CN106164289A - 癌症对免疫疗法的反应的决定因素 - Google Patents
癌症对免疫疗法的反应的决定因素 Download PDFInfo
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| CN109371005B (zh) * | 2018-11-12 | 2022-09-30 | 上海市东方医院(同济大学附属东方医院) | 一种hla-0201限制性padi4表位多肽及其应用 |
| EP3893932A4 (en) * | 2018-12-12 | 2022-09-07 | Medimmune, LLC | BLOOD-BASED TUMORMUTATION LOAD AS A PREDICTOR OF OVERALL SURVIVAL IN NON-SMALL CELL LUNG CANCER |
| US20220081723A1 (en) * | 2018-12-21 | 2022-03-17 | Agency For Science, Technology And Research | Method of predicting for benefit from immune checkpoint inhibition therapy |
| WO2021067550A1 (en) | 2019-10-02 | 2021-04-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions for identifying neoantigens for use in treating and preventing cancer |
| NL2024107B1 (en) * | 2019-10-26 | 2021-07-19 | Vitroscan B V | Compositions for Patient Specific Immunotherapy |
| GB202007099D0 (en) | 2020-05-14 | 2020-07-01 | Kymab Ltd | Tumour biomarkers for immunotherapy |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| EP4000596A1 (en) * | 2020-11-17 | 2022-05-25 | The Boots Company plc | Tetrapeptide and compositions comprising tetrapeptides |
| EP4000595A1 (en) * | 2020-11-17 | 2022-05-25 | The Boots Company plc | Tetrapeptide and compositions comprising tetrapeptides |
| US20240192195A1 (en) * | 2021-04-10 | 2024-06-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | A multiomic approach to modeling of gene regulatory networks in multiple myeloma |
| WO2023025404A1 (en) | 2021-08-24 | 2023-03-02 | BioNTech SE | In vitro transcription technologies |
| WO2024083345A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Methods and uses associated with liquid compositions |
| WO2024216165A1 (en) | 2023-04-12 | 2024-10-17 | Icahn School Of Medicine At Mount Sinai | Computational methods for selecting personalized neoantigen vaccines |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110190149A1 (en) * | 2001-12-04 | 2011-08-04 | Michael Tainsky | Neoepitope detection of disease using protein arrays |
| WO2012159643A1 (en) * | 2011-05-24 | 2012-11-29 | Biontech Ag | Individualized vaccines for cancer |
| CN103180730A (zh) * | 2010-05-14 | 2013-06-26 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9826143D0 (en) * | 1998-11-27 | 1999-01-20 | Ludwig Inst Cancer Res | Tumour rejection antigens |
| WO2006050172A2 (en) * | 2004-10-29 | 2006-05-11 | University Of Southern California | Combination cancer immunotherapy with co-stimulatory molecules |
| US20100099090A1 (en) * | 2007-03-05 | 2010-04-22 | Bristol-Mayers Squibb Company | Biomarkers and methods for determining sensitivity to ctla-4 antagonists |
| GB201103955D0 (en) * | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
-
2014
- 2014-12-23 AU AU2014374020A patent/AU2014374020A1/en not_active Abandoned
- 2014-12-23 BR BR112016015399A patent/BR112016015399A2/pt not_active IP Right Cessation
- 2014-12-23 CN CN201480075287.2A patent/CN106164289A/zh active Pending
- 2014-12-23 EP EP14876694.2A patent/EP3090066A4/en not_active Withdrawn
- 2014-12-23 US US15/109,464 patent/US20160326597A1/en not_active Abandoned
