CN106153436A - A kind of annealing device of slide glass Samples detection - Google Patents
A kind of annealing device of slide glass Samples detection Download PDFInfo
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- CN106153436A CN106153436A CN201610798074.3A CN201610798074A CN106153436A CN 106153436 A CN106153436 A CN 106153436A CN 201610798074 A CN201610798074 A CN 201610798074A CN 106153436 A CN106153436 A CN 106153436A
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- 239000011521 glass Substances 0.000 title claims abstract description 144
- 238000001514 detection method Methods 0.000 title claims abstract description 24
- 238000000137 annealing Methods 0.000 title claims abstract description 21
- 238000010438 heat treatment Methods 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 18
- 239000012530 fluid Substances 0.000 claims abstract description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 7
- 230000004807 localization Effects 0.000 claims description 26
- 238000009835 boiling Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 230000000712 assembly Effects 0.000 claims description 5
- 238000000429 assembly Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 230000005674 electromagnetic induction Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000007901 in situ hybridization Methods 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000002331 protein detection Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 13
- 238000010586 diagram Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 238000011017 operating method Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000011079 streamline operation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention discloses the annealing device of a kind of slide glass Samples detection, mainly includes container, heater, leakage fluid dram, inlet, controller and thermocouple.When assembly of the invention is used together to the device (such as slide glass cover plate and slide mount) of relevant invention, a large amount of slide glass specimen can be made to carry out reagent pipetting volume in same device, clean, heat treatment, insulation, the step of the common slide glass Samples detections such as dehydration, especially such as SABC, in situ hybridization and other slide glass specimen Protein Detection, the multi-step operation of DNA nucleotide and gene test etc., the detection making all slide glass specimen is from start to finish carried out in same device, and ensure that all slide glass specimen from start to finish obtain being completely covered of reagent, ensure that all slide glass specimen carry out heat treatment under homogeneous temperature controls.Simplify operating process, improve the reproducibility and reliability of slide glass sample disposal.
Description
Technical field
The invention belongs to biological sample process field, particularly relate to the device of a kind of slide glass sample disposal.
Background technology
Albumen in slide glass specimen, pathogen or gene test are (such as immunohistochemistry and be hybrid gene detection originally
Deng) whole process tens complicated steps of needs, environment and manual operation various factors badly influence the standard of test result
Really property.Streamline operation, minimizing are to improve Samples detection efficiency and the task of top priority of accuracy by the factor of environment shadow.
Generally, the midway of sample disposal process, overwhelming majority specimen needs heat treated, and this is to make albumen or gene test
Reach step necessary to due sensitivity and specificity.Heating typically carries out at a temperature of 80-121 DEG C and maintains 3-60
Minute.Most common method is that pressure cooker boils, typically boiling is boiled, microwave oven boils, hot bath adds the methods such as goods in great demand baking.So
And, container or the carrier of the slide glass sample disposal that operation is conventional are the most thermo-labile at present, the most do not possess heatable function.At slide glass
The midway of sample disposal is carried out in needing slide glass specimen is transferred to heatable container, needs the most again to transfer to the behaviour of room temperature
In station, add complexity and the operating error of operating process.
The present invention realizes the annealing device during slide glass specimen, is used together to relevant invention, it is possible to achieve carry
Needs during sheet sample disposal and need not each step of heating, can carry out in same device, simplify
The operating procedure of slide glass sample disposal, improves efficiency and the reliability of slide glass sample disposal.
Summary of the invention
In order to solve the problems referred to above, it is proposed that the annealing device of a kind of slide glass Samples detection, it is possible to make large batch of load
Sheet is closely placed in heatable container and configures liquid filling and pumping equipment, it is achieved need during slide glass sample disposal and not
Need each step of heating, can carry out in same device, simplify the operating procedure of slide glass sample disposal, improve
The efficiency of slide glass sample disposal and reliability.
The purpose of the present invention realizes at least through one of following technical scheme.
The annealing device of a kind of slide glass Samples detection, including container, base, heater, leakage fluid dram, inlet, control
Device and thermocouple；
Heater is positioned at above base and is positioned at below container；Container adds thermal medium for placement and more than one slide glass props up
Frame；Controller is used for controlling heater starting and stopping, and heater is for adding the medium in heat container；Thermocouple is placed in container
In, thermocouple senses the temperature in container in real time, and sensed data is passed to controller；
What inlet allowed to be stored in external container add thermal medium or reagent is quantitatively adding in container when needed；Leakage fluid dram is permitted
Permitted container to add thermal medium or liquid amount discharge container.
