CN106232617B - 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 - Google Patents

多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 Download PDF

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Publication number
CN106232617B
CN106232617B CN201580011858.0A CN201580011858A CN106232617B CN 106232617 B CN106232617 B CN 106232617B CN 201580011858 A CN201580011858 A CN 201580011858A CN 106232617 B CN106232617 B CN 106232617B
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compound
group
groups
nitrogen
alkyl
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Chinese (zh)
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CN106232617A (zh
Inventor
帕梅拉·布朗
迈克尔·道森
莫娜·西莫诺维克
史蒂文·博克斯
伊斯特·杜珀尔奇
史蒂文·詹姆斯·斯坦威
安托瓦妮特·威尔逊
斯蒂芬·弗雷德里克·莫斯
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Yunding Xinyao Pharmaceutical Technology Co ltd
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Yunding Xinyao Pharmaceutical Technology Co ltd
New Pharma Licence Holdings Ltd
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Priority claimed from GB201404301A external-priority patent/GB201404301D0/en
Priority claimed from GB201421019A external-priority patent/GB201421019D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580011858.0A 2014-03-11 2015-03-11 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途 Active CN106232617B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201404301A GB201404301D0 (en) 2014-03-11 2014-03-11 Compounds and combinations
GB1404301.2 2014-03-11
GB1421019.9 2014-11-26
GB201421019A GB201421019D0 (en) 2014-11-26 2014-11-26 Compounds
PCT/EP2015/055046 WO2015135976A1 (en) 2014-03-11 2015-03-11 Polymyxin derivatives and their use in combination therapy together with different antibiotics

Publications (2)

Publication Number Publication Date
CN106232617A CN106232617A (zh) 2016-12-14
CN106232617B true CN106232617B (zh) 2022-06-24

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CN201580011858.0A Active CN106232617B (zh) 2014-03-11 2015-03-11 多粘菌素衍生物及其在与不同抗生素的联合疗法中的用途

Country Status (21)

Country Link
US (3) US20170073373A1 (https=)
EP (1) EP3116897B1 (https=)
JP (1) JP6785659B2 (https=)
KR (2) KR20230152779A (https=)
CN (1) CN106232617B (https=)
AU (1) AU2015228898B2 (https=)
CA (1) CA2940455C (https=)
CY (1) CY1125175T1 (https=)
DK (1) DK3116897T3 (https=)
ES (1) ES2910072T3 (https=)
HR (1) HRP20220387T1 (https=)
IL (1) IL247243B (https=)
LT (1) LT3116897T (https=)
MX (1) MX359104B (https=)
PL (1) PL3116897T3 (https=)
PT (1) PT3116897T (https=)
RS (1) RS63138B1 (https=)
RU (1) RU2740190C2 (https=)
SI (1) SI3116897T1 (https=)
TW (1) TWI709575B (https=)
WO (1) WO2015135976A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012016A2 (pt) * 2011-11-18 2017-05-16 Cantab Anti-Infectives Ltd compostos
US10047126B2 (en) 2014-04-01 2018-08-14 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
US9771394B2 (en) 2014-12-16 2017-09-26 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
CN105030744B (zh) * 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用
EP3356387B1 (en) * 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds
JP6744622B2 (ja) * 2016-06-16 2020-08-19 学校法人上智学院 ピペリジン化合物の製造方法
AU2018359018B2 (en) * 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
MD3810633T2 (ro) * 2018-06-25 2024-05-31 Spero Therapeutics Inc Compuşi
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN116847735B (zh) * 2021-02-02 2026-02-03 韩国生命工学研究院 含有联苯基衍生物化合物作为有效成分的抗菌佐剂及其用途
CN120574287A (zh) * 2025-06-10 2025-09-02 中国药科大学 一种抗菌肽、组合物及应用
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2013072695A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
HUE028271T2 (en) * 2006-08-11 2016-12-28 Northern Antibiotics Oy Polymixin derivatives and their applications
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
US8415307B1 (en) * 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
JP6643758B2 (ja) * 2013-05-22 2020-02-12 スペロ・セラピューティクス・インコーポレーテッド 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2013072695A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antimicrobial Activity of Various Aminocyclohexylcarbonyl-polymyxin B(2-10) Derivatives;Keiko Okimura等;《Peptide Science》;20081231(第45期);图1及表1 *

Also Published As

Publication number Publication date
EP3116897B1 (en) 2022-03-02
IL247243B (en) 2020-04-30
AU2015228898B2 (en) 2018-11-15
US20230322858A1 (en) 2023-10-12
LT3116897T (lt) 2022-05-10
JP6785659B2 (ja) 2020-11-18
ES2910072T3 (es) 2022-05-11
RS63138B1 (sr) 2022-05-31
KR20160135739A (ko) 2016-11-28
MX359104B (es) 2018-09-14
IL247243A0 (en) 2016-09-29
DK3116897T3 (da) 2022-03-28
CA2940455C (en) 2023-03-21
TW201617362A (zh) 2016-05-16
CN106232617A (zh) 2016-12-14
CY1125175T1 (el) 2024-12-13
JP2017510570A (ja) 2017-04-13
RU2016139978A3 (https=) 2018-10-17
US20210221848A1 (en) 2021-07-22
WO2015135976A1 (en) 2015-09-17
CA2940455A1 (en) 2015-09-17
RU2740190C2 (ru) 2021-01-12
PT3116897T (pt) 2022-04-07
HRP20220387T1 (hr) 2022-05-27
KR20230152779A (ko) 2023-11-03
PL3116897T3 (pl) 2022-05-30
TWI709575B (zh) 2020-11-11
AU2015228898A1 (en) 2016-10-20
RU2016139978A (ru) 2018-04-13
MX2016011682A (es) 2017-04-27
US20170073373A1 (en) 2017-03-16
EP3116897A1 (en) 2017-01-18
SI3116897T1 (sl) 2022-06-30

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