CN205719679U - Slot apparatus installed by a kind of multichannel slide glass - Google Patents

Slot apparatus installed by a kind of multichannel slide glass Download PDF

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Publication number
CN205719679U
CN205719679U CN201620216662.7U CN201620216662U CN205719679U CN 205719679 U CN205719679 U CN 205719679U CN 201620216662 U CN201620216662 U CN 201620216662U CN 205719679 U CN205719679 U CN 205719679U
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China
Prior art keywords
slide glass
slot
container
cover plate
plate
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Withdrawn - After Issue
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CN201620216662.7U
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Chinese (zh)
Inventor
郭金灿
郭恩明
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Xiamen Talent Biomedical Technology Co Ltd
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Ascend Biotechnology Co Ltd
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Priority to CN201620216662.7U priority Critical patent/CN205719679U/en
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Abstract

The open one of this utility model can heat multichannel slide glass and install slot apparatus, mainly includes, by slot container, cover plate, slide glass, flat spring, left side brackets, right side support and heater, using exotic material to make by slot container.Slot of the present utility model is erect or is obliquely installed, can the multiple slide glass specimen to be checked of compact placement;Slide glass and cover plate load and unload simple and convenient from slot;Specimen can carry out heating and being incubated in container, need not during making sample disposal transfer to specimen other heatable container is carried out, realize slide glass specimen from start to finish to carry out in same device, be beneficial to simplify manual steps or be combined integration automatic flow with the instrument possessing sample-adding function.This utility model ensures that section preparation moment during sample disposal obtains the covering of reagent, improves the reproducibility and reliability of heat treatment process, simplifies operating procedure, improve the quality of sample disposal and be easy to be integrated into full-automatic operation.

