CN106232583B - 用于抑制肌成束蛋白的化合物和方法 - Google Patents

用于抑制肌成束蛋白的化合物和方法 Download PDF

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CN106232583B
CN106232583B CN201580009687.8A CN201580009687A CN106232583B CN 106232583 B CN106232583 B CN 106232583B CN 201580009687 A CN201580009687 A CN 201580009687A CN 106232583 B CN106232583 B CN 106232583B
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cancer
compound
fascin
independently
compounds
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CN106232583A (zh
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黄新云
克里斯蒂·永·舒尔
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Cornell University
Novita Pharmaceuticals Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201580009687.8A 2014-02-20 2015-02-19 用于抑制肌成束蛋白的化合物和方法 Active CN106232583B (zh)

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PCT/US2015/016686 WO2015127125A1 (en) 2014-02-20 2015-02-19 Compounds and methods for inhibiting fascin

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9484964B2 (en) 2012-09-07 2016-11-01 Adori Labs, Inc. Interactive entertainment system
HK1255468A1 (zh) 2016-01-05 2019-08-16 The Regents Of The University Of California 苯并噻唑两亲物
ES2924359T3 (es) 2017-04-11 2022-10-06 Sunshine Lake Pharma Co Ltd Compuestos de indazol sustituidos con flúor y usos de los mismos
CA3071525A1 (en) 2017-08-02 2019-02-07 Spinogenix, Inc. Benzothiazole and related compounds
EP3713570A4 (en) * 2017-11-22 2021-08-04 Cornell University CO THERAPIES WITH A METASTASIS INHIBITOR
EP3843846A4 (en) * 2018-08-27 2022-09-07 Spinogenix, Inc. FASCIN-BINDING COMPOUNDS FOR SPINOGENESIS
EP3628330A1 (en) * 2018-09-28 2020-04-01 Fundacion Universitaria San Antonio Imipramine for use as inhibitor of fascin1 overexpression
WO2020150417A2 (en) * 2019-01-17 2020-07-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
US12486287B2 (en) 2019-01-31 2025-12-02 Spinogenix, Inc. Solid forms of a promoter of spinogenesis
TW202317087A (zh) 2021-08-10 2023-05-01 美商Ｉｆｍ Ｄｕｅ有限公司 用於治療與sting活性相關病況之化合物及組合物
WO2025001864A1 (en) * 2023-06-30 2025-01-02 Beijing Double-Crane Runchuang Technology Co., Ltd. Fascin inhibitors
WO2024109642A1 (zh) * 2023-07-28 2024-05-30 常州大学 一种苯并氮杂环类化合物作为β2-肾上腺素受体别构调节剂的应用
WO2025111414A1 (en) * 2023-11-21 2025-05-30 Katholieke Universiteit Leuven Trpm3-modulating benzofuran derivatives

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1589269A (zh) * 2001-10-26 2005-03-02 康涅狄格大学 杂1,2－二氢化茚:一类新型有效的大麻配体
WO2006015263A2 (en) * 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs
CN1784396A (zh) * 2003-03-03 2006-06-07 阵列生物制药公司 p38抑制剂及它们的使用方法
CN1879619A (zh) * 2005-05-18 2006-12-20 永信药品工业股份有限公司 癌症治疗
CN101528708A (zh) * 2006-11-01 2009-09-09 霍夫曼-拉罗奇有限公司 用作l-cpt1抑制剂的吲唑衍生物
WO2009121623A2 (en) * 2008-04-04 2009-10-08 Summit Corporation Plc Compounds for treating muscular dystrophy
CN101594862A (zh) * 2006-12-20 2009-12-02 内尔维阿诺医学科学有限公司 作为激酶抑制剂的取代吲唑衍生物
WO2014031732A2 (en) * 2012-08-22 2014-02-27 Cornell University Methods for inhibiting fascin

