CN108051270A - For the discharger of micro slide reaction solution - Google Patents
For the discharger of micro slide reaction solution Download PDFInfo
- Publication number
- CN108051270A CN108051270A CN201711479780.2A CN201711479780A CN108051270A CN 108051270 A CN108051270 A CN 108051270A CN 201711479780 A CN201711479780 A CN 201711479780A CN 108051270 A CN108051270 A CN 108051270A
- Authority
- CN
- China
- Prior art keywords
- drain
- micro slide
- reaction solution
- outside portion
- contact site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012530 fluid Substances 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000012295 chemical reaction liquid Substances 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000007792 addition Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Abstract
The present invention relates to a kind of dischargers for micro slide reaction solution, its structure includes drainage region, the drainage region includes two drain side walls and the leakage fluid dram limited by drain side wall, plane intersects with plane where micro slide where the drain side wall, protrusion is equipped with contact outside portion on the drain side wall, drain mesospore is additionally provided between two drain side walls, protrusion is equipped with intermediate contact site on the drain mesospore, the height of projection of the intermediate contact site is more than contact outside portion, and the height of projection in the intermediate contact site and contact outside portion is respectively less than the thickness of micro slide；When drainage region and micro slide coordinate, the contact outside portion and intermediate contact site are in contact simultaneously with micro slide one side.The present invention can avoid the discharger of reaction liquid from polluting other structures in discharge process.
Description
Technical field
The present invention relates to a kind of liquid discharge devices, particularly a kind of discharger for micro slide reaction solution.
Background technology
In Bioexperiment, sample is handled by early period, then by by a series of dyeing and remaining processing, makes experimenter can be with
The clear situation for observing sample.Common processing includes the series of steps such as pretreatment and dyeing, and people is used under regular situation
Work operates, and sample tissue is placed on micro slide, and by dewaxing, repairing, dyeing and being dehydrated, above-mentioned steps need to be by cover plate
Carry out filling operation is removed from micro slide, again covers cover plate after operation.This process takes longer, and needs personal monitoring,
Therefore occur can apply to automation means progress tissue treatment, need to carry out the discharge of reaction solution in automation process, into
And generate the discharger dedicated for this kind of automatic biological experiment.
A kind of existing discharger for micro slide reaction solution, should by setting protrusion on leakage fluid dram two side
One of protrusion act as positioning micro slide, another effect is to play attraction and drainage effect by the protrusion, makes reaction solution
Leakage fluid dram is flowed into along side wall, but the discharger has the following problems：When reaction solution and projection contacts, which can not
The side wall of side wall or separate leakage fluid dram that reaction solution is flowed to leakage fluid dram is controlled well, therefore partial reaction liquid is easily from row
Go out outflow on the outside of device, other structures can be polluted, if things go on like this, instrument can be damaged.
The content of the invention
The technical problems to be solved by the invention be to provide one kind in discharge process, can avoid reaction liquid from polluting other
The discharger of structure.
Technical solution is used by the present invention solves above-mentioned technical problem：
A kind of discharger for micro slide reaction solution, structure include drainage region, and the drainage region includes two rows
Liquid side wall and the leakage fluid dram limited by drain side wall, plane intersects with plane where micro slide where the drain side wall, described
Protrusion is equipped with contact outside portion on drain side wall, is additionally provided with drain mesospore between two drain side walls, the drain mesospore is convex
It rises and is equipped with intermediate contact site, the height of projection of the intermediate contact site is more than contact outside portion, and the intermediate contact site and outer
The height of projection of side joint contact portion is respectively less than the thickness of micro slide；When drainage region and micro slide coordinate, the contact outside portion and
Intermediate contact site is in contact simultaneously with micro slide one side.It, can be to centre when surface where liquid overflows micro slide due to tension
It concentrates, and intermediate contact site understands first contact liq and plays drainage effect since height of projection is higher, and flowed through in liquid
After have trace, very strong attraction is so just generated to liquid next time, like that just can further centre concentrate liquid simultaneously
The possibility that liquid is contacted with contact outside portion is reduced, liquid is avoided to pollute other structures.
Preferably, the contact outside portion is apart from 0.4~0.8mm of micro slide upper surface, the intermediate contact site distance
0.2~0.6mm of micro slide upper surface.According to the rate behavior that liquid tension and gravity characteristic association reaction liquid add in, it is above-mentioned away from
Ensure that liquid is not flowed out from the outside of leakage fluid dram from scope, also can guarantee that more than 95% reaction liquid energy is contacted by centre
It discharges in portion.
