CN106177118A - A kind of five-ester soft capsule and preparation method thereof - Google Patents
A kind of five-ester soft capsule and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of five-ester soft capsule, preparation method is: take Fructus Schisandrae Chinensis, adds the water of 10 times of weight of schisandra chinensis medicinal material, soaks 0.5h, decoct 1 hour, filtering, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, the steps such as medicinal liquid leaches, and using distinctive concentration and drying equipment, in the five-ester soft capsule prepared, deoxyschizandrin content is high, and finds the application in preparation suppression Chinese hamster lung CHL cell proliferation of the described five-ester soft capsule.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of five-ester soft capsule and preparation method thereof.
Background technology
Five-ester soft capsule can reduce serum glutamic pyruvic transminase, can be used for chronic hepatitis glutamate pyruvate transaminase rising person.Have aobvious
The hepatocyte injury antagonism write, it is possible to strengthen hepatocyte to the defensive ability/resistance ability of poisonous substance and injury repairing ability and mutation
Ability, can promote the biosynthesis of hepatocyte internal protein and glycogen, accelerates aminoacid and penetrates into human liver's speed, improves machine
The body utilization to sugar, improves the recovery of human body energy supply, beneficially hepatocyte function.Preparation method of the prior art, work
Skill is coarse, backward, and impurity is many, and active constituent content is low, causes patient's consumption excessive, it has not been convenient to take, had a strong impact on this product
Apply clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of five-ester soft capsule and preparation thereof
Method.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of five-ester soft capsule, preparation method is: take Fructus Schisandrae Chinensis, adds the water of 10 times of weight of schisandra chinensis medicinal material, soaks 0.5h,
Decocting 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, dense
Being reduced to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, and stirring, standing, filtration, filtrate is dense
Being reduced to relative density when 65 DEG C is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, described macroporous resin essence
Method processed is: be added on macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, recovered under reduced pressure second
Alcohol, is concentrated and dried, and adds vegetable oil, fill, is prepared as five-ester soft capsule.
The preparation method of described five-ester soft capsule, described macroporous adsorptive resins model is D101, D201, D301.
Described five-ester soft capsule, concentrates for three times in above-mentioned preparation method and uses device, including tank body, be arranged on described tank body
On charging aperture and be arranged on the discharge nozzle of described tank base, in described tank body, be provided with shaft, on described shaft
It is provided with stirring paddle, is provided with the stirring motor being connected with described shaft at the top of described tank body, at the inwall of described tank body
Being provided with annular groove, the bottom of described annular groove, near the diapire of described tank body, is provided with annular in described annular groove
Spill spin block, is provided with driving motor in the sidewall of described tank body, is provided with driving fluted disc, in institute on the main shaft of described driving motor
The outer ring surface stating ring rotation block is provided with the teeth groove mutually ratcheting with described driving fluted disc, at the inner ring surface of described ring rotation block
On be uniformly provided with at least three and scrape muscle, described in scrape the diapire of muscle and be pressed on the diapire upper surface of described tank body, at described tank body
It is provided with the actuator being connected with described driving motor.
Described five-ester soft capsule, in above-mentioned preparation method, described in enrichment facility, the roof of annular groove is uniformly provided with diapire
Ball, upper surface and the lower surface of described ring rotation block are pressed on described ball.
Described five-ester soft capsule, ring rotation block described in enrichment facility and the company of described annular groove in above-mentioned preparation method
Junction is provided with sealing metal bar, and described ball is arranged on the medial extremity of described sealing metal bar and annular groove.
Described five-ester soft capsule, is additionally provided with cooler on discharge nozzle described in enrichment facility in above-mentioned preparation method, described
Moisture determination instrument it is provided with in tank body.
Described five-ester soft capsule, is dried in above-mentioned preparation method and uses device, including body, be arranged in described body
Axis, the rotation being arranged on described axis outer wall holds dish, is provided with vibration motor in the lower end of described axis, at described body
Top be provided with vapours conveyance conduit, it is characterised in that: in described axis, be provided with cavity, be provided with at the top of described axis
Disk, described disk is arranged on described rotation and holds the top of dish, is provided with the most penetrating pore, described on described disk
It is provided with the heat conduction mast being connected with described cavity in disk, in described cavity, is provided with electrical heating block, on described heat conduction mast
Being provided with heat conduction thorn post, described heat conduction thorn post stretches in described pore, is provided with temperature sensor, at described cavity in described body
Inside being provided with the driver being connected with described temperature sensor, described driver switchs with the control of described electrical heating block and is connected
Connect.