Description

Slot apparatus installed by a kind of multichannel slide glass
Technical field
This utility model belongs to biological sample process field, particularly relates to a kind of multichannel slide glass and installs slot apparatus.
Background technology
The whole process of immunohistochemistry needs nearly 30 steps, including: a) dewaxing, aquation, cleaning, high-temperature hot reparation, cool down, clean, one anti-hatch, clean, drain with wiping, two resist hatch, clean, drain hatch with wiping, synergist, clean, drain with wiping, develop the color, clean, serve as a contrast dye, clean, be dehydrated, the step such as mounting.Affected by the technical merit between hospital and hospital and operating habit difference, it is difficult to standardization.The efficiency and the reliability that improve sample disposal become the task of top priority.
At present in checkout procedure, specimen section tiling is laid, and takes up space big;Reagent pipetting volume sprays sample-adding above thin slice, and load position error is big, and reagent covering in section is with randomness, it is difficult to guaranteeing to cover whole section, some specimen do not obtain the covering of reagent and false negative occur.Needing high-temperature heating during sample disposal, this is to make antigen or pathogen characteristic protein reply step necessary to original shape.It is to maintain the whole vital factor of detection specificity that antigen or pathogen characteristic protein restore to the original state.Heating requirements 80-100 DEG C or higher temperature also maintain 5-40 minute.Most common method is that pressure cooker boils, typically boiling is boiled or the method such as hot water temperature bath.
But, the container of at present conventional slide glass sample disposal or carrier the most do not possess can heating function or possess the resistance to performance being heated.Carry out in the midway of slide glass sample disposal needs slide glass specimen is transferred to heatable container, need the most again to transfer on the operating board of room temperature, add complexity and the operating error of operating process.
Realize slide glass specimen to carry out heat treated in position and can greatly simplify slide glass specimen processing operation step, improve the repeatability of slide glass sample disposal result and be easier to carry out full-automatic operation flow process, meet the simpler reliable requirement of slide glass sample disposal.
Utility model content
In order to solve the problems referred to above, the utility model proposes a kind of multichannel slide glass and install slot apparatus, between cover plate and slide glass, precision-fit forms the molectron of a relative closure, and the container of sample disposal arranges the installation slot of inclination, the compact placement of molectron can be made, take minimum space;Slide glass cover plate forms fine gap when combining with slide glass, and this micro gap can produce capillary siphonage so that sample-adding reagent is by capillary siphonage uniform fold specimen on slide glass;Of the present utility model assign slot device use exotic material make and possess Contiuum type or separate type heater.Meet that to save space, section preparation sample-adding uniformly reliable simultaneously, can the requirement of heat treated etc. in position.
The purpose of this utility model realizes at least through one of following technical scheme.
A kind of multichannel slide glass installs slot apparatus, including by slot container, cover plate, slide glass, flat spring, left side brackets and right side support;Being mirror image between left side brackets and right side support, both collectively form the installation slot rest of slide glass and cover plate combination part, install slot rest and slide glass cover plate assembly is positioned at by slot container;Left side brackets includes side plate and the U-type groove in more than one projecting plate face being fixed on side plate, and more than one U-type groove is arranged along side plate length linear array, and U-type groove is made up of bracer of drawing money on credit, short bracer and bottom limited block;The length of described bracer of drawing money on credit is than short support block length, and both sides are parallel;U-type groove is obliquely installed and short bracer is positioned on bracer of drawing money on credit;Flat spring includes waveform reed and the location-plate linked into an integrated entity;Waveform reed a side of location-plate and and location-plate between there is an opening so that flat spring can be enclosed within short bracer of specular on left side brackets and right side support;Location-plate is fixed on short bracer, produces support force, and waveform reed has the wavy bulge that can produce elastic deformation;The molectron that slide glass and cover plate coordinate, the U-type groove along support inserts, the waveform reed of the surface compacting flat spring of cover plate, and the waveform reed generation spring pressure that is squeezed is applied on slide glass and cover plate, uses and compresses between slide glass and cover plate.
The most optimally, install bottom slot rest and be provided with runners so that slide glass and cover plate combination part are kept at a distance with by slot container bottom.
