CN105362140A - Non-cosmetics preservative composition with anticorrosion effect and application of non-cosmetics preservative composition - Google Patents
Non-cosmetics preservative composition with anticorrosion effect and application of non-cosmetics preservative composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a non-cosmetics preservative composition with an anticorrosion effect. The non-cosmetics preservative composition is characterized by comprising, by weight, caprylhydroxamic acid, 1, 2-octylene glycol and traditional Chinese medicine compositions; the traditional Chinese medicine compositions of the non-cosmetics preservative composition comprise syzygium aromaticum, scutellaria baicalensis and cortex cinnamomi which are extracted and refined to obtain the traditional Chinese medicine compositions. A method for preparing the non-cosmetics preservative composition includes mixing the caprylhydroxamic acid, the 1, 2-octylene glycol and the traditional Chinese medicine compositions with one another to obtain mixtures; uniformly stirring and dissolving the mixtures to obtain the non-cosmetics preservative composition. The non-cosmetics preservative composition has the advantages that excellent anticorrosion effects can be realized by the non-cosmetics preservative composition, the non-cosmetics preservative composition is made of safe and non-irritant chemical compounds and is free of injury to the skins of human bodies, and the shortcoming of severe injury to the skins of human bodies due to existing preservatives can be overcome by the aid of the non-cosmetics preservative composition; excellent anti-allergy and free radical scavenging effects can be realized by the caprylhydroxamic acid in the non-cosmetics preservative composition, excellent moisture retention effects can be realized by the 1, 2-octylene glycol, and free radical scavenging and whitening effects can be realized by the traditional Chinese medicine compositions.
Description
Technical field
The present invention relates to a kind of non-cosmetics preservative compositions and the application thereof with preservative efficacy, belong to cosmetic field.
Background technology
China " cosmetics health specification " (2007) define 67 kinds of antiseptic and use limitation thereof that can use in cosmetics.At present, conventional in cosmetics antiseptic has p-Hydroxybenzoate, imidazolidinyl urea, interior uride, isothiazolone, phenyl phenol etc.These antiseptic have certain injury to human body skin, easily cause skin allergy.
Along with the raising of living standards of the people, for cosmetic allergic contact dermatitis problem pay attention to day by day.In order to comply with the consumption demand of the people, the research for the cosmetics not adding antiseptic becomes focus.But cosmetics are products of very easy microbiological contamination, how to accomplish anticorrosion? from can be used at present screening the non-antiseptic raw material of cosmetics and natural product, the non-antiseptic composition with preservative efficacy can only be obtained.
Summary of the invention
Object of the present invention is exactly from conventional cosmetic material, filter out the compound with preservative efficacy, and carries out optimum organization, finally provides a kind of non-stimulated, non-antiseptic composition with preservative efficacy that safety is high.
To achieve the object of the present invention, present invention employs following technical scheme:
There is a non-cosmetics preservative compositions for preservative efficacy, it is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 5-20%, 1,2-ethohexadiol 15-30%, Chinese medicine composition 50-80%.
Preferably, a kind of non-cosmetics preservative compositions with preservative efficacy, is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 15%, 1,2-ethohexadiol 20%, Chinese medicine composition 65%.
Preferably, a kind of non-cosmetics preservative compositions with preservative efficacy, is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 12%, 1,2-ethohexadiol 24%, Chinese medicine composition 64%.
Preferably, a kind of non-cosmetics preservative compositions with preservative efficacy, is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 10%, 1,2-ethohexadiol 25%, Chinese medicine composition 65%.
Preferably, a kind of non-cosmetics preservative compositions with preservative efficacy, is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 16%, 1,2-ethohexadiol 18%, Chinese medicine composition 66%.
Above-mentioned Chinese medicine composition is by following percentage by weight Chinese drug preparation: Flos Caryophylli 15-30%, Radix Scutellariae 45-75%, Cortex Cinnamomi 10-25%.Preparation method is: after Flos Caryophylli, Radix Scutellariae, Cortex Cinnamomi being pulverized, cross 40 mesh sieves, mix homogeneously, add Extraction solvent, soak 0.5-2h together with Extraction solvent after, extract with high pressure homogenization method machine under room temperature, extracting solution, through centrifugalize, after concentrating under reduced pressure, then goes up macroporous resin column purification, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 2, adds the 1,3 butylene glycol with extracting solution equal in quality, be uniformly dissolved, obtained Chinese medicine composition; Extraction solvent is water, ethanol, alcohol-water mixed solution.
The preparation method of above-mentioned non-cosmetics preservative compositions, is characterized in that: by caprylhydroxamic acid, 1,2-ethohexadiol, Chinese medicine composition mixing, stirring and dissolving is even.
