KR20170002744A

KR20170002744A - Composition of preservatives and cosmetic composition comprising the same

Info

Publication number: KR20170002744A
Application number: KR1020150092105A
Authority: KR
Inventors: 유현오; 석창현
Original assignee: 주식회사 제닉
Priority date: 2015-06-29
Filing date: 2015-06-29
Publication date: 2017-01-09

Abstract

The present invention relates to a preservative composition, and to a cosmetic composition comprising the same. More particularly, the present invention relates to a preservative composition comprising raspberry ketone and polyol. In the present invention, a natural preservative composition having excellent antibacterial activity and a wide range of antibacterial spectrum while being safe to human body, and a cosmetic composition comprising the natural preservative composition are obtained. Particularly, the preservative composition of the present invention exhibits excellent preservative effects for germs and yeast fungus.

Description

TECHNICAL FIELD [0001] The present invention relates to a preservative composition and a cosmetic composition containing the same. BACKGROUND OF THE INVENTION < RTI ID = 0.0 >

More particularly, the present invention relates to a preservative composition having a sufficient preservative effect and being safe for human body, and more particularly to a preservative composition suitable for cosmetics and a cosmetic composition containing the same.

Preservatives are added to many products such as foods, medicines, and cosmetics widely used in daily life to prevent changes in internal properties and to preserve them for a certain period of time.

Especially, in various kinds of cosmetics, Preservatives are incorporated in cosmetics. They are used for the purpose of preventing the change of products by inhibiting the growth of microorganisms that contaminate or alter cosmetics from the outside, In order to secure the buoyancy of the room, aseptic manufacturing process is required, complicated means are required such as limiting the amount of contents or the period of use, or making the container specially, and the tendency to lack economical versatility increases.

Some of the materials used as preservatives are derived from natural sources, but mostly chemically synthesized artificial materials are used. Preservatives which are most safely used as conventional preservatives and which are generally used for cosmetics and medicines include, for example, paraoxybenzoic acid esters commonly known as parabens, imidazolidinyl urea, phenoxyethanol, methylchloroisothiazolinone, Methylisothiazolinone, and chlorphenesin. However, even these preservatives of parabens have a problem as skin allergies, environmental hormones, and resistance to bacteria.

As described above, the danger of artificial preservatives is emerging, and many people feel the necessity of natural preservatives. However, studies on natural preservatives that are superior in safety and economy continue to be made, but in reality, they are expensive, In addition, there is a limitation in application to practical products because of the problem of lowering of safety such as discoloration and breaking when used at a high capacity.

On the other hand, raspberry ketone is 4- (4-hydroxyphenyl) -2-butanone and / or p-hydroxybenzyl acetone, and the raspberry ketone is one of fragrant components of raspberry. Raspberry ketone is derived from natural materials such as plants (e.g., bushes, fruit) of plants belonging to the rose and raspberry (e.g., raspberry), and can be obtained by chemical synthesis. Korean Patent Application No. 2005-7009507 As you can see, it is a substance that is considered to be safe enough to be used as a food. It is a substance that is mainly used for the improvement of obesity by promoting fat decomposition.

By using such a human-safe ingredient, it is expected that it will be usefully used in related fields when a composition having safe and satisfactory preservative effect is developed without using any chemical preservative such as parabens at all.

Accordingly, one aspect of the present invention is to provide a preservative composition that is harmless to humans and combines chemically stable components to exhibit sufficient preservative effect.

Another aspect of the present invention is to provide a cosmetic composition comprising the preservative composition.

According to one aspect of the present invention, there is provided a preservative composition comprising raspberry ketone and a polyol.

The raspberry ketone and the polyol are preferably mixed in a weight ratio of 1: 2 to 2: 1.

The antiseptic composition is intended to prevent corruption by bacteria and yeast.

The bacterium and the yeast are selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa and Staphlyococcus aureus, Candida albicans, Aspergillus niger, niger, Bacillus subtilis, Bacillus megaterium, and Exophiala moniliae.

The polyol is selected from the group consisting of benzyl glycol, butoxy diglycol, diglycerin, butylene glycol, propylene glycol, propanediol, pentaerythritol, and phage-6 and phage-8. Or more.

