CN106109541A - A kind of health product improving immunity of organisms, resisting fatigue - Google Patents
A kind of health product improving immunity of organisms, resisting fatigue Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of health product improving immunity of organisms, resisting fatigue, it is made up of the raw material of following weight portion: 150 250 parts of peacilomyce hepiahi bacterium powder, Radix Panacis Quinquefolii 200 300 parts, Herba Epimedii 500 600 parts, Herb Gynostemmae Pentaphylli 500 700 parts.These health product are with peacilomyce hepiahi bacterium powder, Radix Panacis Quinquefolii, Herba Epimedii, Herb Gynostemmae Pentaphylli as crude drug, add the preparation that pharmaceutically acceptable adjuvant is conventionally prepared from.By the synergistic function that each raw material is mutual, to improve resistance against diseases, to strengthen immune effect, alleviating physical fatigue, there is the feature of instant, safety and Health, stable curative effect.
Description
Technical field
The present invention relates to a kind of health product, a kind of health product improving immunity of organisms, resisting fatigue.
Background technology
Immunity is the defense mechanism of human body self, is human bioequivalence and elimination exotic invasive foreign body, processes old and feeble, damage
Wound, dead, the own cells of degeneration and identification and process vivo mutations cell and the ability of virus infected cell.Modern immunity
Think, immunity is human bioequivalence and the physiological reaction getting rid of " dissident ".Hypoimmunity then immune system can not normally be sent out
Waving protective effect, in the case, easily infected by antibacterial, virus, fungus etc., therefore hypoimmunity just the most directly shows
It is liable to illness.Frequent sick meeting increases the weight of the consumption of body, thus typically have a delicate constitution, malnutrition, lethargy, tired
Unable, appetite reduction, sleep disorder etc., disease Chang Fanfu such as flu, tonsillitis, asthma, bronchitis, pneumonia, diarrhoea is sent out
Making, each persistent period is long, and teenager body development if things go on like this can be caused bad, and adult the most easily induces major disease.
Tired (fatigue) is the physiological acoustic signals process of a kind of complexity of body.Physical fatigue be due to motion or
Physical work and cause organism physiology process can not by its function continue can not maintain it at each organ of a specified level or body
The phenomenon of original function level.Its generation is reminded worker should lower working strength or terminates motion in order to avoid body injury.?
When carrying out over loading physical exertion, muscle group persistently or exceedingly shrinks, the energy substance in a large amount of consumer of meeting, produces breast
The metabolites (medically known as ponogen) such as acid, carbon dioxide, water, the acidity in blood also can increase.When these metabolism are produced
Thing gather a certain amount of after, so that it may affect the telescopic movable of muscle, and stimulate cerebral central nervous system, make people produce tired nothing
The uncomfortable sensations such as power, irritated unhappy, sleepy, muscular soreness, anorexia, work lose interest, health tires out to make people feel, muscle power is tired
Labor the most just creates.Physical fatigue is a complicated physiological process, in terms of subjective feeling when physical fatigue athlete
Generally there is limbs fatigue, pale complexion, muscular soreness, pole thinks stop motion, and groups of people are nervous with xerostomia, out of breath, uncomfortable in chest
Sensory symptoms with collapse.Physiology, biochemical indicator aspect: vital capacity declines, steady ability declines, and stand up time shortens, saliva
PH value declines, and visual performance declines, and flicker fusion frequency reduces.
After human society enters 21 century, development speed is advanced by leaps and bounds, and the prosperity of material progress is unprecedented.People exist
While enjoying abundant material life, also subject the heaviest pressure.The Asia such as hypoimmunity, fatigue in recent years
Healthy incidence rate is in the trend constantly risen, and is prevalent in the crowd of all age group, its impact on human health
By global extensive concern, the formidable enemy of 2l century human health will be become.Although subhealth state is not a kind of clear and definite device matter
Property disease, but be the unsound performance of modern's body and mind after all, it is the omen of organic disease, reflects machine to a certain extent
Some of body are abnormal.Subhealth state has become and has a strong impact on human health, causes one of pathogenetic key factor of disease.For prevent in
Possible trouble, World Health Organization (WHO) propose to carry out " preventative health policy ", sub-health state is carried out keypoint control, prevent,
Eliminate subhealth state and be set to the preventative health policy that an emphasis in 2l century is implemented, and then improve the health level of the whole mankind.
