CN105943729A - Infant Qixing tea granules and preparation method thereof - Google Patents
Infant Qixing tea granules and preparation method thereof Download PDFInfo
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- CN105943729A CN105943729A CN201610459859.8A CN201610459859A CN105943729A CN 105943729 A CN105943729 A CN 105943729A CN 201610459859 A CN201610459859 A CN 201610459859A CN 105943729 A CN105943729 A CN 105943729A
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- granule
- erqixingcha
- xiao
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- 238000002360 preparation method Methods 0.000 title claims abstract description 30
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- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims abstract description 10
- 201000005249 lung adenocarcinoma Diseases 0.000 claims abstract description 10
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- 239000000463 material Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract description 7
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- 240000007594 Oryza sativa Species 0.000 abstract 1
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- 241000607122 Uncaria tomentosa Species 0.000 abstract 1
- 235000011472 cat’s claw Nutrition 0.000 abstract 1
- 235000013339 cereals Nutrition 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 235000009566 rice Nutrition 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 6
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 5
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 5
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 5
- 239000001685 glycyrrhizic acid Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
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- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
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Classifications
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention provides infant Qixing tea granules. A preparation method of the infant Qixing tea granules comprises the steps of: decocting 893g of coix seed, 893g of rice grain sprouts, 446g of hawthorn, 670g of lophatherum gracile, 335g of uncaria tomentosa, 112g of cicada slough and 112g of liquorice for 1h, filtering liquid medicine and the like. Specific concentration and drying equipment is adopted in the preparation method. The prepared infant Qixing tea granules are high in glycyrrhizinic acid content, and can inhibit proliferation of human lung adenocarcinoma GLC-82 cells.
Description
Technical field
The present invention relates to Chinese drug preparation technique field, be specifically related to a kind of Xiao ' erqixingcha granule and preparation method thereof.
Background technology
Xiao ' erqixingcha granule prescription is Semen Coicis 893g, Fructus Oryzae Germinatus 893g, Fructus Crataegi 446g, Herba Lophatheri 670g, hook
Rattan 335g, Periostracum Cicadae 112g, Radix Glycyrrhizae 112g, above seven tastes, Semen Coicis, Fructus Oryzae Germinatus boiling secondary, each 2 hours,
Decocting liquid filters, and filtrate merges, and being concentrated into relative density is 1.08～1.12 (55 DEG C), adds people's ethanol and makes alcohol content reach
45%, stand, filter, filtrate recovery second is pure and is condensed into thick paste；The five tastes boiling secondaries such as remaining Fructus Crataegi, every time
2 hours, decocting liquid filtered, and filtrate merges, and filtrate is concentrated in right amount, merges with above-mentioned thick paste, added suitable amount of sucrose powder,
Make granule, be dried, make 1000g, to obtain final product.Preparation method of the prior art, technique is coarse, backward, impurity
Many, active constituent content is low, causes patient's consumption excessive, it has not been convenient to take, has had a strong impact on this product and applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of Xiao ' erqixingcha granule and system thereof
Preparation Method.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of Xiao ' erqixingcha granule, preparation method is as follows: take Herba Polygalae Japonicae 150g, Folium Isatidis 350g, Flos Chrysanthemi Indici 200g,
Spora Lygodii 250g, Herba Hedyotidis Diffusae 250g, Herba Violae 200g, add the water of 10 times of weight of medical material, soaks 0.5h,
Decocting 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice
Decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, quiet
Putting, filter, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, is entered by concentrated solution
Row is dried, and adds adjuvant, obtains Xiao ' erqixingcha granule.
