CN104547855A - Application of tonifying and nourishing pill in preparation of medicine for treating amnesia - Google Patents
Application of tonifying and nourishing pill in preparation of medicine for treating amnesia Download PDFInfo
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- CN104547855A CN104547855A CN201410793727.XA CN201410793727A CN104547855A CN 104547855 A CN104547855 A CN 104547855A CN 201410793727 A CN201410793727 A CN 201410793727A CN 104547855 A CN104547855 A CN 104547855A
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Abstract
The invention belongs to the technical field of medicines, relates to novel application of Chinese patent medicines, and particularly relates to application of a tonifying and nourishing pill in preparation of a medicine for treating amnesia. According to the formula and preparation method of the tonifying and nourishing pill, the pill is prepared by the following steps: grinding the following eighteen components into fine powder: ginseng, rhizoma atractylodis macrocephalae (stir-baked with bran), poria cocos, licorice root, semen lablab album (peeled), Chinese yam, fructus crataegi cuneatae (roasted), medicated leaven (stir-baked with bran), malt, lotus seed, coix seed (stir-baked with bran), semen euryales (stir-baked with bran), rhizoma alismatis, fructus amomi rotundus, exocarpium citrus grandis, pogostemon cablin, platycodon grandiflorum and coptis chinensis; screening, and uniformly mixing. A big honeyed pill is prepared from 100g of powder and 130-140g of refined honey. The pill has the effects of nourishing yin, tonifying qi and regulating spleen and stomach. Discovery proves that the pill can be used for treating amnesia when being orally taken.
Description
Technical field
The invention belongs to medical art, relate to a kind of novelty teabag of Chinese patent medicine, be specifically related to the application of the raw ball of tonification money in preparation treatment amnesia medicine.
Background technology
Old amnesia is normal many with dizzy, poor, cardio palmus shape of sleeping, more common clinically, as treated not in time, easily develops into alzheimer disease.
At present, the medicine being used for the treatment of amnesia medicine is not yet had to come out.
The raw ball (traditional Chinese medicines accurate word Z11021030) of tonification money is the exclusive product of Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd.Also there is no the report of its treatment amnesia at present.
Summary of the invention
Goal of the invention: the object of the present invention is to provide tonification to provide the application of raw ball in preparation treatment amnesia medicine.
Technical scheme: the application of the raw ball of tonification money in preparation treatment amnesia medicine.
Prescription and the preparation method of the raw ball of tonification money are: Radix Ginseng 384g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 384g, Poria 192g, Radix Glycyrrhizae 60g, Semen Lablab Album (peeling) 120g, Rhizoma Dioscoreae 192g, Fructus Crataegi cuneatae (stir-fry) 240g, Massa Medicata Fermentata (parched with bran) 240g, Fructus Hordei Germinatus 192g, Semen Nelumbinis 120g, Semen Coicis (parched with bran) 384g, Semen Euryales (parched with bran) 192g, Rhizoma Alismatis 42g, Fructus Amomi Rotundus 42g, Exocarpium Citri Grandis 240g Herba Pogostemonis 60g, Radix Platycodonis 60g, Rhizoma Coptidis 42g.Above 18 tastes, are ground into fine powder, sieve, mixing.Every 100g powder adds refined honey 130 ~ 140g and makes big honeyed pills, to obtain final product.Its standard is recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China " Traditional Chinese medicine historical preparation (the 7th), standard No. WS3-B-1348-93.This medicine has YIN nourishing and QI supplementing, takes good care of taste.For weakness of the spleen and stomach cause uncomfortable in chest feel sick, inappetence tired mind, diarrhea with loose stool.Now find that it orally can treat amnesia.
Beneficial effect: the raw pill for curing amnesia of tonification money, respond well.
