CN106265377B - A kind of composition and its preparation method and application with antiseptic activity - Google Patents
A kind of composition and its preparation method and application with antiseptic activity Download PDFInfo
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- CN106265377B CN106265377B CN201610891607.2A CN201610891607A CN106265377B CN 106265377 B CN106265377 B CN 106265377B CN 201610891607 A CN201610891607 A CN 201610891607A CN 106265377 B CN106265377 B CN 106265377B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of composition and its preparation method and application with antiseptic activity, the composition are made of the raw material below according to parts by weight: 2-8 parts of myrrh, 7-15 parts of Lygodium japonicum, 12-20 parts of pyrrosia lingua, 15-23 parts of Thesium chinese.By Lygodium japonicum, pyrrosia lingua immersion, refluxing extraction, reduced pressure, ethyl alcohol is added and stands, filter, taking precipitate, dissolves by heating, distilled water is added, mixed solution is made；The ethyl alcohol of Thesium chinese grinding, addition 65wt% is extracted, filters, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated；Myrrh is pulverized and sieved, adds water mixing, thermal agitation, ultrasonic treatment, centrifugal treating, takes supernatant that must not have drug solns；By Thesium chinese ethanol extract, do not have drug solns, mixed solution mixing to be ultrasonically treated, obtained by drying.The present invention has excellent anti-corrosion ability, not only there is outstanding antibacterial activity to fungi, and there are also very high antibacterial universals, small on the influence of the physical and chemical stability of cosmetics, is suitable for large-scale production.
Description
Technical field
The present invention relates to cosmetic technical field, specifically a kind of composition with antiseptic activity and preparation method thereof and
Using.
Background technique
The additive of the not simple corruption for preventing product of cosmetics preservative, being fabricated onto consumer from factory makes
It is finished during commodity, inhibits the inevitable or accidental microorganism being present in product, prevent from drawing because of microbial growth
The cosmetics from deterioration that rises, it is spoiled, corrupt the purpose of the general name of additive added.
Preservative is most of to be simple to manufacture, based on the artificial synthesized substance of the cheap easy mass production of unit price.It is this anti-
In rotten agent representative cosmetics preservative have the methyl p-hydroxybenzoate of P-hydroxybenzoic acid, ethyl-para-hydroxybenzoate,
Propylparaben, butyl p-hydroxybenzoate etc. and quaternary ammonium salt -15, imidazolidinyl urea, bis- (methylol) imidazolidinyls
The chemical preservatives such as urea, Phenoxyethanol, benzalkonium chloride, triclosan.Although this chemical preservative can inhibit the numerous of microorganism
The stability for bringing cosmetics is grown, but it is also the reason of inducing skin irritatin.It is previously considered to safe cosmetics anti-corrosion
Agent, the widely used hydroxybenzoic acid class preservative of medicine product can also cause skin allergy and endocrine is chaotic.It is existing natural
A part of antibiotic property raw material has that the color is too dark and raw material is highly seasoned or stability is very poor, so using having limitation or discomfort
It closes and uses.
Summary of the invention
The purpose of the present invention is to provide a kind of antibacterial activity of broad-spectrum, physical and chemical stability is high, production cost is low
Composition and its preparation method and application with antiseptic activity, to solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme:
A kind of composition with antiseptic activity, is made of the raw material below according to parts by weight: 2-8 parts of myrrh, Lygodium japonicum
7-15 parts, 12-20 parts of pyrrosia lingua, 15-23 parts of Thesium chinese.
As a further solution of the present invention: the composition with antiseptic activity, by below according to the original of parts by weight
Material composition: 4-6 parts of myrrh, 9-13 parts of Lygodium japonicum, 14-18 parts of pyrrosia lingua, 17-21 parts of Thesium chinese.
As a further solution of the present invention: the composition with antiseptic activity, by below according to the original of parts by weight
Material composition: 5 parts of myrrh, 11 parts of Lygodium japonicum, 16 parts of pyrrosia lingua, 19 parts of Thesium chinese.