The most optimally, the angle that U-type groove tilts is 1 ~ 90 degree.
The most optimally, the angle that U-type groove tilts is 15 ~ 90 degree.
The most optimally, waveform reed and the location-plate of flat spring uses sheet copper, spring steel or other elastomeric material to make;Location-plate is fixed on short bracer by bonding way.
The most optimally, the upper ends of slide glass for adhesive label and bar code or identifies labelling;Leave spacing between the plurality of U-type groove, make the bar code of slide glass paste position and do not blocked by adjacent slide glass.
Optimally, the most each by one or more columns per page peace slot rest can be arranged in slot container, make slide glass specimen with single row or multiple rows and single-row or multiple rows of close-packed arrays in by slot container.
The most optimally, by the installation slot rest arranging more than string in slot container, and adjacent two be wherein parallel to each other install in slot rest, also there is between adjacent left side brackets and right side support more than one described U-type groove structure, between the most adjacent left side brackets and right side support, also form described installation slot rest.
The most optimally, every string is installed the inserted sheet quantity of U-type groove in slot rest and can be configured 1-100 as required and open, usually 2 ~ 50 (i.e. 2-50 row).Slot rest is installed as described in slot container arranges multiple row laid parallel, or each as installation slot rest described in multiple row laid parallel can be arranged in slot container, define the arrangement of the slide glass specimen of the cloth configuration of multiple rows of multiple row.1-100 row and 1 ~ 100 row can be set as required, 2-50 row normally can be set and 1-40 arranges.
The most optimally, multichannel slide glass is installed slot apparatus and is used tolerance 80oThe material of C temperatures above is made.
The most optimally, water intaking valve, outlet valve are set by slot container bottom, for manually or automatically controlling feeding and the discharge opeing of container;
The most optimally, the described feeding by slot container and discharge opeing are controlled by external plug-in type feeding and drainage system.
The most optimally, described cover plate includes capillary plane, depth localization face, width locating piece, bottom locating piece, groove side and channel opening face;The both sides of described capillary plane are provided above two depth localization faces, and capillary plane is parallel with depth localization face;Described depth localization face has two, lays respectively at the left and right sides of capillary plane;The plane of the described slide glass part near both sides of the edge is fitted with depth localization face, makes to be formed between slide surface and capillary plane a capillary gap;On each depth localization face, the outer ledge away from capillary plane is provided with more than one described width locating piece;Distance between two locating pieces in left and right mates to play position-limiting action with the width of slide glass;Bottom locating piece is arranged on the bottom in depth localization face;Described channel opening face is connected with capillary plane and forms 1-175 degree angle A1, usually 30-105 degree;Both sides, channel opening face respectively connect a groove side;Described channel opening face and two groove sides and slide glass plane collectively form the loading slot of and described capillary gap area.
Relative to prior art, this utility model has the following advantages and technique effect:
Slot of the present utility model often group can arrange by slotting multiple slide glass specimen, and form that string can assign multiple rows of slide glass specimen assigns groove;Individually or disjunctor is arranged can form single row or multiple rows and the single-row or setting of structuring the formation of multiple row, can closely assign the slide glass specimen to be checked of volume between the column and the column;Cooperation between slide glass and cover plate is compact accurately, produces a capillary gap to guarantee that slide glass specimen obtains the covering of reagent all the time;Slide glass and cover plate load and unload simple and convenient from slot;By slot apparatus possess heat-resisting and can heating function, specimen can fully, uniformly heat and be incubated in by slot container, fundamentally ensure the reproducibility and reliability of hot repair process.Container can tolerate higher temperature, thus need high-temperature to need not when processing will separately process, at sheet cover plate and slide glass, the step that then there is a need to reconfigure during sample disposal, can be implemented in sheet specimen from start to finish to carry out in same device, simplify manual operations, when the instrument with sample-adding function is combined, just can be integrated into full-automatic operation flow process.
Accompanying drawing explanation
Fig. 1 is the structural representation that slot apparatus installed by a kind of multichannel slide glass in example.
Fig. 2 is the structural representation that slot apparatus (removing container) installed by a kind of multichannel slide glass in example.