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244696A (en) * 1968-06-20 1971-09-02 Fuji Photo Film Co Ltd Improvements in colour developer compositions
US3725431A (en) * 1970-09-23 1973-04-03 Ciba Geigy Corp 1-aralkyl-3-aminoindazoles
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4786644A (en) 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
DE19834044A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
AU1324300A (en) 1998-10-26 2000-05-15 Vertex Pharmaceuticals Incorporated Pentacyclic compounds useful as inhibitors of hepatitis c virus ns3 helicase
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
US20040009613A1 (en) 2001-02-16 2004-01-15 Ming-Ming Zhou Methods of identifying modulators of bromodomains
TWI262920B (en) * 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
EP1446394B1 (en) 2001-11-08 2006-11-02 Ortho-McNeil Pharmaceutical, Inc. Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators
US7166293B2 (en) * 2002-03-29 2007-01-23 Carlsbad Technology, Inc. Angiogenesis inhibitors
CA2542716A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having crth2 antagonist activity
US20050130974A1 (en) 2003-10-17 2005-06-16 Rigel Pharmaceuticals, Inc. Benzothiazole compositions and their use as ubiquitin ligase inhibitors
JP2007523197A (ja) 2004-02-23 2007-08-16 プロレキシーズ ファーマシューティカルズ インコーポレイテッド ｐＨＳＰ２０様活性を有する非ペプチジル剤、およびその使用
US20070043057A1 (en) 2005-02-09 2007-02-22 Threshold Pharmaceuticals, Inc. Lonidamine analogs
US20070015771A1 (en) * 2004-07-29 2007-01-18 Threshold Pharmaceuticals, Inc. Lonidamine analogs
WO2006047162A2 (en) 2004-10-21 2006-05-04 The Burnham Institute Compositions and methods for treatment of disease caused by yersinia spp infection
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
JP2009520825A (ja) * 2005-12-20 2009-05-28 武田薬品工業株式会社 グルコキナーゼ活性剤
ES2452343T3 (es) * 2006-09-29 2014-04-01 Glaxosmithkline Llc Compuestos de indol sustituidos
US7968577B2 (en) 2006-11-01 2011-06-28 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20080200458A1 (en) * 2007-01-18 2008-08-21 Joseph Barbosa Methods and compositions for the treatment of body composition disorders
WO2008129276A1 (en) 2007-04-19 2008-10-30 Boehringer Ingelheim International Gmbh Disulfonamides useful in the treatment of inflammation
EP2222343A4 (en) 2007-11-21 2012-03-14 Univ Cornell PROCESS FOR SUPPRESSING FASCINE
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
CN101919145B (zh) 2007-12-21 2013-07-17 桑迪士克科技股份有限公司 可自配置的多调压器专用集成电路核电力输送
CU20080028A6 (es) 2008-02-29 2011-02-24 Ct Ingenieria Genetica Biotech Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus
CA2726987C (en) 2008-06-04 2014-02-18 Baylor College Of Medicine Stat3 inhibitors
US8673910B2 (en) 2008-06-30 2014-03-18 H. Lee Moffitt Cancer Center And Research Institute Proteasome inhibitors for selectively inducing apoptosis in cancer cells
WO2010033986A2 (en) 2008-09-22 2010-03-25 Regents Of The University Of Minnesota Dna cytosine deaminase inhibitors
JO3101B1 (ar) 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
AR075594A1 (es) * 2009-02-26 2011-04-20 Glaxo Group Ltd Derivados de ( 2-tienil)-sulfonil-amino-1h-indazol como antagonistas de ccr4
WO2010102286A2 (en) 2009-03-06 2010-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome inhibitors having chymotrypsin-like activity
US8785499B2 (en) 2009-07-10 2014-07-22 University Of Maryland, Baltimore Targeting NAD biosynthesis in bacterial pathogens
ES2360783B1 (es) 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
KR101632318B1 (ko) 2009-11-05 2016-06-27 재단법인 의약바이오컨버젼스연구단 벤조헤테로사이클 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 암 예방 및 치료용 조성물
EP2528893B1 (en) 2010-01-29 2018-10-10 Dana-Farber Cancer Institute, Inc. Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders
WO2011133862A1 (en) 2010-04-23 2011-10-27 Oregon Health And Science University Methods and compositions for promoting myelination
DE102010040233A1 (de) * 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
JP5937102B2 (ja) 2010-12-14 2016-06-22 エレクトロフォレティクス リミテッド カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤
EP2665707B1 (en) * 2011-01-20 2017-01-18 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
HUE037312T2 (hu) * 2012-12-19 2018-08-28 Celgene Quanticel Res Inc Hiszton demetiláz inhibitorok

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1589269A (zh) * 2001-10-26 2005-03-02 康涅狄格大学 杂1,2－二氢化茚:一类新型有效的大麻配体
CN1784396A (zh) * 2003-03-03 2006-06-07 阵列生物制药公司 p38抑制剂及它们的使用方法
WO2006015263A2 (en) * 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs
CN1879619A (zh) * 2005-05-18 2006-12-20 永信药品工业股份有限公司 癌症治疗
CN101528708A (zh) * 2006-11-01 2009-09-09 霍夫曼-拉罗奇有限公司 用作l-cpt1抑制剂的吲唑衍生物
CN101594862A (zh) * 2006-12-20 2009-12-02 内尔维阿诺医学科学有限公司 作为激酶抑制剂的取代吲唑衍生物
WO2009121623A2 (en) * 2008-04-04 2009-10-08 Summit Corporation Plc Compounds for treating muscular dystrophy
WO2014031732A2 (en) * 2012-08-22 2014-02-27 Cornell University Methods for inhibiting fascin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D Korbonits等.Ring transformation of 3-(2-aminoaryl)-1,2,4-oxadiazoles into 3-acylaminoindazoles *
extension of the Boulton–Katritzky scheme.《Journal of the Chemical Society, Perkin Transactions 1》.1982,第3卷(第3期),第759-766页. *
Syntheses and biological evaluation of indole-2 and 3-carboxamides: new selective cyclooxygenase-2 inhibitors;S Olgen等;《Fortress Press》;20021231;第33卷(第31期);第238-242页 *

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