CN105924453A - Artemisinin extraction method and artemisinin extract - Google Patents
Artemisinin extraction method and artemisinin extract Download PDFInfo
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- CN105924453A CN105924453A CN201610422871.1A CN201610422871A CN105924453A CN 105924453 A CN105924453 A CN 105924453A CN 201610422871 A CN201610422871 A CN 201610422871A CN 105924453 A CN105924453 A CN 105924453A
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- arteannuin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
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Abstract
The invention provides an artemisinin extraction method. The artemisinin extraction method includes taking artemisia apiacea, adding water of weight that is 10 times larger than Artemisia apiacea, soaking for 0.5 h, decocting for 1 h, filtering, adding decoction dregs into water of weight that is 8 times larger than the artemisia apiacea, decocting for 1 h, and filtering soup. With the special concentration and drying device, and high content of artemisinin extract is obtained.
Description
Technical field
The present invention relates to technical field of extraction of Chinese traditional medicine, be specifically related to extracting method and the arteannuin extract of a kind of arteannuin.
Background technology
Arteannuin, arteannuin molecular formula is C15H22O5, molecular weight 282.33, extracts arteannuin at present from Herba Artemisiae Annuae
Method be based on extracting principle, mainly have ether extraction and industrial naptha extraction.Volatile oil mainly uses water
Steam distillation extracts, and reduce pressure separated, and its technique is: feed intake-add water-distill-cool down-oil-water separation-quintessence oil；Non-wave
The property sent out composition mainly uses organic solvent extraction, column chromatography and recrystallization to separate, and basic technology is: be dried-broken-soak,
Extraction (being repeated)-concentrated extracting solution-crude product-refined.Extracting method of the prior art, technique is coarse, backward,
Impurity is many, and active constituent content is low, causes patient's consumption excessive, it has not been convenient to take, has had a strong impact on this product clinically
Application.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide the extracting method of a kind of arteannuin.
Technical scheme: it is an object of the invention to by following scheme realization:
The extracting method of a kind of arteannuin, takes Herba Artemisiae Annuae, adds the water of 10 times of weight of Artemisia annua, soaks 0.5h, decocts 1
Hour, filtering, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice decoction liquor,
Being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, stand, filter,
When filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, receives
Collection eluent, continues to concentrate, is dried by concentrated solution, obtains arteannuin extract.
The extracting method of described arteannuin, described macroporous resin process for purification is: be added on macroporous adsorptive resins, 50%
Ethanol elution, collects 5 times amount column volume eluents, decompression recycling ethanol, is concentrated and dried.
The extracting method of described arteannuin, described macroporous adsorptive resins model is D101, D201, D301.
The extracting method of described arteannuin, concentrates for above-mentioned three times and uses device, including tank body, be arranged on described tank body
Charging aperture and be arranged on the discharge nozzle of described tank base, in described tank body, be provided with shaft, on described shaft
It is provided with stirring paddle, is provided with the stirring motor being connected with described shaft at the top of described tank body, in described tank body
Wall is provided with annular groove, and the bottom of described annular groove, near the diapire of described tank body, is provided with in described annular groove
Ring rotation block, is provided with driving motor in the sidewall of described tank body, is provided with driving tooth on the main shaft of described driving motor
Dish, is provided with the teeth groove mutually ratcheting with described driving fluted disc, in described ring rotation on the outer ring surface of described ring rotation block
Be uniformly provided with at least three on the inner ring surface of block and scrape muscle, described in scrape the diapire of muscle and be pressed on the diapire upper surface of described tank body
On, described tank body is provided with the actuator being connected with described driving motor.
The extracting method of described arteannuin, the roof of annular groove described in above-mentioned enrichment facility and diapire be uniformly provided with ball,
Upper surface and the lower surface of described ring rotation block are pressed on described ball.
The extracting method of described arteannuin, the joint face of ring rotation block described in above-mentioned enrichment facility and described annular groove
Being provided with sealing metal bar, described ball is arranged on the medial extremity of described sealing metal bar and annular groove.
The extracting method of described arteannuin, discharge nozzle described in above-mentioned enrichment facility is additionally provided with cooler, at described tank body
Inside it is provided with moisture determination instrument.
The extracting method of described arteannuin, above-mentioned dry use device, including body, in being arranged in described body
Axle, the rotation being arranged on described axis outer wall holds dish, is provided with vibration motor in the lower end of described axis, at described machine
The top of body is provided with vapours conveyance conduit, it is characterised in that: in described axis, it is provided with cavity, on the top of described axis
Portion is provided with disk, and described disk is arranged on described rotation and holds the top of dish, is provided with the most penetrating thin on described disk
Hole, is provided with the heat conduction mast being connected with described cavity in described disk, is provided with electrical heating block, institute in described cavity
Stating heat conduction mast and be provided with heat conduction thorn post, described heat conduction thorn post stretches in described pore, is provided with temperature and passes in described body
Sensor, in described cavity, it is provided with the driver being connected with described temperature sensor, described driver and described electrical heating
The control switch of block is connected.
