KR20150049027A - Composition of preservatives and cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a preservative composition and a cosmetic composition comprising the same, and more specifically, to a preservative composition containing at least one preservative component selected from a group composed of propanediol, 1,2-hexanediol, ethylhexylglycerin, phenoxyethanol, caprylhydroxamic acid, and glyceryl caprylate, and Magnolia grandiflora extracts, and to a cosmetic composition comprising the same. According to the present invention, obtained are a natural preservative composition having excellent antibacterial activation combined with optimal components, and a broad range with respect to an antibacterial spectrum, and a cosmetic composition containing the same. Particularly, the preservative composition of the present invention represents an excellent preservative effect on yeast fungus as well as bacteria.

Description

TECHNICAL FIELD [0001] The present invention relates to a preservative composition and a cosmetic composition containing the same. BACKGROUND OF THE INVENTION < RTI ID = 0.0 >

More particularly, the present invention relates to a preservative composition safe for human body having a sufficient preservative effect including a broad spectrum antibacterial effect while reducing skin irritation. More particularly, the present invention relates to a natural preservative composition suitable for cosmetics, To a cosmetic composition containing the same.

Preservatives are added to many products such as foods, medicines, and cosmetics widely used in daily life to prevent changes in internal properties and to preserve them for a certain period of time.

Especially, in various kinds of cosmetics, Preservatives are incorporated in cosmetics. They are used for the purpose of preventing the change of products by inhibiting the growth of microorganisms that contaminate or alter cosmetics from the outside, In order to secure the buoyancy of the room, aseptic manufacturing process is required, complicated means are required such as limiting the amount of contents or the period of use, or making the container specially, and the tendency to lack economical versatility increases.

Some of the materials used as preservatives are derived from natural sources, but mostly chemically synthesized artificial materials are used. Preservatives which are most safely used as conventional preservatives and which are generally used for cosmetics and medicines include, for example, paraoxybenzoic acid esters commonly known as parabens, imidazolidinyl urea, phenoxyethanol, methylchloroisothiazolinone, Methylisothiazolinone, and chlorphenesin. However, even these preservatives of parabens have a problem as skin allergies, environmental hormones, and resistance to bacteria.

As described above, the danger of artificial preservatives is emerging, and many people feel the necessity of natural preservatives. However, studies on natural preservatives that are superior in safety and economy continue to be made, but in reality, they are expensive, In addition, there is a limitation in application to practical products because of the problem of lowering of safety such as discoloration and breaking when used at a high capacity.

Therefore, it is expected that a composition which is safe to the skin and has a satisfactory preservative effect without using a chemical preservative such as parabens at all is expected to be useful in related fields.

Accordingly, one aspect of the present invention is to provide a preservative composition that combines harmless preservative ingredients to the human body to reduce skin irritation and exhibit sufficient preservative effect.

Another aspect of the present invention is to provide a cosmetic composition comprising the preservative composition.

According to one aspect of the present invention, there is provided a pharmaceutical composition comprising at least one preservative selected from the group consisting of propanediol, 1,2-hexanediol, ethylhexyl glycerin, phenoxyethanol, caprylhydroxamic acid and glyceryl caprylate; And an antioxidant extract are provided.

The preservative component and the magnolia seed extract are preferably mixed at a weight ratio of 0.1 to 1: 1.

The antiseptic composition is preferably used for preventing the decay of bacteria and yeast.

The above-mentioned bacteria are preferably at least one selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa, and Staphlyococcus aureus.

The yeast is preferably at least one member selected from the group consisting of Candida albicans, Aspergillus niger, Bacillus megaterium and Exophiala moniliae .

According to another aspect of the present invention, there is provided a cosmetic composition comprising the preservative composition of the present invention.

It is preferable that the cosmetic composition has at least one form selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, and body wash.

The cosmetic composition preferably contains the preservative composition in an amount of 0.01 to 5% by weight based on the total weight of the cosmetic composition.

According to the present invention, it is possible to obtain a human-safe natural preservative composition and a cosmetic composition containing the same, which have a wide range of antimicrobial activity and a wide range of antimicrobial spectrum, Exhibits an excellent preservative effect not only against bacteria but also against yeast strains.