Described five-ester soft capsule, in above-mentioned preparation method, pore described in dry use device is the loudspeaker that big bottom, top is little
Shape hole, described heat conduction thorn post stretches into the middle part in described horn-like hole, is provided with the most penetrating conduction net on described horn-like hole
Hole.
Described five-ester soft capsule, is dried in above-mentioned preparation method and uses the bottom surface of body described in device to be provided with chamber door, described
Chamber door is arranged on to rotate and holds the lowermost end of dish, and described heat conduction mast be silver-colored or aluminum or copper mast.
The application in preparation suppression Chinese hamster lung CHL cell proliferation of the described five-ester soft capsule.
In prior art, five-ester soft capsule uses the method for alcohol extraction, and technique is coarse, backward, and impurity is many, causes patient's consumption
Excessive, it has not been convenient to take, deoxyschizandrin yield prepared by the present invention increases, and content is high.Concentrator structure in the present invention
Simply, simple operation, heating concentrate time, can by drive motor drive ring rotation block rotate so that scraping muscle at tank
The bottom surface of body scrapes, thus can effectively prevent the diapire of tank body from luming, and can improve heating thickening efficiency to a certain extent, solves
Conventional art Chinese medicinal concentration equipment tank bottoms easy caking thus affect the technical deficiency of the efficiency of heating surface, stability in use is good, medicine
The stable effective ingredients of thing is not destroyed.This drying equipment structure is simple, and simple operation is provided with disk at the top of axis, and
And on disk, it is provided with pore, and vapours can be made to pass through disk, and in axis, be provided with electrical heating block and heat conduction mast, can
To start electrical heating block as required, and realize temperature transfer by heat conduction mast, and mix with by the vapours of disk
Closing, thereby may be ensured that the temperature of vapours, regulation performance is good, and stability in use is strong, efficiently solves heat in conventional art and steams
The uncontrollable technical deficiency of temperature in vapour heating drier.And find that described five-ester soft capsule is at preparation suppression Chinese hamster lung
Application in CHL cell proliferation.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Taking Fructus Schisandrae Chinensis 1000g, add the water of 10 times of weight of schisandra chinensis medicinal material, soak 0.5h, decoct 1 hour, filter, medicinal residues are again
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C of relative densities and is
1.05, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand, filter, relative density when filtrate is concentrated into 65 DEG C
Being 1.25, and reclaim ethanol, obtain concentrated solution, using macroporous resin to refine, be added on macroporous adsorptive resins, 50% ethanol is washed
De-, collect 5 times amount column volume eluents, decompression recycling ethanol, be concentrated and dried, add vegetable oil, fill, be prepared as five-ester soft
Capsule.
The preparation method of described five-ester soft capsule, described macroporous adsorptive resins model is D101.
See Fig. 1: the preparation method of described five-ester soft capsule, above-mentioned No. three enrichment facilities, including tank body 1, be arranged on described
Charging aperture on tank body 12 and be arranged on the discharge nozzle 3 bottom described tank body 1, is provided with shaft 4, in institute in described tank body 1
State shaft 4 and be provided with stirring paddle 5, be provided with the stirring motor 6 being connected with described shaft 4 at the top of described tank body 1,
The inwall of described tank body 1 is provided with annular groove 7, and the bottom of described annular groove 7 is near the diapire of described tank body 1, described
It is provided with ring rotation block 8 in annular groove 7, in the sidewall of described tank body 1, is provided with driving motor 9, at described driving motor 9
Main shaft is provided with driving fluted disc 10, is provided with mutually ratcheting with described driving fluted disc 10 on the outer ring surface of described ring rotation block 8
Teeth groove 11, is uniformly provided with at least three on the inner ring surface of described ring rotation block 8 and scrapes muscle 12, described in scrape the diapire of muscle 12 and compress
On the diapire upper surface of described tank body 1, described tank body 1 is provided with the actuator 13 being connected with described driving motor 9, adjusts
Joint device is to have used structure on market, it is only necessary to connects according to its connection request and uses.Driven by control in use
Motor, makes driving driven by motor ring rotation block rotate, so that scraping muscle diapire at tank body under the drive of ring rotation block
End face scrapes, such that it is able to pine scraped by the medicinal residues that oar accumulates in tank body diapire end face, thus can prevent caking.