Further, drain antetheca and drain rear wall are further included, the leakage fluid dram is by drain side wall, drain antetheca and drain
Rear wall limits, and the contact outside portion is located off the position of drain antetheca and drain rear wall.By set drain antetheca and
Drain rear wall, when preventing reaction solution along side wall or mesospore discharge, from both ends, outflow leakage fluid dram pollutes other structures, and outer side joint
Contact portion, which leaves front and rear wall, prevents liquid outflow leakage fluid dram pollution other structures on the outside of front and rear wall.
Further, drain mesospore setting equidirectional with drain side wall and connected drainage antetheca and drain rear wall, institute
State the position that intermediate contact site is located off drain antetheca and drain rear wall.Drain mesospore and the equidirectional setting energy of drain side wall
It is enough to carry out drain using the space of leakage fluid dram as far as possible, and centre contact site is located off front and rear wall and prevents liquid from front and rear
Outflow leakage fluid dram pollution other structures on the outside of wall.
Preferably, the contact outside portion and intermediate contact site rear are connected with arc-shaped notch.When fluid flow is excessive
When, reaction solution may cross contact site, and the arc-shaped notch connected by rear can smoothly discharge the partial reaction liquid.
Preferably, contact outside portion and the one side close fit of intermediate contact site and micro slide.Contact site and micro slide
Fitting, it is possible to reduce reaction solution flows into the possibility of micro slide bottom along the gap between micro slide and contact site, prevents from polluting it
His structure.
Further, heating zone is further included, the heating zone is connected to the front end of drainage region, the heating zone and drainage region
Between be provided with every liquid bath.The drain plot structure can be engaged with heating zone, and the row of inflow can be prevented every liquid bath by setting
Wall of the reaction solution of liquid mouth along drainage region flows into heating zone, prevents pollution other structures.
Preferably, the heating zone one side is provided with locator.Discharge is stablized in the setting of locator during the reaction
Device avoids the reaction solution generated due to offset from leaking situation.
The present invention compared with the existing technology has the following advantages and effect：This discharger can be such that reaction solution concentrates from row
Discharge among liquid mouth, so as to which reaction solution be avoided to be flowed outwardly from leakage fluid dram part, drain antetheca, drain rear wall, drain mesospore, arc
The setting of shape recess and the position of contact point further reduce the possibility of reaction solution outflow；The cooperation of contact point and micro slide
Relation, every the setting of liquid bath and locator avoid reaction solution flowed out between micro slide and contact point pollution other structures can
It can property.
Description of the drawings
It in order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without having to pay creative labor, may be used also
To obtain other attached drawings according to these attached drawings.
Fig. 1 is the structural diagram of the present invention.
Fig. 2 is the structure diagram when present invention coordinates with micro slide.
Fig. 3 is the lateral plan when present invention coordinates with micro slide.
Fig. 4 is the sectional view in A-A faces in Fig. 3.
Label declaration：
1 drain side wall of drainage region, 11 contact outside portion 111
12 drain rear wall of drain antetheca, 13 drain mesospore 14
Intermediate 141 arc-shaped notch of contact site, 15 leakage fluid dram 16
2 locator 21 of heating zone is every liquid bath 3
Micro slide 4
Specific embodiment
With reference to embodiment, the present invention is described in further detail, following embodiment be explanation of the invention and
The invention is not limited in following embodiments.
Embodiment 1：
As shown in Figure 1, the present embodiment is made of drainage region 1 and heating zone 2, heating zone 2 is connected to the front end of drainage region 1,
It is provided between the two and concave downwards flows to heating zone 2, the one side of heating zone 2 from drainage region 1 every liquid bath 3 for obstructing reaction solution
It sets there are two locator 21, locator 21 is used to this discharger being located in reaction unit (not shown).Drain
1 surrounding of area, which is surrounded, two drain side walls 11, drain antetheca 12 and drain rear wall 13, and leakage fluid dram 16, row are formed between above-mentioned side wall
The middle part that liquid mesospore 14 is arranged on leakage fluid dram 16 is connected with drain antetheca 12 and drain rear wall 13, and parallel to drain side wall 11；
Protrusion is provided with contact outside portion 111 on drain side wall 11, and protrusion is provided with intermediate contact site 141 on drain mesospore 14, contact
Portion is arranged on apart from the position of the about 1mm of drain antetheca 12.As shown in Fig. 2 to 3, when micro slide 4 is with originally going out device cooperation, loading
The main body of piece 4 is placed on heating zone 2, and one end is erected at the drain side wall 11 before drain antetheca 12 and contact site and drain mesospore
On 14, and with contact outside portion 111 and intermediate 141 snug fit of contact site, contact outside portion 111 and intermediate contact site 141
Rear is connected with arc-shaped notch 15.As shown in figure 4, the height of projection of contact outside portion 111 and intermediate contact site 141 is respectively less than and carries
The thickness of object piece 4, so as to which when reaction solution is after being paved with and overflowing on micro slide 4, reaction liquid energy contacts first with contact site to be played
Be introduced into the effect of the discharge of leakage fluid dram 16, wherein among 141 height of contact site than 111 high 0.2mm of contact outside portion, in indirectly
Contact portion 141 away from micro slide upper surface 0.6mm, contact outside portion 111 apart from micro slide upper surface 0.8mm, at this time about 95% it is anti-
Liquid energy is answered to be discharged along drain mesospore 14 from leakage fluid dram 16.