The extracting method of described arteannuin, pore described in above-mentioned dry use device is the horn-like hole that big bottom, top is little,
Described heat conduction thorn post stretches into the middle part in described horn-like hole, is provided with the most penetrating conduction mesh on described horn-like hole.
The extracting method of described arteannuin, the bottom surface of body described in above-mentioned dry use device is provided with chamber door, described chamber door
Being arranged on to rotate and hold the lowermost end of dish, described heat conduction mast be silver-colored or aluminum or copper mast.
In prior art, arteannuin uses the method for alcohol extraction, and technique is coarse, backward, and impurity is many, causes patient's consumption
Excessive, it has not been convenient to take, arteannuin yield prepared by the present invention increases, and content is high, and purity reaches 98-99%.The present invention
In concentrator simple in construction, simple operation, heating concentrate time, can by drive motor drive ring rotation block
Rotate, scrape in the bottom surface of tank body so that scraping muscle, thus can effectively prevent the diapire of tank body from luming, to a certain extent
Heating thickening efficiency can be improved, solve the tank bottoms easy caking of conventional art Chinese medicinal concentration equipment thus affect the efficiency of heating surface
Technical deficiency, stability in use is good, and the stable effective ingredients of medicine is not destroyed.This drying equipment structure is simple, operation
Convenient, it is provided with disk at the top of axis, and on disk, is provided with pore, vapours can be made to pass through disk, and
In axis, it is provided with electrical heating block and heat conduction mast, electrical heating block can be started as required, and realized by heat conduction mast
Temperature transfer, and mix with by the vapours of disk, thereby may be ensured that the temperature of vapours, regulation performance is good,
Stability in use is strong, efficiently solves in conventional art the uncontrollable technical deficiency of temperature in vapours heating drier.
Accompanying drawing explanation
In order to make present disclosure be more likely to be clearly understood, below according to specific embodiment and combine accompanying drawing, to this
Invention is described in further detail, wherein:
Fig. 1 is the structural representation of enrichment facility of the present invention.
Fig. 2 is the structural representation of drying device of the present invention.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
It is interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention
Belong to the scope of the present invention.
Embodiment 1
Take Herba Artemisiae Annuae 1000g, add the water of 10 times of weight of Artemisia annua, soak 0.5h, decoct 1 hour, filter, medicinal residues
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C relatively
Density is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, and stirring, standing, filtration, filtrate is concentrated into
When 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, collects eluent, continue
Continuous concentration, is dried concentrated solution, obtains arteannuin extract.
The extracting method of described arteannuin, described macroporous resin process for purification is: be added on macroporous adsorptive resins, 50%
Ethanol elution, collects 5 times amount column volume eluents, decompression recycling ethanol, is concentrated and dried.
The extracting method of described arteannuin, described macroporous adsorptive resins model is D101.
See Fig. 1: the extracting method of described arteannuin, above-mentioned No. three enrichment facilities, including tank body 1, be arranged on described tank
Charging aperture on body 12 and be arranged on the discharge nozzle 3 bottom described tank body 1, is provided with shaft 4 in described tank body 1,
Described shaft 4 is provided with stirring paddle 5, is provided with and stirring that described shaft 4 is connected at the top of described tank body 1
Mixing motor 6, be provided with annular groove 7 on the inwall of described tank body 1, the bottom of described annular groove 7 is near described tank
The diapire of body 1, is provided with ring rotation block 8 in described annular groove 7, is provided with driving in the sidewall of described tank body 1
Motor 9, is provided with driving fluted disc 10, on the main shaft of described driving motor 9 on the outer ring surface of described ring rotation block 8
Be provided with the teeth groove 11 mutually ratcheting with described driving fluted disc 10, the inner ring surface of described ring rotation block 8 is uniformly provided with to
Scrape muscle 12 for few three, described in scrape the diapire of muscle 12 and be pressed on the diapire upper surface of described tank body 1, at described tank body 1
Being provided with the actuator 13 being connected with described driving motor 9, actuator is to have used structure on market, it is only necessary to according to
The connection of its connection request uses.In use by controlling driving motor, driving driven by motor ring rotation block is made to revolve
Turning, scraping, such that it is able to oar accumulates in tank body so that scraping the muscle diapire end face at tank body under the drive of ring rotation block
Pine scraped by the medicinal residues of diapire end face, thus can prevent caking.
Roof and diapire at described annular groove 7 is uniformly provided with ball 14, the upper surface of described ring rotation block 8 and
Lower surface is pressed on described ball 14.It is provided with ball, it is ensured that the normal rotation of ring rotation block, reduces annular
Friction between spill spin block and annular groove, thus improve service life and stability in use.