The second object of the present invention is used in cosmetics by above-mentioned non-cosmetics preservative compositions, makes stable in properties, cosmetics that antiseptic effect is good.
For realizing the second object of the present invention, present invention employs following technical scheme: above-mentioned non-cosmetics preservative compositions is used for preparing cosmetics, it is characterized in that its consumption is 0.5-15%, and preferable amount is 2-10% containing above-mentioned non-cosmetics preservative compositions in anti-aging cosmetics.
The dosage form of cosmetics is not particularly limited, and can be solution, emulsion, paste, foundation emulsion, spray, facial film etc.
The invention has the beneficial effects as follows: in compositions of the present invention, often kind of composition does not belong to the antiseptic of regulation in " cosmetics health specification " (2007), but after optimum organization, have good antiseptic effect.Raw material used is all conventional composition in cosmetics, is some safety, non-stimulated compound, to human body skin fanout free region, overcomes current antiseptic and injure large defect to human body skin.Especially, the caprylhydroxamic acid in compositions has good antiallergic, free radical resisting effect, and 1,2-ethohexadiol also has good moisture-keeping efficacy, and Chinese medicine composition also has free radical resisting, white-skinned face function.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
non-cosmetics preservative compositions (I) of embodiment 1 and preparation method thereof
Non-cosmetics preservative compositions (I) is composed as follows by weight percentage: caprylhydroxamic acid 15%, 1,2-ethohexadiol 20%, Chinese medicine composition 65%.Wherein Chinese medicine composition is prepared as follows: after Flos Caryophylli 25g, Radix Scutellariae 60g, Cortex Cinnamomi 15g being pulverized, cross 40 mesh sieves, mix homogeneously, add the ethanol 1kg that mass fraction is 50%, after soaking 1h, extract with high pressure homogenization method machine under room temperature, extracting solution, through centrifugalize, after concentrating under reduced pressure, then goes up macroporous resin column purification, collect the ethanol elution part that mass fraction is 50%-80%, be evaporated to extracting solution 50g, add 1,3 butylene glycol 50g, be uniformly dissolved, obtained Chinese medicine composition.
Compositions (I) preparation method is: by caprylhydroxamic acid, 1,2-ethohexadiol, Chinese medicine composition mixing, stirring and dissolving is even.
non-cosmetics preservative compositions (II) of embodiment 2 and preparation method thereof
Non-cosmetics preservative compositions (II) is composed as follows by weight percentage: caprylhydroxamic acid 12%, 1,2-ethohexadiol 24%, Chinese medicine composition 64%.Wherein Chinese medicine composition is prepared as follows: after Flos Caryophylli 20g, Radix Scutellariae 60g, Cortex Cinnamomi 20g being pulverized, cross 40 mesh sieves, mix homogeneously, add the ethanol 1kg that mass fraction is 50%, after soaking 1h, extract with high pressure homogenization method machine under room temperature, extracting solution, through centrifugalize, after concentrating under reduced pressure, then goes up macroporous resin column purification, collect the ethanol elution part that mass fraction is 50%-80%, be evaporated to extracting solution 50g, add 1,3 butylene glycol 50g, be uniformly dissolved, obtained Chinese medicine composition.
Compositions (II) preparation method is: by caprylhydroxamic acid, 1,2-ethohexadiol, Chinese medicine composition mixing, stirring and dissolving is even.
non-cosmetics preservative compositions (III) of embodiment 3 and preparation method thereof
Non-cosmetics preservative compositions
(III)composed as follows by weight percentage: caprylhydroxamic acid 8%, 1,2-ethohexadiol 28%, Chinese medicine composition 64%.Wherein Chinese medicine composition is prepared as follows: after Flos Caryophylli 28g, Radix Scutellariae 50g, Cortex Cinnamomi 22g being pulverized, cross 40 mesh sieves, mix homogeneously, add the ethanol 1kg that mass fraction is 50%, after soaking 1h, extract with high pressure homogenization method machine under room temperature, extracting solution, through centrifugalize, after concentrating under reduced pressure, then goes up macroporous resin column purification, collect the ethanol elution part that mass fraction is 50%-80%, be evaporated to extracting solution 50g, add 1,3 butylene glycol 50g, be uniformly dissolved, obtained Chinese medicine composition.