Embodiment 2
The present embodiment is substantially the same manner as Example 1, and difference lies in intermediate contact sites 141 away from micro slide upper surface 0.4mm, outside
Side joint contact portion 111 is apart from micro slide upper surface 0.7mm, and the reaction liquid energy more than 95% is along drain mesospore 14 from leakage fluid dram 16 at this time
Discharge, and add in rate quickening even if reaction solution and also can smoothly be discharged from leakage fluid dram 16.
Embodiment 3
The present embodiment is substantially the same manner as Example 1, and difference lies in intermediate contact sites 141 away from micro slide upper surface 0.2mm, outside
Side joint contact portion 111 is apart from micro slide upper surface 0.4mm, and about 95% reaction liquid energy is along drain mesospore 14 from 16 row of leakage fluid dram at this time
Go out.
Embodiment 4
The present embodiment is substantially the same manner as Example 1, difference lies in the two drain side walls 11 of connection of drain mesospore 14, and parallel to
Drain antetheca 12 and drain rear wall 13, intermediate contact site 141 are arranged on the middle part of drain mesospore 14, and it is recessed that both sides are equipped with arc
Mouthfuls 15, arcuately recess 15 and drain mesospore 14 are discharged from leakage fluid dram 16 after contact site 141 among reaction solution contact.
Embodiment 5
The present embodiment is substantially the same manner as Example 1, and difference lies in be not provided with drain antetheca 12 and drain rear wall 13, drain side
Wall 11 and drain mesospore 14 are directly connected to every liquid bath 3, and the length of drain side wall 11 and drain mesospore 14 (can also be more than for 5mm
5mm), contact site is arranged on the middle part of drain side wall 11 and drain mesospore 14.
Furthermore, it is necessary to illustrate, the specific embodiment described in this specification, the shape of parts and components is named
Title etc. can be different.The equivalent or simple change that all construction, feature and principles according to described in inventional idea of the present invention are done, is wrapped
It includes in the protection domain of patent of the present invention.Those skilled in the art can be to described specific implementation
Example is done various modifications or additions or is substituted in a similar way, without departing from structure of the invention or surmounts this
Scope as defined in the claims, is within the scope of protection of the invention.
Claims (8)
1. a kind of discharger for micro slide reaction solution, it is characterised in that：Including drainage region, the drainage region includes two
Drain side wall and the leakage fluid dram limited by drain side wall, plane intersects with plane where micro slide where the drain side wall, institute
It states on drain side wall protrusion and is equipped with contact outside portion, be additionally provided with drain mesospore between two drain side walls, on the drain mesospore
Protrusion is equipped with intermediate contact site, and the height of projection of the intermediate contact site is more than contact outside portion, and the intermediate contact site and
The height of projection in contact outside portion is respectively less than the thickness of micro slide；When drainage region and micro slide coordinate, the contact outside portion
It is in contact simultaneously with micro slide one side with intermediate contact site.
2. the discharger according to claim 1 for micro slide reaction solution, it is characterised in that：The contact outside portion
Apart from 0.4~0.8mm of micro slide upper surface, the intermediate contact site is apart from 0.2~0.6mm of micro slide upper surface.
3. the discharger according to claim 1 or 2 for micro slide reaction solution, it is characterised in that：Further include drain
Antetheca and drain rear wall, the leakage fluid dram are limited by drain side wall, drain antetheca and drain rear wall, and the contact outside portion is set
Leaving the position of drain antetheca and drain rear wall.
4. the discharger according to claim 3 for micro slide reaction solution, it is characterised in that：The drain mesospore with
Drain side wall it is equidirectional set and connected drainage antetheca and drain rear wall, the intermediate contact site be located off drain antetheca and
The position of drain rear wall.
5. the discharger according to claim 4 for micro slide reaction solution, it is characterised in that：The contact outside portion
Arc-shaped notch is connected with intermediate contact site rear.
6. the discharger according to claim 1 or 2 for micro slide reaction solution, it is characterised in that：Contact outside portion
With the one side close fit of intermediate contact site and micro slide.