The described ring rotation block 8 joint face with described annular groove 7 is provided with sealing metal bar 15, described ball
It is arranged on the medial extremity of described sealing metal bar and annular groove.
Described discharge nozzle is additionally provided with cooler 16, in described tank body, is provided with moisture determination instrument 17.
See Fig. 2, the extracting method of described arteannuin, above-mentioned dry use device, including body 1, be arranged on described machine
Axis 2 in body 1, the rotation being arranged on described axis 2 outer wall holds dish 3, is provided with in the lower end of described axis 2
Vibration motor 4, is provided with vapours conveyance conduit 5 at the top of described body 1, is provided with cavity 6 in described axis 2,
Be provided with disk 7 at the top of described axis 2, described disk 7 is arranged on described rotation and holds the top of dish 3, described
Disk 7 is provided with the most penetrating pore 8, and vapours, through disk, enters rotation and holds dish, in described disk 7
It is provided with the heat conduction mast 9 being connected with described cavity 6, in described cavity 6, is provided with electrical heating block 10, described heating column
Bar 9 be provided with heat conduction thorn post 11, described heat conduction thorn post 11 stretch in described pore 8, can be greatly improved vapours with
Temperature mixing between electrical heating block, improves temperature controlled efficiency, be provided with in described body 1 temperature sensor 12,
The driver 13 being connected with described temperature sensor 12, described driver 13 and described electricity it is provided with in described cavity 6
The control switch of heat block 10 is connected.In the present embodiment, temperature sensor and driver are the most already present product,
It has only to be attached according to the corresponding description of product in use.
Described pore is the horn-like hole that big bottom, top is little, and described heat conduction thorn post stretches into the middle part in described horn-like hole,
Described horn-like hole is provided with the most penetrating conduction mesh 14.
Be provided with chamber door 15 in the bottom surface of described body, described chamber door is arranged on and rotates the lowermost end holding dish.
Described heat conduction mast is silver or aluminum or copper mast.
Embodiment 2
Take Herba Artemisiae Annuae 1000g, add the water of 10 times of weight of Artemisia annua, soak 0.5h, decoct 1 hour, filter, medicinal residues
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C relatively
Density is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, and stirring, standing, filtration, filtrate is concentrated into
When 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, collects eluent, continue
Continuous concentration, is dried concentrated solution, obtains arteannuin extract.
The extracting method of described arteannuin, described macroporous resin process for purification is: be added on macroporous adsorptive resins, 50%
Ethanol elution, collects 5 times amount column volume eluents, decompression recycling ethanol, is concentrated and dried.
The extracting method of described arteannuin, described macroporous adsorptive resins model is D201.
Concentrate with drying device ibid.
Embodiment 3
Take Herba Artemisiae Annuae 1000g, add the water of 10 times of weight of Artemisia annua, soak 0.5h, decoct 1 hour, filter, medicinal residues
Adding the water of 8 times of weight of medical material, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, is concentrated into 60 DEG C relatively
Density is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, and stirring, standing, filtration, filtrate is concentrated into
When 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, collects eluent, continue
Continuous concentration, is dried concentrated solution, obtains arteannuin extract.
The extracting method of described arteannuin, described macroporous resin process for purification is: be added on macroporous adsorptive resins, 50%
Ethanol elution, collects 5 times amount column volume eluents, decompression recycling ethanol, is concentrated and dried.
The extracting method of described arteannuin, described macroporous adsorptive resins model is D301.
Concentrate with drying device ibid.
In above-described embodiment, Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae Annuae Artemisia annua L..
Embodiment 4: artemislnin content determination experiment research data in arteannuin extract of the present invention
1.1 Experimental agents: arteannuin extract of the present invention: prepare by embodiment 1-3 method.Matched group uses the commonly side of concentration
Method prepares arteannuin extract.
1.2 instruments: high performance liquid chromatograph system includes high performance liquid chromatograph (Waters 515)；P200 high-pressure pump；Waters
2487 UV-detector and GJ605 type high pressure six-way injection valve；Data acquisition and process use HS Data Processing in Chromatography Workstation
V4.0+ (Hangzhou English spectrum science and technology)
1.3 condition determinations: measure according to high performance liquid chromatography (Chinese Pharmacopoeia two annex V D of version in 2000).With
SymmetryC18 chromatographic column (4.6mm × 250mm, 5 μm) is detached dowel, and acetonitrile water (45: 55) is flowing phase, stream
Speed 1.0mL/min, ultraviolet spectrometry detection wavelength 205nm.
