CN106038657A - Blood activating and pain stopping tablets and preparation method thereof - Google Patents
Blood activating and pain stopping tablets and preparation method thereof Download PDFInfo
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- CN106038657A CN106038657A CN201610543777.1A CN201610543777A CN106038657A CN 106038657 A CN106038657 A CN 106038657A CN 201610543777 A CN201610543777 A CN 201610543777A CN 106038657 A CN106038657 A CN 106038657A
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- blood
- pain stopping
- tank body
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- activating pain
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- 208000002193 Pain Diseases 0.000 title claims abstract description 55
- 230000036407 pain Effects 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000008280 blood Substances 0.000 title abstract description 7
- 210000004369 blood Anatomy 0.000 title abstract description 7
- 230000003213 activating effect Effects 0.000 title abstract 5
- 239000003814 drug Substances 0.000 claims abstract description 10
- 239000004863 Frankincense Substances 0.000 claims abstract description 7
- 230000004663 cell proliferation Effects 0.000 claims abstract description 6
- 239000000052 vinegar Substances 0.000 claims abstract description 6
- 235000021419 vinegar Nutrition 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 239000000284 extract Substances 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 239000012567 medical material Substances 0.000 claims description 10
- 208000028591 pheochromocytoma Diseases 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 8
- 210000003205 muscle Anatomy 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 230000001629 suppression Effects 0.000 claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 5
- 241000717739 Boswellia sacra Species 0.000 claims description 5
- 241001489978 Eupolyphaga Species 0.000 claims description 5
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 5
- 241000180649 Panax notoginseng Species 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 230000033228 biological regulation Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 abstract description 6
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 abstract description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 abstract description 2
- 229940114124 ferulic acid Drugs 0.000 abstract description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 abstract description 2
- 235000001785 ferulic acid Nutrition 0.000 abstract description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 abstract description 2
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 2
- 240000007551 Boswellia serrata Species 0.000 abstract 2
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 2
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 201000003352 adrenal gland pheochromocytoma Diseases 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 230000000452 restraining effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 18
- 229960004756 ethanol Drugs 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
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- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 230000001919 adrenal effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
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- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
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- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/42—Heating means
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides blood activating and pain stopping tablets. A preparation method includes the steps that 22 g of radix angelica sinensis, 44 g of pseudo-ginseng, 44 g of vinegar frankincense, 11 g of frankincense, 111 g of ground beetles and 67 g of forged native copper are taken and prepared into the blood activating and pain stopping tablets through specific concentration and drying equipment. The content of ferulic acid in the blood activating and pain stopping tablets is high, and application of the blood activating and pain stopping tablets to preparation of medicine for restraining rat adrenal gland pheochromocytoma PC-12 cell proliferation is found.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of blood-activating pain stopping tablet and preparation method thereof.
Background technology
Blood-activating pain stopping tablet promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For traumatic injury, swelling and pain due to blood stasis.Preparation side of the prior art
Method, technique is coarse, backward, and impurity is many, and active constituent content is low, causes patient's consumption excessive, it has not been convenient to take, have a strong impact on
This product is applied clinically.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of blood-activating pain stopping tablet and preparation thereof
Method.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of blood-activating pain stopping tablet, preparation method is: take Radix Angelicae Sinensis 22g, Radix Notoginseng 44g, Olibanum (processed with vinegar) 44g, Borneolum Syntheticum 11g, Eupolyphaga Seu Steleophaga
111g, Pyritum (calcined) 67g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add medical material 8 times
The water of weight, decocts 1 hour, and medicinal liquid leaches, and merges twice decoction liquor, and being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes
The percent by volume of alcohol content reaches 75%, and stirring, standing, filtration, when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims
Ethanol, obtains concentrated solution, uses microwave extracting, obtains extract, continues to concentrate, is dried by concentrated solution, pelletizes, and tabletting to obtain final product
Blood-activating pain stopping tablet.
