KR100481637B1 - Non-Preservative Cosmetic Composition - Google Patents

Non-Preservative Cosmetic Composition Download PDF

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KR100481637B1
KR100481637B1 KR10-2002-0087631A KR20020087631A KR100481637B1 KR 100481637 B1 KR100481637 B1 KR 100481637B1 KR 20020087631 A KR20020087631 A KR 20020087631A KR 100481637 B1 KR100481637 B1 KR 100481637B1
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cosmetic composition
skin
labeled
ingredients
preservative
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KR10-2002-0087631A
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Korean (ko)
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KR20040060632A (en
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조자운
윤여필
임태형
유성수
김현수
김경남
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주식회사풀무원
풀무원건강생활 주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic

Abstract

본 발명은 항균 작용(Antimicrobial activity) 기능을 갖는 원료를 혼합한 화장품 조성물에 관한 것이다. 기존 화장품 조성물은 방부제(표시지정 성분)를 첨가하지 아니하고 제조하였을 시 미생물 오염이 쉽게 이루어질 수 있으며 피부안전성에 문제가 야기될 수 있다. 표시지정 성분이란 인체에의 유해성을 우려하여 사용할 경우 식품의약품 안전청에서 반드시 그 성분을 표기하도록 하고 허용 함량을 법적으로 지정해 놓은 성분들을 말하며 타르색소, 방부, 살균제, 항히스타민제, 자외선차단제, 금박, 두발제품에 한해서 전인산염의 항목으로서 인산염이 있다.The present invention relates to a cosmetic composition in which a raw material having an antimicrobial activity function is mixed. Existing cosmetic compositions can be easily made microbial contamination when not prepared without the addition of preservatives (designated ingredients) and may cause problems with skin safety. Labeled ingredients are those ingredients that must be labeled by the Korea Food and Drug Administration when using them in consideration of danger to the human body, and have legally designated allowable contents. Only phosphate is a product of total phosphate.

본 화장품 조성물은 방부제(표시지정 성분)를 첨가하지 않고 방부 효과와 피부에 안전한 화장품 조성물을 얻을 수가 있다.This cosmetic composition can obtain the cosmetic composition which is safe for an antiseptic effect and skin, without adding a preservative (labeled designation component).

Description

무방부제 화장품 조성물{Non-Preservative Cosmetic Composition}Non-preservative cosmetic composition

본 발명은 항균 작용(Antimicrobial activity) 기능을 갖는 원료를 혼합한 화장품 조성물에 관한 것이다. 기존 화장품 조성물은 방부제(표시지정 성분)를 첨가하지 아니하고 제조하였을 시 미생물 오염이 쉽게 이루어질 수 있다. 본 화장품 조성물은 방부제(표시지정 성분)를 첨가하지 않고 방부 효과와 피부에 안전한 화장품 조성물을 얻을 수가 있다.The present invention relates to a cosmetic composition in which a raw material having an antimicrobial activity function is mixed. Existing cosmetic compositions can be easily made microbial contamination when prepared without the addition of preservatives (designated ingredients). This cosmetic composition can obtain the cosmetic composition which is safe for an antiseptic effect and skin, without adding a preservative (labeled designation component).

일반적으로 화장품 조성물은 기름이나 물을 주성분으로 하며 거기에 미생물의 탄소원이 되는 글리세린이나 솔비톨 등 질소원으로는 아미노산 유도체, 단백질 등이 배합된 것이 많으므로 곰팡이나 세균 등의 미생물이 침투하기 쉽다.In general, the cosmetic composition contains oil or water as a main component, and as a nitrogen source such as glycerin or sorbitol, which are carbon sources of microorganisms, many amino acid derivatives and proteins are incorporated, so microorganisms such as molds and bacteria are easily infiltrated.

그래서 사용 중에 손가락 등으로부터 오염되어 미생물이 일으키는 변패, 변취등으로부터 화장품을 장기간 보호하기 위해 방부제를 첨가하지 아니할 수가 없다.Therefore, it is inevitable to add a preservative to protect the cosmetics from the decay and odor caused by microorganisms that are contaminated by fingers and the like during use.