1.4 experimental result
Artemislnin content measurement result in arteannuin extract prepared by each embodiment of table 1
| Sample source | Artemislnin content (%) |
| Embodiment 1 | 98 |
| Embodiment 2 | 97 |
| Embodiment 3 | 99 |
| Matched group | 65 |
According to the result of the test of table 1, in arteannuin extract prepared by embodiment of the present invention 1-3, artemislnin content is bright
Aobvious higher than matched group.
Claims (10)
1. the extracting method of an arteannuin, it is characterised in that take Herba Artemisiae Annuae, adds the water of 10 times of weight of Artemisia annua, soaks 0.5h,
Decocting 1 hour, filter, medicinal residues add the water of 8 times of weight of medical material, decoct 1 hour, and medicinal liquid leaches, and merges twice decoction
Liquid, being concentrated into 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, stand, filter,
When filtrate is concentrated into 65 DEG C, relative density is 1.25, and reclaims ethanol, obtains concentrated solution, uses macroporous resin to refine, collects eluting
Liquid, continues to concentrate, is dried by concentrated solution, obtains arteannuin extract.
The extracting method of arteannuin the most according to claim 1, it is characterised in that described macroporous resin process for purification is: be added to
On macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, be concentrated and dried.
The extracting method of arteannuin the most according to claim 2, it is characterised in that described macroporous adsorptive resins model be D101,
D201、D301。
The extracting method of arteannuin the most according to claim 1, it is characterised in that concentrate for above-mentioned three times and use device, including tank
Body, the charging aperture being arranged on described tank body and the discharge nozzle being arranged on described tank base, be provided with shaft in described tank body,
Described shaft is provided with stirring paddle, is provided with the stirring motor being connected with described shaft at the top of described tank body, in institute
The inwall stating tank body is provided with annular groove, and the bottom of described annular groove is near the diapire of described tank body, at described annular groove
Inside it is provided with ring rotation block, in the sidewall of described tank body, is provided with driving motor, the main shaft of described driving motor is provided with driving
Fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc, at described ring rotation block on the outer ring surface of described ring rotation block
Inner ring surface on be uniformly provided with at least three and scrape muscle, described in scrape the diapire of muscle and be pressed on the diapire upper surface of described tank body, in institute
State tank body and be provided with the actuator being connected with described driving motor.
The extracting method of arteannuin the most according to claim 4, it is characterised in that annular groove described in above-mentioned enrichment facility
Roof and diapire are uniformly provided with ball, and upper surface and the lower surface of described ring rotation block are pressed on described ball.
The extracting method of arteannuin the most according to claim 4, it is characterised in that ring rotation block described in above-mentioned enrichment facility
Being provided with sealing metal bar with the joint face of described annular groove, described ball is arranged on described sealing metal bar and annular groove
Medial extremity.
The extracting method of arteannuin the most according to claim 4, it is characterised in that on discharge nozzle described in above-mentioned enrichment facility also
It is provided with cooler, in described tank body, is provided with moisture determination instrument.
The extracting method of arteannuin the most according to claim 1, it is characterised in that above-mentioned dry use device, including body,
Being arranged on the axis in described body, the rotation being arranged on described axis outer wall holds dish, is provided with shake in the lower end of described axis
Galvanic electricity machine, is provided with vapours conveyance conduit at the top of described body, it is characterised in that: in described axis, it is provided with cavity,
The top of described axis is provided with disk, and described disk is arranged on described rotation and holds the top of dish, is provided with up and down on described disk
Penetrating pore, is provided with the heat conduction mast being connected with described cavity in described disk, is provided with electrical heating block in described cavity,
Described heat conduction mast is provided with heat conduction thorn post, and described heat conduction thorn post stretches in described pore, is provided with temperature sensing in described body
Device, in described cavity, it is provided with the driver being connected with described temperature sensor, the control of described driver and described electrical heating block
Switch processed is connected.
The extracting method of arteannuin the most according to claim 8, it is characterised in that pore described in above-mentioned dry use device is
The horn-like hole that big bottom, top is little, described heat conduction thorn post stretches into the middle part in described horn-like hole, is provided with on described horn-like hole
The most penetrating conduction mesh.
The extracting method of arteannuin the most according to claim 8, it is characterised in that body described in above-mentioned dry use device
Bottom surface be provided with chamber door, described chamber door is arranged on to rotate and holds the lowermost end of dish, and described heat conduction mast be silver-colored or aluminum or copper mast.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610422871.1A CN105924453A (en) | 2016-06-14 | 2016-06-14 | Artemisinin extraction method and artemisinin extract |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610422871.1A CN105924453A (en) | 2016-06-14 | 2016-06-14 | Artemisinin extraction method and artemisinin extract |
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| CN112062776A (en) * | 2020-08-11 | 2020-12-11 | 苏州满元生物科技有限公司 | Effective part of sweet wormwood sesquiterpenoids and extraction and purification process thereof |
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Application publication date: 20160907 |