Described in described promoting blood circulation and stopping pain piece preparation method, microwave assisted extraction methods is: put into micro-by the concentrated solution after water extract-alcohol precipitation
Ripple extraction equipment carries out microwave extracting, extracts power 400-600W, extract 2 times, each 4-8 minute, the 70% of addition every time
The amount of ethanol is 2 times of concentrated solution weight, obtains extract, concentrates, and optimum condition is: microwave extracting power 500W, extracts 6 every time
Minute.
Described blood-activating pain stopping tablet, concentrates for three times in above-mentioned preparation method and uses device, including tank body, be arranged on described tank body
On charging aperture and be arranged on the discharge nozzle of described tank base, in described tank body, be provided with shaft, on described shaft
It is provided with stirring paddle, is provided with the stirring motor being connected with described shaft at the top of described tank body, at the inwall of described tank body
Being provided with annular groove, the bottom of described annular groove, near the diapire of described tank body, is provided with annular in described annular groove
Spill spin block, is provided with driving motor in the sidewall of described tank body, is provided with driving fluted disc, in institute on the main shaft of described driving motor
The outer ring surface stating ring rotation block is provided with the teeth groove mutually ratcheting with described driving fluted disc, at the inner ring surface of described ring rotation block
On be uniformly provided with at least three and scrape muscle, described in scrape the diapire of muscle and be pressed on the diapire upper surface of described tank body, at described tank body
It is provided with the actuator being connected with described driving motor.
Described blood-activating pain stopping tablet, in above-mentioned preparation method, described in enrichment facility, the roof of annular groove is uniformly provided with diapire
Ball, upper surface and the lower surface of described ring rotation block are pressed on described ball.
Described blood-activating pain stopping tablet, ring rotation block described in enrichment facility and the company of described annular groove in above-mentioned preparation method
Junction is provided with sealing metal bar, and described ball is arranged on the medial extremity of described sealing metal bar and annular groove.
Described blood-activating pain stopping tablet, is additionally provided with cooler on discharge nozzle described in enrichment facility in above-mentioned preparation method, described
Moisture determination instrument it is provided with in tank body.
Described blood-activating pain stopping tablet, is dried in above-mentioned preparation method and uses device, including casing, be arranged in described casing
Material frame and the blast pipe and the discharge pipe that are arranged on described casing top, it is characterised in that: it is provided with in the sidewall of described casing
The air intake passage being connected with described blast pipe, is provided with the wind being connected with described air intake passage on the sidewall of described casing
Hole, described discharge pipe through described casing roof connection casing in casing outside, be additionally provided with in the sidewall of described casing
Homoiothermic chamber and sterilization chamber, be provided with electrical heating block at described homoiothermic intracavity, and described air intake passage passes described regulation chamber and sterilization chamber
Arrange, in the diapire of described casing, be provided with rotating drum, in described rotating drum, be provided with electric rotating machine, the master of described electric rotating machine
Axle is connected with described material frame, is provided with vibrations groove in described material frame, and the end face at described material frame is provided with and holds plate,
It is provided with shaking device between plate and described vibrations groove described holding.
Described blood-activating pain stopping tablet, is dried in above-mentioned preparation method and uses shaking device described in device to include driving motor, if
Put the eccentric on described driving electric machine main shaft, the wheel limit of described eccentric be pressed on described in hold the bottom center of plate,
Being provided with extension spring between the diapire of the described bottom holding plate and described vibrations groove, described extension spring is right centered by described eccentric
Claim to arrange.
Described blood-activating pain stopping tablet, is dried in above-mentioned preparation method in using casing described in device and is provided with temperature sensor,
The driver being connected with described temperature sensor, described driver and described electrical heating block it is provided with in the sidewall of described casing
Control end to be connected, described casing is additionally provided with chamber door.
Described blood-activating pain stopping tablet answering in preparation suppression Clonal Rat Pheochromocytoma tumor PC-12 cell proliferation
With.