방부제(Preservatives)는 화장품에 배합되어 외부로부터 화장품을 오염시키는 미생물의 증식을 억제하며, 시간 경과와 함께 사멸되며 제품의 변화를 방지하는 목적으로 방부제(Preservatives)가 사용된다. 이와 같이 미생물의 증식을 억제하는 작용을 정균 작용(microbiostasis)이라 하며, 방부제(Preservatives)는 화장품 중에서 정균 작용에 의해 변화를 방지하고 있다. 단독의 방부 효과는 그다지 강하지는 않지만 화장품의 성분과 융합되기 쉬워서 오염된 기존 미생물을 시간을 두고 사멸시켜 가는 것이 일반적이다.Preservatives are formulated in cosmetics to inhibit the growth of microorganisms that contaminate cosmetics from the outside, die over time, and preservatives are used to prevent product changes. As such, the action of inhibiting the growth of microorganisms is called bacteriostatic (microbiostasis), preservatives (Preservatives) to prevent changes by the bacteriostatic action in cosmetics. Although the antiseptic effect alone is not very strong, it is easy to fuse with the components of cosmetics, and it is common to kill existing contaminated microorganisms over time.

대표적인 것은 파라옥시안식향산 에스테르와 이미다졸린계 방부제 등이 있다.Typical examples include paraoxybenzoic acid esters and imidazoline-based preservatives.

이처럼 방부제를 사용하는 이유는 화장품을 사용할 때 각종 세균에 의한 변질을 방지하기 위한 것으로 이 제품을 지속적으로 사용할 시 피부트러블인 뾰루지 같은 피부질환을 유발시킬 수 있는 원인으로 작용 되기도 한다.The reason for using this preservative is to prevent the deterioration caused by various bacteria when using cosmetics, and it can also act as a cause of skin problems such as rashes when skin is used continuously.

이에 본 발명에서는 상기 항균 작용(Antimicrobial activity) 기능을 갖는 원료로 대치하여 피부질환을 유발시킬 수 있는 방부제 사용을 아니하여 보다 안전한 고품질의 화장품 조성물 제조를 그 목적으로 한다.In the present invention, by using the antimicrobial activity (Antimicrobial activity) function as a raw material, instead of using a preservative that can cause skin diseases, the purpose is to produce a safer high-quality cosmetic composition.

본 발명을 좀 더 상세히 설명하면 다음과 같다.The present invention is described in more detail as follows.

본 발명의 항균 작용(Antimicrobial activity) 기능을 갖는 원료로 화장료 조성물에 대하여 테트라아세틸파이토스핑고신, 펜틸렌 글라이콜(Hydrolite-5), 폴리글리세릴-2라우레이트/글리세릴카프레이트/폴리글리세릴-10라우레이트, 자몽 종자 추출물, 동충하초 추출물을 각 처방에 맞게 첨가한 것으로 특징 되어진다.Tetraacetylphytosphingosine, pentylene glycol (Hydrolite-5), polyglyceryl-2 laurate / glyceryl caprate / polyglyceryl- with respect to the cosmetic composition as a raw material having an antimicrobial activity function of the present invention It is characterized by the addition of 10 laurate, grapefruit seed extract, Cordyceps sinensis extract according to each prescription.

여러가지 항균 작용을 하는 원료들을 스크리닝하고, 각 원료를 복합 처방하여 CTFA의 가이드라인(CTFA Microbiology Guidelines) 시험법을 통한 미생물 균주를 사멸하는 효과가 있음을 알게 되었다.Various antimicrobial agents were screened, and each compound was prescribed in combination and found to be effective in killing microbial strains through CTFA Microbiology Guidelines.

본 발명에서 사용되는 항균 작용(Antimicrobial activity) 기능 갖는 원료를 살펴보면 다음과 같다.Looking at the raw material having an antimicrobial activity (Antimicrobial activity) function used in the present invention.

테트라아세틸파이토스핑고신(Tetraacetyl phytosphingosine; Taps) 스핑고지질은 스핑고신 또는 파이토 스핑고신을 기본골격으로 하고, 세라마이드는 여기에 유리 지방산이 연결된 형태를 띄고 있다.Tetraacetyl phytosphingosine (Taps) Sphingolipids are based on sphingosine or phytosphingosine, and ceramides have free fatty acids linked thereto.