The preparation method of described Xiao ' erqixingcha granule, above-mentioned twice concentration uses device, including tank body, is arranged on institute
State the charging aperture on tank body and be arranged on the discharge nozzle of described tank base, described discharge nozzle is provided with discharge valve and mistake
Filter, is provided with shaft in described tank body, is provided with stirring paddle on described shaft, is provided with at the top of described tank body
The stirring motor being connected with described shaft, the diapire in described tank body is provided with vibrations chamber, sets at described vibrations intracavity
There is jolting plate, between described jolting plate and described vibrations chamber, be provided with electromagnetic shaker, the sidewall in described tank body be provided with recessed
Chamber, the end face at described jolting plate is provided with scraper plate, is provided with telescopic cylinder between described scraper plate and described cavity, described in scrape
Plate realizes the scraping to jolting plate surface under the effect of described telescopic cylinder, is provided with described at the center of described jolting plate
The discharging opening that discharge nozzle is connected.
The preparation method of described Xiao ' erqixingcha granule, the connection in jolting plate described in above-mentioned enrichment facility and described vibrations chamber
Place is provided with sealing metal bar, is provided with the shake control device being connected with described electromagnetic shaker on described tank body.
The preparation method of described Xiao ' erqixingcha granule, the bottom of scraper plate described in above-mentioned enrichment facility is provided with metal scraping layer,
Described metal scraping layer is pressed on described jolting plate, is provided be connected with described telescopic cylinder flexible on described tank body
Control knob.
The preparation method of described Xiao ' erqixingcha granule, is provided with water tester in tank body described in above-mentioned enrichment facility,
It is provided with cooler in described discharge nozzle.
The preparation method of described Xiao ' erqixingcha granule, above-mentioned dry use device, including casing, it is arranged on described case
Internal material frame and the blast pipe and the discharge pipe that are arranged on described casing top, it is characterised in that: in the side of described casing
It is provided with the air intake passage being connected with described blast pipe in wall, the sidewall of described casing is provided with and described air intake passage phase
Connection air holes, described discharge pipe through described casing roof connection casing in casing outside, in the side of described casing
Being additionally provided with homoiothermic chamber and sterilization chamber in wall, be provided with electrical heating block at described homoiothermic intracavity, described air intake passage passes described tune
Joint chamber and sterilization chamber are arranged, and be provided with rotating drum, be provided with electric rotating machine in described rotating drum in the diapire of described casing,
The main shaft of described electric rotating machine is connected with described material frame, is provided with vibrations groove in described material frame, at described material
The end face of frame is provided with and holds plate, is provided with shaking device described holding between plate and described vibrations groove.
The preparation method of described Xiao ' erqixingcha granule, shaking device described in above-mentioned dry use device includes driving motor,
Be arranged on the eccentric on described driving electric machine main shaft, the wheel limit of described eccentric be pressed on described in hold in the bottom surface of plate
The heart, is provided with extension spring between the diapire of the described bottom holding plate and described vibrations groove, and described extension spring is with described eccentric
Centered by be symmetrical arranged.
The preparation method of described a kind of Xiao ' erqixingcha granule, is provided with temperature and passes in casing described in above-mentioned dry use device
Sensor, is provided with the driver being connected with described temperature sensor in the sidewall of described casing, and described driver is with described
The control end of electrical heating block is connected, and is additionally provided with chamber door on described casing.
The application in preparation suppression human lung adenocarcinoma GLC-82 cell proliferation of the described Xiao ' erqixingcha granule.
In prior art, Xiao ' erqixingcha granule uses the method for alcohol extraction, and technique is coarse, backward, and impurity is many, causes
Patient's consumption is excessive, it has not been convenient to take, and Xiao ' erqixingcha granule yield prepared by the present invention increases, and content is high, and purity reaches
98-99%.Concentrator simple in construction in the present invention, simple operation, it is provided with jolting plate and electromagnetic shaker, and is additionally provided with
Scraper plate and the telescopic cylinder being connected with described scraper plate, can effectively prevent tank base from luming, can significantly carry to a certain extent
The high efficiency of heating surface, efficiently solves caking bottom easily occurring in conventional art Chinese medicinal concentration equipment and affects the efficiency of heating surface
Technical deficiency, stability in use is good and the suitability strong, and the stable effective ingredients of medicine is not destroyed.This drying equipment structure
Simply, simple and quick, it uses wall box to blow, and is additionally arranged electrical heating block, can be according in case
Temperature is adjusted, thus ensure that the stability of baking temperature, and is provided with electric rotating machine and shaking device, Ke Yi
Rotate and shake holding plate while heating, thus medicine local desiccation can be prevented, thus can carry to a certain extent
The high efficiency being dried, solves the technical deficiency that the drying device drying efficiency of conventional art is low.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
It is interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention
Belong to the scope of the present invention.
