KR101956144B1 - Skin external composition having excellent bactericidal activities - Google Patents

Abstract

The present invention relates to a composition for external application for skin having excellent repelling force without using a chemical preservative, and more particularly, to a composition for external application for skin, which comprises glyceryl undecylate having excellent buoyancy; And a mixture of at least one of mixed extracts of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus, thereby having excellent repellency through synergistic effect on the flotation power of these substances.

Description

[0001] The present invention relates to a skin external composition having excellent buoyancy,

The present invention relates to a composition for external application for skin having excellent repelling force without using a chemical preservative, and more particularly, to a composition for external application for skin, which comprises glyceryl undecylate having excellent buoyancy; And a mixture of at least one of mixed extracts of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus, thereby having excellent repellency through synergistic effect on the flotation power of these substances.

The composition for external application for skin is not particularly limited as long as it can be used in the form of dirt, dirt, dust, dirt or the like which is contaminated by microorganisms adhered to the manufacturing water or raw material transfer pipe, Contamination of microorganisms may occur due to the incorporation of foreign substances. For this reason, in the composition for external application, for the purpose of suppressing the proliferation of contaminated microorganisms and improving the repelling force for destroying the contaminated microorganisms, there are used paraffinic acid esters (parabens), imidazolidinyl urea, phenoxyethanol, , Benzoic acid, sorbic acid, and dehydroacetic acid. However, such a chemical preservative is effective as a preservative used in a composition for external application for skin, but it has disadvantages such as toxicity, skin irritation, irritation and allergy. Therefore, it is necessary to reduce the use of a chemical preservative, There is a demand for.

It is of course possible to produce a composition for external application for skin which is not formulated with a conventional chemical preservative by using a diol which has recently been known to have antibacterial activity or to pack it in a container which prevents the incorporation of microorganisms in the manufacturing process and inhibits the contamination of bacteria It is possible to produce a skin external preparation which does not use a preservative or a preservative smaller than a usual level. However, in the case of diol, skin irritation affects safety, solubilization and stability of emulsified formulations, When the container for inhibiting the inflow of microbes is used, the manufacturing process is complicated, the maintenance cost of the equipment, the cost of the container, and the like are increased, and the economical versatility is lacking.

Accordingly, the present inventors have made it possible to provide a composition for external application for skin having a safe repelling force from a harmful microorganism which is equal to or more than that of a composition for external application of a skin using a chemical preservative without using a conventional chemical preservative. The glyceryl undecylate was dissolved in ethylhexyl Glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate, glyceryl caprylate and glyceryl caprylate.

Accordingly, it is an object of the present invention to provide a composition for external application for skin having excellent repelling force without using a conventional chemical preservative.

In order to achieve the above-mentioned object, the present invention relates to a process for the production of a composition comprising glyceryl undecylate; And at least one of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract.

The present invention provides a repelling force equal to or greater than that obtained by using a chemical preservative without using a conventional chemical preservative and does not cause toxicity, skin irritation, irritation, and allergy due to the use of a chemical preservative, .

FIG. 1 is a flowchart showing a procedure for evaluating the buoyant force.

The present invention relates to glyceryl undecylate; And a mixture of at least one selected from the group consisting of ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus mixed extract.

In the present invention, by using a combination of glyceryl undecylate having antimicrobial effect and ethylhexyl glycerin, glyceryl caprylate, p-anisic acid or citrus mixed extract, a synergistic effect is obtained, And the composition of the present invention may contain 0.025 to 2.5% by weight of glyceryl undecylate, 0.01 to 1.0% by weight of ethylhexyl glycerin, 0.01 to 1.0% by weight of glyceryl caprylate, 0.01 to 1.0% by weight of p-anisic acid, and 0.01 to 1.0% by weight of a citrus mixture extract.

The citrus mixed extract used in the present invention is not limited to citrus plants that can be used as an extract of citrus plants, but may be an extract of grapefruit, bergamot, sweet orange, tangerine, mandarin orange, or a mixture thereof. Extracts from all parts of citrus fruits such as stems, leaves, flowers and fruits can be used, and the extracts are not limited to any particular part. In addition, the extract includes not only the leached liquid obtained by leaching and transferring from the citrus plants but also the concentrate obtained by partially or completely concentrating the leaching solution, or the one prepared by drying the concentrate again, Used in combination with vegetable glycerin. In addition, the extract of the present invention may be obtained by compressing fruit, leaves and stem of a citrus plant, mixing and fermenting the fermented product, centrifuging the fermentation product to obtain a liquid fermentation extract, heat-treating the fermented extract, and mixing with vegetable glycerin .

Thus, by using glyceryl undecylate in combination with ethylhexyl glycerin, glyceryl caprylate, p-anisic acid or citrus mixed extract in appropriate proportions, the present invention can provide a chemical preservative such as paraben or phenoxyethanol, It is possible to provide a composition for external application for skin which secures a sufficient repelling force without blending existing diols that may be caused.

Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples and test examples are presented only for understanding the contents of the present invention, and the scope of the present invention is not limited thereto.

[Referential Example 1] Preparation of Examples 1 to 4 and Comparative Examples 1 to 7

The formulation of lotion was prepared in a conventional manner according to the composition of the following Table 1 (unit: wt%). The citrus mixture extract was a Bio Citro liquid (Quinabra) product, which contained Citrus Paradisi fruit extract, Citrus Aurantium Bergamia ) fruit extract, orange ( Citrus Aurantium Dulcis ) fruit extract, Citrus Tangerina fruit extract and glycerin.

Raw material name Example Comparative Example One 2 3 4 One 2 3 4 5 6 7 Purified water Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Cyclopentasiloxane 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Dipropylene glycol 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 2.50 Dimethicone / Vinyl Dimethicone Crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Hydrolized milk protein / PIPE crosspolymer 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Beta-glucan 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 FAGE -100 stearate 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 Cetyl hexanoate 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Dimethicone 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Cetearyl alcohol 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Silica 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Ammonium acryloyldimethyltaurate / Vpicopolymer 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 Sorbitan sesquioleate 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 Carbomer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.14 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Pigment Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Glyceryl undecylate 0.5 0.5 0.5 0.5 1.00 Ethylhexyl Glycerin 0.1 0.2 Glyceryl caprylate 0.2 0.4 p-Anisan 0.2 0.4 Citrus mixed extract 0.2 0.4 Methylparaben 0.25 Propylparaben 0.1 Phenoxyethanol 0.4

[Test Example 1] Flotation test

In order to evaluate the buoyant force, the test was basically carried out according to the procedure shown in Fig.

Escherichia coli (ATCC 8739 ), Staphlyococcus (Staphylococcus), and Staphylococcus were added to 20 to 30 g of the cosmetics of Examples 1 to 4 and Comparative Examples 1 to 7, aureus ; ATCC 6538), Pseudomonas aeruginosa ; ATCC 99027) and Candida albicans (ATCC 10231) were added at an initial concentration of ⁵ × 10 ⁵ cfu (colony forming unit) / g per sample. 1 g of each cosmetic was taken at intervals of 7, 14, and 28 days while the cells were incubated in a thermostatic chamber at 32 ° C for 4 weeks, and the viable cell counts were measured. The results are shown in Table 2 below.

In the case of fungi, 20 to 30 g of cosmetic preparations of Examples 1 to 4 and Comparative Examples 1 to 7 were mixed with an initial concentration of 1 x 10 ⁵ cfu / g of Aspergillus niger (ATCC 16404) 1 g of each cosmetic was taken at intervals of 7, 14, and 28 days while culturing in a 25 ° C thermostat, and the number of viable cells was measured, and the presence of hyphae and spore formation on the surface of the sample was observed. Respectively.

Cosmetics Bacteria (cfu / g) Initial number of bacteria Day 7 Day 14 Day 28 Lotion Example 1 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 2 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 3 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Example 4 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ² Comparative Example 1 5 × 10 ⁵ > 1 × 10 ⁶ > 1 × 10 ⁶ > 1 × 10 ⁶ Comparative Example 2 5 × 10 ⁵ 5 × 10 ⁵ 3.1 x 10 ³ 1 x 10 ³ Comparative Example 3 5 × 10 ⁵ 4.5 × 10 ⁵ 1 × 10 ⁵ 2 x 10 ³ Comparative Example 4 5 × 10 ⁵ 3.5 × 10 ⁵ 1 × 10 ⁵ 3 x 10 ⁴ Comparative Example 5 5 × 10 ⁵ 3.5 × 10 ⁵ 1 × 10 ⁵ 1 x 10 ⁴ Comparative Example 6 5 × 10 ⁵ 4 × 10 ⁵ 4 × 10 ⁵ 4 × 10 ⁵ Comparative Example 7 5 × 10 ⁵ &Lt; 1 x 10 ³ <1 × 10 ² <1 × 10 ²

Cosmetics Mold (cfu / g) Initial number of bacteria Day 7 Day 14 Day 28 Visual observation Lotion Example 1 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ² 1 x 10 ² clear Example 2 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ³ 1 x 10 ³ clear Example 3 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ² clear Example 4 1 × 10 ⁵ 1 x 10 ⁴ 1 x 10 ³ 1 x 10 ³ clear Comparative Example 1 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ Spore development Comparative Example 2 1 × 10 ⁵ 2.3 x 10 ⁴ 3.6 × 10 ⁴ 1 x 10 ³ clear Comparative Example 3 1 × 10 ⁵ 3 x 10 ⁴ 2.1 x 10 ⁴ 1 x 10 ³ clear Comparative Example 4 1 × 10 ⁵ 3 x 10 ⁴ 2.1 x 10 ⁴ 1 x 10 ³ clear Comparative Example 5 1 × 10 ⁵ 1 x 10 ³ 1 x 10 ² 1 x 10 ² clear Comparative Example 6 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ 1 × 10 ⁵ Spore development Comparative Example 7 1 × 10 ⁵ 1 x 10 ⁴ 2 x 10 ³ 1 x 10 ³ clear