Fig. 3 is the structural representation that slot apparatus (removing container and right side support) installed by a kind of multichannel slide glass in example.
Fig. 4 is the front projection view of Fig. 3.
Fig. 5 is the close-up schematic view of Fig. 3.
Fig. 6 is the structural representation of support.
Fig. 7 is the front projection view of Fig. 6.
Fig. 8 is the structural representation of flat spring.
Fig. 9 is slide glass and the structural representation of slide glass cover plate combination part.
Figure 10 is the exemplary construction schematic diagram of a kind of improvement of cover plate.
Figure 11 is the structural representation that this utility model is combined with heated base.
Figure 12 is the generalized section of Figure 11.
Figure 13 is the structural representation that this utility model arranges multiple rows of multiple row slide glass slot.
Detailed description of the invention
Although this utility model covers various amendment and alternative method and device, but embodiment of the present utility model shows in the accompanying drawings and will be described in more detail below.It is, however, to be understood that concrete description and accompanying drawing are not intended to be limited to this utility model disclosed concrete form.
As shown in Fig. 1 ~ Fig. 5, slot apparatus installed by a kind of multichannel slide glass, mainly includes by parts such as slot container 1, cover plate 2, slide glass 3, flat spring 4, left side brackets 5, right side supports 6,
Left side brackets 5 and right side support 6 belong to the character shape of specular, and both collectively form the installation slot rest of slide glass cover plate assembly, and both spacing can regulate as required;Such as Fig. 6, Fig. 7, left side brackets 5 is provided with the U-type groove in more than one projecting plate face, and this U-type groove includes draw money on credit bracer 51, short bracer 52 and bottom limited block 53;The length of described bracer 51 of drawing money on credit is longer than short bracer 52, and both sides are parallel;Described U-type groove is fixed on side plate 54, and erects or tilt to put, and angle is 1 ~ 90 degree, usually 15-90 degree;Described U-type groove is arranged with single and multiple rows of and single-row and multiple row array, and the row of layout and columns can be arranged according to user's request.Fig. 5 is described in dotted line one group of slide glass and cover plate assembly is positioned in a U-type groove.
Such as Fig. 8, flat spring 4 includes waveform reed 41 and location-plate 42, uses sheet copper, spring steel or other elastomeric material to make;There is between waveform reed 41 and location-plate 42 opening so that flat spring 4 can put on short bracer 52;Location-plate 42 is fixed on short bracer 52 by the mode such as bonding, produces support force;The wavy bulge of waveform reed 41, can form certain elastic deformation.
The molectron that slide glass 3 and cover plate 2 coordinate, along the U-type groove insertion of support, the waveform reed of the surface compacting flat spring 4 of cover plate 2, produces spring pressure and is applied on slide glass 3 and cover plate 2 with both compressions, in order to avoid in the dead of night.
By left side brackets 5 and right side support 6 and slide glass cover plate assembly thereon, it is arranged on by slot container 1, frame bottom is provided with runners 55, make slide glass 3 and cover plate 2 molectron and by keeping certain distance bottom slot container 1, it is simple to add hydrothermal solution and in bottom circulation and avoid bottom hot-spot phenomenon.
Implementing ground further, the upper ends of slide glass 3 is for adhesive label and bar code or identifies labelling etc.;Appropriately distance should be kept between the multiple U-type groove arranged in left side brackets 5 and right side support 6.
Further, left side brackets 5 and right side support 6 form string and install slot rest, and every string is installed the quantity of U-type groove in slot rest and can be configured as required being 1 ~ 100, and 1-100 can be assigned to open slide glass specimen, and usually 2-50 is individual.
Such as Figure 13, can be arranged as required to, by slot container 1, the installation slot rest that multiple row is parallel, 1 ~ 100 row, usually 1-40 row can be set;Each group (arranging) is installed slot rest and is included left side brackets 5 and right side support 6;Adjacent two rows install left side brackets 5 adjacent in slot rest and right side support 6 also can a permeate part, as long as having both left side brackets 5 and the function of right side support 6.
Further, can arrange water intaking valve and drain valve () at described container bottom, water valve can be manually or electrically valve, for manually or automatically controlling feeding and the discharge opeing of container in figure slightly;The feeding of described container and discharge opeing, it is also possible to carried out by external plug-in type feeding and drainage system.
Such as Fig. 9, Figure 10, implement ground further, can also just optimize cover plate and improve, such as, as a preferred example, described cover plate includes capillary plane 101, depth localization face 102, width locating piece 103, bottom locating piece 104, groove side 106 and channel opening face 107;