At present, the product market of China's enhancing immunity and alleviating physical fatigue, based on medicine, hormone, accounts for whole market share
60%；Health food is auxiliary, accounts for 35%, and other account for 15%.Although medicine effect is more apparent, but the drug resistance that long-term prescription causes
Property, Drug resistance, lesions of liver and kidney etc. may to consumer produce infringement.Additionally, due to medicine to be taken under the guidance of doctor, and
Health food is the most different, and it not only has the health care of enhancing immunity and alleviating physical fatigue, and secondary to human non-toxic
Effect, can take according to being actually needed of oneself.Therefore, occur that much there is enhancing immunity, alleviation on market in recent years
The health product of physical fatigue, but health-care effect is uneven.
Summary of the invention
For problems of the prior art, the invention provides a kind of health care improving immunity of organisms, resisting fatigue
Product.These health product are with peacilomyce hepiahi bacterium powder, Radix Panacis Quinquefolii, Herba Epimedii, Herb Gynostemmae Pentaphylli as crude drug, add pharmaceutically acceptable
The preparation that is conventionally prepared from of adjuvant.By the synergistic function that each raw material is mutual, with improve resistance against diseases,
Strengthen immune effect, alleviating physical fatigue, there is the feature of instant, safety and Health, stable curative effect.
The present invention is by the following technical solutions:
A kind of health product improving immunity of organisms, resisting fatigue, it is characterised in that it is by the raw material system of following weight portion
Become: peacilomyce hepiahi bacterium powder 150-250 part, Radix Panacis Quinquefolii 200-300 part, Herba Epimedii 500-600 part, Herb Gynostemmae Pentaphylli 500-700 part.
Preferably, described raising immunity of organisms, the health product of resisting fatigue, it is characterised in that it is by following weight
The raw material of part is made: 200 parts of peacilomyce hepiahi bacterium powder, Radix Panacis Quinquefolii 250 parts, Herba Epimedii 550 parts, Herb Gynostemmae Pentaphylli 600 parts.
Preferably, described raising immunity of organisms, the health product of resisting fatigue, it is characterised in that with peacilomyce hepiahi
Mycopowder, Radix Panacis Quinquefolii, Herba Epimedii, Herb Gynostemmae Pentaphylli are crude drug, add pharmaceutically acceptable adjuvant and are conventionally prepared from
Preparation.
Preferably, described raising immunity of organisms, the health product of resisting fatigue, it is characterised in that described each raw material is according to quantity
After weighing, conventionally it is prepared as capsule, tablet, granule or pill.
Hypoimmunity and physical fatigue are all relevant with the traditional Chinese medical science " deficient syndrome ", i.e. " weakened body resistance, " " asthenia ".Prophylactic treatment is then to hold up
The most eliminating evil, it is main that qi-restoratives consolidates.So-called " righting ", includes benefit and defends gas, invigorating primordial QI, and nourish blood gas, it is simply that transfer the disease-resistant of body
Power, improves the immunologic function of body, strengthens its stability, improve its immunocompetence.So-called eliminating evil, just include " scattered ailment said due to cold or exposure of dispelling,
Heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis, expelling phlegm and vanishing turbid pathogen, hard masses softening and resolving " etc. the concrete rule for the treatment of, there is suppression immunoreation and regulation immunologic balance
Effect, thus reach improve body resistance against diseases purpose.Strengthening the body resistance is the traditional Chinese medical science in order to help person healthy energy, and it is basic to consolidate
Therapeutic rules, use strengthening the body resistance method, to recover healthy energy, promote visceral-qi regeneration capacity, it is ensured that physical ability rehabilitation is most important.