The results are shown in Tables 2 and 3. In Tables 2 and 3, in Comparative Examples 2 and 3 in which glyceryl undecylate and ethylhexyl glycerin glyceryl caprylate, p-anisic acid and citrus mixed extracts were used, respectively, It can be observed that the use of less than ~6 of the present invention has better buoyancy, and a smaller amount of use compared to the case of Comparative Example 7 using methylparaben, propylparaben and phenoxyethanol, It is possible to confirm that a superior level of buoyancy is exhibited.

[Test Example 2] Usability (stimulus) test

Examples 1 to 4, which are skin external composition compositions according to the present invention, were compared with Comparative Example 1 for subjects sensitized to stimuli such as warmth, warmth, and the like of 15 panelists, and this was compared with Comparative Example 1, Comparative Example 1, 0.5 ml of each of the test samples of Example 2, Comparative Examples 1 and 3, and Comparative Examples 1 and 4 were rubbed to randomly apply the test samples to evaluate irritation such as stinging, itching, and eyesurfing. Table 4 shows the results.

<Evaluation Criteria>

0 ~ 0.4: No stimulation

0.4 to 1.0: light stimulus

1.1 ~ 2.0: Medium Stimulation

2.1 ~ 3.0: Strong stimulation

Usability test result (stimulus value) Comparative Example 1 Example 1 Comparative Example 1 Example 2 Comparative Example 1 Example 3 Comparative Example 1 Example 4 Stinginess 0.09 0.11 0.46 0.27 0.06 0.16 0.20 0.19 Burning 0.20 0.35 0.16 0.34 0.49 0.29 0.42 0.35 Average 0.15 0.23 0.31 0.31 0.28 0.23 0.31 0.27

As shown in Table 4 above, the irritation level of the product obtained by mixing glyceryl undecylate with ethylhexyl glycerin, glyceryl caprylate, p-anisic acid or citrus mixed extract was unstimulated, and the comparison It can be confirmed that there is no significant difference in stimulation when compared with Example 1, and thus there is no increase in stimulation due to the substance used in the present invention.

[Test Example 3] Skin irritation test

To evaluate the skin safety of the mixed extract of glyceryl undecylate, ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus in the human body, a patch test was conducted on 40 subjects for 24 hours. The patches were attached to the upper part of the subject and 20 占 퐇 of the prepared test material was applied using an IQ chamber (chemotechique, Sweeden). Twenty - four hours after removing the patch, the first reading was performed 30 minutes later, and the second reading was performed after 24 hours. In order to examine the intensity of the skin irritation of the sample, a weight was assigned according to the degree of the positive reaction of the skin, and skin irritation of the sample was determined by obtaining the skin average response according to the following formula (1).

<Criteria>

Score <1 (Grade I): No stimulation range

1 to less than 3 (grade II): light stimulus

3 to less than 5 (grade III): moderate irritation

5 or more (grade IV): Strong stimulus

Test results (n = 40) Test substance score Glyceryl undecylate 4% 0.00 Ethylhexyl glycerin 3% 0.31 Glyceryl caprylate 5% 0.94 p-Anisan 1% 0.94 Citrus Mixture Extract 1% 0.00

From the results in Table 5, it can be confirmed that the mixed extract of glyceryl undecylate, ethylhexyl glycerin, glyceryl caprylate, p-anisic acid and citrus is all at a non-stimulating level.

Therefore, even if the composition containing these substances is used as an external preparation for skin, it can be safely used without irritating the skin.

Claims (5)

An antiseptic composition comprising glyceryl undecylate and citrus mixed extract as an active ingredient,
The citrus mixed extract includes Citrus Paradisi fruit extract, Citrus Aurantium Bergamia fruit extract, Citrus Aurantium Dulcis fruit extract, Citrus Tangerina fruit extract and glycerin,
Wherein the mixing ratio of the glyceryl undecylate and the citrus mixed extract is 5: 2 by weight. The preservative composition according to claim 1, wherein the content of glyceryl undecylate is 0.025 to 2.5% by weight based on the total weight of the composition, and the content of the citrus mixed extract is 0.01 to 1.0% by weight. The preservative composition of claim 1, wherein the composition is used in a cosmetic composition. The method according to claim 1, wherein the citrus mixture extract is obtained by compressing grapefruit fruit, bergamot fruit, orange fruit and tangerine fruit, mixing and fermenting the mixture, centrifuging the fermented product to obtain a liquid fermented extract, &Lt; / RTI &gt; and mixtures thereof. delete

Images