Compositions
(III)preparation method is: by caprylhydroxamic acid, 1,2-ethohexadiol, Chinese medicine composition mixing, stirring and dissolving is even.
comparative example 1
Composed as follows by weight percentage: caprylhydroxamic acid 35%, deionized water 65%, mixed dissolution is even.
comparative example 2
Composed as follows by weight percentage: 1,2-ethohexadiol 35%, deionized water 65%, mixed dissolution is even.
comparative example 3
Composed as follows by weight percentage: Chinese medicine composition 65%, deionized water 35%, mixed dissolution is even.Wherein Chinese medicine composition is prepared as follows: preparation method is: after Flos Caryophylli 20g, Radix Scutellariae 60g, Cortex Cinnamomi 20g being pulverized, cross 40 mesh sieves, mix homogeneously, add the ethanol 1kg that mass fraction is 50%, after soaking 1h, extract with high pressure homogenization method machine under room temperature, extracting solution through centrifugalize, after concentrating under reduced pressure, go up macroporous resin column purification again, collect the ethanol elution part that mass fraction is 50%-80%, be evaporated to extracting solution 100g, obtained Chinese medicine composition.
comparative example 4
Composed as follows by weight percentage: caprylhydroxamic acid 15%, 1,2-ethohexadiol 20%, deionized water 65%, mixed dissolution is even.
embodiment 4 cold cream frost
Table 1 provides the cold cream frost formula containing non-cosmetics preservative compositions of the present invention.
Table 1
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5min, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
embodiment 5 facial treatment milk
Table 2 provides the facial treatment milk formula containing non-cosmetics preservative compositions of the present invention, and the consumption of each material represents with mass fraction.
Table 2
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5min, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
the preparation of embodiment 6 surfactant
Table 3 provides the surfactant formula containing non-cosmetics preservative compositions of the present invention, and the consumption of each material represents with mass fraction.
Table 3
Preparation method: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C.
the common surfactant of comparative example 5
Table 4 provides not containing compositions of the present invention, but the common surfactant formula containing Common Preservatives, the consumption of each material represents with mass fraction.
Table 4
Preparation method: deionized water is heated to 85 DEG C, adds hydroxyethyl-cellulose, stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 DEG C, add other compositions, continue stirring and be cooled to 38 DEG C.
experimental example 1 skin irritation evaluation experimental
With 30 women and 20 male for object, getting 30mg sample is placed in the coyote hole of speckle examination adhesive tape, longitudinally be affixed on the normal skin of left forearm by the speckle examination adhesive tape being equipped with sample from bottom immediately, light pressing room, to drive away air, and makes trier be uniformly distributed one by one simultaneously.Labelling is carried out, to observe in test position.Pasted skin once every 24 hours, open half an hour after paster, then check according to the term of CTFA guide (1981).Carrying out 6 patch experiments altogether, the 6th day after subsides skin terminates, in order to observe late response, having carried out additional inspection.Data then utilize last check result, compare.Identify with table 5 as standard is carried out.Substances is respectively the surfactant of embodiment 6 and the common surfactant of comparative example 5, and result is as shown in table 6.
Table 5
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, pimple, vesicle |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Table 6
| Lagging number of times | Comparative example 5 | Blank experiment | Embodiment 6 |
| 1 | 1 time ± | 0 | 0 |
| 2 | 0 | 0 | |
| 3 | 0 | 0 | |
| 4 | 1 time ± | 0 | 0 |
| 5 | 0 | 0 | |
| 6 | 0 | 0 | |
| Terminate latter 6th day | 1 time ± | 0 | 0 |
| Add up to | 3 times ± | 0 | 0 |
By this result of the test, can recognize that blank experiment is non-stimulated, the surfactant of embodiment 6 is to the stimulation of skin, and the irritant reaction of common surfactant to skin of comparative example 5 still exists.Illustrate that cosmetics zest prepared by the cosmetics ratio common preservatives adopting non-cosmetics preservative compositions of the present invention to prepare is little, safer.
experimental example 2 preservation challenge evaluation experimental
1, experimental strain
StaphylococcusaureusATCC6538(staphylococcus aureus)
EscherichiacoliATCC8739 (escherichia coli)
PseudomonasaeruginosaATCC9027 (bacillus pyocyaneus)
CandidaalbicansATCC10231 (candida albicans)
AspergillusnigerATCC9029 (Aspergillus niger)
2, the keeping of experimental strain and condition of culture
(1) antibacterial and candida albicans
Culture medium: TSB
Maintaining requirement: cold preservation 4-8 DEG C
Maintaining requirement: 2 months
(2) Aspergillus niger
Culture medium: PDB
Maintaining requirement: cold preservation 4-8 DEG C
Maintaining requirement: 2 months
3, test bacterium liquid manufacture method
(1) (every gram, the sample of experiment is 10 to antibacterial liquid manufacture method
7cfu)
Three kinds of antibacterials and Candida albicans are respectively got 50 μ L and are added and inoculate in the 5mLTSB culture fluid of sterilization treatment, then cultivate 48 hours at 37 DEG C of shaking tables, obtain the bacterium liquid of each bacterium.According to 10
6, 10
7, 10
8three dilution factor LB culture medium are cultivated, and then confirm the viable count of each bacterium liquid.Each bacterium liquid is got in the 50mL centrifuge tube that 1mL is added to and is mixed, and (concentration of mixed bacteria liquid is for preferably to control 1.0 × 10 to obtain mixed bacteria liquid
9about cfu/mL).