According to another aspect of the present invention, there is provided a cosmetic composition comprising the above-described preservative composition of the present invention.

It is preferable that the cosmetic composition has at least one form selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, and body wash.

The cosmetic composition preferably contains the preservative composition in an amount of 0.01 to 5% by weight based on the total weight of the cosmetic composition.

According to the present invention, it is possible to obtain a human-safe natural antiseptic composition and a cosmetic composition containing the same which have a wide range of antimicrobial activity and excellent antimicrobial activity. In particular, the antiseptic composition of the present invention can be used not only for bacteria, It exhibits an excellent preservative effect.

Hereinafter, preferred embodiments of the present invention will be described. However, the embodiments of the present invention can be modified into various other forms, and the scope of the present invention is not limited to the embodiments described below.

INDUSTRIAL APPLICABILITY According to the present invention, there is provided a natural preservative composition which is safe for human body and which has a wide range of antimicrobial activity and antimicrobial spectrum.

More specifically, the preservative composition of the present invention comprises raspberry ketone and a polyol.

The Raspberry Ketone is a phenol compound having a structure of the following formula (1) and is also referred to as 4- ( p -hydroxyphenyl) -2-butanone (4- (HPB).

[Chemical Formula 1]

Such raspberry ketones can be obtained from natural products or can be obtained by synthesis. Raspberry ketones derived from natural products include, for example, extracts of plants of Rosaceae Rubus (hereinafter referred to as "raspberry extract"Quot;). As the extracting site of the plant for obtaining the raspberry extract, any or all of the plant may be used, and shrubs, fruit and the like are preferable. The extraction conditions such as the extraction solvent and the extraction temperature are not particularly limited.

For example, water, an organic solvent or a mixed solvent thereof. Specific examples thereof include water, methanol, ethanol, propanol, butanol, glycerin, acetone, ethyl acetate, hexane, chloroform, Glycol or a mixed solvent thereof.

The extraction is carried out according to a conventional extraction process and can be carried out at room temperature or by heating. Preferably 50 to 80% ethanol, at a temperature of 50 ° C to 70 ° C for 2 to 4 hours, but is not limited thereto, Can be extracted by any extraction method known in the art.

However, when heating at a temperature higher than the above temperature, the time is reduced but the active ingredient may be destroyed and lost. When heating at a temperature lower than the above temperature, the active ingredient of the mixture is not extracted completely. .

The extract obtained through the extraction step may be centrifuged or filtered to remove impurities by a conventional method, and the filtrate may be used after distillation of the organic solvent and drying or by dissolving in an appropriate solvent.

The preservative composition of the present invention may further combine a polyol with such a raspberry ketone component to obtain a preservative composition having an excellent preservative effect.

When the polyol added to the preservative composition of the present invention is added alone, it is used as a preservative. However, when the polyol is used in combination with the combination of the present invention, the skin irritation is reduced and sufficient preservative effect Lt; / RTI >

In the present specification, at least one species means a mixture of one species and at least two species, and is interpreted to have the same meaning as at least one species.

Preferably, the raspberry ketone and the polyol are mixed in a weight ratio of 1: 2 to 2: 1. If the raspberry ketone is contained more than twice the weight of the polyol, a problem due to skin irritation may occur. If the polyol contains more than twice the weight of the raspberry ketone, the problem may arise that the repellency is decreased.

In particular, the preservative composition of the present invention can be used not only for bacteria but also for prevention of decay by yeast, and exhibits excellent preservative effect in both bacteria and yeast.

In particular, the bacterium and yeast are selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa and Staphlyococcus aureus, Candida albicans, Aspergillus niger, And at least one selected from the group consisting of Aspergillus niger, Bacillus subtilis, Bacillus megaterium and Exophiala moniliae.

According to the present invention, there is provided a cosmetic composition comprising the preservative composition.

The cosmetic composition preferably contains the preservative composition in an amount of 0.01 to 5 wt%, more preferably 0.05 to 2 wt%, based on the total cosmetic composition. When the preservative composition is less than 0.01% by weight, the repelling force can not be maintained for a long period of time. In particular, when the preservative composition is more than 5% by weight, the repelling force is not further increased , There is a problem that skin irritation occurs rather.