In prior art, blood-activating pain stopping tablet uses the method for alcohol extraction, and technique is coarse, backward, and impurity is many, causes patient's consumption
Excessive, it has not been convenient to take, in blood-activating pain stopping tablet prepared by the present invention, ferulic acid yield increases, and content is high.Concentration in the present invention
Device structure is simple, simple operation, when heating concentrates, ring rotation block can be driven to rotate by driving motor, so that
Scrape muscle to scrape in the bottom surface of tank body, thus can effectively prevent the diapire of tank body from luming, heating can be improved to a certain extent and concentrate
Efficiency, solves the tank bottoms easy caking of conventional art Chinese medicinal concentration equipment thus affects the technical deficiency of the efficiency of heating surface, uses steady
Qualitative good, the stable effective ingredients of medicine is not destroyed.This drying equipment structure is simple, simple and quick, and it uses casing
Sidewall is blown, and is additionally arranged electrical heating block, can be adjusted according to the temperature in case, thus ensure that baking temperature
Stability, and be provided with electric rotating machine and shaking device, can rotate and shake holding plate while heating, thus
Can prevent medicine local desiccation, thus can improve dry efficiency to a certain extent, the drying device solving conventional art is done
Dry inefficient technical deficiency.And find that blood-activating pain stopping tablet increases at preparation suppression Clonal Rat Pheochromocytoma tumor PC-12 cell
Grow the application in medicine.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, right
The present invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1
Take Radix Angelicae Sinensis 22g, Radix Notoginseng 44g, Olibanum (processed with vinegar) 44g, Borneolum Syntheticum 11g, Eupolyphaga Seu Steleophaga 111g, Pyritum (calcined) 67g, add medical material 10 times
The water of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid is filtered
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses microwave extraction
Take, obtain extract, continue to concentrate, concentrated solution is dried, pelletize, tabletting, obtain blood-activating pain stopping tablet.
The preparation method of described blood-activating pain stopping tablet, described microwave assisted extraction methods is: put into by the concentrated solution after water extract-alcohol precipitation
Microwave extracting apparatus carries out microwave extracting, extracts power 400W, extract 2 times, each 8 minutes, 70% ethanol of addition every time
Amount is concentrated solution weight 2 times, obtain extract, concentrate.
See Fig. 1: the preparation method of described blood-activating pain stopping tablet, above-mentioned No. three enrichment facilities, including tank body 1, be arranged on described
Charging aperture on tank body 12 and be arranged on the discharge nozzle 3 bottom described tank body 1, is provided with shaft 4, in institute in described tank body 1
State shaft 4 and be provided with stirring paddle 5, be provided with the stirring motor 6 being connected with described shaft 4 at the top of described tank body 1,
The inwall of described tank body 1 is provided with annular groove 7, and the bottom of described annular groove 7 is near the diapire of described tank body 1, described
It is provided with ring rotation block 8 in annular groove 7, in the sidewall of described tank body 1, is provided with driving motor 9, at described driving motor 9
Main shaft is provided with driving fluted disc 10, is provided with mutually ratcheting with described driving fluted disc 10 on the outer ring surface of described ring rotation block 8
Teeth groove 11, is uniformly provided with at least three on the inner ring surface of described ring rotation block 8 and scrapes muscle 12, described in scrape the diapire of muscle 12 and compress
On the diapire upper surface of described tank body 1, described tank body 1 is provided with the actuator 13 being connected with described driving motor 9, adjusts
Joint device is to have used structure on market, it is only necessary to connects according to its connection request and uses.Driven by control in use
Motor, makes driving driven by motor ring rotation block rotate, so that scraping muscle diapire at tank body under the drive of ring rotation block
End face scrapes, such that it is able to pine scraped by the medicinal residues that oar accumulates in tank body diapire end face, thus can prevent caking.
Roof and diapire at described annular groove 7 is uniformly provided with ball 14, the upper surface of described ring rotation block 8 and under
End face is pressed on described ball 14.Be provided with ball, it is ensured that the normal rotation of ring rotation block, reduce ring rotation block with
Friction between annular groove, thus improve service life and stability in use.
Being provided with sealing metal bar 15 on the described ring rotation block 8 joint face with described annular groove 7, described ball sets
Put the medial extremity at described sealing metal bar Yu annular groove.
Described discharge nozzle is additionally provided with cooler 16, in described tank body, is provided with moisture determination instrument 17.