Further, the heater being arranged on container bottom described in uses electrical bar heating, electric-heating-wire-heating, microwave to add
Heat, electromagnetic induction heating or thermal medium circulating-heating mode；Described heater and container are conjoined structure or detachable structure.
Further, described inlet on container and leakage fluid dram also each connect Micropump or electromagnetic valve, controller control
Micropump processed or the work of electromagnetic valve and then realization control liquid filling or discharge opeing from container in container.
Further, container edge is right-angle structure；Container bottom is planar structure.
Further, the annealing device of described a kind of slide glass Samples detection also includes at least one slide mount, carries
The two ends of plate rack hang on the dual-side that container is facing each other, make the slide glass assembly bottom in slide mount stay with container bottom
There is gap；It is provided with V-arrangement that is multiple vertical or that tilt that is integral part of vertical or that tilt on described slide mount and assigns groove, often
Individual V-arrangement is assigned and is fixedly installed spring leaf in groove；Multiple V-arrangements assign groove closely to form a line, described slide mount include string or
Multiple row V-arrangement assigns groove；The profile of slide glass assembly upper end become by slide glass and cover plate combination and the V-arrangement on support assign groove phase
Join so that slide glass assembly can assign into the V-arrangement on slide mount and assign in groove, form multiple compact arranged slide glass assembly；
The V-arrangement of spring leaf and slide mount assigns groove to be integrated attachment structure or independent separate is arranged, and uses independent separate to set
When putting, spring leaf is fixed in V-arrangement assigns groove with chimeric or bonding way；Assign in groove when slide glass assembly assigns into V-arrangement, cover plate
Surface pressing spring sheet, spring leaf plays the effect of clamping slide glass and slide glass cover plate.
Further, each V-arrangement is assigned and has been assigned slide glass assembly in groove, multiple slide glass assemblies in same container by list
One controller heats at a temperature of controlling；Slide glass assembly assign into V-arrangement assign groove be for erect or tilt, slide glass assembly with
The angle of vertical direction is 1 ~ 90 degree.
Further, when slide glass component heat processes, the thermal medium that adds in container can be heated to boiling, solid by using
Determine adding thermal medium and controlling heat treatment temperature of boiling point.
Further, slide glass assembly is made up of slide glass and cover plate；Described cover plate includes capillary plane, depth localization face, width
Degree locating piece, bottom locating piece, groove side and channel opening face；The dual-side facing each other of described capillary plane is provided above
Said two depth localization face, capillary plane is parallel with depth localization face；The plane of described slide glass is near the part of both sides of the edge
Fit with depth localization face, make to be formed between slide surface and capillary plane a capillary gap；On each depth localization face far
Outer ledge from capillary plane is provided with more than one described width locating piece；It is positioned at the width on different depth locating surface fixed
Vertical dimension between the block of position mates to play position-limiting action with the width of slide glass；Bottom locating piece is arranged on depth localization face
Bottom；Described channel opening face is connected with the upper end of capillary plane and forms included angle A 1, and A1 is 1 ~ 175 degree of plane angle；Channel opening face
Both sides respectively connect a groove side；Described channel opening face and two groove sides collectively form one and described hair with slide glass plane
The loading slot of thin gap area, capillary has slit aperture bottom gap；Slide glass cover plate and the length of slide glass quite or equal, groove side
On face, the side i.e. upper end in said two depth localization face with the laminating of slide glass plane is equipped with a slot tag, when pasting on slide glass
When having label, slot tag provide enough space for accommodating the thickness of label, enable slide glass cover plate and slide glass to be adjacent to and not
Affected by the most labeled on slide glass；The outside of two groove sides is provided with top striped, is used for increasing groove side and finger
Between frictional force；Vertical dimension between capillary plane and depth localization face is 0.01 ~ 0.5mm, makes slide glass cover plate and slide glass
After being adjacent to, between slide surface and capillary plane, one spacing of formation is the capillary gap of 0.01 ~ 0.5mm；Described width positions
It is 0.1 ~ 1mm that block exceeds the thickness in depth localization face；Bottom locating piece is upwards hook-shaped, bottom locating piece and width locating piece
Determine together cover plate and slide glass fit after relative position and assist to keep fitting tightly between cover plate and slide glass.
Further, one or more independent container and the most independent heater are set, for carrying out not simultaneously
Synthermal, varying environment or different operating flow process download the heat treatment of sheet specimen.