Kidney, spleen, lung be the person three, lung is all the dominator of QI, the light of healthy energy, and whole body qi-blood circulating is rely and exhaled the old and inhale the new with provisions, outward
Heresy is invaded, and the immunity relied, with anti-heresy, if lung qi wound, is then controlled joint and had no right, and the precise and tiny defeated cloth of QI and blood is not enough, then spleen kidney declines therewith, all
Diease occurrence here.The kidney being the origin of congenital constitution, store essential substances, main water, main fire from the gater of life, function, the residence nephroyin and nephroyang such as main bone, raw marrow, logical brain, makes a living
The origin of life, kidney essense kidney qi, also known as " vigour ".Vigour can not only promote that growth in humans grows, and has strong body, diseases prevention
Disease-resistant function.Kidney essense fills Sheng, and vigour is sufficient, then body is healthy, and immunity is strong with anti-fatigue ability；Asthenia of essence and blood, vigour is lost
Void, the then decline of body function, immunity declines with anti-fatigue ability.Kidney is that immunity is former with what muscle power produced as can be seen here
Power, the kidney invigorating is to strengthen immunity, the key of alleviating physical fatigue.The spleen and stomach provide the material basis of the acquired, and The spleen has the function to transport and transform nutrients, for QI and blood biochemistry
Source, temper fills that to contain then muscle building strong, and i.e. so-called " the spleen controlling the muscles of whole body " (" a Plain Questions flaccidity opinion piece the 44th "), the splenopathy is then
" QI and blood to decline, blockage of vessel, muscles and bones muscle all depletion of QI are with life ", weak and need not, " evil at taste, then sick myalgia ".For
Spleen and tired relation, " Treatise on the spleen and stomach " carry: " the body forced labour then splenopathy ", Jing-Yue Complete Works is also said: " hindering in outward of taste
Person, only overstrain can the impairment of the spleen ".Taste are strong to be transported, and the vital organs of the human body, extremity bones of the body collectively can be nourished, and the whole body energy is supplemented.Cause
This, do not forget strengthening the spleen and stomach while the kidney invigorating.Paying attention to invigorating spleen and kidney, the foundation of acquired constitution is unbeaten, then can promote the recovery that each internal organs are deficient.
How sick three have wound, the most just declining weak and, and three are perfected, and the most prosperous body is strong and sick few.
This formula is based on the principle of " strengthening vital QI to eliminate pathogenic factors, qi-restoratives consolidates ", starts with from " the kidney invigorating lung benefiting ", is formed with the kidney invigorating benefit
Lung, boosting qi and nourishing yin are main, hold concurrently with heat clearing away, the therapy promoting the production of body fluid, calm the nerves.In formula, peacilomyce hepiahi bacterium powder is that Cordyceps mycelium is sent out
Ferment product, nourishing lung and kidney, secret lean gas, for deficiency of both the lung and kidney, vital essence is not enough, chronic cough dyspnea due to deficiency, spiritlessness and weakness, insomnia and amnesia, waist
Knee joint is soft, menoxenia, impotence and premature ejaculation, and chronic bronchitis, chronic renal insufficiency, hyperlipemia, liver cirrhosis are shown in above-mentioned card
Hou Zhe etc., for monarch drug in side.Radix Panacis Quinquefolii sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, for gas
Empty yin deficiency, deficiency-heat is tired of tired, and interior-heat is quenched one's thirst, dryness of the mouth and throat etc., for ministerial drug in side.The monarch and his subjects share, both the kidney invigorating lung benefiting, and QI invigorating is supported again
The moon, reach mend and the driest.Lung kidney is with mending, and kidney essense fills Sheng, and lung qi fills, and vigour is sufficient, the most energetic.Herba Epimedii acrid in the mouth, property
Sweet, temperature, return liver, kidney channel, kidney-replenishing, bone and muscle strengthening, for kidney yang deficiency, impotence and seminal emission etc..Herb Gynostemmae Pentaphylli bitter in the mouth, micro-sweet, cold in nature, return
Lung, spleen, kidney channel, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, supplementing QI and nourishing YIN, slow down aging, vexed for chest and diaphragm painful abdominal mass, stagnation of phlegm blood stasis, cardiopalmus gas
Short, dizziness and headache, forgetful tinnitus, unconsciously sweat and tire, old cough etc..Side applies Herba Epimedii principal drug assistance with kidney-replenishing, use strand
Indigo plant helps Radix Panacis Quinquefolii supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid, altogether for adjuvant drug in side.Above four tastes share, kidney-replenishing, lung benefiting gas, born fluid, strong
Muscles and bones plays the merit of the kidney invigorating lung benefiting, boosting qi and nourishing yin altogether, reaches immunity and strengthens and the significant effect of anti-fatigue effect.
