CN106176530A - A kind of biological skin-protecting face nursing product and preparation method thereof - Google Patents
A kind of biological skin-protecting face nursing product and preparation method thereof Download PDFInfo
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- CN106176530A CN106176530A CN201610675624.2A CN201610675624A CN106176530A CN 106176530 A CN106176530 A CN 106176530A CN 201610675624 A CN201610675624 A CN 201610675624A CN 106176530 A CN106176530 A CN 106176530A
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- stem cell
- human
- nursing product
- face nursing
- protecting face
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
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Abstract
The present invention relates to a kind of biological skin-protecting face nursing product, containing activity in human stem cell composition and Human-like Collagen, described activity in human stem cell component content is 0.001 49%, and described Human-like Collagen content is 0.001 49%；The invention also discloses the preparation method of above-mentioned biological skin-protecting face nursing product.Creating synergism in the product of the present invention between Human-like Collagen and activity in human stem cell composition, Human-like Collagen, as the existence environment of somatomedin, effectively extends the activity of cell growth factor；Activity in human stem cell composition constantly acts on Skin Cell simultaneously, promotes the more collagen protein of fibroblasts to secrete, and both complement each other, and reaches the effect of optimum skin Caring skin protection.
Description
Technical field
The invention belongs to beauty and skin care technical field, be specifically related to a kind of biological skin-protecting face nursing product and preparation method thereof.
Background technology
Skin is subdivided into the shallow relatively thin epidermis of table, the corium containing more multifilament and subcutaneous tissue.Epidermis is by being covered in embryo
The ectoderm on tire surface differentiates, and is made up of multilamellar squamous epithelial cancer, from the eyelid skin that thick scalp to whole body is the thinnest, its
Thickness is each different.Epidermis can be subdivided into again epithelial cells, dentritic cell and Michael cell；Corium is mainly by middle embryo
Layer is grown, and is positioned under epidermis, separates by one layer of basement membrane zone between epidermis.Corium is mainly made up of connective tissue,
Also include blood vessel, nerve, muscle, lymph, sweat gland and sebaceous gland, shallow at the relatively thin papillary layer that is referred to as, and deep layer is thicker
Then it is referred to as lamina reticularis.The main component of corium is collagen, and collagen fiber are little and irregular arrangement at papillary layer content, but
Internet is then parallel to surface alignment in pencil；Subcutaneous tissue or claim adipose membrane, is the superficial fascia of body surface, by loose connective tissue and
Fatty tissue is constituted.Corium stretches out the collagenous fiber bundle that many differs in size in subcutaneously organizing, make skin and subcutaneous tissue jail
It is solidly connected, between the two without obvious boundary.
Stem cell is the pluripotent cell that a class has the of self-replication capacity.Under certain condition, it can be divided into many
Plant functioning cell.It is divided into embryonic stem cell and adult stem cell according to the stage of development residing for stem cell.Sending out according to stem cell
Educate potential to be divided three classes: myeloid-lymphoid stem cell, pluripotent stem cell and unipotent stem cell (specially energy stem cell).Stem cell is that one is not filled
Differentiation, the most jejune cell, there is the various histoorgans of regeneration and the potential function of human body, referred to as " general-purpose is thin for medical circle
Born of the same parents ".Scientific investigations showed that have two kinds of adult stem cells to be identified and be present in human body skin, one is epidermal stem cells, and it is deposited
Being the basal layer of epidermis, its major function is that supplementary table chrotoplast maintains the balance of Skin Cell and repairs impaired group
Knit；Another kind is present in dermal papilla corium stem cell, has the ability of stronger self renewal, can induce the formation of hair follicle
And migrating into across hair follicle skin corium, they are bred and are divided into fibroblast (fibroblast energy extracellular matrix secretion
Composition), major function be allow skin be full of elasticity, subtract light wrinkle.However as the growth at age, skin renewal becomes slow
Slowly, activity and the quantity of stem cell is gradually lowered；Ultraviolet can produce toxin and active oxygen on skin, and these all can damage
Sensitive stem cell；Meanwhile, the barrier function of the sudden change infringement skin of low temperature, low humidity and environment.Above-mentioned inherence or external
Environmental factors all can affect the function of stem cell.