The most optimally, during heat treatment, simply the thermal medium that adds in container can be heated to boiling, by selecting phase
The boiling point control heat treatment temperature of thermal medium should be added, reach the homogeneity of heat treatment, reproducibility and reliability.Slide glass sample disposal
Overall process slide glass be on same position not mobile.
Relative to prior art, the present invention has the following advantages and technique effect:
The overall process of slide glass sample disposal all without artificially taking or shifting slide glass, reduces manual intervention and intervention, can save
Time, simplify operation and can reduce again operating error.
When slide glass component heat processes, multiple slide glass assemblies enter under being controlled by single heating controller in same container
OK, it is ensured that the homogeneity of heat treatment.
During slide glass specimen heat treatment, thermal medium extremely boiling can be added simply, by adding the boiling point control heat treatment of thermal medium
Temperature, reaches the homogeneity of heat treatment, and has high reliability and repeatable feature.
The process of slide glass sample disposal does not haves the probability that slide glass specimen is withered.
V-arrangement assigns the respective outer side edges of groove and slide glass assembly, and holder device structure is simpler compact, makes container to accommodate more
Many slide glass assemblies, only need to clamp the striped position, top of two groove sides, be inserted by slide glass assembly easily with finger during use
Assign in groove, it is to avoid during pressing slide glass top, unbalance stress or Impact direction have deviation to cause slide glass to disengage slide glass cover plate, ensure
The formation in capillary gap and accuracy, operate more simple and efficient.It addition, the arrangement of slide glass assembly can be more tight, enter one
Step reduces space, improves treatment effeciency.
Accompanying drawing explanation
Fig. 1 is the annealing device schematic diagram of a kind of slide glass Samples detection of the present invention.
Fig. 2 is the annealing device profile chart of a kind of slide glass Samples detection of the present invention.
Fig. 3 is the axonometric chart of annealing device shown in Fig. 1.
Fig. 4 is the schematic diagram of a kind of slide mount in example.
Fig. 5 is to arrange multiple row in example to assign the slide mount schematic diagram of groove.
Fig. 6 is the schematic diagram having assigned slide glass assembly on a kind of slide mount shown in Fig. 4.
Fig. 7 is the cover plate schematic diagram of slide glass assembly in example.
Fig. 8 is slide glass component diagram in example.
Fig. 9 a is the front projection view of Fig. 8.
Fig. 9 b is the side view of Fig. 8.
Fig. 9 c is the partial enlarged drawing of Fig. 8.
In Figure 10 a, Figure 10 b respectively example, the container suspension multiple row V-arrangement of annealing device assigns the slide mount of groove
Top view and sectional view.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but the enforcement of the present invention and protection are not limited to
This.
As shown in Figure 1, Figure 2, the annealing device of a kind of slide glass Samples detection, including container 301, base 302, heater 303,
Leakage fluid dram 307, inlet 308, controller 309 and thermocouple 312；
Heater 303 is positioned at above base 302 and is positioned at below container 301；Container 301 for placement add thermal medium and one with
On slide mount 602；Controller 309 is used for controlling heater starting and stopping, and heater is for adding Jie in heat container 301
Matter；Thermocouple 312 is placed in container, and thermocouple 312 senses the temperature in container 301 in real time, and sensed data is passed to
Controller 309.
What inlet 308 allowed to be stored in external container add thermal medium or reagent is quantitatively adding container 301 when needed
In；Leakage fluid dram 307 allows to add thermal medium or liquid amount discharge container in container 301.Described inlet 308 on container and row
Liquid mouth 307 also each connects Micropump or electromagnetic valve, and controller controls Micropump or the work of electromagnetic valve and then realizes controlling to appearance
Liquid filling or discharge opeing from container in device.In this example, leakage fluid dram 307 connects draining pump 310, for discharging the most from container
Liquid；Inlet 308 connects intake pump 311: irrigate liquid in container for if desired.In example, this device additionally provides
Heat treatment time (temperature retention time) display module 314, for showing the length of heat treatment time；Temperature retention time adjusting key 315, uses
In the length arranging temperature retention time.
As an example, pouring into and discharge and can also utilizing the work of gravity by controlling the opening and closing of electromagnetic valve of thermal medium is added
With pouring in container or discharging in container.Described controller uses PIC single chip microcomputer, 51 single-chip microcomputers or PLC etc.
Controller, is controlled energising and the power-off of relay by controller, thus realize to the start and stop of heating function,
Realize inlet port and the control of outlet folding.