Embodiment 1
Take Herba Polygalae Japonicae 150g, Folium Isatidis 350g, Flos Chrysanthemi Indici 200g, Spora Lygodii 250g, Herba Hedyotidis Diffusae 250g, purple
Flower Herba Violae 200g, adds the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add medical material
The water of 8 times of weight, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05,
Adding ethanol makes the percent by volume of alcohol content reach 75%, and stirring, standing, filtration, filtrate is concentrated into when 65 DEG C the closeest
Degree is 1.25, and reclaims ethanol, obtains concentrated solution, is dried by concentrated solution, adds adjuvant, obtains Xiao ' erqixingcha granule.
Seeing Fig. 1: the preparation method of described Xiao ' erqixingcha granule, above-mentioned twice concentration uses device, including tank body 1,
The charging aperture 2 that is arranged on described tank body 1 and be arranged on the discharge nozzle 3 bottom described tank body 1, at described discharge nozzle 3
It is provided with discharge valve 4 and filter 5, in described tank body 1, is provided with shaft 6, described shaft 6 is provided with
Stirring paddle 7, is provided with the stirring motor 8 being connected with described shaft 6 at the top of described tank body 1, at described tank body 1
Interior diapire is provided with vibrations chamber 9, is provided with jolting plate 10 in described vibrations chamber 9, in described jolting plate 10 and described shake
It is provided with electromagnetic shaker 11 between dynamic chamber 9, jolting plate can be made to shake by electromagnetic shaker, thus can effectively prevent drug particles collection
Knot is on jolting plate, thus can prevent drug particles from luming on jolting plate, the sidewall in described tank body 1 is provided with recessed
Chamber 12, the end face at described jolting plate 10 is provided with scraper plate 13, is provided with and stretches between described scraper plate 13 and described cavity 12
Contracting cylinder 14, can control telescopic cylinder as required, makes scraper plate scrape on the surface of jolting plate, thus part is assembled
Drug particles on jolting plate surface scrapes, and described scraper plate 13 realizes jolting plate under the effect of described telescopic cylinder 14
The scraping on 10 surfaces, is provided with the discharging opening 15 being connected with described discharge nozzle 3 at the center of described jolting plate 10.
It is provided with sealing metal bar 16 in the junction of described jolting plate 10 with described vibrations chamber 9, described tank body is provided with
The shake control device 17 being connected with described electromagnetic shaker.
Be provided with metal scraping layer 18 in the bottom of described scraper plate, described metal scraping layer is pressed on described jolting plate,
Described tank body is provided with the extension and contraction control button 19 being connected with described telescopic cylinder.
In described tank body, it is provided with water tester 21, in described discharge nozzle, is provided with cooler 20.