See Fig. 2: the preparation method of described blood-activating pain stopping tablet, above-mentioned dry use device, including casing 1, be arranged on described
Material frame 2 in casing 1 and the blast pipe 3 and the discharge pipe 4 that are arranged on described casing 1 top, set in the sidewall of described casing 1
There is the air intake passage 5 being connected with described blast pipe 3, the sidewall of described casing 1 is provided with and is connected with described air intake passage 5
Air holes 6, fresh air inlet is arranged on sidewall, it is ensured that the uniformity of ventilation, and can be greatly improved and the contacting of medicine
Area, described discharge pipe 4 is through outside, in the sidewall of described casing 1 with casing 1 in the roof connection casing 1 of described casing 1
Being additionally provided with homoiothermic chamber 7 and sterilization chamber 8, be provided with electrical heating block 9 in described homoiothermic chamber 7, being provided with electrical heating block can be as required
Being adjusted the temperature of blast pipe, it is ensured that the stability of baking temperature, described air intake passage 5 is through described regulation chamber 7 and goes out
Bacterium chamber 8 is arranged, and is provided with rotating drum 10 in the diapire of described casing 1, is provided with electric rotating machine 11 in described rotating drum 10, described
The main shaft of electric rotating machine 11 is connected with described material frame 2, is provided with vibrations groove 12, at described material in described material frame 2
The end face of frame 2 is provided with and holds plate 13, is provided with shaking device 14 described holding between plate 13 and described vibrations groove 12.
Described shaking device 14 includes driving motor 141, is arranged on the eccentric 142 on described driving motor 141 main shaft,
The wheel limit of described eccentric 142 holds the bottom center of plate 13 described in being pressed on, in the described bottom holding plate 13 and described shake
Being provided with extension spring 15 between the diapire of dynamic groove 12, described extension spring is symmetrical arranged centered by described eccentric, passes through in use
Compressing of eccentric makes to hold plate rising, when the recess of eccentric compresses and holds plate, holds plate and resets under the effect of extension spring,
Make the disengaging of thing material fall again after holding plate in dropping process and hold the vibrations realizing material on plate.
In described casing 1, it is provided with temperature sensor 16, is provided with in the sidewall of described casing and described temperature sensor
The driver 17 being connected, described driver is connected with the control end of described electrical heating block.Temperature passes dry device and driver is
Existing prior art on market, it has only to when using and connecting connect according to corresponding connection description.
Described casing is additionally provided with chamber door 18.
Embodiment 2
Take Radix Angelicae Sinensis 22g, Radix Notoginseng 44g, Olibanum (processed with vinegar) 44g, Borneolum Syntheticum 11g, Eupolyphaga Seu Steleophaga 111g, Pyritum (calcined) 67g, add medical material 10 times
The water of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid is filtered
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses microwave extraction
Take, obtain extract, continue to concentrate, concentrated solution is dried, pelletize, tabletting, obtain blood-activating pain stopping tablet.
The preparation method of described blood-activating pain stopping tablet, described microwave assisted extraction methods is: put into by the concentrated solution after water extract-alcohol precipitation
Microwave extracting apparatus carries out microwave extracting, extracts power 600W, extract 2 times, each 4 minutes, 70% ethanol of addition every time
Amount is concentrated solution weight 2 times, obtain extract, concentrate.
Concentrate with drying device ibid.
Embodiment 3
Take Radix Angelicae Sinensis 22g, Radix Notoginseng 44g, Olibanum (processed with vinegar) 44g, Borneolum Syntheticum 11g, Eupolyphaga Seu Steleophaga 111g, Pyritum (calcined) 67g, add medical material 10 times
The water of weight, soaks 0.5h, decocts 1 hour, filters, and medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid is filtered
Going out, merge twice decoction liquor, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%,
Stirring, stands, and filters, and when filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses microwave extraction
Take, obtain extract, continue to concentrate, concentrated solution is dried, pelletize, tabletting, obtain blood-activating pain stopping tablet.
The preparation method of described blood-activating pain stopping tablet, described microwave assisted extraction methods is: put into by the concentrated solution after water extract-alcohol precipitation
Microwave extracting apparatus carries out microwave extracting, extracts power 500W, extract 2 times, each 6 minutes, 70% ethanol of addition every time
Amount is concentrated solution weight 2 times, obtain extract, concentrate.