Existing cosmetics are stem cell stock solution than higher-end, but are all that plant stem cell stock solution belongs to the allos factor
And albumen, easy allergy.People's derived stem cell stock solution occurs recent years the most in succession, but is substantially adult fat source or god
Through stem cell stock solution, because being all adult stem cell, lack of drying, differentiation potential is not enough.And stem cell extracting solution effect is former
Reason determines its metabolism cycle acting on Skin Cell, takes effect slow.It it is exactly also the cell growth in stem cell stock solution
The half-life of the factor is comparatively short, can continue to play a role, it is necessary to have one to preserve cell growth factor and energy
The medium keeping its activity exists.Also having a kind of skin-protection product is collagen protein, but existing collagen protein major part is
Thing source property, easily infect, allergy, and the easily drawback such as degraded, collagen protein is consumptive simultaneously, for the support of skin
Effect is short-term, without lasting effect.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that the active duration of a kind of Stem Cell Activity composition
Long, be difficult to allergy, the most degradable and activity in human stem cell composition produces synergistic biological skin protection with Human-like Collagen and supports
Face product.
The present invention the technical scheme is that a kind of biological skin-protecting face nursing product for achieving the above object, dry thin containing people
Cytoactive composition and Human-like Collagen, described activity in human stem cell component content is 0.001-49%, described class people's collagen egg
Bai Hanliang is 0.001-49%；
Further, the preparation method of described activity in human stem cell composition is as follows:
(1) the primary stem cell of people is prepared；
(2) stem cell primary to people is cultivated, and within every 1-5 days, changes a cell culture fluid；
(3) when the primary stem cell growth of people to 60-80% degrees of fusion, had digestive transfer culture, pass in 1:3-1:10 ratio
Culture；
(4) low-speed centrifugal collects the cell culture fluid after passing on, and uses the mode of ultrafiltration concentration, lyophilization or extraction to obtain
To Stem Cell Activity composition；
Further, the primary stem cell of described people is cord blood stem cell, umbilical cord mesenchymal stem cells, human amnion mesenchymal
Any one or several in stem cell, mesenchymal stem cells MSCs, fat stem cell, neural stem cell, embryonic stem cell；
Further, described activity in human stem cell component content is 0.001-20%, and described Human-like Collagen content is
0.005-30%；
Further, described biological skin-protecting face nursing product contains following composition the most by mass percentage:
Activity in human stem cell component content is 0.001%-5%
Human-like Collagen content is 0.005%-10%
Glycerol three (thylhexoic acid) ester 5.0-9.0%
Isopropyl palmitate 3.5-5.5%
PEG-20 anhydrous sorbitol isostearate 4.0-6.0%
Glyceryl stearate 2.0-5.0%
Hydroxyethyl cellulose 1.0-3.0%
Hyaluronate sodium 1.0-3.0%
Carbomer 0.8-2.5%
Triethanolamine 0.5-2.0%
EDETATE SODIUM 0.3-1.5%
Glycerol 10-20%
Triethoxy octyl group silane 4.0-6.0%
Tocopherol acetas 2.0-5.0%
Methyl hydroxybenzoate 0.5-1.0%
Surplus is water；
Further, described activity in human stem cell component content be 0.003%-0.03%, Human-like Collagen content be
0.006%-0.06%；
Further, the form of affiliated biological skin-protecting face nursing product is mastic, emulsion, curry or colloid.
The invention also discloses the preparation method of above-mentioned biological skin-protecting face nursing product, specifically comprise the following steps that less than 50
At a temperature of DEG C, interpolation enters the activity in human stem cell composition obtained count by weight percentage and Human-like Collagen obtains institute
State biological skin-protecting face nursing product；
Further, specifically comprise the following steps that
(1) by the EDETATE SODIUM obtained count by weight percentage, it is added to the water stirring, is heated to 70-90 simultaneously
It is incubated 0.5-1 hour after DEG C；
(2) in the mixture that step (1) obtains, it is sequentially added into hyaluronate sodium, the card obtained count by weight percentage
Ripple nurse, glycerol three (thylhexoic acid) ester, isopropyl palmitate, PEG-20 anhydrous sorbitol isostearate, glyceryl stearate,
Hydroxyethyl cellulose also stirs to being completely dissolved；
(3) add glycerol, triethoxy octyl group silane, tocopherol acetas, methyl hydroxybenzoate when being cooled to 50-60 DEG C and stir
Mix to being completely dissolved；
(4) the activity in human stem cell composition obtained count by weight percentage and class people's glue are added when being cooled to 40-50 DEG C
Former albumen also stirs to after being completely dissolved, and adds the triethanolamine obtained count by weight percentage stirring 1-3 hour and obtains
Biological skin-protecting face nursing product；
Further, step (4) cooling temperature is 40-45 DEG C.