Another object of the present invention is to provide a kind of preparation method of composition with antiseptic activity, by following steps group
At:
1) Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, two are added for the first time
The water that 5 times of person's weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70
DEG C it is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood
More than for 24 hours, filtering, taking precipitate is dissolved by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made；
2) Thesium chinese is ground, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extracts, Extracting temperature 72
DEG C, it is filtered after extraction, filtering and collecting filter liquid, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated；
3) myrrh be crushed into 120 meshes, is then mixed with 5 times of its weight of water, 70 DEG C at a temperature of stir 20-
30min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasonic power 700W, then in the centrifugation of 3000r/min
5min is handled under speed, takes supernatant, must not have drug solns；
4) by Thesium chinese ethanol extract, do not have drug solns, mixed solution mix after, then 65 DEG C at a temperature of be ultrasonically treated
20min, ultrasonic power 1000W, then again at a temperature of 80 DEG C drying to get composition.
Another object of the present invention is to provide application of the composition in cosmetics.
Myrrh has the effect of scattered stasis pain, detumescence and promoting granulation.It is usually used in chest impediment and cardialgia, gastral cavity pain, dysmenorrhea menostasis, postpartum
Stasis blocking , abdominal mass and abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the illnesss such as carbuncle swells sore.
Lygodium japonicum eliminating dampness and heat, treating stranguria analgesic.For heat gonorrhea, urolithiasis, blood strangury, cream leaching, Urethra astringent pain.
Pyrrosia lingua has the effects of promoting diuresis for stranguria, clearing lung-heat expel the heat-evil.Can clearing away damp-heat, inducing diuresis for treating strangurtia, control knife wound, scald, take off power it is deficient.
Thesium chinese is clearing heat and detoxicating, kidney tonifying arresting seminal emission.Control acute mastitis, pneumonia, lung abscess, tonsillitis, upper respiratory tract sense
Dye, lumbago due to the kidney deficiency is dizzy, spermatorrhea.
Compared with prior art, the beneficial effects of the present invention are:
The present invention uses pure natural raw material, by composition made from a series of preparation process, in the collaboration of each raw material
Under effect, there is excellent anti-corrosion ability, not only there is outstanding antibacterial activity to fungies such as mould and yeast, there are also very high
Antibacterial universal.It is small on the influence of the physical and chemical stability of cosmetics, it is stimulated than general chemical preservative low.Present invention preparation
Process is simple, easy to control, and raw material is few, and extensively, production cost is low for materials, is suitable for large-scale production.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of composition with antiseptic activity is made of the raw material below according to parts by weight: not having
2 parts of medicine, 7 parts of Lygodium japonicum, 12 parts of pyrrosia lingua, 15 parts of Thesium chinese.
Both Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, be added for the first time
The water that 5 times of weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70 DEG C
It is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood for 24 hours
More than, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made.Thesium chinese is ground
Mill, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extract, and Extracting temperature is 72 DEG C, filter after extraction, after filtering
Filtrate is collected, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated.Myrrh be crushed into 120 meshes, it is then heavy with its
Amount 5 times water mixing, 70 DEG C at a temperature of stir 20min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasound
Power is 700W, then handles 5min under the centrifugal speed of 3000r/min, takes supernatant, must not have drug solns.By Thesium chinese second
Alcohol extracting thing, do not have drug solns, mixed solution mixing after, then 65 DEG C at a temperature of be ultrasonically treated 20min, ultrasonic power is
1000W, then again at a temperature of 80 DEG C drying to get composition.
Embodiment 2
In the embodiment of the present invention, a kind of composition with antiseptic activity is made of the raw material below according to parts by weight: not having
8 parts of medicine, 15 parts of Lygodium japonicum, 20 parts of pyrrosia lingua, 23 parts of Thesium chinese.
Both Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, be added for the first time
The water that 5 times of weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70 DEG C
It is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood for 24 hours
More than, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made.Thesium chinese is ground
Mill, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extract, and Extracting temperature is 72 DEG C, filter after extraction, after filtering
Filtrate is collected, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated.Myrrh be crushed into 120 meshes, it is then heavy with its
Amount 5 times water mixing, 70 DEG C at a temperature of stir 30min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasound
Power is 700W, then handles 5min under the centrifugal speed of 3000r/min, takes supernatant, must not have drug solns.By Thesium chinese second
Alcohol extracting thing, do not have drug solns, mixed solution mixing after, then 65 DEG C at a temperature of be ultrasonically treated 20min, ultrasonic power is
1000W, then again at a temperature of 80 DEG C drying to get composition.