As an example, the heater 303 being arranged on container bottom described in uses electrical bar heating, electric-heating-wire-heating, microwave
Heating, electromagnetic induction heating or thermal medium circulating-heating mode；Described heater 303 maybe can divide for conjoined structure with container 301
From formula structure.
Such as Fig. 1 or Fig. 3, container edge is right-angle structure, and the right-angle structure of container edge is conducive to making full use of container pendulum
Put slide mount 602.Container bottom is planar structure, is conducive to the liquid draining in container.
Such as Fig. 4, Fig. 5, described slide mount 602 being provided with integral part of multiple V-arrangement and assigns groove 604, each V-arrangement is pacified
Slot 604 is fixedly installed spring leaf 603；Multiple V-arrangements assign groove closely to form a line, and Fig. 4 show to be had string V-arrangement and assign
The slide mount 602 of groove, Fig. 5 show to be had multiple row V-arrangement and assigns the slide mount 602b of groove.Many groups of placement can be hung on container
The slide mount (602 or 602b) that (multiple row) is parallel.Slide mount 602 is manufactured by heat proof material, can bear slide glass Samples detection
Time heat treatment process.Spring leaf uses heat proof material with slide mount, and spring leaf can also use sheet metal to make.Each
V-arrangement is assigned and has been assigned slide glass assembly in groove 604, and multiple slide glass assemblies are controlled temperature by Single Controller in same container 301
Carry out under degree heating rather than the separately heating of each slide glass specimen, temperature control alone.Slide glass 101 and slide glass cover plate 601 coordinate
Molectron, insert along the groove 604 of assigning on slide mount 602, the surface of slide glass cover plate 601 compacting flat spring
603, produce spring pressure and be applied on slide glass 101 and slide glass cover plate 601 to realize pressuring action.
Such as Fig. 7, Fig. 8, Fig. 9 a ~ Fig. 9 c, slide glass assembly is made up of slide glass 101 and cover plate 601；Described cover plate includes that capillary is put down
Face 1, depth localization face 2, width locating piece 3, bottom locating piece 4, groove side 6 and channel opening face 7；The phase of described capillary plane 1
Mutually the most just to dual-side be provided above said two depth localization face 2, capillary plane 1 is parallel with depth localization face；Described load
The plane of the sheet part near both sides of the edge is fitted with depth localization face 2, makes to form one between slide surface and capillary plane 1
Capillary gap；On each depth localization face 2, the outer ledge away from capillary plane 1 is provided with more than one described width locating piece
3；The vertical dimension between width locating piece 3 on different depth locating surface 2 is mated to play spacing with the width of slide glass
Effect；Bottom locating piece 4 is arranged on the bottom in depth localization face 2；Described channel opening face 7 is connected also with the upper end of capillary plane 1
Forming included angle A 1, A1 is 1 ~ 175 degree of plane angle；Both sides, channel opening face 7 respectively connect a groove side 6；Described channel opening face 7 and
Two groove sides 6 and slide glass plane collectively form the loading slot of and described capillary gap area, and capillary has bottom gap
Slit aperture；Slide glass cover plate and the length of slide glass quite or equal, with the side i.e. said two of slide glass plane laminating on groove side 6
The upper end in depth localization face 2 is equipped with a slot tag 9, and when label on slide glass, slot tag provides enough spaces to use
In the thickness of receiving label, slide glass cover plate is enable to be adjacent to slide glass and not affected by the most labeled on slide glass；Two
The outside of groove side 6 is provided with top striped 10, for increasing the frictional force between groove side 6 and finger；Capillary plane 1 and the degree of depth
Vertical dimension between locating surface 2 is 0.01 ~ 0.5mm, slide surface and capillary plane 1 after making slide glass cover plate and slide glass be adjacent to
Between form the capillary gap that spacing is 0.01 ~ 0.5mm；Described width locating piece 3 exceeds the thickness in depth localization face 2
0.1~1mm；Bottom locating piece 4 be upwards hook-shaped, and bottom locating piece 4 determines cover plate and slide glass patch together with width locating piece 3
Relative position after conjunction also assists to keep fitting tightly between cover plate and slide glass.Bottom in described capillary plane 1 also sets
Put two channelization angles 11；Form a flared flow-guiding mouth 5 between two described channelization angles and allow in capillary plane
Solution flows out from flow-guiding mouth.