Activity in human stem cell composition used in the present invention, main component is the cytokine of umbilical cord MSCs paracrine, bag
Include FGF, EGF, VEGF, PDGF etc. at more than 100 kind of interior effective active composition, also include the regulation and control egg of regulating cell growth cycle
White matter, can act on Skin Cell, promotes fibroblasts to secrete more autologous collagen albumen.Class people's glue used in the present invention
Former albumen is purchased from Novus Biologicals company of the U.S..
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:
(1) selecting Human-like Collagen supplementing as stem cell stock solution, Human-like Collagen is different from common collagen
Albumen, is humanized, does not have the harm of animal derived collagen protein.Human-like Collagen is as the knot of extracellular matrix
Structure protein, as support and " spring " support skin, is filled between dermal matrix layer, so that skin is plentiful, wrinkle relaxes
Exhibition, improves skin density simultaneously, produces tension force, increases skin elasticity, uses the initial skin smooth, youth, flexible of just making.
The cytokine of stem cell extracting solution and albumen all effective ingredient lasting metabolism cycle acting on Skin Cell simultaneously, at all
The amount of the endogenous collagen protein of upper guarantee, it is ensured that the lasting effectiveness of looks improving and the skin nourishing product.So this kind of biological skin maintenance is produced
Product take effect to being eager and require that the client of persistently improvement is all suitable for；
(2) Human-like Collagen as the medium of somatomedin, can extend the active phase of cell growth factor so that it is energy
The lasting metabolism cycle acting on Skin Cell；
(3) being synergism between Human-like Collagen and stem cell stock solution, Human-like Collagen is cell growth factor
Medium, as the existence environment of somatomedin, extend the activity of cell growth factor.Cell growth factor constantly acts on simultaneously
In Skin Cell, promote the more collagen protein of fibroblasts to secrete.Both complement each other, and reach the skin Caring skin protection of optimum
Effect.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Describe wholely.Based on the embodiment in the present invention, those of ordinary skill in the art are institute under not making creative work premise
The every other embodiment obtained, broadly falls into the scope of protection of the invention.
Embodiment 1
A kind of biological skin-protecting face nursing product, comprises following component by weight:
Activity in human stem cell component content is 0.005%
Human-like Collagen content is 0.01%
Glycerol three (thylhexoic acid) ester 9.0%
Isopropyl palmitate 3.5%
PEG-20 anhydrous sorbitol isostearate 6.0%
Glyceryl stearate 2.0%
Hydroxyethyl cellulose 3.0%
Hyaluronate sodium 1.0%
Carbomer 2.5%
Triethanolamine 0.5%
EDETATE SODIUM 1.5%
Glycerol 10%
Triethoxy octyl group silane 6.0%
Tocopherol acetas 2.0%
Methyl hydroxybenzoate 0.5%
Surplus is water.
Its preparation method comprises the following steps:
(1) by the EDETATE SODIUM obtained count by weight percentage, it is added to the water stirring, after being heated to 70 DEG C simultaneously
It is incubated 1 hour；
(2) in the mixture that step (1) obtains, it is sequentially added into hyaluronate sodium, the card obtained count by weight percentage
Ripple nurse, glycerol three (thylhexoic acid) ester, isopropyl palmitate, PEG-20 anhydrous sorbitol isostearate, glyceryl stearate,
Hydroxyethyl cellulose also stirs to being completely dissolved；
(3) add glycerol, triethoxy octyl group silane, tocopherol acetas, methyl hydroxybenzoate when being cooled to 50 DEG C and stir
To being completely dissolved；
(4) the activity in human stem cell composition obtained count by weight percentage and class people's collagen egg are added when being cooled to 40 DEG C
White and stir to after being completely dissolved, triethanolamine that addition obtains count by weight percentage also stirs 3 hours and obtains biology and protect
Skin skin care product.
Embodiment 2
A kind of biological skin-protecting face nursing product, comprises following component by weight:
Activity in human stem cell component content is 0.01%
Human-like Collagen content is 0.02%
Glycerol three (thylhexoic acid) ester 5.0%
Isopropyl palmitate 5.5%
PEG-20 anhydrous sorbitol isostearate 4.0%
Glyceryl stearate 5.0%
Hydroxyethyl cellulose 1.0%
Hyaluronate sodium 3.0%
Carbomer 0.8%
Triethanolamine 1.0%
EDETATE SODIUM 1.5%
Glycerol 15%
Triethoxy octyl group silane 6.0%
Tocopherol acetas 5.0%
Methyl hydroxybenzoate 0.5%
Surplus is water.