Embodiment 3
In the embodiment of the present invention, a kind of composition with antiseptic activity is made of the raw material below according to parts by weight: not having
4 parts of medicine, 9 parts of Lygodium japonicum, 14 parts of pyrrosia lingua, 17 parts of Thesium chinese.
Both Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, be added for the first time
The water that 5 times of weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70 DEG C
It is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood for 24 hours
More than, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made.Thesium chinese is ground
Mill, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extract, and Extracting temperature is 72 DEG C, filter after extraction, after filtering
Filtrate is collected, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated.Myrrh be crushed into 120 meshes, it is then heavy with its
Amount 5 times water mixing, 70 DEG C at a temperature of stir 25min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasound
Power is 700W, then handles 5min under the centrifugal speed of 3000r/min, takes supernatant, must not have drug solns.By Thesium chinese second
Alcohol extracting thing, do not have drug solns, mixed solution mixing after, then 65 DEG C at a temperature of be ultrasonically treated 20min, ultrasonic power is
1000W, then again at a temperature of 80 DEG C drying to get composition.
Embodiment 4
In the embodiment of the present invention, a kind of composition with antiseptic activity is made of the raw material below according to parts by weight: not having
6 parts of medicine, 13 parts of Lygodium japonicum, 18 parts of pyrrosia lingua, 21 parts of Thesium chinese.
Both Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, be added for the first time
The water that 5 times of weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70 DEG C
It is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood for 24 hours
More than, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made.Thesium chinese is ground
Mill, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extract, and Extracting temperature is 72 DEG C, filter after extraction, after filtering
Filtrate is collected, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated.Myrrh be crushed into 120 meshes, it is then heavy with its
Amount 5 times water mixing, 70 DEG C at a temperature of stir 25min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasound
Power is 700W, then handles 5min under the centrifugal speed of 3000r/min, takes supernatant, must not have drug solns.By Thesium chinese second
Alcohol extracting thing, do not have drug solns, mixed solution mixing after, then 65 DEG C at a temperature of be ultrasonically treated 20min, ultrasonic power is
1000W, then again at a temperature of 80 DEG C drying to get composition.
Embodiment 5
In the embodiment of the present invention, a kind of composition with antiseptic activity is made of the raw material below according to parts by weight: not having
5 parts of medicine, 11 parts of Lygodium japonicum, 16 parts of pyrrosia lingua, 19 parts of Thesium chinese.
Both Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, be added for the first time
The water that 5 times of weight extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, in 70 DEG C
It is concentrated under reduced pressure into relative density 1.15, concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, is stood for 24 hours
More than, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made.Thesium chinese is ground
Mill, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extract, and Extracting temperature is 72 DEG C, filter after extraction, after filtering
Filtrate is collected, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated.Myrrh be crushed into 120 meshes, it is then heavy with its
Amount 5 times water mixing, 70 DEG C at a temperature of stir 25min, 70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasound
Power is 700W, then handles 5min under the centrifugal speed of 3000r/min, takes supernatant, must not have drug solns.By Thesium chinese second
Alcohol extracting thing, do not have drug solns, mixed solution mixing after, then 65 DEG C at a temperature of be ultrasonically treated 20min, ultrasonic power is
1000W, then again at a temperature of 80 DEG C drying to get composition.
Comparative example 1
In addition to without containing Thesium chinese, formula and preparation process and embodiment 5 are unanimously.
Comparative example 2
Only contain Thesium chinese, preparation process and embodiment 5 are consistent.
The test of 6 anti-corrosive properties of embodiment
After anti-corrosion effect is microbe inoculation, the challenge test (Challenge Test) of inhibitory effect is confirmed, with
CTFA experimental method is standard.
The inoculum concentration of mould and bacterium is respectively that (CFU is bacterium colony list to 100000cfu/g (ml) and 1000000cfu/g (ml)
Position), it is desirable that at the 7th day, mould reduced by 90%, and bacterium reduces by 99.9%, and bacterium number continues to decline in 28 days.That is, if single
The average value of any micro organism quantity, dropped to 100cfu/g (ml) at the 7th day in three parallel tests of bacterium inoculation
Hereinafter, 28 days all 0, then it is considered as excellent effect and passes through challenge test；If drop at the 7th day 1000cfu/g (ml) with
Under, then it is considered as and scrapes；If above-mentioned standard is not achieved in any microorganism of single bacterium inoculation, any one Duplicate Samples, prevent
Rotten system is then assessed as in vain.