Roof and diapire at described annular groove 7 is uniformly provided with ball 14, the upper surface of described ring rotation block 8 and under
End face is pressed on described ball 14.Be provided with ball, it is ensured that the normal rotation of ring rotation block, reduce ring rotation block with
Friction between annular groove, thus improve service life and stability in use.
Being provided with sealing metal bar 15 on the described ring rotation block 8 joint face with described annular groove 7, described ball sets
Put the medial extremity at described sealing metal bar Yu annular groove.
Described discharge nozzle is additionally provided with cooler 16, in described tank body, is provided with moisture determination instrument 17.
See Fig. 2, the preparation method of described five-ester soft capsule, above-mentioned dry use device, including body 1, be arranged on described
Axis 2 in body 1, the rotation being arranged on described axis 2 outer wall holds dish 3, is provided with vibrations electricity in the lower end of described axis 2
Machine 4, is provided with vapours conveyance conduit 5 at the top of described body 1, is provided with cavity 6 in described axis 2, at described axis 2
Top is provided with disk 7, and described disk 7 is arranged on described rotation and holds the top of dish 3, is provided with the most penetrating on described disk 7
Pore 8, vapours through disk, enters rotation and holds dish, be provided with and leading that described cavity 6 is connected in described disk 7
Plume bar 9, is provided with electrical heating block 10 in described cavity 6, and described heat conduction mast 9 is provided with heat conduction thorn post 11, and described heat conduction is stung
Post 11 stretches in described pore 8, can be greatly improved the temperature mixing between vapours and electrical heating block, improves temperature controlled
Efficiency, is provided with temperature sensor 12 in described body 1, is provided with is connected with described temperature sensor 12 in described cavity 6
Driver 13, the control of described driver 13 and described electrical heating block 10 switchs and is connected.Temperature sensor in the present embodiment
Being the most already present product with driver, it has only to be attached according to the corresponding description of product in use.
Described pore is the horn-like hole that big bottom, top is little, and described heat conduction thorn post stretches into the middle part in described horn-like hole,
Described horn-like hole is provided with the most penetrating conduction mesh 14.
Be provided with chamber door 15 in the bottom surface of described body, described chamber door is arranged on and rotates the lowermost end holding dish.
Described heat conduction mast is silver or aluminum or copper mast.
Embodiment 2
Taking Fructus Schisandrae Chinensis 1000g, add the water of 10 times of weight of schisandra chinensis medicinal material, soak 0.5h, decoct 1 hour, filter, medicinal residues are again
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C of relative densities and is
1.05, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand, filter, relative density when filtrate is concentrated into 65 DEG C
Being 1.25, and reclaim ethanol, obtain concentrated solution, using macroporous resin to refine, be added on macroporous adsorptive resins, 50% ethanol is washed
De-, collect 5 times amount column volume eluents, decompression recycling ethanol, be concentrated and dried, add vegetable oil, fill, be prepared as five-ester soft
Capsule.
The preparation method of described five-ester soft capsule, described macroporous adsorptive resins model is D201.
Concentrate with drying device ibid.
Embodiment 3
Taking Fructus Schisandrae Chinensis 1000g, add the water of 10 times of weight of schisandra chinensis medicinal material, soak 0.5h, decoct 1 hour, filter, medicinal residues are again
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C of relative densities and is
1.05, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand, filter, relative density when filtrate is concentrated into 65 DEG C
Being 1.25, and reclaim ethanol, obtain concentrated solution, using macroporous resin to refine, be added on macroporous adsorptive resins, 50% ethanol is washed
De-, collect 5 times amount column volume eluents, decompression recycling ethanol, be concentrated and dried, add vegetable oil, fill, be prepared as five-ester soft
Capsule.