See Fig. 2: the preparation method of described Xiao ' erqixingcha granule, above-mentioned dry use device, including casing 1, arrange
Material frame 2 in described casing 1 and the blast pipe 3 and the discharge pipe 4 that are arranged on described casing 1 top, at described case
Be provided with the air intake passage 5 being connected with described blast pipe 3 in the sidewall of body 1, the sidewall of described casing 1 is provided with
The air holes 6 that described air intake passage 5 is connected, fresh air inlet is arranged on sidewall, it is ensured that the uniformity of ventilation, and
Can be greatly improved the contact area with medicine, described discharge pipe 4 through in the roof connection casing 1 of described casing 1 with
Casing 1 is outside, is additionally provided with homoiothermic chamber 7 and sterilization chamber 8, sets in described homoiothermic chamber 7 in the sidewall of described casing 1
Having electrical heating block 9, being provided with electrical heating block can be adjusted the temperature of blast pipe as required, it is ensured that baking temperature
Stability, described air intake passage 5 is arranged through described regulation chamber 7 and sterilization chamber 8, sets in the diapire of described casing 1
There is rotating drum 10, in described rotating drum 10, be provided with electric rotating machine 11, the main shaft of described electric rotating machine 11 and described thing
Bin 2 is connected, and is provided with vibrations groove 12 in described material frame 2, and the end face at described material frame 2 is provided with and holds plate
13, it is provided with shaking device 14 described holding between plate 13 and described vibrations groove 12.
Described shaking device 14 includes driving motor 141, is arranged on the eccentric 142 on described driving motor 141 main shaft,
The wheel limit of described eccentric 142 holds the bottom center of plate 13, in the described bottom holding plate 13 and institute described in being pressed on
Stating and be provided with extension spring 15 between the diapire of vibrations groove 12, described extension spring is symmetrical arranged centered by described eccentric, makes
Used time makes to hold plate rising by compressing of eccentric, when the recess of eccentric compresses and holds plate, holds plate in extension spring
Effect is lower to be resetted, and makes the disengaging of thing material fall after holding plate again and holding the vibrations realizing material on plate in dropping process.
In described casing 1, it is provided with temperature sensor 16, is provided with in the sidewall of described casing and described temperature sensor
The driver 17 being connected, described driver is connected with the control end of described electrical heating block.Temperature passes dry device and driver
For prior art existing on market, it has only to when using and connecting connect according to corresponding connection description.
Described casing is additionally provided with chamber door 18.
Embodiment 2
By standards of pharmacopoeia: take Herba Polygalae Japonicae 150g, Folium Isatidis 350g, Flos Chrysanthemi Indici 200g, Spora Lygodii 250g, Agkistrodon
SHECAO 250g, Herba Violae 200g, preparation method is above Six-element, boiling secondary, each 1.5 hours, decocting liquid
Filtering, filtrate merges, and is evaporated to appropriate, adds appropriate sucrose and dextrin, make granule, is dried, makes 1000g
Or 700g；Or add appropriate dextrin and steviosin 0.75g, make granule, be dried, make 250g, to obtain final product.
Concentrate and be dried and use conventional equipment.
Embodiment 3
Glycyrrhizic acid content determination experiment research data in Xiao ' erqixingcha granule of the present invention
1.1 Experimental agents: Xiao ' erqixingcha granule of the present invention: prepare by embodiment 1 method.Matched group is used by embodiment 2
Common concentration prepares Xiao ' erqixingcha granule with drying means.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；Waters
2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column is Zorbax Eclipse XDBC18 post；Number
HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology) is used according to gathering and processing
1.3 condition determinations: use high performance liquid chromatography, chromatographic column be Zorbax Eclipse XDBC18 post (150mm ×
4.6mm, 5 μm), flowing is methanol-water (62:38) mutually, detects wavelength 289nm, column temperature 30 DEG C, flow velocity 1.0mL/min.
1.4 experimental result
Glycyrrhizic acid content measurement result in Xiao ' erqixingcha granule prepared by each embodiment of table 1
| Sample source | Glycyrrhizic acid content (%) |
| Embodiment 1 | 0.8 |
| Embodiment 2 | 0.2 |
According to the result of the test of table 1, in the Xiao ' erqixingcha granule of the embodiment of the present invention 1 preparation, glycyrrhizic acid content is bright
Aobvious higher than matched group embodiment 2, illustrate that common technique can destroy glycyrrhizic acid.