Amnesia etiology and pathogenesis is complicated, comprehensive successive dynasties document and modern clinical research, and we think that this sick position is at brain, the closest with kidney, heart relation.Most deficiency in origin and excess in superficiality, deficiency in origin is mainly deficiency of kidney essence, and causes disarmony between the heart and kidney, and heart and brain lose supports, and mark is real is expectorant turbid congestion impatency brain key, dysfunction of the mind and be forgetful." Lei Zheng Zhi Cai " proposes: " the refreshing residence of madam is in the heart; the essence of the heart depends on kidney; and the brain being the house of mentality; the sea of marrow, real memory institute with also " the kidney generating marrow and dominating bone, the brain being the reservoir of the marrow, marrow in brain is by the life of essence in kidney instituteization, the prosperity and decline of essence in kidney is directly connected to the profit and loss of brains and the normal performance of brain function, therefore memory is attributed to brain, and supports as at all with kidney essense.People's old renal failure marrow is its basic natural law less, ponders over accumulating in the course of time if be added with, and requires mental skill and spends time and energy excessively; Weak and sickly, obstinate disease; Do not know to conserve one's health, intemperate sexual intercourse more secretly can consume essence and blood, and brain god loses and supports, and is forgetful.Old people due to the damage of essence marrow of kidney few, Kidney-Yin insufficiency of kidney-YANG, can not change angry blood, insufficiency of vital energy and blood, and the heart loses and makes moist in replenishing vital QI with drugs of warm nature, and between heart kidney, balance coordination relation is destroyed, thus causes disarmony between the heart and kidney, and refreshing machine apraxia is forgetful without note.Old people's why physical weakness, each function fails, and basic reason is spleen and stomach function diminuendo, and abilities of digestive and absorption is strong, so no matter have a meal or medication, effect is very not good.Weakness of the spleen and stomach, inside has turbid damp, spleen sun is not risen, transporting reduced capability, and the ability of transferring of the evaporating of kidney qi, temper wastes away, and the poly-and raw expectorant of liquid, stops and be drink, forming expectorant turbid, the turbid upper criminal's head of expectorant, hoodwinking sun clearly, and sees the slow-witted disease such as blunt, forgetful, dizzy.Phlegm retention turbid damp stops in body, hinders the normal circulation of QI and blood, makes blood vessels stagnate and be congestion.In addition, old function goes down, and QI-blood circulation is not normal, and in congestion, life hinders in heart and brain, all can lose to gods and support, sudden inspiration apraxia.
The spleen and the stomach are interior-exteriorly related, and spleen is raw turbid damp easily, and insufficiency of stomach easily makes food stagnation, therefore controls middle void except invigorating spleen and reinforcing stomach, must damp eliminatingization turbid, consumer product dredge stasis, whetting appetite, many methods use, soup, ball slow-readjustment, can receive merit.The raw ball of money implements the model of above thought just, Gai Fangcan, art, Siberian cocklebur, Rhizoma Dioscoreae, Semen Lablab Album invigorating spleen and reinforcing stomach, and Semen Euryales, Semen Coicis, Fructus Amomi Rotundus, Herba Pogostemonis, Rhizoma Coptidis, Rhizoma Alismatis are turbid with damp eliminatingization, comprise damp eliminating three method of sweet light eliminating dampness by diuresis, dispelling the damp pathogen with drugs of bitter in taste and cold in nature, removing dampness by means of aromatics.Because of " insufficiency of the spleen resulting in production of dampness " damp eliminating therefore spleen invigorating must be held concurrently, the medicine of the wonderful full fragrance in side that damp eliminatingization is turbid, because of " damp being a kind of YIN pathogen, non-Wen Buhua ", in the side of being, Fructus Amomi Rotundus, Herba Pogostemonis leaf removing dampness by means of aromatics, spleen invigorating help fortune two to arrogate to oneself its merit, indispensable.Fructus Hordei Germinatus, Fructus Crataegi, Pericarpium Citri Reticulatae eliminate food stagnation, and hold concurrently with whetting appetite, so, taste are strong, wet removing food stagnancy, and diet increases, then the strong fortune in Central Region, and the day after tomorrow must support, hale and hearty, and all diseases fade.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
The clinical data of the raw pill for curing amnesia of tonification money
Clinical medicine: the raw ball of tonification money, (being produced by Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd).