Hereinafter, preferred embodiments of the present invention will be described. However, the embodiments of the present invention can be modified into various other forms, and the scope of the present invention is not limited to the embodiments described below.

According to the present invention, there is provided a natural preservative composition which is safe for a human body, which is combined with an optimal component, has excellent antimicrobial activity, and has a wide range in antimicrobial spectrum.

The preservative composition of the present invention comprises at least one preservative selected from the group consisting of propanediol, 1,2-hexanediol, ethylhexyl glycerin, phenoxyethanol, caprylhydroxamic acid and glyceryl caprylate; And magnolius extract.

The Magnolia grandiflorum is a plant belonging to the magnolia grandiflorum and magnolia. The scientific name is Magnolia grandiflora. The magnolia species which can be used in the present invention are preferably leaf extract of magnolia species.

The preservative composition of the present invention comprises such a natural component and further selected from the group consisting of propanediol, 1,2-hexanediol, ethylhexylglycerin, phenoxyethanol, caprylhydroxamic acid and glyceryl caprylate A preservative composition having an excellent preservative effect can be obtained.

More preferably, the preservative composition of the present invention comprises at least one preservative selected from the group consisting of 1,2-hexanediol, ethylhexyl glycerin, and phenoxyethanol, and a magnolia extract.

In the present specification, at least one species means a mixture of one species and at least two species, and is interpreted to have the same meaning as at least one species.

The antioxidant extract or the antiseptic component added to the antiseptic composition of the present invention, when added singly, has a somewhat lacking preservative effect because it is used as a preservative. However, when the antioxidant extract or the antioxidant component is mixed in the same combination as the present invention, And can exhibit a sufficient preservative effect.

The preservative component and the magnolia seed extract are preferably mixed at a weight ratio of 0.1 to 1: 1. If the preservative component is contained in the above range, the overall preservative effect may be insufficient. If the preservative component is contained in the above range, a problem due to skin irritation may occur.

In particular, the preservative composition of the present invention can be used not only for bacteria but also for prevention of decay by yeast, and exhibits excellent preservative effect in both bacteria and yeast.

In particular, the bacteria may be at least one selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa, and Staphlyococcus aureus.

The yeast may be at least one selected from the group consisting of Candida albicans, Aspergillus niger, Bacillus megaterium and Exophiala moniliae. have.

The above-mentioned magnolia tree extract can be extracted with water, an organic solvent, or a mixed solvent thereof. Specific examples thereof include water, methanol, ethanol, propanol, butanol, glycerin, acetone, ethyl acetate, hexane, chloroform, -Butylene glycol, or a mixed solvent thereof.

The extraction is carried out according to a conventional extraction process and can be carried out at room temperature or by heating. Preferably 50 to 80% ethanol, at a temperature of 50 ° C to 70 ° C for 2 to 4 hours, but is not limited thereto, Can be extracted by any extraction method known in the art.

However, when heating at a temperature higher than the above temperature, the time is reduced but the active ingredient may be destroyed and lost. When heating at a temperature lower than the above temperature, the active ingredient of the mixture is not extracted completely. .

The extract obtained through the extraction step may be centrifuged or filtered to remove impurities by a conventional method, and the filtrate may be used after distillation of the organic solvent and drying or by dissolving in an appropriate solvent.

According to the present invention, there is provided a cosmetic composition comprising the above-mentioned preservative composition.

The cosmetic composition preferably contains the preservative composition in an amount of 0.01 to 5 wt%, more preferably 0.05 to 2 wt%, based on the total cosmetic composition. When the preservative composition is less than 0.01% by weight, the repelling force can not be maintained for a long period of time. In particular, when the preservative composition is more than 5% by weight, the repelling force is not further increased , There is a problem that skin irritation occurs rather.

It is preferable that the cosmetic composition has at least one form selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, and body wash.

Meanwhile, the pack may be a hydrogel mask pack or an essence mask pack formed of a hydrogel mask composition. The hydrogel mask composition that can be used herein may be prepared as follows, but is not limited thereto.

First, a solution obtained by dissolving a gelated polymer in a polyhydric alcohol and dissolving a preservative composition in a polyhydric alcohol is mixed with the solution, and then the mixture is heated to a temperature of 45 to 95 ° C. to prepare a gel solution. Other active ingredients such as skin active ingredients, fragrances, surfactants, and the like are added to produce a hydrogel composition in a flow state. The thus-prepared hydrogel composition can be produced in the form of a sheet or a patch and applied to the skin.