The invention has the beneficial effects as follows: first, in formula for a product of the present invention, Radix Panacis Quinquefolii, Herba Epimedii, Herb Gynostemmae Pentaphylli are natural planting
Thing, peacilomyce hepiahi bacterium powder is Cordyceps, and each raw material makes any one dosage form on pharmaceutics through modern crafts, by recommended dose
Edible, have no side effect.Proving through acute toxicity test, this product belongs to nontoxic level simultaneously；Genetic toxicity test (bone marrow cells in mice
Micronucleus test, mouse inbred strain, Salmonella reversion test) three results are showed no mutagenic action, nutrition purposes, especially for feeding animals growth in 30 days
Grow normal, poisoning symptom and death do not occur.Secondly, raw materials used effect with mutual Synergistic of this product, can show
Write improve body resistance against diseases, strengthen immune effect, alleviating physical fatigue, there is instant, safety and Health, be easy to carry and
Long-term taking, the feature of stable curative effect, its immunity improves effect and is significantly higher than the effect of any one-component, is highly suitable for existing
It is eaten for a long time for vast sub-health population.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
A kind of health product improving immunity of organisms, resisting fatigue, it is made up of the raw material of following weight portion: Hepialus armorieanus Oberthur is intended
Penicillium sp mycopowder 150 parts, Radix Panacis Quinquefolii 200 parts, Herba Epimedii 500 parts, Herb Gynostemmae Pentaphylli 500 parts.
Above-mentioned raw materials is added customary adjuvant conventional method according to conventional dose method and is prepared as tablet, 0.4g/ sheet.
Embodiment 2
A kind of health product improving immunity of organisms, resisting fatigue, it is made up of the raw material of following weight portion: Hepialus armorieanus Oberthur is intended
Penicillium sp mycopowder 250 parts, Radix Panacis Quinquefolii 300 parts, Herba Epimedii 600 parts, Herb Gynostemmae Pentaphylli 700 parts.
Above-mentioned raw materials is added customary adjuvant conventional method according to conventional dose method and is prepared as capsule, 0.4g/
Grain.
Embodiment 3
A kind of health product improving immunity of organisms, resisting fatigue, it is made up of the raw material of following weight portion: Hepialus armorieanus Oberthur is intended
Penicillium sp mycopowder 200 parts, Radix Panacis Quinquefolii 250 parts, Herba Epimedii 550 parts, Herb Gynostemmae Pentaphylli 600 parts.
Above-mentioned raw materials is added customary adjuvant conventional method according to conventional dose method and is prepared as granule, 0.5g/
Bag.
Embodiment 4
A kind of health product improving immunity of organisms, resisting fatigue, it is made up of the raw material of following weight portion: Hepialus armorieanus Oberthur is intended
Penicillium sp mycopowder 200 parts, Radix Panacis Quinquefolii 260 parts, Herba Epimedii 580 parts, Herb Gynostemmae Pentaphylli 550 parts.
Above-mentioned raw materials is added customary adjuvant conventional method according to conventional dose method and is prepared as pill, 0.4g/ ball.
Immunologic function of the present invention is tested
Impact on Phagocytosis By The Peritoneal Macrophages In Mice
Taking mice 90, body weight, at 20-25g, is uniformly divided into 9 groups at random, test group 1-8 group, matched group the 9th group, test
The health product that above-described embodiment 1-4 prepares are mixed in normal diet by group 1-4 respectively, three times a day, and a 20mg；5th, 6,7,8
Organizing difference feeding and test group bat Paecilomyces varioti mycopowder, Radix Panacis Quinquefolii, Herba Epimedii and the Herb Gynostemmae Pentaphylli with dosage, feeding method is with test
Group；Matched group the 9th group mixes the starch of same dosage in normal diet, every day feeding 3 times, continuous 7 days.It is administered in last 1 time
Rear 1h, every mouse peritoneal injects 5% chicken red blood cell suspension 0.4ml, and after to chicken red blood cell, 4h puts to death mice, by tradition poison
Chicken red blood cell method in pharmacologic test surveys Phagocytosis By The Peritoneal Macrophages In Mice.Result of the test is shown in Table 1.