Section preparation is pasted on slide glass and is on the slide surface in capillary gap；When reagent is added to loading slot, by
In gravity and capillary siphonage, reagent enters capillary gap from loading slot, covers in specimen.Finger clamp only need to be used during use
Live the striped position, top of two groove sides, easily slide glass assembly is inserted and assign in groove, it is to avoid stress during pressing slide glass top
Inequality causes slide glass to disengage slide glass cover plate, ensures formation and the accuracy in capillary gap, operates more simple and efficient.It addition, carry
The arrangement of chip module can be more tight, reduces space further, improves treatment effeciency.
The all parts of this example all use and are resistant to 80oMore than C and indeformable or soften material manufacture.
As an example, one or more independent container and the most independent heater can be set, for entering simultaneously
Row different temperatures, varying environment or different operating flow process download the heat treatment of sheet specimen.When slide glass component heat processes, can will hold
The thermal medium that adds in device 301 is heated to boiling, by using fixing the adding thermal medium of boiling point to control heat treatment temperature, reaches heat
The homogeneity processed, and have the advantages that reliability is high and repeatable.
The announcement of book and teaching according to the above description, aforesaid way can also be entered by those skilled in the art in the invention
Row change and amendment.Therefore, the invention is not limited in concrete mode disclosed and described above, some amendments to the present invention
With in the scope of the claims that change should also be as falling into the present invention.
Claims (10)
1. the annealing device of a slide glass Samples detection, it is characterised in that include container (301), base (302), heater
(303), leakage fluid dram (307), inlet (308), controller (309) and thermocouple (312)；
Heater (303) is positioned at base (302) top and is positioned at container (301) lower section；Container (301) adds thermal medium for placement
With more than one slide mount (602)；Controller (309) is used for controlling heater starting and stopping, and heater is used for heating
Medium in container (301)；Thermocouple (312) is placed in container, and thermocouple (312) senses the temperature in container (301) in real time
Degree, and sensed data is passed to controller (309)；
What inlet (308) allowed to be stored in external container add thermal medium or reagent is quantitatively adding container (301) when needed
In；Leakage fluid dram (307) allows to add thermal medium or liquid amount discharge container in container (301).
The annealing device of a kind of slide glass Samples detection the most according to claim 1, it is characterised in that be arranged on appearance described in:
Heater (303) bottom device uses electrical bar heating, electric-heating-wire-heating, microwave heating, electromagnetic induction heating or thermal medium to follow
Ring mode of heating；Described heater (303) and container (301) are conjoined structure or detachable structure.
The annealing device of a kind of slide glass Samples detection the most according to claim 1, it is characterised in that described on container
Inlet (308) and leakage fluid dram (307) also each connect Micropump or electromagnetic valve, and controller controls Micropump or the work of electromagnetic valve
And then realize controlling liquid filling or discharge opeing from container in container.
The annealing device of a kind of slide glass Samples detection the most according to claim 1, it is characterised in that: container edge is straight
Corner structure.
The annealing device of a kind of slide glass Samples detection the most according to claim 1, it is characterised in that: container bottom is flat
Face structure.
The annealing device of a kind of slide glass Samples detection the most according to claim 1, it is characterised in that: also include at least one
Individual slide mount (602), the two ends of slide mount (602) hang on the dual-side that container is facing each other, make slide mount (602)
In slide glass assembly bottom and container bottom leave gap；Be provided with on described slide mount (602) integral part of vertically or
The multiple V-arrangements tilted assign groove (604), and each V-arrangement is assigned and is fixedly installed spring leaf (603) in groove (604)；Multiple V-arrangements are assigned
Groove closely forms a line, and described slide mount includes that one or more columns per page V-arrangement assigns groove；Combined by slide glass (101) and cover plate (601)
The profile of the slide glass assembly upper end become assigns groove (604) to match with the V-arrangement on support so that slide glass assembly can assign into slide glass
V-arrangement on support (602) assigns groove (603) inner, forms multiple compact arranged slide glass assembly；
The V-arrangement of spring leaf (603) and slide mount assigns groove (604) to be integrated attachment structure or independent separate is arranged, and uses
When independent separate is arranged, spring leaf is fixed in V-arrangement assigns groove (604) with chimeric or bonding way；When slide glass assembly assigns into V
Shape assigns groove (604) inner, surface pressing spring sheet (603) of cover plate (601), and spring leaf plays clamping slide glass (101) and slide glass
The effect of cover plate (601).
The annealing device of a kind of slide glass Samples detection the most according to claim 6, it is characterised in that: each V-arrangement is assigned
Groove (604) has been assigned slide glass assembly, multiple slide glass assemblies in same container (301) by Single Controller control at a temperature of
Heat.