효과는 지루성 피부를 악화시키는 원인균 억제, 피부보습 기능 촉진, 피부세포의 활성 촉진, 피부 유해 물질의 침입과 성장을 억제하여 최적의 피부 미생물 분포를 유지시킴, 항균 항염증 효과, 자외선에 의한 피부자극 완화, 주름개선효과가 우수하여 피부 노화를 효과적으로 완화시킴The effect is to inhibit the causative bacteria that exacerbate seborrheic skin, to promote skin moisturizing function, to promote the activity of skin cells, to maintain the optimum distribution of skin microorganisms by inhibiting the invasion and growth of harmful substances of skin, antibacterial anti-inflammatory effect, skin irritation by UV rays Effectively alleviates skin aging with excellent relief and wrinkle improvement

펜틸렌 글라이콜(Hydrolite-5)는 INCI name, Pentylene Glycol (1,2-pentanediol)로서 에칠렌 옥사이드 프리타입(EO Free Type)의 계면활성제로 피부안전성이 우수하고 강한 항균 특성을 나타냄, 식품 첨가물에도 사용 가능한 순수한 천연 성분으로 구성됨. 효과로는 보습작용, 항-미생물 작용Pentylene Glycol (Hydrolite-5) is an INCI name, Pentylene Glycol (1,2-pentanediol), a surfactant of ethylene oxide free type, which shows excellent skin safety and strong antibacterial properties. Composed of pure natural ingredients that can also be used. The effect is moisturizing, anti-microbial

폴리글리세릴-2라우레이트/글리세릴카프레이트/폴리글리세릴-10라우레이트(Polyglyceryl-2 Laurate/Glyceryl Caprate/Polyglyceryl-10 Laurate)의 원료특성은 Ethylene Oxide Free 계면활성제이고, 강한 항-박테리아 성질을 갖고 있다. 식품첨가제로 사용 가능하며 순수하게 자연에서 채취된 원료로 구성되어 있다.The raw material of Polyglyceryl-2 Laurate / Glyceryl Caprate / Polyglyceryl-10 Laurate is Ethylene Oxide Free Surfactant and has strong anti-bacterial properties. Have It can be used as a food additive and consists of purely natural raw materials.

자몽 종자 추출물(Grapefruit Seed extract)은 Ascorbic acid가 존재하고 있으며, 이 성분은 metal ion들의 환원제로서 산소계 특히, hydroxy radical을 생성시켜 이것이 세포막에 분포되어 있는 효소활성을 저해하여 세포막 기능을 약화시키고, 낮은 농도로도 미생물의 세포 호흡작용을 저해하여 미생물의 정상적인 생육을 억제한다. 즉, 세포막의 투과성 약화와 세포 호흡작용의 억제를 도모함으로써 미생물의 살균을 도모할수 있다.Grapefruit Seed extract contains Ascorbic acid, which is a reducing agent for metal ions, which produces oxygen-based, especially hydroxy radicals, which inhibits the enzyme activity distributed in the cell membranes, thereby degrading cell membrane function. Concentration also inhibits microbial cell respiration, thereby inhibiting normal growth of microorganisms. That is, microorganisms can be sterilized by reducing the permeability of cell membranes and suppressing cellular respiration.

특히 세균, 곰팡이, 바이러스등의 부패성 및 병원성 미생물에 대해 강력하게 살균, 살바이러스, 살곰팡이 작용을 한다.In particular, it strongly acts on sterilization, killer virus, and fungus against decaying and pathogenic microorganisms such as bacteria, fungi and viruses.

동충하초 추출물은 공정서명(식품공전), 밀리타리스 (C.Militaris) 동충하초로서 누에유충에서 기생하는 균주로부터 만들어지는 것으로서 전래의 영약으로 코디세핀(Cordycepin 3' deoxyadenosine)성분 함유, 코디세핀의 구조는 핵산물질인 데옥시아데노신의 구조와 유사하며, 세포의 유전자 정보에 관여하면서 저하된 면역기능을 활성화하고 정상세포가 암세포로 되는 것을 방지하는 작용을 하며 다당체는 면역기능을 증강시키는 역할과 암을 억제하고 항산화 효과, 미백 및 노화방지 기능이 있다.Cordyceps sinensis extract is a process signature (Food Codex), Militaris (C.Militaris) cordyceps, which is made from strains parasitic from silkworm larvae. It is similar to the structure of deoxyadenosine, a nucleic acid substance, and activates the reduced immune function while preventing the involvement of normal cells into cancer cells by being involved in the genetic information of the cell, and the polysaccharide enhances immune function and inhibits cancer. It has an antioxidant effect, whitening and anti-aging.

다음의 실시예는 본 발명을 좀더 상세히 설명한 것이지만 본 발명의 범주를 한정한 것은 아니다.The following examples further illustrate the invention but do not limit the scope of the invention.