- 2014-12-23 SG SG10201805674YA patent/SG10201805674YA/en unknown
- 2014-12-23 JP JP2016544613A patent/JP2017504324A/ja active Pending
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- 2014-12-23 RU RU2016131207A patent/RU2707530C2/ru not_active IP Right Cessation
- 2014-12-23 CA CA2935214A patent/CA2935214A1/en not_active Abandoned
- 2014-12-23 WO PCT/US2014/072125 patent/WO2015103037A2/en not_active Ceased
- 2014-12-23 MX MX2016008771A patent/MX2016008771A/es unknown
- 2014-12-23 SG SG11201605432RA patent/SG11201605432RA/en unknown
- 2014-12-23 KR KR1020167021093A patent/KR20160102314A/ko not_active Withdrawn
-
2016
- 2016-07-01 CL CL2016001708A patent/CL2016001708A1/es unknown
- 2016-07-04 PH PH12016501329A patent/PH12016501329A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110190149A1 (en) * | 2001-12-04 | 2011-08-04 | Michael Tainsky | Neoepitope detection of disease using protein arrays |
| CN103180730A (zh) * | 2010-05-14 | 2013-06-26 | 综合医院公司 | 鉴定肿瘤特异性新抗原的组合物和方法 |
| WO2012159643A1 (en) * | 2011-05-24 | 2012-11-29 | Biontech Ag | Individualized vaccines for cancer |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110997943A (zh) * | 2017-07-05 | 2020-04-10 | 弗朗西斯.克里克研究所 | 评估癌症免疫疗法的适合性的方法 |
| CN111432837A (zh) * | 2017-09-25 | 2020-07-17 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
| CN111566484A (zh) * | 2017-11-09 | 2020-08-21 | 宾夕法尼亚大学董事会 | 细胞外囊泡蛋白及其在癌症诊断、预测对疗法的反应和治疗中的用途 |
| CN110770838A (zh) * | 2017-12-01 | 2020-02-07 | Illumina公司 | 用于确定体细胞突变克隆性的方法和系统 |
| US12367978B2 (en) | 2017-12-01 | 2025-07-22 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
| CN110770838B (zh) * | 2017-12-01 | 2023-12-19 | Illumina公司 | 用于确定体细胞突变克隆性的方法和系统 |
| CN110295218B (zh) * | 2018-03-22 | 2023-09-01 | 长庚医疗财团法人嘉义长庚纪念医院 | 量化靶基因的突变型等位基因负担的方法 |
| CN110295218A (zh) * | 2018-03-22 | 2019-10-01 | 长庚医疗财团法人嘉义长庚纪念医院 | 量化靶基因的突变型等位基因负担的方法 |
| CN112424382A (zh) * | 2019-04-05 | 2021-02-26 | Illumina公司 | Hla多样性的定量评分 |
| CN112424382B (zh) * | 2019-04-05 | 2024-05-28 | Illumina公司 | Hla多样性的定量评分 |
| US12031181B2 (en) | 2019-04-05 | 2024-07-09 | Illumina, Inc. | Quantitative score of HLA diversity |
| CN114245874A (zh) * | 2019-05-24 | 2022-03-25 | 艾迪菲斯健康有限公司 | 用于癌症免疫疗法的精准医学方法 |
| CN111088349A (zh) * | 2020-02-14 | 2020-05-01 | 深圳市宝安区妇幼保健院 | Kir3dl1基因分型引物组及其应用 |
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| EP3090066A2 (en) | 2016-11-09 |
| RU2707530C2 (ru) | 2019-11-27 |
| RU2016131207A3 (enExample) | 2018-06-22 |
| RU2016131207A (ru) | 2018-02-07 |
| CL2016001708A1 (es) | 2017-03-17 |
| SG11201605432RA (en) | 2016-07-28 |
| MX2016008771A (es) | 2016-12-20 |
| PE20161344A1 (es) | 2016-12-23 |
| JP2017504324A (ja) | 2017-02-09 |
| WO2015103037A2 (en) | 2015-07-09 |
| BR112016015399A2 (pt) | 2017-10-24 |
| PH12016501329A1 (en) | 2016-10-03 |
| KR20160102314A (ko) | 2016-08-29 |
| CA2935214A1 (en) | 2015-07-09 |
| EP3090066A4 (en) | 2017-08-30 |
| SG10201805674YA (en) | 2018-08-30 |
| US20160326597A1 (en) | 2016-11-10 |
| AU2014374020A1 (en) | 2016-08-18 |
| WO2015103037A3 (en) | 2015-11-05 |
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