The both sides of described capillary plane 101 are provided above two depth localization faces 102, and capillary plane 101 is parallel with depth localization face;Described depth localization face 102 has two, lays respectively at the left and right sides of capillary plane 101;The plane of the described slide glass part near both sides of the edge is fitted with depth localization face 102, makes to be formed between slide surface and capillary plane 101 a capillary gap;On each depth localization face 102, the outer ledge away from capillary plane 101 is provided with more than one described width locating piece 103;Distance between two locating pieces in left and right mates to play position-limiting action with the width of slide glass;Bottom locating piece 104 is arranged on the bottom in depth localization face 102;The bottom of capillary plane 101 is provided with bottom boss 105.
Described channel opening face 107 is connected with capillary plane 101 and forms 1 ~ 175 degree of Plane Angle angle A1;Both sides, channel opening face 107 respectively connect a groove side 106;Described channel opening face 107 and two groove sides 106 and slide glass plane collectively form the loading slot 109 of and described capillary gap area.
Such as Figure 11, Figure 12, this example also includes be positioned at the heater by slot container 1 bottom part down, heater be Contiuum type or separate type structure by slot container 1, such as use disjunctor or separate type heating rod, heating plate, Electromagnetic Heating induction system carries out electromagnetic induction heating or perfusion hot liquid carries out temperature bath and heats.Heating plate 122 is provided with and adds heat pipe () in figure slightly, be arranged in heater canister 123;Add heat pipe to be connected with external power supply, and controlled power and the time of heating in figure slightly by controller ();Add heat produced by heat pipe and pass to heating plate 122.It is made of metal by slot container 1, is operationally placed in heating plate 122, accept the heat of heating plate 122 to heat by the liquid in slot container 1.The top of slot container 1 being provided with upper water inlet 124 and bottom is provided with lower discharge outlet 112, upper water inlet 124 is coaxial with lower discharge outlet 112;Upper water inlet and lower discharge outlet 124 are provided with valve () in figure slightly, can be controlled the opening and closing at the upper and lower mouth of a river 124 by manually or electrically controller () in figure slightly.Heater canister 123 is provided with a spike 111;Heater canister 123 is made up of insulation material, plays the effect of insulation.
Case study on implementation: slide glass cover plate is sized such that depth localization face 2 length 54mm, distance between inside two width locating pieces 3 is 20mm, D1=0.15mm, D2=0.5mm, the a length of 40mm of capillary plane, width are 20mm, and the angle between channel opening face and depth localization face is 30 degree.Length 75mm of slide glass, width 25mm.U-shaped slot tilts 45 degree, spacing 7mm between bracer and short bracer of drawing money on credit, container depth 41mm.Multichannel slide glass is installed slot apparatus and is used tolerance 80oC The material of temperatures above makes (such as Merlon).Experiment shows that slot compact can insert multiple slide glass slide glass to be checked specimen;Cooperation between slide glass and cover plate is compact accurately;Slide glass and cover plate load and unload simple and convenient from slot;Specimen can fully, uniformly heat and be incubated in a reservoir, fundamentally ensure hot repair process reproducibility and reliability, ensure reagent to specimen being completely covered from start to finish, ensure uniformity and repeatability that reagent covers.
The slot of this example can be erect or be obliquely installed, can compact placement multiple slide glass specimen to be checked;Cooperation between slide glass and cover plate is compact accurately;Slide glass and cover plate load and unload simple and convenient from slot;Specimen can carry out heating and being incubated in container, need not during making sample disposal transfer to specimen other heatable container is carried out, be beneficial to simplify manual steps or reorganization automatic flow, and fundamentally ensure hot repair process required during sample disposal reproducibility and reliability, ensure reagent to specimen being completely covered from start to finish, ensure uniformity and repeatability that reagent covers.Container can tolerate higher temperature and possess Contiuum type or separate type heating function, thus need high-temperature to need not when processing will separately process, at sheet cover plate and slide glass, the step that then there is a need to reconfigure during sample disposal, can be implemented in sheet specimen from start to finish to carry out in same device, it is simple to carry out full-automatic operation.
The announcement of book and teaching according to the above description, above-mentioned embodiment can also be changed and revise by this utility model those skilled in the art.Therefore, this utility model is not limited to detailed description of the invention disclosed and described above, should also be as falling in scope of the claims of the present utility model to modifications and changes more of the present utility model.