Concentrate with drying device ibid.
In above-described embodiment, raw material all meets standards of pharmacopoeia.
Embodiment 4: ferulaic acid content determination experiment research data in blood-activating pain stopping tablet of the present invention
1.1 Experimental agents: blood-activating pain stopping tablet of the present invention: prepare by embodiment 1-3 method.Matched group uses the commonly side of concentration
Method prepares blood-activating pain stopping tablet extract.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；
Waters2487 UV-detector and GJ605 type high pressure six-way injection valve；Chromatographic column is ODS-C18 (diamond) chromatographic column (250mm
×4.6mm,5μm)；Data acquisition and process use HS Data Processing in Chromatography Workstation V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (Chinese Pharmacopoeia two annex V D of version in 2000).Use
ODS-C18 (diamond) chromatographic column (250mm × 4.6mm, 5 μm), flowing is acetonitrile-1% glacial acetic acid (20:80) mutually, and flow velocity is
1.0mL/min, detection wavelength is 322nm, and sample size is 10 μ L.
1.4 experimental result
Ferulaic acid content measurement result in blood-activating pain stopping tablet prepared by each embodiment
| Sample source | Ferulaic acid content (%) |
| Embodiment 1 | 3.15 |
| Embodiment 2 | 3.46 |
| Embodiment 3 | 2.87 |
| Matched group | 0.59 |
According to the result of the test of upper table, in blood-activating pain stopping tablet prepared by embodiment of the present invention 1-3, ferulaic acid content is bright
Aobvious higher than matched group.
Embodiment 5: the experiment of blood-activating pain stopping tablet of the present invention suppression Clonal Rat Pheochromocytoma tumor PC-12 cell proliferation is ground
Study carefully data
1 experiment material
1.1 experiment cell strains
Clonal Rat Pheochromocytoma tumor PC-12 cell, Nanjing Medical University's laboratory cell storehouse, DMEM+10%FBS is normal
Rule are cultivated.
1.2 Experimental agents
Drugs: blood-activating pain stopping tablet of the present invention: prepare by embodiment 1 method.
Medicinal liquid liquid storage: weigh 100mg blood-activating pain stopping tablet, is dissolved in 5ml dehydrated alcohol, and 0.2 μm filter filters, 500 μ
Ldoff pipe subpackage ,-20 DEG C of storages, 0.2 μm filter filters dehydrated alcohol in case matched group is used simultaneously.
1.3 experiment reagent
DMEM (GIBCO company Cat.No.12100-061 Lot.No.758137)；Hyclone (Hangzhoupro, sky, Zhejiang biology section
Skill company limited Lot.No.100419)；NaHCO3 (the long hundred million chemical reagent company limited Cat.No.11810-033 in Shanghai
Lot.No.1088387)；Trypsin (AMRESCO company lot number: 2010/04)；EDTA (AMRESCO company lot number: 2009/
10)；Penicillin G Sodium Salt (AMRESCO company lot number: 2010242)；Streptomycin Sulfate
(AMRESCO company lot number: 2010382)；Dehydrated alcohol (Nanjing Chemistry Reagent Co., Ltd.'s lot number: 080310182)；MTT
(Biosharp lot number: 0793)；PBS (laboratory autogamy)；
1.4 experiment equipment
Lycra inverted microscope (Germany Leica model: DM1L)；Visible-ultraviolet light microwell plate detector (MD company of the U.S.
Model: SPECTRA MAX 190)；CO2 incubator (FORMA model: 3111)；Super-clean bench (safe and sound company of Su Jing group manufacture type
Number: SW-CJ-ZFD)；Pure water instrument (Spring company of U.S. model: S/N 020579)；Accurate pipettor (Gilson Inc of France
Model: P2)；Electronic balance (Sai Duolisi company limited of Germany model: BT323S)；Full-automatic high-pressure autoclave (Japan SANYO
Company's model: MLS-3020)；Table electrothermal air dry oven (Shanghai precision experimental facilities company model: DHG9123A)；Refrigerator
(Siemens Company's model: KG18V21TI)；Liquid nitrogen container (CBS model: 2001)；Low speed centrifuge (Anting Scientific Instrument Factory, Shanghai
Model: KA-1000)；0.2 μm filter (MILLIPORE model: SLGP033RB)；10cm culture dish (NEST company), 96 hole trainings
Support plate (NEST company)；Cell counting count board；Centrifuge tube, pipet, Tips are some.