1 clinical data
1.1 case selection standards
1.1.l inclusive criteria: traditional Chinese medical science inclusive criteria, with reference to Shanghai science tech publishing house " practical Chinese Internal Medicine " " forgetful " one joint in 1984, selects " amnesia " Syndrome Diagnostic to select syndrome of disharmony between heart and kidney.
Doctor trained in Western medicine receives American Psychiatric Association's " mental disorder diagnostic & statistical manual " DSM-IV standard that people's standard is formally announced with reference to WHO, determines dysmnesia.
Selector close state diagnosis have dysmnesia symptom person, the age, schooling was more than elementary age level at 40 ~ 75 years old, and main suit's memory continues obviously to decline more than 6 months persons.Measure memory quotient MQ value according to Wechsler Memory Scale (WMS), memory is detected as hypomnesis person, 75≤MQ≤100.
1.1.2 exclusion standard: take Chinese and Western nootropics person in 1 month and in therapeutic process before the treatment; By the diseases such as dementia, depression cause memory dysfunction person, dull-witted exclusive method MMSE scale, depression exclusive method Zung scale.
1.2 physical data
The 60 routine objects of observation, man 33 example, female 27 example, 50.2 years old mean age.By randomly assigne, tonification is divided into provide raw pill for curing group 30 example, aniracetam matched group 30 example.Two groups of there are no significant in sex, age, the course of disease, the state of an illness, schooling etc. differences, have comparability.
2 research methoies
2.1 Therapeutic Method
Test by randomized, double-blind double dummy technique.Raw ball 2 ball for the treatment of group oral tonification money/time, 3 times/d; Give starch capsule (packing similar to Aniracetami Capsule), 2 tablets/time, 3 times/d simultaneously.The oral Aniracetami Capsule of matched group, 2 tablets/time, 3 times/d; Give starch capsule (it is identical that packaging and tonification provide raw ball), 3 tablets/time, 3 times/d simultaneously.45d was 1 course for the treatment of, 1 course for the treatment of of medication.
2.2 efficacy evaluation
2.2.1 Efficacy of Traditional Chinese Medicine evaluation: according to tcm syndrome, the feature of disarmony between the heart and kidney amnesia main clinic symptoms, determines that tcm symptom evaluation is scored.Primary symptom (forgetful without note, waist soreness) is designated as 0 point, 2 points, 4 points, 6 points respectively, secondary disease (dizzy, sleep less, dreaminess, uncomfortable in chest indigestion and loss of appetite) is designated as 0 point, 1 point, 2 points, 3 points respectively, tongue arteries and veins (the few tongue of red tongue or pale tongue with white fur greasy, thready and rapid pulse or stringy and rolling pulse) by with or without being designated as 1 point, 0 point respectively.
Adopt nimodipine method: integration × 100% before curative effect percent=(before treatment the rear integration of integration-treatment)/treatment.Effective: curative effect percent >=50%, effectively: 20%≤curative effect percent < 50%, invalid: curative effect percent < 20%.
2.2.2 doctor trained in Western medicine efficacy evaluation: with MQ increment before and after patient for foundation.Effective: MQ rises in value > 16 points; Effective: 8 points of < MQ rise in value≤16 points; Invalid: MQ increment≤8 points.
2.2.3 general curative effect evaluation: to the west of medical treatment effect be assessed as general curative effect evaluating basis.
3 results
3.1 comprehensive therapeutic effect the results are shown in Table 1.Comprehensive therapeutic effect analysis (example) before and after table 1 medication
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate/% |
| Treatment group | 30 | 9 | 9 | 12 | 60.0 |
| Matched group | 30 | 10 | 8 | 12 | 60.0 |
Note: analyze P>0.05 through Ridit
3.2 tcm symptom efficacy results are in table 2.