The annealing device of a kind of slide glass Samples detection the most according to claim 7, it is characterised in that: slide glass group heat treatment
Time, the thermal medium that adds in container (301) can be heated to boiling, by using fixing the adding thermal medium of boiling point to control at heat
Reason temperature.
The annealing device of a kind of slide glass Samples detection the most according to claim 7, it is characterised in that: slide glass assembly is by carrying
Sheet (101) and cover plate (601) composition；Described cover plate includes capillary plane (1), depth localization face (2), width locating piece (3), the end
Portion's locating piece (4), groove side (6) and channel opening face (7)；The dual-side facing each other of described capillary plane (1) is provided above
Having said two depth localization face (2), capillary plane (1) is parallel with depth localization face；The plane of described slide glass is near dual-side
The part of edge is fitted with depth localization face (2), makes to be formed between slide surface and capillary plane (1) a capillary gap；Each
On depth localization face (2), the outer ledge away from capillary plane (1) is provided with more than one described width locating piece (3)；It is positioned at
The vertical dimension between width locating piece (3) on different depth locating surface (2) mates to play spacing work with the width of slide glass
With；Bottom locating piece (4) is arranged on the bottom of depth localization face (2)；Described channel opening face (7) and the upper end of capillary plane (1)
Connecting and form included angle A 1, A1 is 1 ~ 175 degree of plane angle；Channel opening face (7) both sides respectively connect a groove side (6)；Described
Channel opening face (7) and two groove sides (6) and slide glass plane collectively form the loading slot of and described capillary gap area, hair
Bottom thin gap, there is slit aperture；Quite or equal, groove side (6) are upper fits with slide glass plane for slide glass cover plate and the length of slide glass
The side i.e. upper end of said two depth localization face (2) be equipped with a slot tag (9), when label on slide glass, mark
Sign groove provide enough space for accommodating the thickness of label, enable slide glass cover plate and slide glass to be adjacent to and not by slide glass whether
Labeled impact；The outside of two groove sides (6) is provided with top striped (10), be used for increasing groove side (6) and finger it
Between frictional force；Vertical dimension between capillary plane (1) and depth localization face (2) is 0.01 ~ 0.5mm, make slide glass cover plate and
Slide glass forms, after being adjacent to, the capillary gap that spacing is 0.01 ~ 0.5mm between slide surface and capillary plane (1)；Described
It is 0.1 ~ 1mm that width locating piece (3) exceeds the thickness in depth localization face (2)；Bottom locating piece (4) is upwards hook-shaped, bottom
Locating piece (4) determine together with width locating piece (3) cover plate and slide glass fit after relative position assisting keep cover plate and
Fitting tightly between slide glass.
10. according to the annealer device of a kind of slide glass Samples detection described in any one of claim 1 ~ 9, it is characterised in that:
One or more independent container and the most independent heater are set, for carry out simultaneously different temperatures, varying environment or
Different operating flow process downloads the heat treatment of sheet specimen.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610798074.3A CN106153436B (en) | 2016-08-31 | 2016-08-31 | Heat treatment device for slide specimen detection |
| CA3018633A CA3018633A1 (en) | 2016-03-21 | 2017-03-21 | Heat treatment device for slide specimen testing |
| JP2019500722A JP2019510243A (en) | 2016-03-21 | 2017-03-21 | Heat treatment device for sample slide detection |
| EP17769427.0A EP3435064A4 (en) | 2016-03-21 | 2017-03-21 | Heat treatment device for slide specimen testing |
| US16/087,099 US11221281B2 (en) | 2016-03-21 | 2017-03-21 | Heat treatment device for slide specimen testing |
| PCT/CN2017/077572 WO2017162150A1 (en) | 2016-03-21 | 2017-03-21 | Heat treatment device for slide specimen testing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610798074.3A CN106153436B (en) | 2016-08-31 | 2016-08-31 | Heat treatment device for slide specimen detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106153436A true CN106153436A (en) | 2016-11-23 |
| CN106153436B CN106153436B (en) | 2021-05-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610798074.3A Active CN106153436B (en) | 2016-03-21 | 2016-08-31 | Heat treatment device for slide specimen detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106153436B (en) |
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| CN108051270A (en) * | 2017-12-29 | 2018-05-18 | 杭州依美洛克医学科技有限公司 | For the discharger of micro slide reaction solution |
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