2 experimental techniques
1) Clonal Rat Pheochromocytoma tumor PC-12 cell DMEM+10%FBS in 37 DEG C, 5%CO2 carry out conventional training
Supporting (10cm culture dish), when cell grows to logarithmic (log) phase, collect cell, discard culture fluid, PBS rinses 3 times, adds 3ml
0.25% trypsin-0.04%EDTA, after 37 DEG C of digestion 2min, is added thereto in 5ml complete medium and reacts, piping and druming
Being proceeded to after cell in centrifuge tube, 1000rpm is centrifuged 5min, adjusts 3 × 104/ml of concentration of cell suspension.
2) entering in 96 well culture plates by cell kind, every hole adds cell suspension 180 μ l, and culture plate is put in cell culture incubator
(37 DEG C, 5%CO2) cellar culture.
3) according to cell growth status, general long to 50%-70%, add blood-activating pain stopping tablet solution, continue to cultivate 24h.
4) add 20 μ l MTT solution (5mg/ml, i.e. 0.5%MTT) after 24h, continue to cultivate 4h.
5) after 4h, buckle method removes supernatant, pats dry gently with absorbent paper, and every hole adds 200 μ l dimethyl sulfoxide, puts shaking table
Upper low-speed oscillation 10min, makes crystal fully dissolve.The light absorption value in each hole is measured at enzyme-linked immunosorbent assay instrument 490nm.
6) arranging background (being not added with cell, only add culture fluid), (cell, the medicine dissolution of same concentrations are situated between control wells simultaneously
Matter, culture fluid, MTT, dimethyl sulfoxide), often group sets 6 multiple holes.
7) suppression ratio of cell is represented by result with medicine:
Cell proliferation suppression ratio (%)=(control wells OD value-dosing holes OD value)/control wells OD value × 100%.Experiment weight
Multiple 3 times.
3 statistical dispositions
Use the correlation analysis in Microsoft Excel 2003 software and Student t inspection, data with mean ±
S.D. represent.
4 experimental results
Statistical result showed after mtt assay experiment, compares with matched group, when dosage reaches 5mg/ml, to adult rat adrenal tissue
Pheochromocytoma PC-12 cell inhibitory effect variant (P < 0.05), dosage this difference when 10mg/ml have significance (P <
0.01) pole significant difference (P < 0.001), is had when dosage reaches 15-20mg/ml.
Blood-activating pain stopping tablet is to Clonal Rat Pheochromocytoma tumor PC-12 cell inhibitory effect influence research
Note: compare with matched group, * P < 0.01；**P<0.001
5 experiment conclusion
Blood-activating pain stopping tablet can suppress Clonal Rat Pheochromocytoma tumor PC-12 cell proliferation, reduce adult rat adrenal tissue addicted to
The cell growing number of chromium glucagonoma PC-12 cell, this effect is dose dependent.
Claims (10)
1. a blood-activating pain stopping tablet, it is characterised in that preparation method is: take Radix Angelicae Sinensis 22g, Radix Notoginseng 44g, Olibanum (processed with vinegar) 44g, Borneolum Syntheticum
11g, Eupolyphaga Seu Steleophaga 111g, Pyritum (calcined) 67g, add the water of 10 times of weight of medical material, soaks 0.5h, decocts 1 hour, filters, and medicinal residues are again
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C of relative densities and is
1.05, add ethanol and make the percent by volume of alcohol content reach 75%, stir, stand, filter, relative density when filtrate is concentrated into 65 DEG C
It is 1.25, and reclaims ethanol, obtain concentrated solution, use microwave extracting, obtain extract, continue to concentrate, concentrated solution is dried, system
Grain, tabletting, obtain blood-activating pain stopping tablet.