Embodiment 4: the experimentation data of Xiao ' erqixingcha granule suppression human lung adenocarcinoma GLC-82 Cells Cell Proliferation
1 experiment material
1.1 experiment cell strains
Human lung adenocarcinoma GLC-82 cell, Nanjing Medical University's laboratory cell storehouse, DMEM+10%FBS routine is trained
Support.
1.2 Experimental agents
Drugs: Xiao ' erqixingcha granule of the present invention: prepare by embodiment 3 method.
Medicinal liquid liquid storage: weigh 100mg Xiao ' erqixingcha granule, is dissolved in 5ml dehydrated alcohol, and 0.2 μm filter filters,
500 μ l doff pipe subpackages ,-20 DEG C of storages, 0.2 μm filter filters dehydrated alcohol in case matched group is used simultaneously.
1.3 experiment reagent
DMEM (GIBCO company Cat.No.12100-061Lot.No.758137)；Hyclone (Hangzhoupro, sky, Zhejiang
Bio tech ltd Lot.No.100419)；NaHCO3 (the long hundred million chemical reagent company limited Cat. in Shanghai
No.11810-033Lot.No.1088387)；Trypsin (AMRESCO company lot number: 2010/04)；EDTA
(AMRESCO company lot number: 2009/10)；Penicillin G Sodium Salt (AMRESCO company lot number:
2010242)；Streptomycin Sulfate (AMRESCO company lot number: 2010382)；Dehydrated alcohol (Nanjing
Reagent company limited lot number: 080310182)；MTT (Biosharp lot number: 0793)；PBS (laboratory autogamy)；
1.4 experiment equipment
Lycra inverted microscope (Germany Leica model: DM1L)；Visible-ultraviolet light microwell plate detector (U.S. MD
Company's model: SPECTRA MAX 190)；CO2 incubator (FORMA model: 3111)；Super-clean bench (Su Jing
Safe and sound company of group manufactures model: SW-CJ-ZFD)；Pure water instrument (Spring company of U.S. model: S/N 020579)；
Accurate pipettor (Gilson Inc of France model: P2)；Electronic balance (Sai Duolisi company limited of Germany model:
BT323S)；Full-automatic high-pressure autoclave (SANYO company of Japan model: MLS-3020)；Table electrothermal air blast is done
Dry case (Shanghai precision experimental facilities company model: DHG9123A)；Refrigerator (Siemens Company's model:
KG18V21TI)；Liquid nitrogen container (CBS model: 2001)；Low speed centrifuge (Anting Scientific Instrument Factory, Shanghai's model:
KA-1000)；0.2 μm filter (MILLIPORE model: SLGP033RB)；10cm culture dish (NEST company),
96 well culture plates (NEST company)；Cell counting count board；Centrifuge tube, pipet, Tips are some.
2 experimental techniques
1) human lung adenocarcinoma GLC-82 cell DMEM+10%FBS in 37 DEG C, 5%CO2 carry out cellar culture (10
Cm culture dish), when cell grows to logarithmic (log) phase, collect cell, discard culture fluid, PBS rinses 3 times, adds 3ml
0.25% trypsin-0.04%EDTA, after 37 DEG C of digestion 2min, is added thereto to 5ml complete medium and neutralizes
Reaction, is proceeded in centrifuge tube after piping and druming cell, and 1000rpm is centrifuged 5min, adjusts concentration of cell suspension 3 × 104
Individual/ml.
2) entering in 96 well culture plates by cell kind, every hole adds cell suspension 180 μ l, and culture plate is put in cell culture incubator
(37 DEG C, 5%CO2) cellar culture.
3) according to cell growth status, general long to 50%-70%, add Xiao ' erqixingcha particle solution, continue to cultivate 24h.
4) add 20 μ l MTT solution (5mg/ml, i.e. 0.5%MTT) after 24h, continue to cultivate 4h.