[실시예 1]Example 1

[실시예 2]Example 2

[실시예 3]Example 3

실험에 필요한 미생물 균주는 이래와 같으며 스타필로코커스 아우레루스(Staphylococcus aureus), 에스케리치아 코리(Escherichia coli), 엔터로박터 크로아카(Enterobacter cloacae), 슈도모나스 아에루기노사(Paeudomonas aeruginosa), 캔디다 알비칸스(Candida albicans), 아스퍼질러스 나이거(Aspergillus niger)등 이고, 미생물을 접종하여 사멸 여부를 확인하는 방법을 Challenge test, inoculum test라고 하고, CTFA의 가이드라인(CTFA Microbiology Guidelines) 시험법을 사용하였다.The microbial strains required for the experiment are as follows: Staphylococcus aureus, Escherichia coli, Enterobacter cloacae, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger, and the method of inoculating microorganisms and confirming their death are called challenge tests, inoculum tests, and CTFA microbiology guidelines. Was used.

진균(곰팡이, 효모)은 제품 1g당 1×105개가 되도록 접종하고 세균은 제품 1g당 1×106개가 되도록 접종하여, 1일 ~ 28일까지 시간 경과 관찰을 하였다.Fungi (fungus, yeast) were inoculated to be 1 × 10 5 per 1g of product and bacteria were inoculated to be 1 × 10 6 per 1g of product, and observed over time from 1 day to 28 days.

Challenge test 28일차에 박테리아, 곰팡이 균주가 모두 사멸하였다.On the 28th day of challenge test, both bacteria and fungi were killed.

<그림 1> 첼린지 테스트 0일차 (박테리아)<Figure 1> Challenge Test Day 0 (Bacteria)

<그림 2> 첼린지 테스트 28일차 (박테리아)<Figure 2> Challenge Test Day 28 (Bacteria)

<그림3> 첼린지 테스트 0일차 (곰팡이)<Figure 3> Challenge Test Day 0 (fungus)

<그림4> 첼린지 테스트 28일차 (곰팡이)<Figure 4> Day 28 of the Chelsea Test (fungus)

<제품 안정성 평가><Product Stability Evaluation>

상기 스킨 로션 크림의 화장품 조성물 제형 안정도를 알아보기 위하여 저장조건을 각각 1개월동안 보관 후 안정도를 평가 하였다.In order to determine the stability of the cosmetic composition formulation of the skin lotion cream, the storage conditions were evaluated for storage stability after 1 month each.

<인체 피부 일차 자극 실험><Human Skin Primary Stimulation Experiment>

상기 시험은 인체피부 일차 자극 시험으로 인체 첩포시험(human patch test)으로 하였다 건강한 20∼30대 여성 30명을 대상으로 CTFA 가이드 라인(The Cosmetic Toiletry and Fragrance association, Safety testing guidelines)에 따라 실시하였다. 핀 챔버(Finn Chamber)에 준비된 화장품 조성물 각각을 1g을 적하시킨 후 시험 부위인 우측 상완 내측에 첩포검사를 실시 하였다. 첩포는 24시간 도포하며 첩포를 제거한 후는 마킹 펜(marking pen)으로 시험부위를 표시하며 30분, 24시간, 48시간 후에 각 시험 부위의 피부반응을 관찰하여 국제 접촉 피부염 연구회(International Contact Research Group; ICDRG)의 규정에 따라 판정하였다. 최종 판독 결과는 모두 음성반응을 보여 피부 안전성이 우수한 것으로 나타났다.The test was a human patch test as the primary skin irritation test. Thirty healthy women in their 20s to 30s were tested according to the CTFA guidelines (The Cosmetic Toiletry and Fragrance association, Safety testing guidelines). 1 g of each of the cosmetic compositions prepared in the Finn Chamber was dropped and a patch test was performed on the inside of the right upper arm, which is a test site. The patch is applied for 24 hours. After the patch is removed, the test site is marked with a marking pen. After 30 minutes, 24 hours, and 48 hours, the skin reaction of each test site is observed. The International Contact Research Group (International Contact Research Group) ; ICDRG). The final readings were all negative, indicating good skin safety.

이상에서 설명한 바와 같이 본 발명에 따른 화장품 조성물은 파라옥시안식향산 에스테르, 이미다졸린계 등의 방부제(Preservatives)를 사용하지 않고 방부 효과와 피부 안전한 화장품 조성물을 얻을 수 있음을 알수 있다.As described above, it can be seen that the cosmetic composition according to the present invention can obtain a preservative effect and a skin safe cosmetic composition without using preservatives such as paraoxybenzoic acid ester and imidazoline.