Meanwhile, the pack may be a hydrogel mask pack or an essence mask pack formed of a hydrogel mask composition. The hydrogel mask composition that can be used herein may be prepared as follows, but is not limited thereto.

First, a solution obtained by dissolving a gelated polymer in a polyhydric alcohol and dissolving a preservative composition in a polyhydric alcohol is mixed with the solution, and then the mixture is heated to a temperature of 45 to 95 ° C. to prepare a gel solution. Other active ingredients such as skin active ingredients, fragrances, surfactants, and the like are added to produce a hydrogel composition in a flow state. The thus-prepared hydrogel composition can be produced in the form of a sheet or a patch and applied to the skin.

The preservative composition may be directly added to the dissolved gelled polymer solution, or may be added after mixing with the skin active ingredient, surfactant, etc., if necessary.

The gelling agent that may be added to the hydrogel composition may be carrageenan, locust bean gum, konjac, agar, sodium alginic acid, gellan, galactomannan, glucocomannan, or guar gum. The gelling agent may be a polyhydric alcohol And most preferably, glycerin can be used.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto.

Example

Manufacturing example One: Hydrogel Mask pack Produce

Example One

17 g of glycerin, 6 g of carrageenan and 1.5 g of locust bean gum were mixed with stirring and added with 3.0 g of glycerin and the contents of the preservative composition of the present invention as described in the following Table 1, Was added to a total of 100 g and the temperature was raised to 85 캜 to prepare a gel solution.

2.0 g of aloe extract, 0.5 g of collagen, 0.15 g of polysorbate 80 and 0.37 g of chitosan solution were sequentially added to the gel solution while maintaining the temperature of the gel solution at 85 캜 to prepare a cosmetic pack hydrogel composition.

Example 2 and 3

A hair cosmetic composition was prepared by the same procedures as in Example 1, except that the components and contents described in Examples 2 and 3 were used in Table 1 below.

Comparative Example 1 and 2

The hair gel composition for hair clip was prepared by the same procedure as in Example 1 except that the ingredients and the contents described in Comparative Examples 1 and 2 were used in Table 1 below.

Particularly, in this comparative example, at least one conventional preservative component selected from the group consisting of methylparaben, ethylparaben, phenoxyethanol, imidazolidinyl urea and the like was added in the contents shown in the following Table 1 instead of the preservative composition of the present invention, A hydrogel composition was prepared.

division ingredient Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Paid Polysorbate 80 0.15 0.15 0.15 0.15 0.15 Carrageenan gum 6.00 6.00 6.00 6.00 6.00 Locust Blind Sword 1.50 1.50 1.50 1.50 1.50 glycerin 20.00 20.00 20.00 20.00 20.00 Awards Aloe extract 2.00 2.00 2.00 2.00 2.00 Collagen 0.50 0.50 0.50 0.50 0.50 Chitosan solution 0.37 0.37 0.37 0.37 0.37 Purified water To 100 To 100 To 100 To 100 To 100 Antiseptic composition Raspberry ketone 0.15 0.15 0.15 Butoxydiglycol 0.35 Benzyl glycol 0.50 Diglycerin 0.50 Butylene glycol 0.50 0.50 Methylparaben 0.20 Ethyl paraben 0.15 Phenoxyethanol 0.20 Imidazolidinyl urea 0.25

(Unit: wt%)

Comparative Example 3 and 4

The hair gel pack composition of the present invention was prepared in the same manner as in Example 1, except that the components and contents described in Comparative Examples 3 and 4 were used in the following Table 2.

division ingredient Comparative Example 3 Comparative Example 4 Paid Polysorbate 80 0.15 0.15 Carrageenan gum 6.00 6.00 Locust Blind Sword 1.50 1.50 glycerin 20.00 20.00 Awards Aloe extract 2.00 2.00 Collagen 0.50 0.50 Chitosan solution 0.37 0.37 Purified water To 100 To 100 Antiseptic composition Raspberry ketone 2.0 - Butoxydiglycol - 2.0

Comparative Example 5 and 6

In the following Table 3, the composition and the contents described in Comparative Examples 5 and 6 were used, and the same procedure as in Example 1 was carried out to prepare a cosmetic pack hydrogel composition.