(2) (every gram, the sample of experiment is 10 to the manufacture method of fungus liquid
5cfu)
Reference culture bacterium (Aspergillus niger) is inoculated in culture medium, then after cultivating spore fully inside the incubator being placed on 25 DEG C, be inoculated in culture fluid PDB10mL by the spore platinum inoculating loop of cultured black, fully spore evenly, then scrapes off by concussion inside culture medium.After the spore scraped off and fluid medium fully being mixed, the bacterium liquid got above is collected in centrifuge tube, obtains fungus liquid.By fungus liquid (about 10
7cfu) be diluted on PDA after cultivation as far as possible, confirm the bacterium number of survival.
4, experimental technique
(1) preparation of sample
Anticorrosive composite prepared by embodiment 1,2,3 and comparative example 1,2,3,4 is added in table 7 formula respectively, is uniformly dissolved and makes sample.
Table 7
(2) antibacterial preservative challenge test method
This laboratory reference cosmetics, toilet articles and fragrance association (CTFA) microbiological test methods be namely: add a certain amount of mixed microorganism bacteria suspension in cosmetics, adds mixed vaccine amount and be respectively: antibacterial 3.0 × 10
7cFU/g (CFU/m1) and mycete 1.0 × 10
5cFU/g (CFU/m1)), mixed sample observes the survival condition of microorganism in special time separation detection: 0 hour (namely sampling at once after inoculation), 7 days, 14 days, 21 days and 28 days results, require that the antibacterial the 7th day time reduces by 99.9%, mycete reduces by 90%; And in 28 days, continuous decrease is zero to judge the antiseptic effect of antiseptic, concrete judged result reference table 8.
Table 8
| Strain name | 0d | 7d | 14d | 21d | 28d |
| Fungus (cfu/g) | 1.0×10 5 | ≤100 | 0 | 0 | 0 |
| Antibacterial (cfu/g) | 3.0×10 7 | 0 | 0 | 0 | 0 |
5, result
The results are shown in Table shown in 9.
Table 9
As shown in Table 9, all have passed preservation challenge test with the sample that embodiment 1,2,3 makes, there is potent antiseptic effect.As time goes on, antibacterial and total number of fungi all have decline to the sample that comparative example 1,2,3 makes, and illustrate all there is certain antiseptic effect, but are not all tested by preservation challenge.
In addition, also can be found out by table 9, the antiseptic effect of comparative example 4 is better than the antiseptic effect of comparative example 1,2, caprylhydroxamic acid is described and 1,2-ethohexadiol is composite can improve antiseptic effect.And by caprylhydroxamic acid, 1,2-ethohexadiol, Chinese medicine composition three kinds of materials by science composite after embodiment 1,2,3 all much better than the antiseptic effect of comparative example 1,2,3,4; Illustrate that three is composite and serve synergistic function, improve antiseptic power.
Claims (2)
1. there is a non-cosmetics preservative compositions for preservative efficacy, it is characterized in that being made up of the component of following percentage by weight: caprylhydroxamic acid 5-20%, 1,2-ethohexadiol 15-30%, Chinese medicine composition 50-80%; Described Chinese medicine composition is by following percentage by weight Chinese drug preparation: Flos Caryophylli 15-30%, Radix Scutellariae 45-75%, Cortex Cinnamomi 10-25%; The preparation method of described Chinese medicine composition is: after Flos Caryophylli, Radix Scutellariae, Cortex Cinnamomi being pulverized, cross 40 mesh sieves, mix homogeneously, add Extraction solvent, soak 0.5-2h together with Extraction solvent after, extract with high pressure homogenization method machine under room temperature, extracting solution through centrifugalize, after concentrating under reduced pressure, go up macroporous resin column purification again, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 1, obtained Chinese medicine composition; Extraction solvent is water, ethanol, alcohol-water mixed solution.
2. a kind of application of non-cosmetics preservative compositions in preparing cosmetics with preservative efficacy according to claim 1, is characterized in that its consumption is 0.5-15% containing above-mentioned a kind of non-cosmetics preservative compositions with preservative efficacy in cosmetics.
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| CN107308064A (en) * | 2017-08-08 | 2017-11-03 | 广州蜜妆生物科技有限公司 | A kind of compound natural preservative |
| CN114344226A (en) * | 2022-02-25 | 2022-04-15 | 河南科技大学 | Traditional Chinese medicine preservative, preparation method and application |
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| CN105362140B (en) | 2018-09-25 |
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