The table 1 impact on normal Phagocytosis By The Peritoneal Macrophages In Mice
The impact that normal mouse hemolysin is formed
Mouse species number, be grouped, be administered all the same, in being administered the 1st day, every Mus lumbar injection 5% chicken red blood cell physiology salt
Aqueous suspension 0.2ml carries out immunity, and after last after medicine 2h, mouse orbit takes blood, examines by serum hemolysin spectrophotometric
Survey method surveys hemolysin formational situation.
The impact that normal mouse hemolysis plaque is formed
Mouse species number, it is grouped, is administered and immunity is all the same, 2h after last administration, mice is taken off cervical vertebra and puts to death,
Dissect and take out spleen, two mouse spleens are put together and is homogenized, by Traditional pharmacological testing inspection hemolysis plaque by homogenizer
Method detects this test formational situation.
The impact that normal mouse lymphocyte is converted
Mouse species number, be grouped, be administered all the same, in first 3 days be administered, every mice intramuscular injection every day plant blood clotting
Element 8mg/kg, 2h after last administration, mice cuts tail and takes blood, push jack, and Switzerland's dye liquor dyeing, with oil sem observation periphery stranguria with blood
Bar cell transformation rate.Result of the test is shown in Table 2.
The table 2 impact on the conversion of normal mouse hemolysin, hemolysis plaque formation and lymphocyte
The data of contrast Tables 1 and 2, we are it is found that Turnover of Mouse Peritoneal Macrophages is swallowed by the health product of the present invention
Function, mice hemolysin, hemolysis plaque are formed and the conversion aspect of lymphocyte is respectively provided with preferable immune effect, and will compare
Single composition of raw materials has more preferable immunologic function；By tested group of 1-8 group respectively compared with matched group it is found that for drench
Bar cell transformation rate amplification aspect, the effect of product of the present invention will apparently higher than the summation of single raw material effect, this mainly by
Synergism between reasonable raw material proportioning of the present invention, each raw material, significantly improves the immunocompetence of body, alleviating physical fatigue.
Anti-fatigue effect is tested
This experiment is designed with reference to " function of health food assessment process and the method for inspection ".
Experiment material
Laboratory animal: three monthly age kunming mices 80 (purchased from Hebei Medical University's biotic experiment center), body weight 18-22g.
Laboratory sample: the sample that embodiment 3 prepares.
Dosage choice and sample treatment: experiment sets blank group, matched group 1 (bat Paecilomyces varioti mycopowder), matched group 2
Basic, normal, high three the dosage groups of (Radix Panacis Quinquefolii), matched group 3 (Herba Epimedii), matched group 4 (Herb Gynostemmae Pentaphylli) and experimental group, the most often group is each
10.Each tested group of medicine is prepared as powder, then with the consumption distilled water of every mice 0.2ml every day be equipped to solution to
Mouse stomach, experimental group each mice gavage every day (low dosage: 0.1mg/10g/day, middle dosage: 0.53mg/10g/day, height
Dosage: 5.3mg/10g/day, is respectively equivalent to 2 times of human body recommended amounts, 10 times, 100 times), matched group 1,2,3,4 is adopted respectively
Test with 10 times of human body recommended dose, be carried out continuously 30 days, extend to 45 days if desired.
Key instrument and reagent: swimming trunk (size about 50cm × 50cm × 40cm), electronic balance, sheet lead；Diameter 1cm,
The Glass rod of long 25cm, after sand papering, upper end is fixed on plank and makes pole-climbing frame；Multi-functional microplate reader (synergy
Biotech), centrifuge (Thermo), Lactic acid Kit (100T/48 sample, Nanjing is built up), lactic dehydrogenase enzyme reagent kit (100T/
48 samples, Nanjing is built up), glycogen test kit (100T/48 sample, Nanjing is built up).