The preparation method of described five-ester soft capsule, described macroporous adsorptive resins model is D301.
Concentrate with drying device ibid.
In above-described embodiment, Fructus Schisandrae Chinensis is magnoliaceae schisandra Schisandra chinensis (Turcz.)
Baill. dry mature fruit.
Embodiment 4: deoxyschizandrin assay experimentation data in five-ester soft capsule of the present invention
1.1 Experimental agents: five-ester soft capsule of the present invention: prepare by embodiment 1-3 method.Matched group uses common concentration
Method prepares five-ester soft capsule.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Data acquisition and process use the work of HS chromatographic data
Stand V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (general rule 0512).Chromatographic condition and system suitability
With octadecylsilane chemically bonded silica as filler；With methanol-water (60:40) for flowing phase；Detection wavelength is 250nm；Theoretical
Plate number is calculated by deoxyschizandrin peak should be not less than 2000.Take deoxyschizandrin reference substance appropriate, accurately weighed, add methanol and make
Every lm l solution containing 5ug, to obtain final product.The preparation of need testing solution takes this product under content uniformity item, finely ground, takes about 0.5g, essence
Close weighed, put in 25ml measuring bottle, add methanol 20ml, supersound process (power 250W, frequency 40kHz) 30 minutes, let cool, add methanol
To scale, shake up, filter, take subsequent filtrate, to obtain final product.Precision draws reference substance solution and need testing solution each 20ul injection liquid respectively
Chromatography, measures, to obtain final product.
1.4 experimental result
Deoxyschizandrin assay result in five-ester soft capsule prepared by each embodiment
According to the result of the test of upper table, in five-ester soft capsule prepared by embodiment of the present invention 1-3, deoxyschizandrin contains
Amount is apparently higher than matched group.
Embodiment 5: the experimentation data of five-ester soft capsule of the present invention suppression Chinese hamster lung CHL cell proliferation
1 experiment material
1.1 experiment cell strains
Chinese hamster lung CHL cell, Nanjing Medical University's laboratory cell storehouse, DMEM+10%FBS cellar culture.
1.2 Experimental agents
Drugs: five-ester soft capsule of the present invention: prepare by embodiment 1 method.
Medicinal liquid liquid storage: weigh 100mg five-ester soft capsule, is dissolved in 5ml dehydrated alcohol, and 0.2 μm filter filters, 500 μ l
Doff pipe subpackage ,-20 DEG C of storages, 0.2 μm filter filters dehydrated alcohol in case matched group is used simultaneously.
1.3 experiment reagent
DMEM (GIBCO company Cat.No.12100-061Lot.No.758137)；Hyclone (Hangzhoupro, sky, Zhejiang biology section
Skill company limited Lot.No.100419)；NaHCO3 (the long hundred million chemical reagent company limited Cat.No.11810-033 in Shanghai
Lot.No.1088387)；Trypsin (AMRESCO company lot number: 2010/04)；EDTA (AMRESCO company lot number: 2009/
10)；Penicillin G Sodium Salt (AMRESCO company lot number: 2010242)；Streptomycin Sulfate
(AMRESCO company lot number: 2010382)；Dehydrated alcohol (Nanjing Chemistry Reagent Co., Ltd.'s lot number: 080310182)；MTT
(Biosharp lot number: 0793)；PBS (laboratory autogamy)；
1.4 experiment equipment
Lycra inverted microscope (Germany Leica model: DM1L)；Visible-ultraviolet light microwell plate detector (MD company of the U.S.