Its preparation method comprises the following steps:
(1) by the EDETATE SODIUM obtained count by weight percentage, it is added to the water stirring, after being heated to 90 DEG C simultaneously
It is incubated 0.5 hour；
(2) in the mixture that step (1) obtains, it is sequentially added into hyaluronate sodium, the card obtained count by weight percentage
Ripple nurse, glycerol three (thylhexoic acid) ester, isopropyl palmitate, PEG-20 anhydrous sorbitol isostearate, glyceryl stearate,
Hydroxyethyl cellulose also stirs to being completely dissolved；
(3) add glycerol, triethoxy octyl group silane, tocopherol acetas, methyl hydroxybenzoate when being cooled to 60 DEG C and stir
To being completely dissolved；
(4) the activity in human stem cell composition obtained count by weight percentage and class people's collagen egg are added when being cooled to 50 DEG C
White and stir to after being completely dissolved, triethanolamine that addition obtains count by weight percentage also stirs 1 hour and obtains biology and protect
Skin skin care product.
Comparative example 1
A kind of biological skin-protecting face nursing product, comprises following component by weight:
Activity in human stem cell component content is 0.02%
Glycerol three (thylhexoic acid) ester 5.0%
Isopropyl palmitate 5.5%
PEG-20 anhydrous sorbitol isostearate 4.0%
Glyceryl stearate 5.0%
Hydroxyethyl cellulose 1.0%
Hyaluronate sodium 3.0%
Carbomer 0.8%
Triethanolamine 1.0%
EDETATE SODIUM 1.5%
Glycerol 15%
Triethoxy octyl group silane 6.0%
Tocopherol acetas 5.0%
Methyl hydroxybenzoate 0.5%
Surplus is water.
Its preparation method comprises the following steps:
(1) by the EDETATE SODIUM obtained count by weight percentage, it is added to the water stirring, after being heated to 90 DEG C simultaneously
It is incubated 0.5 hour；
(2) in the mixture that step (1) obtains, it is sequentially added into hyaluronate sodium, the card obtained count by weight percentage
Ripple nurse, glycerol three (thylhexoic acid) ester, isopropyl palmitate, PEG-20 anhydrous sorbitol isostearate, glyceryl stearate,
Hydroxyethyl cellulose also stirs to being completely dissolved；
(3) add glycerol, triethoxy octyl group silane, tocopherol acetas, methyl hydroxybenzoate when being cooled to 60 DEG C and stir
To being completely dissolved；
(4) add the activity in human stem cell composition obtained count by weight percentage when being cooled to 50 DEG C and stir to completely
After dissolving, add the triethanolamine that obtains count by weight percentage and stir 1 hour and obtain biological skin-protecting face nursing product.
The biological skin-protecting face nursing product of embodiment 1-2 contrasts with the properties of the biological skin-protecting face nursing product of comparative example 1
Test is such as following table.
Table 1 properties contrast test
Above-described embodiment simply to illustrate that the technology design of the present invention and feature, its objective is to be to allow in this area
Those of ordinary skill will appreciate that present disclosure and implements according to this, can not limit the scope of the invention with this.All
It is the change according to the equivalence done by the essence of present invention or modification, all should contain within the scope of the present invention.
Claims (10)
1. a biological skin-protecting face nursing product, it is characterised in that described biological skin-protecting face nursing product includes that activity in human stem cell becomes
Dividing and Human-like Collagen, described activity in human stem cell component content is 0.001-49%, and described Human-like Collagen content is
0.001-49%.
2. a kind of biological skin-protecting face nursing product as claimed in claim 1, it is characterised in that described activity in human stem cell composition
Preparation method is as follows:
(1) the primary stem cell of people is prepared；
(2) stem cell primary to people is cultivated, and within every 1-5 days, changes a cell culture fluid；
(3) when the primary stem cell growth of people to 60-80% degrees of fusion, had digestive transfer culture, carry out passing on training in 1:3-1:10 ratio
Support；
(4) low-speed centrifugal collects the cell culture fluid after passing on, and uses the mode of ultrafiltration concentration, lyophilization or extraction to obtain people
Stem Cell Activity composition.