5) after 4h, buckle method removes supernatant, pats dry gently with absorbent paper, and every hole adds 200 μ l dimethyl sulfoxide, puts on shaking table
Low-speed oscillation 10min, makes crystal fully dissolve.The light absorption value in each hole is measured at enzyme-linked immunosorbent assay instrument 490nm.
6) background (being not added with cell, only add culture fluid) is set simultaneously, control wells (cell, the medicine dissolution medium of same concentrations,
Culture fluid, MTT, dimethyl sulfoxide), often group sets 6 multiple holes.
7) suppression ratio of cell is represented by result with medicine:
Cell proliferation suppression ratio (%)=(control wells OD value-dosing holes OD value)/control wells OD value × 100%.Experiment weight
Multiple 3 times.
3 statistical dispositions
Using the correlation analysis in Microsoft Excel 2003 software and Student t inspection, data are with mean ± S.D.
Represent.
4 experimental results
Statistical result showed after mtt assay experiment, compares with matched group, when dosage reaches 5mg/ml, to human lung adenocarcinoma
GLC-82 Cells Cell Proliferation suppresses variant (P < 0.05), and dosage this difference when 10mg/ml has significance
(P < 0.01), has pole significant difference (P < 0.001) when dosage reaches 15-20mg/ml.
Table 1 Xiao ' erqixingcha granule is to human lung adenocarcinoma GLC-82 cell inhibitory effect influence research
Note: compare with matched group, * P < 0.01；**P<0.001
5 experiment conclusion
Xiao ' erqixingcha granule can suppress human lung adenocarcinoma GLC-82 Cells Cell Proliferation, reduces human lung adenocarcinoma GLC-82
The cell growing number of cell, this effect is dose dependent.
Claims (9)
1. an Xiao ' erqixingcha granule, it is characterised in that preparation method is as follows: take Semen Coicis 893g, Fructus Oryzae Germinatus 893g, Fructus Crataegi
446g, Herba Lophatheri 670g, Ramulus Uncariae Cum Uncis 335g, Periostracum Cicadae 112g, Radix Glycyrrhizae 112g, add the water of 10 times of weight of medical material, soaks 0.5h,
Decocting 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice decoction
Liquid, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, stand, filter,
When filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, is dried by concentrated solution, adds adjuvant,
Obtain Xiao ' erqixingcha granule.
A kind of Xiao ' erqixingcha granule, it is characterised in that in above-mentioned preparation method, twice concentration uses
Device, including tank body, the charging aperture being arranged on described tank body and the discharge nozzle being arranged on described tank base, in described discharging
Pipe is provided with discharge valve and filter, is provided with shaft in described tank body, is provided with stirring paddle on described shaft, in institute
The top stating tank body is provided with the stirring motor being connected with described shaft, and the diapire in described tank body is provided with vibrations chamber, in institute
State vibrations intracavity and be provided with jolting plate, between described jolting plate and described vibrations chamber, be provided with electromagnetic shaker, the sidewall in described tank body
Being provided with cavity, the end face at described jolting plate is provided with scraper plate, is provided with telescopic cylinder, institute between described scraper plate and described cavity
State scraper plate under the effect of described telescopic cylinder, realize the scraping to jolting plate surface, be provided with described at the center of described jolting plate
The discharging opening that discharge nozzle is connected.
Xiao ' erqixingcha granule the most according to claim 1, it is characterised in that shake described in enrichment facility in above-mentioned preparation method
Dynamic plate is provided with sealing metal bar with the junction in described vibrations chamber, is provided with the vibrations being connected with described electromagnetic shaker on described tank body
Controller.
Xiao ' erqixingcha granule the most according to claim 1, it is characterised in that scrape described in enrichment facility in above-mentioned preparation method
The bottom of plate is provided with metal scraping layer, and described metal scraping layer is pressed on described jolting plate, is provided with described on described tank body
The extension and contraction control button that telescopic cylinder is connected.