Model: SPECTRA MAX 190)；CO2 incubator (FORMA model: 3111)；Super-clean bench (safe and sound company of Su Jing group manufacture type
Number: SW-CJ-ZFD)；Pure water instrument (Spring company of U.S. model: S/N 020579)；Accurate pipettor (Gilson Inc of France
Model: P2)；Electronic balance (Sai Duolisi company limited of Germany model: BT323S)；Full-automatic high-pressure autoclave (Japan SANYO
Company's model: MLS-3020)；Table electrothermal air dry oven (Shanghai precision experimental facilities company model: DHG9123A)；Refrigerator
(Siemens Company's model: KG18V21TI)；Liquid nitrogen container (CBS model: 2001)；Low speed centrifuge (Anting Scientific Instrument Factory, Shanghai
Model: KA-1000)；0.2 μm filter (MILLIPORE model: SLGP033RB)；10cm culture dish (NEST company), 96 hole trainings
Support plate (NEST company)；Cell counting count board；Centrifuge tube, pipet, Tips are some.
2 experimental techniques
1) Chinese hamster lung CHL cell DMEM+10%FBS in 37 DEG C, 5%CO2 carry out cellar culture (10cm cultivate
Ware), when cell grows to logarithmic (log) phase, collect cell, discard culture fluid, PBS rinses 3 times, adds 3ml 0.25% Trypsin
Enzyme-0.04%EDTA, after 37 DEG C of digestion 2min, is added thereto in 5ml complete medium and reacts, by its turn after piping and druming cell
Entering in centrifuge tube, 1000rpm is centrifuged 5min, adjusts 3 × 104/ml of concentration of cell suspension.
2) entering in 96 well culture plates by cell kind, every hole adds cell suspension 180 μ l, and culture plate is put in cell culture incubator
(37 DEG C, 5%CO2) cellar culture.
3) according to cell growth status, general long to 50%-70%, add five-ester soft capsule solution, continue to cultivate 24h.
4) add 20 μ l MTT solution (5mg/ml, i.e. 0.5%MTT) after 24h, continue to cultivate 4h.
5) after 4h, buckle method removes supernatant, pats dry gently with absorbent paper, and every hole adds 200 μ l dimethyl sulfoxide, puts shaking table
Upper low-speed oscillation 10min, makes crystal fully dissolve.The light absorption value in each hole is measured at enzyme-linked immunosorbent assay instrument 490nm.
6) arranging background (being not added with cell, only add culture fluid), (cell, the medicine dissolution of same concentrations are situated between control wells simultaneously
Matter, culture fluid, MTT, dimethyl sulfoxide), often group sets 6 multiple holes.
7) suppression ratio of cell is represented by result with medicine:
Cell proliferation suppression ratio (%)=(control wells OD value-dosing holes OD value)/control wells OD value × 100%.Experiment weight
Multiple 3 times.
3 statistical dispositions
Use the correlation analysis in Microsoft Excel 2003 software and Student t inspection, data with mean ±
S.D. represent.
4 experimental results
Statistical result showed after mtt assay experiment, compares with matched group, when dosage reaches 5mg/ml, to Chinese hamster lung
CHL cell inhibitory effect variant (P < 0.05), dosage this difference when 10mg/ml has significance (P < 0.01), works as dosage
Reach during 15-20mg/ml, there is pole significant difference (P < 0.001).
Five-ester soft capsule is to Chinese hamster lung CHL cell inhibitory effect influence research
Note: compare with matched group, * P < 0.01；**P<0.001
5 experiment conclusion
Five-ester soft capsule can suppress Chinese hamster lung CHL cell proliferation, and the cell reducing Chinese hamster lung CHL cell is raw
Long number, this effect is dose dependent.
Claims (10)
1. a five-ester soft capsule, it is characterised in that preparation method is: take Fructus Schisandrae Chinensis, adds the water of 10 times of weight of schisandra chinensis medicinal material,
Soaking 0.5h, decoct 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice
Decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, stand, mistake
Filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, described greatly
Hole resin purification method is: be added on macroporous adsorptive resins, 50% ethanol elution, collects 5 times amount column volume eluents, decompression
Reclaim ethanol, be concentrated and dried, add vegetable oil, fill, be prepared as five-ester soft capsule.
Five-ester soft capsule the most according to claim 1, it is characterised in that macroporous adsorptive resins described in above-mentioned preparation method
Model is D101, D201, D301.