The preservative composition may be directly added to the dissolved gelled polymer solution, or may be added after mixing with the skin active ingredient, surfactant, etc., if necessary.

The gelling agent that may be added to the hydrogel composition may be carrageenan, locust bean gum, konjac, agar, sodium alginic acid, gellan, galactomannan, glucocomannan, or guar gum. The gelling agent may be a polyhydric alcohol And most preferably, glycerin can be used.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto.

Example

1. A composition comprising a preservative composition Cosmetics  Preparation of composition

Example  One

17 g of glycerin, 6 g of carrageenan and 1.5 g of locust bean gum were mixed with stirring while stirring at room temperature. Further, 3.0 g of glycerin, 0.5 g of magnolia seed extract, 0.2 g of phenoxyethanol, 0.2 g of ethylhexyl glycerol , 68.73 g of deionized water was added thereto, and the temperature was raised to 85 ° C to prepare a gel solution. The extracts of the perennials were obtained by extracting the leaves of the perennials. 2.0 g of aloe extract, 0.1 g of collagen 0.5 g of polysorbate 80 and 0.37 g of chitosan solution were added sequentially to the gel solution while maintaining the temperature at 85 캜 to prepare a cosmetic pack hydrogel composition.

Example  2

Magnolia extract; 0.3g; 0.3 g of phenoxyethanol (PE) and 0.07 g of ethylhexylglycerin (EHG) as a preservative component; And purified water (68.81 g) were prepared in the same manner as in Example 1 above.

Example  3

0.5 gram of Magnolia plant extract; 0.3 g of phenoxyethanol (PE) as an anticorrosive component and 0.5 g of 1,2-hexanediol; And purified water (68.18 g) were prepared in the same manner as in Example 1.

Example  4

Magnolia extract; 0.1 g; 0.5 g of ethylhexyl glycerin (EHG) as preservative component, 0.5 g of propanediol and 0.1 g of glyceryl caprylate; And purified water (68.28 g) were prepared in the same manner as in Example 1, except that the hydrogel mask was used.

Example  5

1g of Magnolia plant extract; 0.5 g of 1,2-hexanediol, 0.1 g of propanediol, 0.1 g of ethylhexyl glycerin and 0.1 g of caprylic hydroxamic solution as antiseptic ingredients; And purified water (67.68 g) were prepared in the same manner as in Example 1, except that the hydrogel mask was prepared in the same manner as in Example 1.

Comparative Example  One

A hydrogel mask was prepared in the same manner as in Example 1 except that only 0.5 g of the extract of Magnoliaceae extract was added and 68.98 g of purified water was added.

Comparative Example  2

Except that 0.8 g of methyl paraben and 0.1 g of propylparaben were added as a preservative and 68.58 g of purified water was added.

2. For bacteria Buoyancy  evaluation

(ATCC 11775), Pseudomonas aeruginosa (ATCC 10145), and the like were added to 10 g of the hydrogel mask prepared in Examples 1 to 5 and Comparative Example 1, , And Staphlyococcus aureus (ATCC 6538) were added to an initial concentration of 10 ⁶ cfu (colony forming unit) / g per g of sample.

1 g of each sample was taken at intervals of 3, 7, 14, 21, and 28 days, and the number of viable cells was measured. The results are shown in Table 1 below.

Germ Inoculation dose (CFU / g) 3 days (CFU / g) 7 days (CFU / g) 14 days (CFU / g) 21 days (CFU / g) 28 days (CFU / g) Comparative Example 1 4 * 10 ⁸ 5.9 * 10 ⁶ 7.2 * 10 ⁴ <10 <10 <10 Comparative Example 2 3 * 10 ⁹ 1.1 * 10 ⁵ <10 <10 <10 <10 Example 1 4 * 10 ⁸ 9 * 10 ⁵ <10 <10 <10 <10 Example 2 2 * 10 ⁸ 4 * 10 ⁴ <10 <10 <10 <10 Example 3 2 * 10 ⁸ 6 * 10 ⁴ <10 <10 <10 <10 Example 4 2 * 10 ⁸ 4 * 10 ⁶ 4.6 * 10 ⁵ <10 <10 <10 Example 5 2 * 10 ⁸ 9 * 10 ¹ <10 <10 <10 <10

2. For yeast Buoyancy  evaluation

Candida albicans (ATCC 10231) and Aspergillus brasiliensis (Aspergillus brasiliensis) were added to 10 g of the hydrogel mask prepared in Examples 1 to 5 and Comparative Example 1 to evaluate the buoyancy against yeast (mold) ATCC 16404) was added at an initial concentration of 10 ⁶ cfu / g per sample.