Experimental technique: by Loaned swimming test, pole-jump test, blood lactase acid determination experiment, measuring content of lactic dehydrogenase
Test, hepatic glycogen and muscle glycogen measure and carry out assessment of function.
Experimental result:
1, the product of the present invention impact on the mice burden swimming time.
The most direct tired and the most objectively performance is the decline of exercise tolerance, and swimming time is made all the time
For reflecting the important indicator of exercise tolerance.Concrete outcome is as shown in table 3.
Table 3 walking weight load experimental result
From data in table 3, mouse swimming power compared with blank group of gavage high, medium and low dosage group exhausts the time
Having increased, and the basic, normal, high dosage group increase time presents the trend gradually risen, this is from macroscopically embodying the present invention
Health product have good anti-fatigue ability.And compared with blank, compare 1 swimming time amplification less, and compare 2, compare
3, comparison 4 is compared with blank group, and the swimming time of mice has extended, but after extending, swimming time is all not as the present invention 3
The mice swimming time of individual experimental group is long, and the present invention test the swimming time amplification of high dose group than 4 matched groups time
Between the summation of amplification also want big, each component synergism of this explanation present invention, than single any component or appoint several components
Simple combination effect will get well, achieve unforeseeable effect, there is the effect of significant resisting fatigue.
2, the product of the present invention impact on the mice pole-climbing time
The raising of exercise tolerance is that anti-fatigue ability strengthens the strongest macro manifestations, and the length of pole-climbing time can be reacted
Animal quiet firmly time tired degree.Concrete outcome is as shown in table 4.
Table 4 Grasping clubglass test result
As can be seen from Table 4, compared with blank group, basic, normal, high three dosage group pole-climbing times all rise appreciably,
Illustrate that health product of the present invention have good antifatigue effect.Compare 1,2,3,4 groups compared with blank, all have certain anti-tired
Work use, but the product that its resisting fatigue effect does not all have the present invention is good, and this is that the synergism of each component due to the present invention shows
Write.
3, the product of the present invention impact on Mouse Blood lactic acid
Blood lactase acid is an important indicator of evaluation organism fatigue degree, and it is glucolytic product, to glycolysis energy supply
System is very sensitive.Under anaerobic environment, body still using glycogen as energy substance, except that, carbohydrate metabolism mistake now
Journey is anerobic glycolysis, and the energy that anerobic glycolysis not only produces is considerably less, and its product lactic acid is cause organism fatigue sense straight
Connect the factor, so by the lactic acid content of body after motion, we can judge that body is to the picked-up of oxygen and Utilization ability.
Table 5 blood lactase acid measurement result
| Group | Animal number of elements (only) | Blood lactase acid value (mmol/L) after motion |
| Experimental group low dosage | 10 | 4.85±0.3 |
| Dosage in experimental group | 10 | 4.76±0.5 |
| Experimental group high dose | 10 | 4.45±0.3 |
| Blank group | 10 | 5.77±0.36 |
| Matched group 1 | 10 | 5.66±0.9 |
| Matched group 2 | 10 | 5.31±0.8 |
| Matched group 3 | 10 | 5.05±0.8 |
| Matched group 4 | 10 | 5.21±0.4 |
As shown in Table 5, mice blank group blood lactase acid level after exercise is higher, is administered low dosage, middle dosage, high agent
Amount group mice blood lactase acid level compared with matched group significantly reduces, and this shows that the health product of the present invention can be by minimizing campaign
The generation of lactic acid, reaches the effect of delay fatigue.Compare 1,2,3,4 groups of blood lactase acid levels to compare the most with blank group
Reduce, but overall reducing effect is good not as experimental group dose effect of the present invention.
The health product of the present invention are carried out clinical trial applied research
Clinical data: randomly selecting the patient of 300 example hypoimmunities, the maleest 180 examples, female 120 example, age distribution exists
10-75 year, patient take the embodiment of the present invention 3 preparation capsule, three times a day, each 2, after taking continuously one month observe
Clinical effectiveness.