Blood-activating pain stopping tablet the most according to claim 1, it is characterised in that described in above-mentioned preparation method, microwave assisted extraction methods is:
Concentrated solution after water extract-alcohol precipitation is put in microwave extracting apparatus and carries out microwave extracting, extract power 400-600W, extract 2 times,
4-8 minute every time, amount is concentrated solution weight 2 times of 70% ethanol every time added, obtain extract, concentrate, optimum condition is:
Microwave extracting power 500W, every time extraction 6 minutes.
Blood-activating pain stopping tablet the most according to claim 1, it is characterised in that concentrate for three times in above-mentioned preparation method and use device, bag
Include tank body, the charging aperture being arranged on described tank body and the discharge nozzle being arranged on described tank base, it is provided with in described tank body
Shaft, is provided with stirring paddle on described shaft, is provided with the stirring being connected with described shaft at the top of described tank body
Motor, is provided with annular groove on the inwall of described tank body, and the bottom of described annular groove is near the diapire of described tank body, in institute
It is provided with ring rotation block in stating annular groove, in the sidewall of described tank body, is provided with driving motor, the master of described driving motor
Axle is provided with driving fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc on the outer ring surface of described ring rotation block,
Be uniformly provided with at least three on the inner ring surface of described ring rotation block and scrape muscle, described in scrape the diapire of muscle and be pressed on the end of described tank body
On wall upper surface, described tank body is provided with the actuator being connected with described driving motor.
Blood-activating pain stopping tablet the most according to claim 3, it is characterised in that in above-mentioned preparation method, described in enrichment facility, annular is recessed
The roof of groove and diapire are uniformly provided with ball, and upper surface and the lower surface of described ring rotation block are pressed on described ball.
Blood-activating pain stopping tablet the most according to claim 3, it is characterised in that annular rotation described in enrichment facility in above-mentioned preparation method
Switch block is provided with sealing metal bar with the joint face of described annular groove, and described ball is arranged on described sealing metal bar and annular
The medial extremity of groove.
Blood-activating pain stopping tablet the most according to claim 3, it is characterised in that discharge nozzle described in enrichment facility in above-mentioned preparation method
On be additionally provided with cooler, in described tank body, be provided with moisture determination instrument.
Blood-activating pain stopping tablet the most according to claim 1, it is characterised in that be dried in above-mentioned preparation method and use device, including case
Body, the material frame being arranged in described casing and the blast pipe and the discharge pipe that are arranged on described casing top, it is characterised in that:
It is provided with the air intake passage being connected with described blast pipe in the sidewall of described casing, the sidewall of described casing is provided with described
The air holes that air intake passage is connected, described discharge pipe through described casing roof connection casing in casing outside, described
Being additionally provided with homoiothermic chamber and sterilization chamber in the sidewall of casing, be provided with electrical heating block at described homoiothermic intracavity, described air intake passage passes
Described regulation chamber and sterilization chamber are arranged, and be provided with rotating drum, be provided with electric rotating in described rotating drum in the diapire of described casing
Machine, the main shaft of described electric rotating machine is connected with described material frame, is provided with vibrations groove in described material frame, at described material
The end face of frame is provided with and holds plate, is provided with shaking device described holding between plate and described vibrations groove.
Blood-activating pain stopping tablet the most according to claim 1, it is characterised in that be dried in above-mentioned preparation method to use and shake described in device
Dynamic device includes driving motor, is arranged on the eccentric on described driving electric machine main shaft, and the wheel limit of described eccentric is pressed on institute
State the bottom center holding plate, between the diapire of the described bottom holding plate and described vibrations groove, be provided with extension spring, described in draw
Spring is symmetrical arranged centered by described eccentric.
Blood-activating pain stopping tablet the most according to claim 1, it is characterised in that be dried in above-mentioned preparation method and use case described in device
Internal it is provided with temperature sensor, in the sidewall of described casing, is provided with the driver being connected with described temperature sensor, described
Driver is connected with the control end of described electrical heating block, is additionally provided with chamber door on described casing.
The most according to claim 1, blood-activating pain stopping tablet is at preparation suppression Clonal Rat Pheochromocytoma tumor PC-12 cell proliferation
Application in medicine.
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