CN106232617B - 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 - Google Patents

多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 Download PDF

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Publication number
CN106232617B
CN106232617B CN201580011858.0A CN201580011858A CN106232617B CN 106232617 B CN106232617 B CN 106232617B CN 201580011858 A CN201580011858 A CN 201580011858A CN 106232617 B CN106232617 B CN 106232617B
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compound
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groups
nitrogen
alkyl
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Chinese (zh)
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CN106232617A (zh
Inventor
帕梅拉·布朗
迈克尔·道森
莫娜·西莫诺维克
史蒂文·博克斯
伊斯特·杜珀尔奇
史蒂文·詹姆斯·斯坦威
安托瓦妮特·威尔逊
斯蒂芬·弗雷德里克·莫斯
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Yunding Xinyao Pharmaceutical Technology Co ltd
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Yunding Xinyao Pharmaceutical Technology Co ltd
New Pharma Licence Holdings Ltd
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Priority claimed from GB201404301A external-priority patent/GB201404301D0/en
Priority claimed from GB201421019A external-priority patent/GB201421019D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580011858.0A 2014-03-11 2015-03-11 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 Active CN106232617B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201404301A GB201404301D0 (en) 2014-03-11 2014-03-11 Compounds and combinations
GB1404301.2 2014-03-11
GB201421019A GB201421019D0 (en) 2014-11-26 2014-11-26 Compounds
GB1421019.9 2014-11-26
PCT/EP2015/055046 WO2015135976A1 (en) 2014-03-11 2015-03-11 Polymyxin derivatives and their use in combination therapy together with different antibiotics

Publications (2)

Publication Number Publication Date
CN106232617A CN106232617A (zh) 2016-12-14
CN106232617B true CN106232617B (zh) 2022-06-24

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Country Status (21)

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US (3) US20170073373A1 (https=)
EP (1) EP3116897B1 (https=)
JP (1) JP6785659B2 (https=)
KR (2) KR20230152779A (https=)
CN (1) CN106232617B (https=)
AU (1) AU2015228898B2 (https=)
CA (1) CA2940455C (https=)
CY (1) CY1125175T1 (https=)
DK (1) DK3116897T3 (https=)
ES (1) ES2910072T3 (https=)
HR (1) HRP20220387T1 (https=)
IL (1) IL247243B (https=)
LT (1) LT3116897T (https=)
MX (1) MX359104B (https=)
PL (1) PL3116897T3 (https=)
PT (1) PT3116897T (https=)
RS (1) RS63138B1 (https=)
RU (1) RU2740190C2 (https=)
SI (1) SI3116897T1 (https=)
TW (1) TWI709575B (https=)
WO (1) WO2015135976A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855916A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
JP2017512818A (ja) 2014-04-01 2017-05-25 モナシュ、ユニバーシティＭｏｎａｓｈ Ｕｎｉｖｅｒｓｉｔｙ 抗菌性化合物としてのポリミキシン誘導体
US12146004B2 (en) 2014-11-26 2024-11-19 Spero Therapeutics, Inc. Polymyxin compounds and uses thereof
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
CN105030744B (zh) * 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用
EP3356387B1 (en) * 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds
JP6744622B2 (ja) * 2016-06-16 2020-08-19 学校法人上智学院 ピペリジン化合物の製造方法
CN111527100A (zh) * 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
RS65128B1 (sr) * 2018-06-25 2024-02-29 Spero Therapeutics Inc Jedinjenja
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
WO2022098950A1 (en) 2020-11-06 2022-05-12 Spero Therapeutics, Inc. Compounds
JP7621502B2 (ja) 2021-02-02 2025-01-24 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー ビフェニル誘導体化合物を有効成分として含有する抗菌補助剤及びこの用途
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2013072695A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
BRPI0715095B8 (pt) * 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
US8415307B1 (en) * 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
KR102354902B1 (ko) * 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2013072695A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antimicrobial Activity of Various Aminocyclohexylcarbonyl-polymyxin B(2-10) Derivatives;Keiko Okimura等;《Peptide Science》;20081231(第45期);图1及表1 *

Also Published As

Publication number Publication date
EP3116897A1 (en) 2017-01-18
MX2016011682A (es) 2017-04-27
DK3116897T3 (da) 2022-03-28
KR20230152779A (ko) 2023-11-03
LT3116897T (lt) 2022-05-10
RU2016139978A (ru) 2018-04-13
HRP20220387T1 (hr) 2022-05-27
RU2016139978A3 (https=) 2018-10-17
EP3116897B1 (en) 2022-03-02
US20230322858A1 (en) 2023-10-12
PT3116897T (pt) 2022-04-07
CA2940455C (en) 2023-03-21
CY1125175T1 (el) 2024-12-13
TWI709575B (zh) 2020-11-11
ES2910072T3 (es) 2022-05-11
SI3116897T1 (sl) 2022-06-30
JP2017510570A (ja) 2017-04-13
RU2740190C2 (ru) 2021-01-12
TW201617362A (zh) 2016-05-16
AU2015228898B2 (en) 2018-11-15
IL247243A0 (en) 2016-09-29
US20170073373A1 (en) 2017-03-16
WO2015135976A1 (en) 2015-09-17
CN106232617A (zh) 2016-12-14
JP6785659B2 (ja) 2020-11-18
KR20160135739A (ko) 2016-11-28
MX359104B (es) 2018-09-14
PL3116897T3 (pl) 2022-05-30
AU2015228898A1 (en) 2016-10-20
CA2940455A1 (en) 2015-09-17
US20210221848A1 (en) 2021-07-22
RS63138B1 (sr) 2022-05-31
IL247243B (en) 2020-04-30

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