Claims (10)

1. slot apparatus installed by a multichannel slide glass, it is characterised in that include by slot container (1), cover plate (2), slide glass (3), flat spring (4), left side brackets (5) and right side support (6);
Being mirror image between left side brackets (5) and right side support (6), both collectively form slide glass (3) and the peace slot rest of cover plate (2) molectron, install slot rest and slide glass cover plate assembly is positioned at by slot container (1);Left side brackets (5) includes side plate (54) and the U-type groove in more than one projecting plate face being fixed on side plate (54), more than one U-type groove is arranged along side plate (54) length linear array, and U-type groove is made up of bracer of drawing money on credit (51), short bracer (52) and bottom limited block (53);The length of described bracer of drawing money on credit (51) is longer than short bracer (52), and both sides are parallel;U-type groove is obliquely installed and short bracer (52) is positioned on bracer of drawing money on credit (51), and the angle that U-type groove tilts is 1 ~ 90 degree;
Flat spring (4) includes waveform reed (41) and the location-plate (42) linked into an integrated entity;Waveform reed (41) be positioned at location-plate (42) a side and and location-plate (42) between there is an opening so that flat spring (4) can be enclosed within short bracer (52) of the upper specular of left side brackets (5) and right side support (6);Location-plate (42) is fixed on short bracer (52), produces support force, and waveform reed (41) has the wavy bulge that can produce elastic deformation;
The molectron that slide glass (3) and cover plate (2) coordinate, U-type groove along support is inserted, the waveform reed on surface compacting flat spring (4) of cover plate (2), waveform reed be squeezed generation spring pressure be applied on slide glass (3) and cover plate (2), use slide glass (3) and cover plate (2) between compression.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: install and be provided with runners (55) bottom slot rest so that slide glass (3) and cover plate (2) molectron are kept at a distance with by slot container (1) bottom.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: also include being positioned at the heater by slot container (1) bottom part down, heater be Contiuum type or separate type structure by slot container (1).
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: the waveform reed (41) of flat spring (4) and location-plate (42) use sheet copper, spring steel or other elastomeric material to make;Location-plate (42) is fixed on short bracer (52) by bonding way.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: left side brackets (5) and right side support (6) composition string install slot rest, and each column can assign the slide glass specimen of more than.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 5, it is characterized in that: by the installation slot rest arranging more than string in slot container (1), and adjacent two be wherein parallel to each other install in slot rest, also there is between adjacent left side brackets (5) and right side support (6) more than one described U-type groove structure, between the most adjacent left side brackets (5) and right side support (6), also form described installation slot rest.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: multichannel slide glass is installed slot apparatus and is used tolerance 80oThe material of C temperatures above is made.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: multichannel slide glass installs slot apparatus employing disjunctor or separate type heating rod, heating plate, EM induction system carries out electromagnetic induction heating or perfusion hot liquid carries out temperature bath heating.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: water intaking valve and outlet valve are set by slot container (1) bottom, for the feeding manually or automatically controlled to slot container and discharge opeing;Or the described feeding by slot container (1) and discharge opeing can also be by external plug-in type feeding and drainage systems.
Slot apparatus installed by a kind of multichannel slide glass the most according to claim 1, it is characterised in that: the both sides of described capillary plane are provided above two depth localization faces, and capillary plane is parallel with depth localization face;Described depth localization face has two, lays respectively at the left and right sides of capillary plane;The plane of the described slide glass part near both sides of the edge is fitted with depth localization face, makes to be formed between slide surface and capillary plane a capillary gap;On each depth localization face, the outer ledge away from capillary plane is provided with more than one described width locating piece;Distance between two locating pieces in left and right mates to play position-limiting action with the width of slide glass;Bottom locating piece is arranged on the bottom in depth localization face;Described channel opening face is connected with capillary plane and forms 1 ~ 175 degree of plane angle (A1);Both sides, channel opening face respectively connect a groove side;Described channel opening face and two groove sides and slide glass plane collectively form the loading slot of and described capillary gap area.
CN201620216662.7U 2016-03-21 2016-03-21 Slot apparatus installed by a kind of multichannel slide glass Withdrawn - After Issue CN205719679U (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN205719679U true CN205719679U (en) 2016-11-23

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105699147A (en) * 2016-03-21 2016-06-22 广州深达生物制品技术有限公司 Multichannel slide glass mounting slot device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105699147A (en) * 2016-03-21 2016-06-22 广州深达生物制品技术有限公司 Multichannel slide glass mounting slot device
CN105699147B (en) * 2016-03-21 2019-04-12 厦门通灵生物医药科技有限公司 A kind of multichannel slide glass installation slot apparatus

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Effective date of registration: 20181227

Address after: 361028 Floor 3 and 4 of Building B10, Xiamen Biomedical Industrial Park, 2068 Wengjiao West Road, Haicang District, Xiamen City, Fujian Province

Patentee after: Xiamen Tongling biological medicine technology Co., Ltd.

Address before: 511458 North 502 Software Building of Nansha Information Technology Park, Nansha Development Zone, Guangzhou City, Guangdong Province

Patentee before: ASCEND BIOTECHNOLOGY CO., LTD.

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Granted publication date: 20161123

Effective date of abandoning: 20190412