Effective evaluation standard:
Effective: body constitution is remarkably reinforced, extremity are strong, and energy and face have taken a turn for the better, and sleep and the Asia of the aspect such as digestion
Health status is obviously improved；
Taking a turn for the better: body constitution has strengthened, and extremity are more powerful, energetic, face improves, and sleeps and the Asia of the aspect such as digestion is good for
Health state also makes moderate progress；
Invalid: symptom and every inspection have no improvement.
Therapeutic outcome: result shows by clinical observation, the most effective example 275 example, account for 91.7%；Improvement example 24 example, accounts for
8%；Invalid example 1 example, accounts for 0.3%；Total effective rate reaches 99.7%.The patient of all uses health product of the present invention all without any not
Good reaction and malaise symptoms.
Example 1: Lee, man, 17 years old, high school senior, owing to high three learning pressures increase the weight of, just adds body constitution own
Difference, so usually feeling dizzy weak, have a sleepless night in the evening, feels sleepy daytime, attends class and cannot concentrate on, has had a strong impact on his review
Appendix.Taking health product of the present invention after one month, above-mentioned symptom is obviously improved, and can sleep sound in the evening, and daytime also can concentrate essence
God attends class, and then continues to take two months, and above-mentioned symptom is wholly absent, and body constitution has had the biggest improvement than before.
Example 2: Cai so-and-so, female, 25 years old, city white collar, because being busy with one's work, it is often necessary to works extra shifts or extra hours, stay up late all night,
To such an extent as to health occurs in that sub-health state, work always cannot be concentrated on, and slightly does something and just feels tired out, goes to hospital
Check and the most do not find what organic disease.After taking health product two weeks of the present invention, spirit is obviously improved, and sense tired out is
The strongest, after taking January, the recovery of energy can be clearly felt that, continue to take health product of the present invention afterwards and consolidate,
Health obtains the biggest improvement, works energetic.
Example 3: Lin, man, 65 years old, due to the increase at age, every function of health fell into a decline, and body constitution reduces, food
It is intended to the symptoms such as depressed, sleep disorder and annoyings him always.Taking health product of the present invention after one month, appetite substantially increases, sleep
Might as well be a lot, after persistently take health product of the present invention, contrast the old people with age bracket, body constitution significantly improves a lot.
Claims (4)
1. the health product improving immunity of organisms, resisting fatigue, it is characterised in that it is by the raw material system of following weight portion
Become: peacilomyce hepiahi bacterium powder 150-250 part, Radix Panacis Quinquefolii 200-300 part, Herba Epimedii 500-600 part, Herb Gynostemmae Pentaphylli 500-700 part.
Raising immunity of organisms the most according to claim 1, the health product of resisting fatigue, it is characterised in that it is by following
The raw material of weight portion is made: 200 parts of peacilomyce hepiahi bacterium powder, Radix Panacis Quinquefolii 250 parts, Herba Epimedii 550 parts, Herb Gynostemmae Pentaphylli 600 parts.
Raising immunity of organisms the most according to claim 1 and 2, the health product of resisting fatigue, it is characterised in that with Hepialus armorieanus Oberthur
Paecilomyces varioti mycopowder, Radix Panacis Quinquefolii, Herba Epimedii, Herb Gynostemmae Pentaphylli are crude drug, add pharmaceutically acceptable adjuvant and conventionally make
Standby preparation.
Raising immunity of organisms the most according to claim 3, the health product of resisting fatigue, it is characterised in that described each raw material
After weighing according to quantity, conventionally it is prepared as capsule, tablet, granule or pill.
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| CN106109535A (en) * | 2016-06-28 | 2016-11-16 | 张标 | A kind of Lepidinm meyenii Walp ginseng and pilose antle health product of resisting fatigue |
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| CN106109535A (en) * | 2016-06-28 | 2016-11-16 | 张标 | A kind of Lepidinm meyenii Walp ginseng and pilose antle health product of resisting fatigue |
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