3. a kind of biological skin-protecting face nursing product as claimed in claim 2, it is characterised in that the primary stem cell of described people is umbilical cord
Hemocytoblast, umbilical cord mesenchymal stem cells, human amnion mesenchymal stem cell, mesenchymal stem cells MSCs, fat stem cell, nerve
One or more in stem cell, embryonic stem cell.
4. a kind of biological skin-protecting face nursing product as claimed in claim 1, it is characterised in that described activity in human stem cell composition contains
Amount is 0.001-20%, and described Human-like Collagen content is 0.005-30%.
5. a kind of biological skin-protecting face nursing product as claimed in claim 1, it is characterised in that described biological skin-protecting face nursing product contains
There is a following composition the most by mass percentage:
Activity in human stem cell component content is 0.001%-5%
Human-like Collagen content is 0.005%-10%
Glycerol three (thylhexoic acid) ester 5.0-9.0%
Isopropyl palmitate 3.5-5.5%
PEG-20 anhydrous sorbitol isostearate 4.0-6.0%
Glyceryl stearate 2.0-5.0%
Hydroxyethyl cellulose 1.0-3.0%
Hyaluronate sodium 1.0-3.0%
Carbomer 0.8-2.5%
Triethanolamine 0.5-2.0%
EDETATE SODIUM 0.3-1.5%
Glycerol 10-20%
Triethoxy octyl group silane 4.0-6.0%
Tocopherol acetas 2.0-5.0%
Methyl hydroxybenzoate 0.5-1.0%
Surplus is water.
6. a kind of biological skin-protecting face nursing product as claimed in claim 5, it is characterised in that described activity in human stem cell composition contains
Amount is 0.006%-0.06% for 0.003%-0.03%, Human-like Collagen content.
7. a kind of biological skin-protecting face nursing product as claimed in claim 5, it is characterised in that affiliated biological skin-protecting face nursing product
Form is mastic, emulsion, curry.
8. the preparation method of a biological skin-protecting face nursing product as claimed in claim 1, it is characterised in that described preparation method
Specifically comprise the following steps that at a temperature of less than 50 DEG C, be added into the activity in human stem cell obtained count by weight percentage and become
Divide and Human-like Collagen obtains described biological skin-protecting face nursing product.
9. the preparation method of a biological skin-protecting face nursing product as claimed in claim 5, it is characterised in that concrete steps are such as
Under:
(1) by the EDETATE SODIUM obtained count by weight percentage, it is added to the water stirring, after being heated to 70-90 DEG C simultaneously
It is incubated 0.5-1 hour；
(2) in the mixture that step (1) obtains, it is sequentially added into hyaluronate sodium, the card ripple obtained count by weight percentage
Nurse, glycerol three (thylhexoic acid) ester, isopropyl palmitate, PEG-20 anhydrous sorbitol isostearate, glyceryl stearate and
Hydroxyethyl cellulose also stirs to being completely dissolved；
(3) add glycerol, triethoxy octyl group silane, tocopherol acetas and methyl hydroxybenzoate when being cooled to 50-60 DEG C and stir
To being completely dissolved；
(4) the activity in human stem cell composition obtained count by weight percentage and class people's collagen egg are added when being cooled to 40-50 DEG C
White and stir to after being completely dissolved, triethanolamine that addition obtains count by weight percentage also stirs 1-3 hour and obtains biology
Skin-protecting face nursing product.
The preparation method of a kind of biological skin-protecting face nursing product the most as claimed in claim 9, it is characterised in that step (4) is lowered the temperature
Temperature is 40-45 DEG C.
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| CN201610675624.2A CN106176530A (en) | 2016-08-16 | 2016-08-16 | A kind of biological skin-protecting face nursing product and preparation method thereof |
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| CN201610675624.2A CN106176530A (en) | 2016-08-16 | 2016-08-16 | A kind of biological skin-protecting face nursing product and preparation method thereof |
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ID=57521967
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108567596A (en) * | 2018-06-27 | 2018-09-25 | 吉林大学珠海学院 | A kind of biological medicine skin care and preparation method thereof |
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| CN105055265A (en) * | 2015-07-21 | 2015-11-18 | 北京博士园科技发展有限公司 | Product capable of maintaining beauty and keeping young and preparation method of product |
| CN105709267A (en) * | 2015-12-04 | 2016-06-29 | 陕西巨子生物技术有限公司 | Mucosa-repairing gel containing human-like collagen |
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Application publication date: 20161207 |