717051D0 (en) 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
IL301285A (en) 2020-09-10 2023-05-01 Precirix N V Antibody fragment against fap
CN112107580A (zh) * 2020-09-29 2020-12-22 北京鑫开元医药科技有限公司 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
JP2025517625A (ja) 2022-05-02 2025-06-10 プレシリックス・ナームローゼ・ベンノートシヤープ プレターゲティング
WO2024243025A1 (en) * 2023-05-19 2024-11-28 Ikena Oncology, Inc. Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions

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CN104024244B (zh) * 2011-11-02 2016-09-14 勃林格殷格翰国际有限公司 杂环化合物、含有所述化合物的药物及其用途和其制备方法

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KR102006612B1 (ko) 2019-08-02
IL232035A (en) 2017-05-29
PH12014500970B1 (en) 2017-10-06
GEP20186880B (en) 2018-07-25
AP2014007670A0 (en) 2014-05-31
US20180194747A1 (en) 2018-07-12
HK1196819A1 (zh) 2014-12-24
EP2773633A1 (en) 2014-09-10
WO2013064450A1 (en) 2013-05-10
JP6091513B2 (ja) 2017-03-08
AU2012331274A1 (en) 2014-04-03
UA115868C2 (uk) 2018-01-10
NZ622469A (en) 2016-08-26
PL2773633T3 (pl) 2018-01-31
NO2773633T3 (enExample) 2017-12-30
US20140228374A1 (en) 2014-08-14
DK2773633T3 (da) 2017-11-13
EA025158B1 (ru) 2016-11-30
EA201400521A1 (ru) 2014-09-30
MX348522B (es) 2017-06-16
US20130109697A1 (en) 2013-05-02
SG11201401907TA (en) 2014-05-29
PE20141607A1 (es) 2014-11-23
ECSP14001929A (es) 2015-11-30
KR20140085498A (ko) 2014-07-07
EP2773633B1 (en) 2017-08-02
BR112014010583A2 (pt) 2020-04-22
PT2773633T (pt) 2017-11-14
AU2012331274B2 (en) 2017-06-08
PH12014500970A1 (en) 2014-06-09
CY1120974T1 (el) 2019-12-11
US9920035B2 (en) 2018-03-20
JP2014534222A (ja) 2014-12-18
CN104024244B (zh) 2016-09-14
CO6940429A2 (es) 2014-05-09
ES2645744T3 (es) 2017-12-07
RS56498B1 (sr) 2018-01-31
CA2854217C (en) 2019-12-31
LT2773633T (lt) 2017-11-10
TN2014000180A1 (en) 2015-09-30
US8759349B2 (en) 2014-06-24
IL232035A0 (en) 2014-05-28
CN106279110A (zh) 2017-01-04
CA2854217A1 (en) 2013-05-10
ME02905B (me) 2018-10-20
CL2014001047A1 (es) 2014-11-07
SI2773633T1 (sl) 2017-11-30
US20150336933A1 (en) 2015-11-26
MX2014005166A (es) 2014-05-28
CN104024244A (zh) 2014-09-03
HUE034929T2 (en) 2018-03-28
HRP20171614T1 (hr) 2017-12-01
EA025158B9 (ru) 2018-03-30

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