7. the discharger according to claim 1 or 2 for micro slide reaction solution, it is characterised in that：Further include heating
Area, the heating zone are connected to the front end of drainage region, and the heating zone is provided with drain section every liquid bath.
8. the discharger according to claim 7 for micro slide reaction solution, it is characterised in that：The heating zone one side
It is provided with locator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711479780.2A CN108051270B (en) | 2017-12-29 | 2017-12-29 | Discharge device for slide reaction liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711479780.2A CN108051270B (en) | 2017-12-29 | 2017-12-29 | Discharge device for slide reaction liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108051270A true CN108051270A (en) | 2018-05-18 |
| CN108051270B CN108051270B (en) | 2023-12-15 |
Family
ID=62129089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711479780.2A Active CN108051270B (en) | 2017-12-29 | 2017-12-29 | Discharge device for slide reaction liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108051270B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109406247A (en) * | 2018-10-26 | 2019-03-01 | 杭州依美洛克医学科技有限公司 | Discharger for micro slide experiment liquid |
| CN111562164A (en) * | 2020-05-15 | 2020-08-21 | 河南赛诺特生物技术有限公司 | Liquid cover film |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04310841A (en) * | 1991-04-09 | 1992-11-02 | Chiyoda Manufacturing Co Ltd | Staining device and tray for staining |
| JP2003106958A (en) * | 2002-08-08 | 2003-04-09 | Sysmex Corp | Slide glass storing body |
| JP2003145021A (en) * | 2001-11-14 | 2003-05-20 | Hirano Tecseed Co Ltd | Coating apparatus and coating method |
| WO2010074915A2 (en) * | 2008-12-23 | 2010-07-01 | Ventana Medical Systems, Inc. | Evaporation mitigation for slide staining apparatus |
| DE102014001481A1 (en) * | 2013-10-28 | 2015-04-30 | Euroimmun Medizinische Labordiagnostika Ag | Improved apparatus and method for reactions between a solid and a liquid phase |
| CN204536645U (en) * | 2015-05-08 | 2015-08-05 | 刘翠云 | A kind of Novel glass slide |
| CN106153436A (en) * | 2016-08-31 | 2016-11-23 | 广州深达生物制品技术有限公司 | A kind of annealing device of slide glass Samples detection |
| CN205761264U (en) * | 2016-06-28 | 2016-12-07 | 岳磊 | Glass slide for clinical examination storage device |
| CN207675512U (en) * | 2017-12-29 | 2018-07-31 | 杭州依美洛克医学科技有限公司 | A kind of discharger for micro slide reaction solution |
-
2017
- 2017-12-29 CN CN201711479780.2A patent/CN108051270B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04310841A (en) * | 1991-04-09 | 1992-11-02 | Chiyoda Manufacturing Co Ltd | Staining device and tray for staining |
| JP2003145021A (en) * | 2001-11-14 | 2003-05-20 | Hirano Tecseed Co Ltd | Coating apparatus and coating method |
| JP2003106958A (en) * | 2002-08-08 | 2003-04-09 | Sysmex Corp | Slide glass storing body |
| WO2010074915A2 (en) * | 2008-12-23 | 2010-07-01 | Ventana Medical Systems, Inc. | Evaporation mitigation for slide staining apparatus |
| DE102014001481A1 (en) * | 2013-10-28 | 2015-04-30 | Euroimmun Medizinische Labordiagnostika Ag | Improved apparatus and method for reactions between a solid and a liquid phase |
| CN204536645U (en) * | 2015-05-08 | 2015-08-05 | 刘翠云 | A kind of Novel glass slide |
| CN205761264U (en) * | 2016-06-28 | 2016-12-07 | 岳磊 | Glass slide for clinical examination storage device |
| CN106153436A (en) * | 2016-08-31 | 2016-11-23 | 广州深达生物制品技术有限公司 | A kind of annealing device of slide glass Samples detection |
| CN207675512U (en) * | 2017-12-29 | 2018-07-31 | 杭州依美洛克医学科技有限公司 | A kind of discharger for micro slide reaction solution |
Non-Patent Citations (1)
| Title |
|---|
| 杨鸿剑: "低毛管力助排液研究", 新疆石油学院学报, vol. 7, no. 1, pages 60 - 68 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109406247A (en) * | 2018-10-26 | 2019-03-01 | 杭州依美洛克医学科技有限公司 | Discharger for micro slide experiment liquid |
| CN111562164A (en) * | 2020-05-15 | 2020-08-21 | 河南赛诺特生物技术有限公司 | Liquid cover film |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108051270B (en) | 2023-12-15 |
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