Bacterium and fungi are inoculated into cosmetics sample, the inhibition Antimicrobial situation of confirmation 1~28 day.It is pressed in lotion
According to the ingredient of mass percent: glycine betaine 2%, glycerol 5%, 1,2- pentanediol 2%, butanediol 4%, adhesion agent 8%, neutralizer 0.1%,
Stearine 2%, PEG-100 stearate 2%, cetostearyl alcohol 1%, butter fruit resin 1%, dormant oil 3%, poly dimethyl silicon
Oxygen alkane 2%, essence 0.1%, the composition 0.5% of antiseptic activity, surplus is water.The composition of antiseptic activity is embodiment 1-5 respectively
And the substance of comparative example 1-2.
The strain that above-mentioned experiment uses is bacterium, mould.
In order to confirm the emulsion intercalation method of addition examples detailed above 1-5 and comparative example 1-2 constituent, in each temperature observations
Stability evaluates stability over 1 month as shown in table 1.The different content of the composition of change embodiment 1-5 (it is 0.3% respectively,
0.6%, 0.8%, 1.0%) stability test is carried out, it finds stable.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Comparative example 1 | Comparative example 2 | |
| Room temperature | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize |
| 4℃ | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize | It is unstable |
| 37℃ | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize |
| 45℃ | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize | Stablize |
| Circulation | Stablize | Stablize | Stablize | Stablize | Stablize | It is unstable | It is unstable |
It can confirm the anti-corrosion effect according to no constituent produced by the present invention.The results are shown in Table 1 for it.
Table 2
NI:No Increase
Embodiment 7 confirms irritation
Skin irritation be by leakproofness patch test, the healthy men and women that selects 20~40 years old skin without exception as by
Try object.Recipient site is Medial upper arm.
Irritation tests A: the composition of the embodiment 5 containing 0.5 weight % in lotion.
Irritation test b: the composition of the embodiment 5 of 1 weight % is added in lotion.
Irritation tests C: the composition of the embodiment 5 of 1.5 weight % is added in lotion.
Irritation tests D: containing 0.2 weight % of chemical preservative methyl p-hydroxybenzoate, nipasol 0.1
Weight %, the lotion of 0.2 weight % of imidazolidinyl urea.
Other ingredients in lotion are respectively as follows: glycine betaine 2%, glycerol 5%, 1,2- pentanediol 2%, fourth two according to mass percent
Alcohol 4%, adhesion agent 8%, neutralizer 0.1%, stearine 2%, PEG-100 stearate 2%, cetostearyl alcohol 1%, butter fruit
Resin 1%, dormant oil 3%, dimethyl silicone polymer 2%, essence 0.1%, surplus are water.
Above 4 kinds of a certain amount of tested materials are put into spot tester, the Medial upper arm of subject is spread on, continue 48 hours.
Irritation is confirmed according to erythema degree and to the enquirement of subject.
Detailed method is as follows:
Smearing method: Medial upper arm
Applying amount: 20 μ of μ l~30 l/chamber
It smears number and time limit: sticking 24 hours, observed 24 hours after sticking test.
Observing response: patch test 30 is observed after dividing with 24 hours according to the term (terminology) of CTFA criterion.
Criterion
Level of reaction+(1) dermoreaction: small erythema；
Level of reaction ++ the dermoreaction of (2): medium erythema；
Level of reaction +++ the dermoreaction of (3): strong erythema to oedema；
Level of reaction +++ the dermoreaction of+(4): strong erythema, bleb.
Standards of grading:
Ranking score table is quasi- as shown in table 3.
Table 3
| Grade | Score |
| Grade I (non-stimulated range) | Less than 1 |
| Grade II (subexcite range) | Less than 3 |
| Grade III (weight field stimulation) | Less than 5 |
| Grade IV (strong stimulation range) | 5 or more |
Experimental result is as shown in table 4.