division ingredient Comparative Example 5 Comparative Example 6 Paid Polysorbate 80 0.15 0.15 Carrageenan gum 6.00 6.00 Locust Blind Sword 1.50 1.50 glycerin 20.00 20.00 Awards Aloe extract 2.00 2.00 Collagen 0.50 0.50 Chitosan solution 0.37 0.37 Purified water To 100 To 100 Antiseptic composition Raspberry ketone 0.5 1.5 Butoxydiglycol 1.5 0.5

Manufacturing example 2: Lotion formulation

The ingredients of Table 4 below were mixed to prepare cosmetic formulations of cosmetic lotion formulations.

division ingredient Content (% by weight) Paid ethanol 5.00 Pigment 60-Hydrogenated Castor Oil 0.40 Spices 0.10 Awards glycerin 7.00 Butylene glycol 5.00 Purified water To 100 antiseptic Raspberry ketone 0.15 Benzyl glycol 0.35

Manufacturing example 3: Cream Formulation

The ingredients of Table 5 below were mixed to prepare a cosmetic cream formulation.

division Raw material name Content (% by weight) Paid Polysorbate 80 1.50 Sorbitan stearate 0.80 Beads wax 1.50 Squalane 3.00 Octyldodecyl myristate 15.00 Cetyl alcohol 1.20 Awards glycerin 7.00 Butylene glycol 5.00 Carbomer 0.20 Triethanolamine 0.20 Purified water To 100 antiseptic Raspberry ketone 0.35 Butoxydiglycol 0.50

Manufacturing example 4: Cleanser Formulation

The ingredients of Table 6 below were mixed to prepare cosmetic formulations of the cleanser formulation.

division Raw material name Content (% by weight) Paid Sodium laureth sulfate 5.00 Sodium lauryl sulfate 16.00 Cocamidopropyl betaine 1.00 Cocamide dihey 1.00 Cetyl alcohol 0.50 Bis (C13-15 alkoxy) Fiji-amodimicicone 0.80 Spices 1.00 Awards Polyquaternium-10 0.10 Purified water To 100 antiseptic Raspberry ketone 0.50 Benzyl glycol 0.45 Butoxydiglycol 0.50

Experimental Example One: Buoyancy evaluation

(1) Confirming buoyancy against bacteria

In the hydrogel mask packs of Examples 1 to 3 and Comparative Examples 1 and 2 prepared according to Production Example 1, in order to evaluate the flushing force against bacteria, the hydrogel mask packs 20 to 30g were filled with Escherichia coli A mixture of each strain of each strain of each strain of Entericia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 9027) and Staphlyococcus aureus (ATCC 6538) at an initial concentration of 10 ⁶ cfu per gram of sample (colony forming unit; colony forming unit) / g.

These hydrogel mask packs to which the mycelial liquid was added were cultured in a thermostatic chamber at 30 to 32 ° C for 4 weeks and 1 g of each cosmetic material was taken at intervals of 3, 7, 14, 21, and 28 days, Table 7 shows the results.

Inoculum number 3 days 7 days 14 days 21st 28th Comparative Example 1 3.2 x 10 ⁶ 6.0 x 10 ³ 2.3 x 10 ¹ <10 <10 <10 Comparative Example 2 1.3 x 10 ⁶ 2.2 x 10 ² <10 <10 <10 <10 Comparative Example 3 4.0 x 10 ⁶ 3.2 x 10 ⁴ 2.3 x 10 ² <1000 <100 <10 Comparative Example 4 2.2 x 10 ⁶ 6.2 x 10 ⁴ 4.3 x 10 ³ <1000 <100 <100 Comparative Example 5 2.2 x 10 ⁶ 6.2 x 10 ⁴ 4.3 x 10 ³ <1000 <1000 <1000 Comparative Example 6 3.2 x 10 ⁶ 4.5 x 10 ³ 1.1 x 10 ¹ <10 <10 <10 Example 1 2.6 x 10 ⁶ 7.1 x 10 ¹ <10 <10 <10 <10 Example 2 2.8 x 10 ⁶ <10 <10 <10 <10 <10 Example 3 3.1 x 10 ⁶ 1.4 x 10 ² <10 <10 <10 <10