Claims (3)

화장수류에서 프로필렌 글라이콜 4.0 ∼ 8.0중량%(이하 '중량' 은 생략), 에탄올 3.0 ∼ 7.0%, 테트라아세틸파이토스핑고신 0.2 ∼ 0.5%, 자몽 종자 추출물0.5 ∼ 1.5%, 동충하초 추출물0.1 ∼ 0.5%의 화장품 조성물Propylene glycol 4.0 to 8.0% by weight (hereinafter 'weight' is omitted), ethanol 3.0 to 7.0%, tetraacetylphytosphingosine 0.2-0.5%, grapefruit seed extract 0.5-1.5%, Cordyceps sinensis extract 0.1-0.5% Cosmetic composition 유액류에서 프로필렌 글라이콜 4.0 ∼ 8.0%, 펜틸렌 글라이콜 2.0 ∼ 8.0%, 테트라아세틸파이토스핑고신 0.2 ∼ 0.5%, 폴리글리세릴-2라우레이트/글리세릴카프레이트/폴리글리세릴-10라우레이트 0.8 ∼ 1.5%, 자몽 종자 추출물0.5 ∼ 1.5%, 동충하초 추출물0.1 ∼ 0.5%의 화장품 조성물Propylene glycol 4.0-8.0%, pentylene glycol 2.0-8.0%, tetraacetyl phytosphingosine 0.2-0.5% in emulsion, polyglyceryl-2 laurate / glyceryl caprate / polyglyceryl-10 laurate Cosmetic composition of 0.8-1.5%, grapefruit seed extract 0.5-1.5%, Cordyceps sinensis extract 0.1-0.5% 크림류에서 프로필렌 글라이콜 4.0 ∼ 8.0%, 펜틸렌 글라이콜 2.0 ∼ 8.0%, 테트라아세틸파이토스핑고신 0.2 ∼ 0.5%, 자몽 종자 추출물 0.5 ∼ 1.5%, 동충하초 추출물0.1 ∼ 0.5%의 화장품 조성물Cosmetic composition of propylene glycol 4.0-8.0%, pentylene glycol 2.0-8.0%, tetraacetylphytosphingosine 0.2-0.5%, grapefruit seed extract 0.5-1.5%, Cordyceps sinensis extract 0.1-0.5% in cream
KR10-2002-0087631A 2002-12-30 2002-12-30 Non-Preservative Cosmetic Composition KR100481637B1 (en)

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* Cited by examiner, † Cited by third party
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KR20170001901A (en) 2015-06-26 2017-01-05 혜전대학 산학협력단 Manufacturing method of multi-functional fine particles having ultraviolet-proof and antibiotic functions and the multi-functional fine particles manufactured therefrom
KR102085292B1 (en) 2019-07-08 2020-03-05 주식회사 지에스비신바람홈케어 Cosmetic composition containing extract of Yucca schidigera, Paeonia suffruticosa root, Lithosperum erythrorhizon root and Triticum vulgare germ
KR20200090481A (en) 2019-01-21 2020-07-29 (주)휴앤스킨 Composition of antibacterial agent containing industrial preservatives

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KR100785486B1 (en) * 2005-08-24 2007-12-12 한국콜마 주식회사 A substitute for preservatives in cosmetics and a cosmetic composition of non­preservative containing the same
CN111956548A (en) * 2020-08-24 2020-11-20 耒阳市刘燕酿制生物科技有限公司 Preparation method of essence with whitening effect

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Publication number Priority date Publication date Assignee Title
KR20170001901A (en) 2015-06-26 2017-01-05 혜전대학 산학협력단 Manufacturing method of multi-functional fine particles having ultraviolet-proof and antibiotic functions and the multi-functional fine particles manufactured therefrom
KR20200090481A (en) 2019-01-21 2020-07-29 (주)휴앤스킨 Composition of antibacterial agent containing industrial preservatives
KR102189174B1 (en) 2019-01-21 2020-12-11 (주)휴앤스킨 Composition of antibacterial agent containing industrial preservatives
KR102085292B1 (en) 2019-07-08 2020-03-05 주식회사 지에스비신바람홈케어 Cosmetic composition containing extract of Yucca schidigera, Paeonia suffruticosa root, Lithosperum erythrorhizon root and Triticum vulgare germ

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