Xiao ' erqixingcha granule the most according to claim 4, it is characterised in that tank described in enrichment facility in above-mentioned preparation method
Internal it is provided with water tester, in described discharge nozzle, is provided with cooler.
Xiao ' erqixingcha granule the most according to claim 1, it is characterised in that be dried in above-mentioned preparation method and use device,
Including casing, the material frame being arranged in described casing and the blast pipe and the discharge pipe that are arranged on described casing top, its feature exists
In: in the sidewall of described casing, be provided with the air intake passage being connected with described blast pipe, the sidewall of described casing is provided with
The air holes that described air intake passage is connected, described discharge pipe through described casing roof connection casing in casing outside, in institute
Being additionally provided with homoiothermic chamber and sterilization chamber in stating the sidewall of casing, be provided with electrical heating block at described homoiothermic intracavity, described air intake passage passes
Described regulation chamber and sterilization chamber are arranged, and be provided with rotating drum, be provided with electric rotating machine in described rotating drum in the diapire of described casing,
The main shaft of described electric rotating machine is connected with described material frame, is provided with vibrations groove in described material frame, at described material frame
End face is provided with and holds plate, is provided with shaking device described holding between plate and described vibrations groove.
Xiao ' erqixingcha granule the most according to claim 6, it is characterised in that be dried in above-mentioned preparation method and use device institute
Stating shaking device to include driving motor, be arranged on the eccentric on described driving electric machine main shaft, the wheel limit of described eccentric is pressed on
The described bottom center holding plate, is provided with extension spring between the diapire of the described bottom holding plate and described vibrations groove, described in draw
Spring is symmetrical arranged centered by described eccentric.
A kind of Xiao ' erqixingcha granule, it is characterised in that be dried in above-mentioned preparation method and use dress
It is provided with temperature sensor in putting described casing, in the sidewall of described casing, is provided with the driver being connected with described temperature sensor,
Described driver is connected with the control end of described electrical heating block, is additionally provided with chamber door on described casing.
The most according to claim 1, Xiao ' erqixingcha granule is in preparation suppression human lung adenocarcinoma GLC-82 cell proliferation
Application.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904732A (en) * | 2018-08-08 | 2018-11-30 | 合肥市绿之林农业开发有限公司 | A kind of seven-star tea herbal tea particle and preparation method thereof improving digestant for baby function |
| CN112044102A (en) * | 2020-08-31 | 2020-12-08 | 江苏康祥实业集团有限公司 | A multistage evaporation plant for evaporation of sodium hypophosphite aqueous solution |
| CN115290769A (en) * | 2022-07-04 | 2022-11-04 | 广州中医药大学(广州中医药研究院) | Method for detecting effective components of children's Qixing tea granules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856473A (en) * | 2010-06-22 | 2010-10-13 | 中山市恒生药业有限公司 | Xiao'erqixingcha oral liquid and preparation method thereof |
-
2016
- 2016-06-22 CN CN201610459859.8A patent/CN105943729A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856473A (en) * | 2010-06-22 | 2010-10-13 | 中山市恒生药业有限公司 | Xiao'erqixingcha oral liquid and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904732A (en) * | 2018-08-08 | 2018-11-30 | 合肥市绿之林农业开发有限公司 | A kind of seven-star tea herbal tea particle and preparation method thereof improving digestant for baby function |
| CN112044102A (en) * | 2020-08-31 | 2020-12-08 | 江苏康祥实业集团有限公司 | A multistage evaporation plant for evaporation of sodium hypophosphite aqueous solution |
| CN115290769A (en) * | 2022-07-04 | 2022-11-04 | 广州中医药大学(广州中医药研究院) | Method for detecting effective components of children's Qixing tea granules |
| CN115290769B (en) * | 2022-07-04 | 2024-05-14 | 广州中医药大学(广州中医药研究院) | Method for detecting effective components of pediatric Qixing tea particles |
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