Table 4
In four kinds of irritation tests, composition of the invention is almost non-stimulated to skin.But methyl hydroxybenzoate, hydroxyl
The preservative that propyl benzoate, imidazolidinyl urea form is confirmed as irritating.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (4)
1. a kind of composition with antiseptic activity, which is characterized in that be made of the raw material below according to parts by weight: myrrh 2-8
Part, 7-15 parts of Lygodium japonicum, 12-20 parts of pyrrosia lingua, 15-23 parts of Thesium chinese；
The preparation method of the composition with antiseptic activity, comprises the steps of:
1) Lygodium japonicum, pyrrosia lingua are soaked in water into 2h, soaking temperature is 68 DEG C, is then refluxed for extracting 2 times, and the two weight is added for the first time
The water of 5 times of amount extracts 3.5h, and second of the water that 3 times of weight of the two is added extracts 2h, and filtering merges filtrate twice, subtracts in 70 DEG C
Pressure is concentrated into relative density 1.15, and concentrate is put to room temperature, and being added with stirring ethyl alcohol makes alcohol content reach 80%, stand for 24 hours with
On, filtering, taking precipitate dissolves by heating, and the distilled water of 3 times of weight of the two is added, and mixed solution is made；
2) Thesium chinese being ground, the ethyl alcohol that 65wt% is added after grinding into Thesium chinese slag extracts, and Extracting temperature is 72 DEG C,
It is filtered after extraction, filtering and collecting filter liquid, Thesium chinese ethanol extract is obtained after filter vacuum is concentrated；
3) myrrh be crushed into 120 meshes, is then mixed with 5 times of its weight of water, 70 DEG C at a temperature of stir 20-30min,
70 DEG C at a temperature of carry out ultrasonic treatment 25min, ultrasonic power 700W, then under the centrifugal speed of 3000r/min
5min is managed, supernatant is taken, must not have drug solns；
4) by Thesium chinese ethanol extract, do not have drug solns, mixed solution mix after, then 65 DEG C at a temperature of be ultrasonically treated
20min, ultrasonic power 1000W, then 80 DEG C at a temperature of drying to get composition.
2. the composition according to claim 1 with antiseptic activity, which is characterized in that by below according to the original of parts by weight
Material composition: 4-6 parts of myrrh, 9-13 parts of Lygodium japonicum, 14-18 parts of pyrrosia lingua, 17-21 parts of Thesium chinese.
3. the composition according to claim 1 with antiseptic activity, which is characterized in that by below according to the original of parts by weight
Material composition: 5 parts of myrrh, 11 parts of Lygodium japonicum, 16 parts of pyrrosia lingua, 19 parts of Thesium chinese.
4. application of the composition a method according to any one of claims 1-3 in cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610891607.2A CN106265377B (en) | 2016-10-13 | 2016-10-13 | A kind of composition and its preparation method and application with antiseptic activity |
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| CN201610891607.2A CN106265377B (en) | 2016-10-13 | 2016-10-13 | A kind of composition and its preparation method and application with antiseptic activity |
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| Publication Number | Publication Date |
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| CN106265377A CN106265377A (en) | 2017-01-04 |
| CN106265377B true CN106265377B (en) | 2019-03-12 |
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| CN201610891607.2A Active CN106265377B (en) | 2016-10-13 | 2016-10-13 | A kind of composition and its preparation method and application with antiseptic activity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735903A (en) * | 2013-12-30 | 2014-04-23 | 广西梧州制药（集团）股份有限公司 | Chinese medicinal composition for resisting bacteria and suppressing calculi and preparation method thereof |
| CN105395930A (en) * | 2015-11-30 | 2016-03-16 | 梁苡玮 | Antisepsis and anti-inflammation drug for external use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735903A (en) * | 2013-12-30 | 2014-04-23 | 广西梧州制药（集团）股份有限公司 | Chinese medicinal composition for resisting bacteria and suppressing calculi and preparation method thereof |
| CN105395930A (en) * | 2015-11-30 | 2016-03-16 | 梁苡玮 | Antisepsis and anti-inflammation drug for external use |
Non-Patent Citations (2)
| Title |
|---|
| 抗菌中草药百蕊草的研究进展;刘永松等;《药学进展》;20060630;第30卷(第6期);第252-256页 |
| 没药研究进展;赵金凤等;《中国药房》;20110731;第22卷(第7期);第661-665页 |
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