(Unit: CFU / g)

(2) Confirming buoyancy against fungi (yeast)

In the hydrogel mask packs of Examples 1 to 3 and Comparative Examples 1 and 2 prepared according to Production Example 1, 20 to 30 g of these hydrogel mask packs were tested for candida albicans (fungi) The mixture was mixed with Candida albicans (ATCC 10231) and Aspergillus niger ATCC 8734 to an initial concentration of 10 ⁶ cfu / g per sample, followed by culturing for 4 weeks in a 25 ° C thermostat 1 g of each cosmetic material was taken at intervals of 3, 7, 14, 21, and 28 days, and viable cell counts were measured. The results are shown in Table 8 below.

Inoculum number 3 days 7 days 14 days 21st 28th Comparative Example 1 3.4 x 10 ⁶ 4.6 x 10 ² 1.5 x 10 ¹ <10 <10 <10 Comparative Example 2 6.7 x 10 ⁶ 1.6 x 10 ³ 1.6 x 10 ² <10 <10 <10 Comparative Example 3 4.4 x 10 ⁶ 3.6 x 10 ⁴ 1.5 x 10 ³ <100 <10 <10 Comparative Example 4 8.7 x 10 ⁶ 1.6 x 10 ⁵ 1.2 x 10 ³ 5.2 x 10 ³ <100 <100 Comparative Example 5 8.7 x 10 ⁶ 1.6 x 10 ⁵ 1.2 x 10 ³ 5.2 x 10 ³ <100 <100 Comparative Example 6 3.5 x 10 ⁶ 5.5 x 10 ³ 3.1 x 10 ¹ <10 <10 <10 Example 1 3.5 x 10 ⁶ 3.7 x 10 ² 1.1 x 10 ¹ <10 <10 <10 Example 2 1.2 x 10 ⁶ <10 <10 <10 <10 <10 Example 3 4.0 x 10 ⁶ 4.6 x 10 ¹ <10 <10 <10 <10

(Unit: CFU / g)

As can be seen from Tables 7 and 8, when the preservative composition according to the present invention was used, it was confirmed that both bacterial and yeast bacteria had a remarkably improved preservative effect as compared with the conventional chemical preservative.

Experimental Example 2: skin irritation test

The mask caps prepared according to the above Example and Comparative Example 6 were applied to the lower limbs of 50 male and female workers according to the closure pellet test method, and the plastic caps were covered, and the degree of irritation was observed for 1 hour after use. The criteria for the degree of stimulation are as follows.

0: No stimulation

1: slight irritation

2: erythema,

3: Severe irritation such as erythema and edema

4: Severe irritation such as erythema and edema

The degree of stimulation of each subject was measured and then divided by the number of subjects and the average degree of stimulation was calculated. Table 9 below is an average of the degree of stimulation calculated by the above determination method.

Example 1 Example 2 Comparative Example 6 medium 0 0 2.5

As can be seen from the results of Table 9, it can be seen that the mask pack manufactured according to the present invention has little skin irritation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be obvious to those of ordinary skill in the art.

Claims

A preservative composition comprising raspberry ketone and a polyol.

The preservative composition of claim 1, wherein the raspberry ketone and polyol are mixed in a weight ratio of 1: 2 to 2: 1.

The preservative composition according to claim 1, wherein the preservative composition is a composition for preventing the decay of bacteria and yeast.

4. The method according to claim 3, wherein the bacteria and yeast are selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa and Staphlyococcus aureus, Candida albicans, Wherein the preservative composition is selected from the group consisting of Aspergillus niger, Bacillus subtilis, Bacillus megaterium and Exophiala moniliae.

4. The composition of claim 3, wherein the polyol is selected from the group consisting of benzyl glycol, butoxy diglycol, diglycerin, butylene glycol, propylene glycol, propanediol, pentaerythritol, 8 < / RTI >

A cosmetic composition comprising the preservative composition of any one of claims 1 to 5.

The cosmetic composition according to claim 6, wherein the cosmetic composition is at least one selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, &Lt; / RTI >

The cosmetic composition according to claim 6, wherein the cosmetic composition comprises 0.01 to 5% by weight of the preservative composition based on the total weight of the cosmetic composition.