Tcm symptom efficacy analysis (example) before and after table 2 medication
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate/% |
| Treatment group | 30 | 3 | 21 | 6 | 80.0 |
| Matched group | 30 | 2 | 16 | 12 | 60.0 |
Note: analyze P>0.05 through Ridit
3.3 TCM symptom score situations of change the results are shown in Table 3.
TCM symptom score situation of change (x ± s) before and after table 3 medication
| Group | Number of cases | Before treatment | After treatment | Integration differential |
| Treatment group | 30 | 13.9±3.5 | 9.9±3.5** | 4.0±2.6 |
| Matched group | 30 | 14.1±4.1 | 10.7±3.4** | 3.3±2.4 |
Note: compare * * P<0.01 with before treatment
3.4 memory quotient (MQ value) situation of change the results are shown in Table 4.
Memory quotient (MQ value) situation of change (x ± s) before and after table 4 medication
| Group | Number of cases | Before treatment | After treatment | Integration differential |
| Treatment group | 30 | 88.5±9.6 | 99.8±19.5** | 11.2±13.1 |
| Matched group | 30 | 90.7±8.2 | 101.6±16.3** | 10.4±10.0 |
Note: compare * * P<0.01 with before treatment
4. untoward reaction
The raw pill for curing group of tonification money has no untoward reaction, and 29 example reaction appetites increase, and spiritual head takes a turn for the better.
There is xerostomia in aniracetam matched group 5 example, anorexia appears in 2 examples, and constipation appears in 6 examples, and 1 example occurs dizzy, and 1 example occurs drowsiness.
Claims (1)
1. the application of the raw ball of tonification money in preparation treatment amnesia medicine, it is characterized in that, prescription and the preparation method of the raw ball of described tonification money are: Radix Ginseng 384g, Rhizoma Atractylodis Macrocephalae 384g, Poria 192g, Radix Glycyrrhizae 60g, Semen Lablab Album 120g, Rhizoma Dioscoreae 192g, Fructus Crataegi cuneatae 240g, Massa Medicata Fermentata 240g, Fructus Hordei Germinatus 192g, Semen Nelumbinis 120g, Semen Coicis 384g, Semen Euryales 192g, Rhizoma Alismatis 42g, Fructus Amomi Rotundus 42g, Exocarpium Citri Grandis 240g Herba Pogostemonis 60g, Radix Platycodonis 60g, Rhizoma Coptidis 42g, above 18 tastes, be ground into fine powder, sieve, mixing, every 100g powder adds refined honey 130 ~ 140g and makes big honeyed pills, obtain.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929538A (en) * | 2017-12-26 | 2018-04-20 | 广西壮要方医院有限公司 | A kind of medicine for treating amnesia |
| CN107929537A (en) * | 2017-12-25 | 2018-04-20 | 广西壮要方医院有限公司 | A kind of medicine for treating amnesia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100261464B1 (en) * | 1997-12-01 | 2000-07-01 | 박태식 | Preparing method of tea |
| CN101352552A (en) * | 2008-08-01 | 2009-01-28 | 方云朝 | Capsules for promoting children's intelligence, growth and development |
-
2014
- 2014-12-20 CN CN201410793727.XA patent/CN104547855A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100261464B1 (en) * | 1997-12-01 | 2000-07-01 | 박태식 | Preparing method of tea |
| CN101352552A (en) * | 2008-08-01 | 2009-01-28 | 方云朝 | Capsules for promoting children's intelligence, growth and development |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部: "补益资生丸", 《《中华人民共和国卫生部药品标准》中药成方制剂》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929537A (en) * | 2017-12-25 | 2018-04-20 | 广西壮要方医院有限公司 | A kind of medicine for treating amnesia |
| CN107929538A (en) * | 2017-12-26 | 2018-04-20 | 广西壮要方医院有限公司 | A kind of medicine for treating amnesia |
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Application publication date: 20150429 |
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