Five-ester soft capsule the most according to claim 1, it is characterised in that concentrate for three times in above-mentioned preparation method and use device, bag
Include tank body, the charging aperture being arranged on described tank body and the discharge nozzle being arranged on described tank base, it is provided with in described tank body
Shaft, is provided with stirring paddle on described shaft, is provided with the stirring being connected with described shaft at the top of described tank body
Motor, is provided with annular groove on the inwall of described tank body, and the bottom of described annular groove is near the diapire of described tank body, in institute
It is provided with ring rotation block in stating annular groove, in the sidewall of described tank body, is provided with driving motor, the master of described driving motor
Axle is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc on the outer ring surface of described ring rotation block,
Be uniformly provided with at least three on the inner ring surface of described ring rotation block and scrape muscle, described in scrape the diapire of muscle and be pressed on the end of described tank body
On wall upper surface, described tank body is provided with the actuator being connected with described driving motor.
Five-ester soft capsule the most according to claim 3, it is characterised in that in above-mentioned preparation method, described in enrichment facility, annular is recessed
The roof of groove and diapire are uniformly provided with ball, and upper surface and the lower surface of described ring rotation block are pressed on described ball.
Five-ester soft capsule the most according to claim 3, it is characterised in that annular rotation described in enrichment facility in above-mentioned preparation method
Switch block is provided with sealing metal bar with the joint face of described annular groove, and described ball is arranged on described sealing metal bar and annular
The medial extremity of groove.
Five-ester soft capsule the most according to claim 3, it is characterised in that discharge nozzle described in enrichment facility in above-mentioned preparation method
On be additionally provided with cooler, in described tank body, be provided with moisture determination instrument.
Five-ester soft capsule the most according to claim 1, it is characterised in that be dried in above-mentioned preparation method and use device, including machine
Body, is arranged on the axis in described body, and the rotation being arranged on described axis outer wall holds dish, sets in the lower end of described axis
There is vibration motor, be provided with vapours conveyance conduit at the top of described body, it is characterised in that: in described axis, it is provided with sky
Chamber, is provided with disk at the top of described axis, and described disk is arranged on described rotation and holds the top of dish, sets on described disk
There is the most penetrating pore, in described disk, be provided with the heat conduction mast being connected with described cavity, be provided with in described cavity
Electrical heating block, described heat conduction mast is provided with heat conduction thorn post, and described heat conduction thorn post stretches in described pore, sets in described body
Having temperature sensor, be provided with the driver being connected with described temperature sensor in described cavity, described driver is with described
The control switch of electrical heating block is connected.
Five-ester soft capsule the most according to claim 7, it is characterised in that be dried described in use device thin in above-mentioned preparation method
Hole is the horn-like hole that big bottom, top is little, and described heat conduction thorn post stretches into the middle part in described horn-like hole, in described horn-like hole
It is provided with the most penetrating conduction mesh.
Five-ester soft capsule the most according to claim 7, it is characterised in that be dried in above-mentioned preparation method and use machine described in device
The bottom surface of body is provided with chamber door, and described chamber door is arranged on and rotates the lowermost end holding dish, and described heat conduction mast is silver or aluminum or copper
Mast.
Five-ester soft capsule answering in preparation suppression Chinese hamster lung CHL cell proliferation the most according to claim 1
With.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610562734.8A CN106177118A (en) | 2016-07-16 | 2016-07-16 | A kind of five-ester soft capsule and preparation method thereof |
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| CN201610562734.8A CN106177118A (en) | 2016-07-16 | 2016-07-16 | A kind of five-ester soft capsule and preparation method thereof |
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| CN106177118A true CN106177118A (en) | 2016-12-07 |
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| CN201610562734.8A Withdrawn CN106177118A (en) | 2016-07-16 | 2016-07-16 | A kind of five-ester soft capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905241A (en) * | 2018-06-29 | 2018-11-30 | 江苏海容热能环境工程有限公司 | A kind of brine concentration and concentration regulator |
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| CN104547035A (en) * | 2014-12-19 | 2015-04-29 | 陕西必康制药集团控股有限公司 | Extraction method of Chinese magnoliavine fruit |
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| CN108905241A (en) * | 2018-06-29 | 2018-11-30 | 江苏海容热能环境工程有限公司 | A kind of brine concentration and concentration regulator |
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