The cells were cultured in a 25 ° C. incubator for 4 weeks, and 1 g of each sample was taken at intervals of 3, 7, 14, 21, and 28 days, and viable cell counts were measured. The results are shown in Table 2 below.

Fungus Inoculation dose (CFU / g) 3 days (CFU / g) 7 days (CFU / g) 14 days (CFU / g) 21 days (CFU / g) 28 days (CFU / g) Comparative Example 1 6 * 10 ⁶ 3.2 * 10 ⁶ 1.7 * 10 ⁶ 2.3 * 10 ⁶ Comparative Example 2 1.4 * 10 ⁹ 2 * 10 ⁵ 4 * 10 ³ <10 <10 <10 Example 1 6 * 10 ⁶ 4 * 10 ⁵ 8.9 * 10 ⁴ 1.8 * 10 ² <10 <10 Example 2 2 * 10 ⁷ 2 * 10 ⁴ 5.6 * 10 ¹ <10 <10 <10 Example 3 2 * 10 ⁷ 1 * 10 ⁷ 1 * 10 ⁶ 3 * 10 ⁵ <10 <10 Example 4 2 * 10 ⁷ 2 * 10 ⁵ 4.8 * 10 ⁴ 4 * 10 ² <10 <10 Example 5 2 * 10 ⁷ 1.3 * 10 ⁴ 2.7 * 10 ³ <10 <10 <10

3. Buoyancy  Evaluation results

As can be seen from Tables 1 and 2, the cosmetic composition comprising the preservative composition according to the present invention has excellent preservative effects similar to those of conventional chemical preservatives in both bacteria and yeast.

4. Evaluation of skin irritation

50 healthy adult men and women were subjected to a skin irritation test on the hydrogel masks prepared in Example 3 and Comparative Example 2. After about 20 minutes, 40 minutes, and 1 hour from the time when the hydrogel mask was attached to the face, the degree of skin irritation was evaluated three times according to the following criteria, and the average value thereof was shown in Table 3 below .

<Criteria>

2: More reddening and tingling than the surrounding area

1: slightly reddish from the surroundings

0: No stimulation at all

Immediately after attachment After 20 minutes After 40 minutes After 60 minutes Example 1 0 0 0 0 Comparative Example 2 0 0.2 0.5 0.6

As can be seen from the above table, it was confirmed that the skin irritation was reduced in Example 1 using the preservative composition according to the present invention, as compared with the case of using the parabenic preservative in Comparative Example 2.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be obvious to those of ordinary skill in the art.

Claims (8)

At least one preservative component selected from the group consisting of propanediol, 1,2-hexanediol, ethylhexyl glycerin, phenoxyethanol, caprylhydroxamic acid and glyceryl caprylate; And a saccharide extract.
The preservative composition according to claim 1, wherein the preservative component and the magnolia seed extract are mixed in a weight ratio of 0.1 to 1: 1.
The preservative composition according to claim 1, wherein the preservative composition is a composition for preventing bacterial and yeast-induced decay.
The preservative composition according to claim 3, wherein the bacteria are at least one selected from the group consisting of Eacherichia coli, Pseudomonas aeruginosa, and Staphlyococcus aureus.
The method according to claim 3, wherein the yeast is selected from the group consisting of Candida albicans, Aspergillus niger, Bacillus megaterium and Exophiala moniliae At least one preservative composition.
A cosmetic composition comprising the preservative composition of any one of claims 1 to 5.
The cosmetic composition according to claim 6, wherein the cosmetic composition is at least one selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, &Lt; / RTI &gt;
The cosmetic composition according to claim 6, wherein the cosmetic composition comprises 0.01 to 5% by weight of the preservative composition based on the total weight of the cosmetic composition.